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Autoantibodies directed to novel components of the PM/Scl complex, the human exosome
Springer Science and Business Media LLC - Tập 4 - Trang 1-5 - 2001
The autoantigenic polymyositis/scleroderma (PM/Scl) complex was recently shown to be the human homologue of the yeast exosome, which is an RNA-processing complex. Our aim was to assess whether, in addition to targeting the known autoantigens PM/Scl-100 and PM/Scl-75, autoantibodies also target recently identified components of the PM/Scl complex. The prevalence of autoantibodies directed to six no......
IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
Springer Science and Business Media LLC - Tập 3 - Trang 1-10 - 2001
The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo models, addition of IL-17 enhanced IL-6 production and collagen destruction, and inhibited collagen synthesis by RA synovium explants. On mouse cartilage, IL-17 enhanced cartilage proteoglycan loss and inhibited its synthesis. On human......
Development of a convolutional neural network for the identification and the measurement of the median nerve on ultrasound images acquired at carpal tunnel level
Springer Science and Business Media LLC - Tập 24 - Trang 1-8 - 2022
Deep learning applied to ultrasound (US) can provide a feedback to the sonographer about the correct identification of scanned tissues and allows for faster and standardized measurements. The most frequently adopted parameter for US diagnosis of carpal tunnel syndrome is the increasing of the cross-sectional area (CSA) of the median nerve. Our aim was to develop a deep learning algorithm, relying ......
MRI evidence of structural changes in the sacroiliac joints of patients with non-radiographic axial spondyloarthritis even in the absence of MRI inflammation
Springer Science and Business Media LLC - Tập 19 - Trang 1-10 - 2017
Studies have shown that structural lesions may be present in patients with non-radiographic axial spondyloarthritis (nr-axSpA). However, the relevance of structural lesions in these patients is unclear, particularly without signs of inflammation on magnetic resonance imaging (MRI). We assessed the presence of structural lesions at baseline on MRI in the sacroiliac joints (SIJ) of patients with nr-......
Does persistence to methotrexate treatment in early rheumatoid arthritis have a familial component?
Springer Science and Business Media LLC - Tập 24 - Trang 1-9 - 2022
To assess whether persistence to treatment with methotrexate (MTX) in early rheumatoid arthritis (RA) is shared among first-degree relatives with RA and to estimate any underlying heritability. First-degree relative pairs diagnosed with RA 1999–2018 and starting MTX (in monotherapy) as their first disease-modifying anti-rheumatic drug (DMARD) treatment were identified by linking the Swedish Rheuma......
Notochordal cell conditioned medium (NCCM) regenerates end-stage human osteoarthritic articular chondrocytes and promotes a healthy phenotype
Springer Science and Business Media LLC - Tập 18 - Trang 1-11 - 2016
Notochordal cell conditioned medium (NCCM) derived from non-chondrodystrophic dogs has pro-anabolic and anti-catabolic effects upon nucleus pulposus (NP) cells. Here, for the first time, we assessed the ability of NCCM to influence the production of extracellular matrix and inflammatory proteins by healthy and osteoarthritic human chondrocytes within engineered cartilage tissues. We hypothesized t......
From perinuclear factor to citrulline, a target structure for autoantibodies in rheumatoid arthritis
Springer Science and Business Media LLC - Tập 3 - Trang 1-2 - 2001
Effect of resistance exercise on serum leptin levels in a prospective longitudinal study of women patients with rheumatoid arthritis
Springer Science and Business Media LLC - - 2022
Exercise has an anti-inflammatory effect and reduces fat mass. Leptin has been known to be proinflammatory adipokines mainly produced by adipocytes. However, few studies have investigated the association between exercise and changes in serum leptin levels of patients with RA. This study evaluated the effect of an individualized resistance exercise on inflammatory markers including leptin as well a......
Neutrophil activation identifies patients with active polyarticular gout
Springer Science and Business Media LLC - Tập 22 - Trang 1-6 - 2020
Gout is the most prevalent inflammatory arthritis in developed countries. A gout flare is mediated by phagocytosis of monosodium urate crystals by macrophages and neutrophils leading to subsequent activation of neutrophils contributing to synovitis, local joint destruction, and systemic inflammation. We hypothesize that biomarkers from activated neutrophils reflect gout disease activity. The objec......
Ultrasound assessment of skin thickness and stiffness: the correlation with histology and clinical score in systemic sclerosis
Springer Science and Business Media LLC - Tập 22 - Trang 1-8 - 2020
Ultrasound is a useful tool to evaluate and quantify skin lesions. Few studies have assessed the criterion validity of skin ultrasound in systemic sclerosis (SSc). The aims of the study were to investigate skin thickness and stiffness using ultrasound and shear wave elastography (SWE) in SSc and to validate skin ultrasound measurements against histological skin thickness. A total of 22 patients wi......
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