Springer Science and Business Media LLC
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Unique primed status of microglia under the systemic autoimmune condition of lupus-prone mice
Springer Science and Business Media LLC - Tập 21 - Trang 1-17 - 2019
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the
production of various autoantibodies. This disease causes disabling
neuropsychiatric symptoms even in the absence of apparent inflammation in the
central nervous system (CNS), but the mechanisms involved remain unknown. Innate
immune-mediated inflammation has attracted attention as a pathogenic mechanism
in neuropsych...
Autoantibodies directed to novel components of the PM/Scl complex, the human exosome
Springer Science and Business Media LLC - Tập 4 - Trang 1-5 - 2001
The autoantigenic polymyositis/scleroderma (PM/Scl) complex was recently shown
to be the human homologue of the yeast exosome, which is an RNA-processing
complex. Our aim was to assess whether, in addition to targeting the known
autoantigens PM/Scl-100 and PM/Scl-75, autoantibodies also target recently
identified components of the PM/Scl complex. The prevalence of autoantibodies
directed to six no...
Correction to: Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration
Springer Science and Business Media LLC - Tập 23 Số 1 - 2021
An amendment to this paper has been published and can be accessed via the
original article.
IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
Springer Science and Business Media LLC - Tập 3 - Trang 1-10 - 2001
The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone
destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex
vivo models, addition of IL-17 enhanced IL-6 production and collagen
destruction, and inhibited collagen synthesis by RA synovium explants. On mouse
cartilage, IL-17 enhanced cartilage proteoglycan loss and inhibited its
synthesis. On human...
Immune complex stimulation of peripheral blood mononuclear cells result in enhancement of suppression of IL-12 production dependent on soluble serum factors
Springer Science and Business Media LLC - - 2001
The association between ANKH promoter polymorphism and chondrocalcinosis is independent of age and osteoarthritis: results of a case–control study
Springer Science and Business Media LLC - Tập 16 - Trang 1-7 - 2014
Chondrocalcinosis (CC) most commonly results from calcium pyrophosphate crystal
deposition (CPPD). The objective of this study is to examine the association
between candidate single-nucleotide polymorphisms (SNPs) and radiographic CC.
SNPs in ankylosis human (ANKH), high ferritin (HFE), tissue non-specific
alkaline phosphatase (TNAP), ecto-neucleotide pyrophosphatase 1 (ENPP1), and
transferrin (TE...
Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration
Springer Science and Business Media LLC - Tập 23 - Trang 1-16 - 2021
Synovial macrophages perform a multitude of functions that include clearance of
cell debris and foreign bodies, tissue immune surveillance, and resolution of
inflammation. The functional diversity of macrophages is enabled by distinct
subpopulations that express unique surface markers. Proteoglycan-4 (PRG4) is an
important regulator of synovial hyperplasia and fibrotic remodeling, and the
involvem...
Treatment modalities and drug survival in a systemic sclerosis real-life patient cohort
Springer Science and Business Media LLC - Tập 22 - Trang 1-8 - 2020
European data indicate that systemic sclerosis (SSc)-related death rates are
increasing, thus raising concerns about SSc’s optimal management. Herein, we
describe current treatment modalities and drug survival in a real-life SSc
cohort. Details on immunosuppressive/antiproliferative (methotrexate,
mycophenolate, cyclophosphamide, azathioprine, rituximab, tocilizumab) and
vasoactive agent [(endothe...
Development of a convolutional neural network for the identification and the measurement of the median nerve on ultrasound images acquired at carpal tunnel level
Springer Science and Business Media LLC - Tập 24 - Trang 1-8 - 2022
Deep learning applied to ultrasound (US) can provide a feedback to the
sonographer about the correct identification of scanned tissues and allows for
faster and standardized measurements. The most frequently adopted parameter for
US diagnosis of carpal tunnel syndrome is the increasing of the cross-sectional
area (CSA) of the median nerve. Our aim was to develop a deep learning
algorithm, relying ...
MRI evidence of structural changes in the sacroiliac joints of patients with non-radiographic axial spondyloarthritis even in the absence of MRI inflammation
Springer Science and Business Media LLC - Tập 19 - Trang 1-10 - 2017
Studies have shown that structural lesions may be present in patients with
non-radiographic axial spondyloarthritis (nr-axSpA). However, the relevance of
structural lesions in these patients is unclear, particularly without signs of
inflammation on magnetic resonance imaging (MRI). We assessed the presence of
structural lesions at baseline on MRI in the sacroiliac joints (SIJ) of patients
with nr-...
Tổng số: 2,225
- 1
- 2
- 3
- 4
- 5
- 6
- 10