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High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain
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Abstract Introduction Excessive mechanical loading of intervertebral discs
(IVDs) is thought to alter matrix properties and influence disc cell metabolism,
contributing to degenerative disc disease and development of discogenic pain.
However, little is known about how mechanical strain induces these changes. This
study investigated the cellular and molecular changes as well as which
inflammatory r...