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Alefacept treatment in psoriatic arthritis: reduction of the synovial inflammatory infiltrate and improvement of clinical signs of arthritis
Springer Science and Business Media LLC - Tập 4 - Trang 1-38 - 2002
MC Kraan, HJ Dinant, AWR van Kuijk, AY Goedkoop, TJM Smeets, MA de Rie, BAC Dijkmans, AK Vaishnaw, PP Tak
Mast Cells and the Rheumatoid Lesion
Springer Science and Business Media LLC - Tập 1 - Trang 1-24 - 1999
David E Woolley, Lynne C Tetlow
Abatacept in rheumatoid arthritis: survival on drug, clinical outcomes, and their predictors—data from a large national quality register
Springer Science and Business Media LLC - Tập 22 - Trang 1-11 - 2020
Giovanni Cagnotto, Minna Willim, Jan-Åke Nilsson, Michele Compagno, Lennart T. H. Jacobsson, Saedis Saevarsdottir, Carl Turesson
There are limited data regarding efficacy of abatacept treatment for rheumatoid arthritis (RA) outside clinical trials. Quality registers have been useful for observational studies on tumor necrosis factor inhibition in clinical practice. The aim of this study was to investigate clinical efficacy and tolerability of abatacept in RA, using a national register. RA patients that started abatacept bet...... hiện toàn bộ
Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis
Springer Science and Business Media LLC - Tập 18 - Trang 1-14 - 2016
Samuel Garcia, Linda M. Hartkamp, B Malvar-Fernandez, Inge E. van Es, Haishan Lin, Justin Wong, Li Long, James A. Zanghi, Andrew L. Rankin, Emma L. Masteller, Brian R. Wong, Timothy R. D. J. Radstake, Paul P. Tak, Kris A. Reedquist
CSF-1 or IL-34 stimulation of CSF1R promotes macrophage differentiation, activation and osteoclastogenesis, and pharmacological inhibition of CSF1R is beneficial in animal models of arthritis. The objective of this study was to determine the relative contributions of CSF-1 and IL-34 signaling to CSF1R in RA. CSF-1 and IL-34 were detected by immunohistochemical and digital image analysis in synovia...... hiện toàn bộ
Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation
Springer Science and Business Media LLC - Tập 12 - Trang 1-9 - 2010
Angus KT Wann, Jiten Mistry, Emma J Blain, Adina T Michael-Titus, Martin M Knight
In inflammatory joint disease, such as osteoarthritis (OA), there is an increased level of proinflammatory cytokines, such as interleukin (IL)-1β. These cytokines stimulate the production of matrix metalloproteinases (MMPs), which leads to the degradation of the cartilage extracellular matrix and the loss of key structural components such as sulphated glycosaminoglycan (sGAG) and collagen II. The ...... hiện toàn bộ
Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and systemic lupus erythematosus
Springer Science and Business Media LLC - Tập 16 Số 1 - Trang 1-11 - 2014
Hanlon, Peter, Avenell, Alison, Aucott, Lorna, Vickers, Mark A
Infection with Epstein-Barr virus (EBV) has been suggested to contribute to the pathogenesis of systemic lupus erythematosus (SLE). We sought to determine whether prior infection with the virus occurs more frequently in patients with SLE compared to matched controls. We performed a systematic review and meta-analyses of studies that reported the prevalence of anti-EBV antibodies in the sera from c...... hiện toàn bộ
Polydatin effectively attenuates disease activity in lupus-prone mouse models by blocking ROS-mediated NET formation
Springer Science and Business Media LLC - Tập 20 - Trang 1-11 - 2018
Pan Liao, Yi He, Fangyuan Yang, Guihu Luo, Jian Zhuang, Zeqing Zhai, Lili Zhuang, Zhuomiao Lin, Jiehuang Zheng, Erwei Sun
Neutrophil extracellular trap (NET) formation has been described to be closely involved in the pathogenesis of systemic lupus erythematosus (SLE). In this study, we aimed to investigate the effect of polydatin (PD) on NET formation and its effects on disease activity in lupus-prone mouse models. In vitro, neutrophils from SLE patients and healthy people stimulated with phorbol 12-myristate 13-acet...... hiện toàn bộ
Implementation of automated behavior metrics to evaluate voluntary wheel running effects on inflammatory-erosive arthritis and interstitial lung disease in TNF-Tg mice
Springer Science and Business Media LLC -
H. Mark Kenney, Ronald W. Wood, G. Ramı́rez, Richard D. Bell, Kiana L. Chen, Lindsay Schnur, Homaira Rahimi, Benjamin Korman, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz, Calvin Cole
Abstract Background Although treatment options and algorithms for rheumatoid arthritis (RA) have improved remarkably in recent decades, there continues to be no definitive cure or pharmacologic intervention with reliable long-term efficacy. For this reason, the combination of medications and healthy...... hiện toàn bộ
Granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-α in combination is a useful diagnostic biomarker to distinguish familial Mediterranean fever from sepsis
Springer Science and Business Media LLC - Tập 23 - Trang 1-9 - 2021
Tomohiro Koga, Kaori Furukawa, Kiyoshi Migita, Shimpei Morimoto, Toshimasa Shimizu, Shoichi Fukui, Masataka Umeda, Yushiro Endo, Remi Sumiyoshi, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Tomoki Origuchi, Takahiro Maeda, Akihiro Yachie, Atsushi Kawakami
To identify potential biomarkers to distinguish familial Mediterranean fever (FMF) from sepsis. We recruited 28 patients diagnosed with typical FMF (according to the Tel Hashomer criteria), 22 patients with sepsis, and 118 age-matched controls. Serum levels of 40 cytokines were analyzed using multi-suspension cytokine array. We performed a cluster analysis of each cytokine in the FMF and sepsis gr...... hiện toàn bộ
Assessing the effect of interventions for axial spondyloarthritis according to the endorsed ASAS/OMERACT core outcome set: a meta-research study of trials included in Cochrane reviews
Springer Science and Business Media LLC - Tập 22 - Trang 1-16 - 2020
Rikke A. Andreasen, Lars E. Kristensen, Xenofon Baraliakos, Vibeke Strand, Philip J. Mease, Maarten de Wit, Torkell Ellingsen, Inger Marie J. Hansen, Jamie Kirkham, George A. Wells, Peter Tugwell, Lara Maxwell, Maarten Boers, Kenneth Egstrup, Robin Christensen
The Assessment of SpondyloArthritis international Society (ASAS) has defined core sets for (i) symptom-modifying anti-rheumatic drugs (SM-ARD), (ii) clinical record keeping, and (iii) disease-controlling anti-rheumatic therapy (DC-ART). These include the following domains for all three core sets: “physical function,” “pain,” “spinal mobility,” “spinal stiffness,” and “patient’s global assessment” ...... hiện toàn bộ
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