Cardiovascular Disease and Risk Factors among Psoriasis Patients in Two US Healthcare Databases, 2001–2002

Dermatology - Tập 217 Số 1 - Trang 27-37 - 2008
Alexa B. Kimball1, Don Robinson2, Ying Wu2, Cynthia Guzzo3, Newman Yeilding3, Clark Paramore4, Kathy Fraeman4, M Bala2
1Harvard Medical School, Boston, Mass
2Johnson & Johnson Pharmaceutical Services, and
3Centocor Research and Development, Centocor, Inc., Malvern, Pa.
4United BioSource Corp (UBC), Bethesda, Md., USA

Tóm tắt

<i>Background:</i> Cardiovascular diseases or risk factors (CVDR) seem to be more common in psoriasis patients than in the general population. <i>Objective:</i> We assessed the relationship of psoriasis with CVDR by analysis of healthcare claims data using a cross-sectional, prevalence-based study design. <i>Patients and Methods:</i> The IMS Health and MarketScan® claims databases were used to identify adults with psoriasis diagnostic codes. Non-psoriasis controls were matched 3:1 based on age, gender, census region and previous medical insurance coverage. Odds ratios evaluated the relative prevalence of CVDR, and Mantel-Haenszel confidence intervals were estimated. <i>Results:</i> CVDR prevalence was generally higher in psoriasis patients than controls in both datasets. Odds ratios for atherosclerosis, congestive heart failure, type 2 diabetes, and peripheral vascular disease were ≧1.20 for psoriasis patients. Elevated disease severity was associated with a higher rate of CVDR, but varied somewhat by dataset and condition. <i>Conclusions:</i> Elevated CVDR rates were found in psoriasis patients compared with controls. This pattern merits further examination.

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Dermatology

Tập 217 Số 1

27-37

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