Unique primed status of microglia under the systemic autoimmune condition of lupus-prone miceSpringer Science and Business Media LLC - Tập 21 - Trang 1-17 - 2019
Atsushi Nomura, Daisuke Noto, Goh Murayama, Asako Chiba, Sachiko Miyake
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of various autoantibodies. This disease causes disabling neuropsychiatric symptoms even in the absence of apparent inflammation in the central nervous system (CNS), but the mechanisms involved remain unknown. Innate immune-mediated inflammation has attracted attention as a pathogenic mechanism in neuropsych...... hiện toàn bộ
Autoantibodies directed to novel components of the PM/Scl complex, the human exosomeSpringer Science and Business Media LLC - Tập 4 - Trang 1-5 - 2001
Rick Brouwer, Wilma TM Vree Egberts, Gerald JD Hengstman, Reinout Raijmakers, Baziel GM van Engelen, Hans Peter Seelig, Manfred Renz, Rudolf Mierau, Ekkehard Genth, Ger JM Pruijn, Walther J van Venrooij
The autoantigenic polymyositis/scleroderma (PM/Scl) complex was recently shown to be the human homologue of the yeast exosome, which is an RNA-processing complex. Our aim was to assess whether, in addition to targeting the known autoantigens PM/Scl-100 and PM/Scl-75, autoantibodies also target recently identified components of the PM/Scl complex. The prevalence of autoantibodies directed to six no...... hiện toàn bộ
IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritisSpringer Science and Business Media LLC - Tập 3 - Trang 1-10 - 2001
Martine Chabaud, Erik Lubberts, Leo Joosten, Wim van den Berg, Pierre Miossec
The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo models, addition of IL-17 enhanced IL-6 production and collagen destruction, and inhibited collagen synthesis by RA synovium explants. On mouse cartilage, IL-17 enhanced cartilage proteoglycan loss and inhibited its synthesis. On human...... hiện toàn bộ
The association between ANKH promoter polymorphism and chondrocalcinosis is independent of age and osteoarthritis: results of a case–control studySpringer Science and Business Media LLC - Tập 16 - Trang 1-7 - 2014
Abhishek Abhishek, Sally Doherty, Rose Maciewicz, Kenneth Muir, Weiya Zhang, Michael Doherty, Anna M Valdes
Chondrocalcinosis (CC) most commonly results from calcium pyrophosphate crystal deposition (CPPD). The objective of this study is to examine the association between candidate single-nucleotide polymorphisms (SNPs) and radiographic CC. SNPs in ankylosis human (ANKH), high ferritin (HFE), tissue non-specific alkaline phosphatase (TNAP), ecto-neucleotide pyrophosphatase 1 (ENPP1), and transferrin (TE...... hiện toàn bộ
Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltrationSpringer Science and Business Media LLC - Tập 23 - Trang 1-16 - 2021
Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Tannin A. Schmidt, Jennifer Totonchy, Khaled A. Elsaid
Synovial macrophages perform a multitude of functions that include clearance of cell debris and foreign bodies, tissue immune surveillance, and resolution of inflammation. The functional diversity of macrophages is enabled by distinct subpopulations that express unique surface markers. Proteoglycan-4 (PRG4) is an important regulator of synovial hyperplasia and fibrotic remodeling, and the involvem...... hiện toàn bộ
Treatment modalities and drug survival in a systemic sclerosis real-life patient cohortSpringer Science and Business Media LLC - Tập 22 - Trang 1-8 - 2020
S. Panopoulos, Κ. Chatzidionysiou, M. G. Tektonidou, V. K. Bournia, A. A. Drosos, Stamatis-Nick C. Liossis, T. Dimitroulas, L. Sakkas, D. Boumpas, P. V. Voulgari, D. Daoussis, K. Thomas, G. Georgiopoulos, G. Vosvotekas, Α. Garyfallos, P. Sidiropoulos, G. Bertsias, D. Vassilopoulos, P. P. Sfikakis
European data indicate that systemic sclerosis (SSc)-related death rates are increasing, thus raising concerns about SSc’s optimal management. Herein, we describe current treatment modalities and drug survival in a real-life SSc cohort. Details on immunosuppressive/antiproliferative (methotrexate, mycophenolate, cyclophosphamide, azathioprine, rituximab, tocilizumab) and vasoactive agent [(endothe...... hiện toàn bộ