Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Genetics in Medicine - Tập 22 Số 1 - Trang 15-25 - 2020
Mev Dominguez‐Valentin1, Julian R. Sampson2, Toni T. Seppälä3, Sanne W. ten Broeke4, John‐Paul Plazzer5, Sigve Nakken1, Christoph Engel6, Stefan Aretz7, Mark A. Jenkins8, Mads Thomassen9, Inge Bernstein10, Mária Judit Molnár11, Francesc Balaguer12, Huw Thomas13, D. Gareth Evans14, John Burn15, Marc S. Greenblatt16, Eivind Hovig1, Wouter H. de Vos tot Nederveen Cappel17, Rolf H. Sijmons18, Lucio Bertario19, Maria Grazia Tibiletti20, Giulia Martina Cavestro21, Annika Lindblom22, Adriana Della Valle23, Francisco López‐Köstner24, Nathan Gluck25, Lior H. Katz26, Karl Heinimann27, Carlos Vaccaro28, Reinhard Büttner29, Heike Görgens30, Elke Holinski‐Feder31, Monika Morak31, Stefanie Holzapfel7, Robert Hüneburg32, Magnus von Knebel Doeberitz33, Markus Loeffler6, Nils Rahner34, J. Han van Krieken30, Verena Steinke‐Lange31, Wolff Schmiegel35, Deepak Vangala35, Kirsi Pylvänäinen36, Laura Renkonen‐Sinisalo3, John L. Hopper8, Aung Ko Win8, Robert W. Haile37, Noralane M. Lindor38, Steven Gallinger39, Loı̈c Le Marchand40, Polly A. Newcomb41, Jane C. Figueiredo42, Stephen N. Thibodeau43, Karin Wadt44, Christina Therkildsen45, Henrik Okkels46, Zohreh Ketabi47, Leticia Moreira12, Ariadna Sánchez12, Miquel Serra‐Burriel48, Marta Pineda49, Katherine L. Nathanson49, Ignacio Blanco49, Kate Green14, Anders Kvist14, Emma J. Crosbie50, James Hill51, Oliver G. Denton2, Ian M. Frayling2, Einar Andreas Rødland1, Johan Hansson52, Emma Tham53, Florencia Neffa23, Patricia Esperón23, Karin Álvarez24, Revital Kariv25, Guy Rosner25, Tamara Alejandra Piñero54, María Laura González28, Pablo Kalfayan28, Douglas Tjandra55, Ingrid Winship55, Finlay Macrae55, Gabriela Möslein56, Jukka‐Pekka Mecklin57, Maartje Nielsen4, Pål Møller58
1Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
2Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK
3Department of Gastrointestinal Surgery, Helsinki University Central Hospital, Helsinki, Finland
4Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
5Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Australia
6Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
7Institute of Human Genetics, University of Bonn, Bonn, Germany
8Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia
9Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark
10Department of Surgical Gastroenterology, Aalborg University Hospital, Aalborg, Denmark
11Hereditary Cancer Program, Institut Catal. d’Oncologia-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain;
12Gastroenterology Department, Hospital Clinic de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
13St Mark’s Hospital, Department of Surgery and Cancer, Imperial College London, London, UK
14Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK
15Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
16University of Vermont College of Medicine, Burlington, VT USA
17Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands
18Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands
19Unit of Hereditary Digestive Tract Tumors IRCCS Istituto Nazionale Tumori and Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
20Ospedale di Circolo ASST Settelaghi, Centro di Ricerca Tumori Eredo-familiari, Università Dell'Insubria, Varese, Italy
21Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy
22Department of Molecular Medicine and Surgery and Department of Clinical Genetics, Karolinska Institutet and University Hospital, Stockholm, Sweden
23Hospital Fuerzas Armadas, Grupo Colaborativo Uruguayo. Investigación de Afecciones Oncológicas Hereditarias (GCU), Montevideo, Uruguay
24Lab. Oncología y Genética Molecular, Unidad de coloproctología, Clínica Las Condes, Santiago, Chile
25Department of Gastroenterology, Tel Aviv Sourasky Medical Centre and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
26High Risk and GI Cancer prevention Clinic, Gastro-Oncology Unit, The Department of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel
27Institute for Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland
28Hereditary Cancer Program (PROCANHE), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
29Institute of Pathology, University of Cologne, Cologne, Germany
30Department of Surgical Research, Technische Universität Dresden, Dresden, Germany
31Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany
32Department of Internal Medicine, University Hospital Bonn, Bonn, Germany
33Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
34Institute of Human Genetics, Medical School, Heinrich-Heine-University, Dusseldorf, Germany
35Department of Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany
36Department of Education and Science, Central Finland Health Care District, Jyväskylä, Finland
37Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University, Palo Alto, CA, USA
38Department of Health Science Research, Mayo Clinic Arizona, Phoenix, AZ, USA
39Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
40University of Hawaii Cancer Center, Honolulu, HI, USA
41Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
42Cedars-Sinai Medical Center, Los Angeles, CA, USA
43Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
44Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark
45The Danish HNPCC Register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark
46Department of Molecular Diagnostics, Aalborg University Hospital, Aalborg, Denmark
47Department of Obstetrics and Gynaecology, Copenhagen University Hospital, Rigshospitalet, Denmark
48Universitat de Barcelona & Centre de Recerca en Economia i Salut (CRES-UPF), Barcelona, Spain
49Hereditary Cancer Program. Institut Català d’Oncologia-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain
50Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester and St Mary’s Hospital, Manchester, UK;
51Department of Surgery, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester, Manchester, UK
52Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands
53Department of Women's and Children's Health, Division of Obstetrics and Gyneacology, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
54Instituto de Medicina Traslacional e Ingenieria Biomedica (IMTIB), CONICET IU, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
55Department of Medicine, Melbourne University, Melbourne, Australia;
56Surgical Center for Hereditary Tumors, HELIOS University Clinic Wuppertal, University of Witten-Hardecke, Wuppertal, Germany
57Departments of Surgery, University of Jyväskylä and Central Finland Central Hospital, Jyväskylä, Finland
58Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway

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Tài liệu tham khảo

Bonadona

Engel

Watson

Vasen

Aarnio

Moller

Moller

Moller

Seppala

Engel

ten Broeke

Senter

Ten Broeke

Ten Broeke

Sjursen

Committee on Practice Bulletins–Gynecology, Society of Gynecologic Oncology.

Roberts

Seppälä

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Thông tin xuất bản

Genetics in Medicine

Tập 22 Số 1

15-25

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