Cell Motility and Cytoskeletal Regulation in Invasion and Metastasis

Journal of Mammary Gland Biology and Neoplasia - Tập 12 - Trang 143-152 - 2007
Dmitriy Kedrin1, Jacco van Rheenen1, Lorena Hernandez1, John Condeelis1,2, Jeffrey E. Segall1
1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, USA
2Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, USA

Tóm tắt

Cell motility and chemotaxis can make important contributions to the metastatic cascade. Cell migration pathways in general play significant roles in a variety of physiological processes that can be “hijacked” by cancer cells. Both growth factors and chemokines provide important chemotactic signals in development and metastasis. Receptor activation, following binding of a growth factor or a chemokine, leads to dynamic morphological changes in the actin cytoskeleton network via a variety of distinct and interconnected pathways, resulting in translocation of the cell up a chemoattractant gradient. Such gradients may be produced by stromal cells in the local microenvironment, including macrophages and fibroblasts. A better understanding of the mechanisms of cell motility and cytoskeletal regulation may provide novel therapeutic strategies that would block metastatic progression, reducing dissemination of tumor cells and increasing patient survival.

Tài liệu tham khảo

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