Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects
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Acheson, 1980, Caffeine and coffe: their influence on metabolic rate and substrate utilization in normal weight and obese individuals, Am. J. Clin. Nutr., 33, 989, 10.1093/ajcn/33.5.989
Achor, 1981, Diet aids, maniaand affective illness, Am. J. Psychiatry, 138, 392, 10.1176/ajp.138.3.392a
Aeschbacher, 1975, The effect of caffeine on barbiturate sleeping time and brain level, J. Pharmacol. Exp. Ther., 192, 635
Ahlijanian, 1986, Cross-tolerance between caffeine and (−)-N6-(phenylisopropyl)-adenosine (PIA) in mice, Life Sci., 38, 577, 10.1016/0024-3205(86)90051-2
Akaike, 1989, Caffeine affects four different ionic currents in the bull-frog sympathetic neurone, J. Physiol., 412, 221, 10.1113/jphysiol.1989.sp017612
Alder, 1950, ffect of various drugs on psychomotor performance at ground level and simulated altitudes of 18,000 feet in a low pressure chamber, J. Aviat. Med., 21, 221
Aldridge, 1981, The disposition of caffeine during and after pregnancy, Semin. Perinatol., 5, 310
Alles, 1942, The influence of benzedrine on work decrement and patellar reflex, Am. J. Physiol., 126, 392, 10.1152/ajplegacy.1942.136.3.392
Alleva, 1978, Individual diferences in barbiturate-induced sleeping time in the mouse, Prog. Neuropsychopharmacol., 2, 451, 10.1016/0364-7722(78)90103-0
Alsott, 1973, Report of human fatality due to caffeine, J. Forensic Sci., 18, 135
American Psychiatric Association Task Force On Nomenclature And Statistics, 1987, 138
Ammon, 1984, Neue Aspekte zum Mechanismus der zentral erregenden Wirkung von Coffein, Dtsch. Med. Wschr., 109, 1491, 10.1055/s-2008-1069401
Ando, 1973, Profile of drug effects on temporally spaced responding in rats, Pharmacol. Biochem. Behav., 3, 833, 10.1016/0091-3057(75)90114-8
Aranda, 1977, Efficacy of caffeine in treatment of apnea in the low-birth-weight infant, J. Pediatr., 90, 467, 10.1016/S0022-3476(77)80718-X
Aranda, 1979, Metabolism of theophylline to caffeine by human fetal liver, Science, 206, 1319, 10.1126/science.515734
Aranda, 1979, Methylxanthines in apnea of prematurity, Clin. Perinatol., 6, 87, 10.1016/S0095-5108(18)31165-5
Arnold, 1982, Caffeine stimulates beta-endorphin release in blood but not in cerebrospinal fluid, Life Sci., 31, 1017, 10.1016/0024-3205(82)90174-6
Arnold, 1987, The effects of caffeine, impulsivity and sex on memory for word lists, Physiol. Behav., 41, 25, 10.1016/0031-9384(87)90126-0
Arogyasami, 1989, Effect of caffeine on glycogenolysis during exercice in endurance trained rats, Med. Sci. Sports Exerc., 21, 173
Arushanian, 1978, The effect of amphetamine and caffeine on neuronal activity in the neocortex of the cat, Neuropharmacology, 17, 1, 10.1016/0028-3908(78)90166-1
Ashton, 1974, The effect of caffeine, nitrazepam and cigarette smoking on the contingent negative variation in man, Electroencephalogr. Clin. Neurophystol, 37, 59, 10.1016/0013-4694(74)90245-4
Askew, 1990, Carnitine excretion following exhaustive exercice at sea level and high altitude: influence of caffeine (Abstract), FASEB, 4, A801
Asmussen, 1948, The effect of alcohol and some drugs on the capacity of work, Acta Physiol. Scand., 15, 109, 10.1111/j.1748-1716.1948.tb00488.x
Atkinson, 1976, Self-administration of caffeine by the rat, Arzneimittelforsch., 26, 2059
Atuk, 1967, Effect of aminophylline on urinary excretion of epinephrine and norepinephrine in man, Circulation, 35, 745, 10.1161/01.CIR.35.4.745
Axelrod, 1953, The fate of caffeine in man and a method for its estimation in biological material, J. Pharmacol. Exp. Ther., 107, 519
Ayers, 1976, Alcoholism, cigarette smoking, coffee drinking and extraversion, J. Stu. Alcohol., 37, 983, 10.15288/jsa.1976.37.983
Bachrach, 1966, Note on the psychological effects of caffeine, Psychol. Rep., 18, 86, 10.2466/pr0.1966.18.1.86
Bahls, 1991, Theophylline-associated seizures with ‘therapeutic’ or low toxic serum concentrations: risk factors for serious outcome in adults, Neurology, 41, 1309, 10.1212/WNL.41.8.1309
Balwin, 1989, Caffeine-induced anxiogenesis: the role of adenosine, benzodiazepine and noradrenergic receptors, Pharmacol. Biochem. Behav., 32, 181, 10.1016/0091-3057(89)90230-X
Balwin, 1986, An investigation of the acute, chronic and withdrawal effects of caffeine on anxiety, exploration and convulsions in the rat (Abstract), Soc. Neurosci. Abstr., 12, 906
Balwin, 1989, Antagonistic effects of caffeine and yohimbine in animal tests of anxiety, Eur. J. Pharmacol., 159, 211, 10.1016/0014-2999(89)90709-7
Barone, 1985, 23, 389
Barone, 1984, Human consumption of caffeine, 59
Bättig, 1985, Physiological effects of coffee consumption, 394
Bättig, 1984, The effects of caffeine on physiological functions and mental performance, Experientia, 40, 1218, 10.1007/BF01946650
Baturin, 1979, Effect of psychostimulants on rats relearning the direction of avoidance in a U-shaped maze, Anim. Learn. Behav., 99
Beavo, 1970, Effects of xanthine derivatives on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activity, Molec. Pharmacol., 6, 597
Bellet, 1968, Response of free fatty acids to coffee and caffeine, Metabolism, 17, 702, 10.1016/0026-0495(68)90054-1
Bellet, 1968, Effect of cola drinks on serum free fatty acids, Arch. Environm. Health, 17, 803, 10.1080/00039896.1968.10665322
Benowitz, 1990, Clinical pharmacology of caffeine, Annu. Rev. Med., 41, 277, 10.1146/annurev.me.41.020190.001425
Bergland, 1982, Effects of caffeine ingestion on exercise performance at low and high altitude in cross-country skiers, Int. J. Sports Med., 3, 234, 10.1055/s-2008-1026094
Berkowitz, 1971, The effect of caffeine and theophylline on the disposition of brain serotonin in the rat, Eur. J. Pharmacol., 16, 322, 10.1016/0014-2999(71)90034-3
Berkowitz, 1971, The interaction of caffeine, theophylline and theobromine with monoamine oxidase inhibitors, Eur. J. Pharmacol., 16, 315, 10.1016/0014-2999(71)90033-1
Berkowitz, 1970, Release of norepinephrine in the central nervous system by theophylline and caffeine, Eur. J. Pharmacol., 10, 64, 10.1016/0014-2999(70)90158-5
Berne, 1981, The local regulation of cerebral blood flow, Prog. Cerebrovasc. Dis., 24, 243, 10.1016/0033-0620(81)90030-X
Biaggioni, 1991, Caffeine and theophylline as adenosine receptor antagonists in humans, J. Pharmacol. Exp. Ther., 258, 588
Bianchi, 1961, The efffect of caffeine on radiocalcium movement in frog sartorius, J. Gen. Physiol., 44, 845, 10.1085/jgp.44.5.845
Bianchi, 1968, Pharmacological action on excitation-contraction coupling in muscle. Introduction: statement of the problem, 28, 1624
Bianchi, 1975, Cellular pharmacology of contraction of skeletal muscle, 485
Billiland, 1980, Interactive effect of introversion-extraversion and alertness induced by caffeine on verbal performance, J. Res. Pers., 14, 482, 10.1016/0092-6566(80)90006-9
Blanchard, 1983, The absolute bioavailability of caffeine in man, Eur. J. Clin. Pharmacol, 24, 93, 10.1007/BF00613933
Blyth, 1960, Effects of amphetamine (dexedrine) and caffeine on subjects exposed to heat and exercice stress, Res. Q., 31, 553
Boissier, 1965, Action de la caféine sur la motilité spontanée de la souris, Arch. Int. Pharmacodyn, 158, 212
Bonati, 1982, Caffeine disposition after oral doses, Clin. Pharmacol Ther., 32, 98, 10.1038/clpt.1982.132
Bonnet, 1979, Effects of flurazepam, pentobarbital and caffeine on arousal treshold, Sleep, 1, 271, 10.1093/sleep/1.3.271
Boulenger, 1989, Caffeine withdrawal affects central adenosine receptors but not benzodiazepine receptors, J. Neural Transm., 78, 9, 10.1007/BF01247109
Boulenger, 1986, Stress and caffeine: effects on central adenosine receptors, Clin. Neurophormacol., 9, 79, 10.1097/00002826-198602000-00009
Boulenger, 1982, Effects of caffeine and theophylline on adenosine and benzodiazepine receptors in human brain, Neurosci. Lett., 30, 161, 10.1016/0304-3940(82)90290-7
Boulenger, 1983, Chronic caffeine consumption increases the number of brain adenosine receptors, Life Sci., 32, 1135, 10.1016/0024-3205(83)90119-4
Boulenger, 1987, Plasma adenosine levels: measurements in humans and relationship to the anxiogenic effects of caffeine, Psychiatry Res., 21, 247, 10.1016/0165-1781(87)90029-1
Boulenger, 1984, Increased sensitivity to caffeine in patients with panic disorders, Arch. Gen. Psychiatry, 41, 1067, 10.1001/archpsyc.1983.01790220057009
Boulenger, 1982, Caffeine consumption and anxiety: preliminary results of the survey comparing patients with anxiety disorders and normal controls, Psychopharmacol. Bull., 18, 53
Boutroy, 1979, Caffeine, a metabolite of theophylline during the treatment of apnea in the premature infant, J. Pediatr., 94, 996, 10.1016/S0022-3476(79)80248-6
Bowen, 1981, Effects of coffee and tea on blood levels and efficacy of antipsychotic drugs, Lancet, 1, 1217, 10.1016/S0140-6736(81)92391-6
Boyd, 1965, The chronic oral toxicity of caffeine, Can. J. Physiol. Pharmacol., 43, 995, 10.1139/y65-105
Braestrup, 1979, Benzodiazepine receptors in the brain are affected by different stresses: the changes are small and not unidirectional, Psychopharmacology, 65, 273, 10.1007/BF00492215
Brazier, 1980, Inhibition by idrocilamide of the disposition of caffeine, Eur. J. Clin. Pharmacol., 17, 37, 10.1007/BF00561675
Brazier, 1983, Pharmacokinetics of caffeine during and after pregnancy, Dev. Pharmacol Ther., 6, 315, 10.1159/000457332
Brezinova, 1974, Effect of caffeine on sleep: EEG study in late middle aged people, Br. J. Clin. Pharmacol., 1, 203, 10.1111/j.1365-2125.1974.tb00237.x
Bridge, 1983, Coffee drinking as a frequent cause of disease, Trans. Assoc. Am. Physicians, 8, 281
Brooks, 1984
Broverman, 1982, Effect of caffeine on performances of a perceptual-restructuring task at different stages of practice, Psychopharmacology, 78, 252, 10.1007/BF00428160
Broverman, 1981, Changes in cognitive task performance across the menstrual cycle, J. Comp. Psychol, 95, 646, 10.1037/h0077796
Bruce, 1990, The anxiogenic effects of caffeine, Postgrad. Med. J., 66, S18
Bruce, 1989, Caffeine abstention in the management of anxiety disorders, Psychol. Med., 19, 211, 10.1017/S003329170001117X
Bruns, 1987, Adenosine and xanthines, 57
Bryant, 1981, Suicide by ingestion of caffeine (Letter), Arch. Pathol. Lab. Med., 105, 685
Buckholtz, 1987, Effects of caffeine and l-phenylisopropyladenosine on locomotor activity in mice, Pharmacol. Biochem. Behav., 28, 179, 10.1016/0091-3057(87)90211-5
Bugyi, 1980, The effects of moderate doses of caffeine on fatigue parameters in the forearm flexor muscles, Am. Correc. Ther. J., 34, 49
Burg, 1975, Effect of orally administered caffeine and theophylline on tissue concentrations of 3′,5′-cyclic AMP and phosphodiesterase (Abstract), 34, 332
Butcher, 1962, Adenosine 3′,5′-monophosphate in biological materials. I. Purification and properties of cyclic 3′,5′-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3′,5′-phosphate in human urine, J. Biol. Chem., 237, 1244, 10.1016/S0021-9258(18)60316-3
Butts, 1985, Effect of caffeine ingestion on cardiorespiratory endurance in men and women, Res. O. Exerc. Sports, 56, 301, 10.1080/02701367.1985.10605333
Calhou, 1971, Central nervous system stimulants, 181
Callahan, 1982, Human metabolism of [1methyl-14C]- and [2-14C]-caffeine after oral administration, Drug Metab. Dispos., 10, 417
Callahan, 1983, Comparison of caffeine metabolism in three non-smoking populations after oral administration of radiolabeled caffeine, Drug Metab. Dispos., 11, 211
Cameron, 1990, Caffeine and human cerebral blood flow: a positron emission tomography study, Life Sci., 47, 1141, 10.1016/0024-3205(90)90174-P
Cappell, 1969, Effects of alcohol and caffeine on the social and emotional behavior of the rat, Q.J. Stud. Alcohol, 30, 345, 10.15288/qjsa.1969.30.345
Cardinali, 1977, Effects of pentoxifylline and theophylline on neurotransmitter uptake and release by synaptosome-rich homogenates of the rat hypothalamus, Neuropharmacology, 16, 785, 10.1016/0028-3908(77)90138-1
Cardinali, 1978, Effect of pentoxifylline and aminophylline on biogenic amine metabolism in the rat brain, Eur. J. Pharmacol, 47, 239, 10.1016/0014-2999(78)90397-7
Cardinali, 1980, Methylxanthines: possible mechanisms of action in brain, Tr. Pharmacol. Sci., 405, 10.1016/0165-6147(80)90064-4
Carney, 1982, Effects of caffeine, theophylline and theobromine on scheduled controlled responding in rats, Br. J. Pharmacol., 75, 451, 10.1111/j.1476-5381.1982.tb09161.x
Carpenter, 1959, The effect of caffeine and alcohol on simple visual reaction time, J. Comp. Physiol. Psychol., 52, 491, 10.1037/h0048652
Carroll, 1989, Behavioral dependence on caffeine and phencyclydine in rhesus monkeys: interactive effects, Pharmacol. Biochem. Behav., 31, 927, 10.1016/0091-3057(88)90406-6
Casai, 1985, Failure of caffeine to affect substrate utilization changes during prolonged running, Med. Sci. Sports Exerc., 17, 174, 10.1249/00005768-198502000-00029
Castellano, 1976, Effects of caffeine on discrimination learning, consolidation and learned behavior in mice, Psychopharmacology, 48, 255, 10.1007/BF00496858
Castellano, 1973, Central stimulant drugs on avoidance behavior in hamsters, Pharmacol. Res. Comm., 5, 287, 10.1016/S0031-6989(73)80008-6
Chad, 1989, The effects of substrate utilization manipulated by caffeine, on post-exercice oxygen consumption in untrained female subjects, Eur. J. Appl. Physiol., 59, 48, 10.1007/BF02396579
Chait, 1988, Discriminative stimulus effects of caffeine and benzphetamine in amphetamine-trained volunteers, Psychopharmacology, 96, 302, 10.1007/BF00216054
Charney, 1984, The effects of caffeine on plasma MHPG, subjective anxiety, autonomic symptoms and blood pressure in healthy humans, Life Sci., 35, 135, 10.1016/0024-3205(84)90132-2
Charney, 1985, Increased anxiogenic effects of caffeine in panic disorders, Arch. Gen. Psychiatry, 42, 233, 10.1001/archpsyc.1985.01790260027003
Cherek, 1984, Regular or decaffeinated coffee and subsequent human aggressive behavior, Psychiatry Res., 11, 251, 10.1016/0165-1781(84)90073-8
Chou, 1979, Differential effects of caffeine on regional brain biogenic amines in rats (Abstract), Soc. Neurosci. Abstr., 5, 551
Chou, 1978, Unit activity in medial thalamus: comparative effects of caffeine and amphetamine (Abstract), 37, 613
Chou, 1980, Unit activity in medial thalamus: comparative effects of caffeine and amphetamine, J. Pharmacol. Exp. Ther., 213, 580
Chou, 1985, Caffeine tolerance: behavioral, electrophysiological and neurochemical evidence, Life Sci., 36, 2347, 10.1016/0024-3205(85)90325-X
Clementz, 1988, Psychotropic effects of caffeine, AFP, 37, 167
Clubey, 1979, Effects of caffeine and cyclizine alone and in combination on human performance, subjective effects and EEG activity, Br. J. Clin. Pharmacol., 7, 157
Cobbs, 1982, Lethargy, anxiety and impotence in a diabetic, Hasp. Pract. (Off.), 17, 67, 10.1080/21548331.1982.11702351
Cobbs, 1982, Lethargy, anxiety and impotence in a diabetic, Hasp. Pract. (Off.), 17, 70
Cobbs, 1982, Lethargy, anxiety and impotence in a diabetic, Hasp. Pract. (Off.), 17, 73
Coffin, 1989, Psychomotor-stimulant effects of 3-isobutyl-1-methylxanthine: comparison with caffeine and 7-(2-chloroethyl)theophylline, Eur. J. Pharmacol., 170, 35, 10.1016/0014-2999(89)90130-1
Cole, 1978, Assessing the subjective effects of stimulants in casual users. A methodology and preliminary results, Clin. Pharmacol. Ther., 24, 243, 10.1002/cpt1978242243
Collins, 1977, Caffeinephenacetin interaction in rat: effects on absorption, metabolism and locomotor activity, J. Pharm. Pharmacol, 29, 217, 10.1111/j.2042-7158.1977.tb11292.x
Collomp, 1990, Influence de la prise aiguë ou chronique de caféine sur la performance et les catécholamines au cours d'un exercice maximal, C.R. Soc. Biol., 184, 87
Colombatto, 1989, Effect of caffeine on ornithine metabolism in rat brain, liver and kidney, Ital. J. Biochem., 28, 75
Colton, 1968, The tolerance of coffee drinkers to caffeine, Clin. Pharmacol. Ther., 9, 31, 10.1002/cpt19689131
Concannon, 1983, Pre- and postnatal effects of caffeine on brain biogenic amines, cyclic nucleotides and behavior in developing rats, J. Pharmacol. Exp. Ther., 226, 673
Corradetti, 1986, Chronic caffeine treatment reduces caffeine but not adenosine effects on cortical acetylcholine release, Br. J. Pharmacol., 88, 671, 10.1111/j.1476-5381.1986.tb10249.x
Corrodi, 1972, Effects of caffeine on central monoamine neurons, J. Pharm. Pharmacol., 24, 155, 10.1111/j.2042-7158.1972.tb08952.x
Costill, 1978, Effects of caffeine ingestion on metabolism and exercice performance, Med. Sci. Sports. Exerc., 10, 155
Crabbe, 1973, Facilitation and disruption of long-term store of memory with neural excitants, Pharmacol. Biochem. Behav., 1, 255, 10.1016/0091-3057(73)90099-3
Curatolo, 1983, The health consequences of caffeine, Ann. Intern. Med., 98, 641, 10.7326/0003-4819-98-5-641
Cuzzone, 1986, Caffeine effects on 5-HT uptake and release in rat cerebral cortex and midbrain raphe region (Abstract), 40, 266
Daly, 1981, Adenosine receptors in the central nervous system: relationship to the central actions of methylxanthines, Life Sci., 28, 2083, 10.1016/0024-3205(81)90614-7
Daly, 1987, Analogues of adenosine, theophyllineand caffeine: selective interactions with A1 and A2 adenosine receptors, 23
Dar, 1988, The biphasic effects of centrally and peripherally administered caffeine on ethanol-induced motor incoordination in mice, J. Pharm. Pharmacol., 40, 482, 10.1111/j.2042-7158.1988.tb05282.x
Daval, 1989, Upregulation of adenosine Al receptors and forskolin binding sites following chronic caffeine treatment with caffeine or carbamazepine: a quantitative autoradiographic study, Epilepsia, 30, 26, 10.1111/j.1528-1157.1989.tb05276.x
Daval, 1986, Effect of chronic caffeine exposure to methylxanthines on diazepam cerebral binding in female rats and their offsprings, Dev. Brain Res., 27, 175, 10.1016/0165-3806(86)90243-9
Davidson, 1991, Caféine and novelty: effects on electrodermal activity and performance, Physiol. Behav., 49, 1169, 10.1016/0031-9384(91)90346-P
Davies, 1984, Effect of some potent adenosine uptake inhibitors on benzodiazepine binding in the CNS, Neurochem. Int., 6, 185, 10.1016/0197-0186(84)90091-3
Davis, 1973, Comparison of the behavioral effects of nicotine, d-amphetamine, caffeine and dimethyltetrahydrocannabinol, Psychopharmacologia., 32, 51, 10.1007/BF00421707
De Angelas, 1982, Interaction of caffeine with benzodiazepines: Behavioral effects in mice, Arch. Int. Pharmacodyn. Ther., 255, 89
De Beer, 1988, Caffeine suppresses length dependency of Ca2+ sensitivity of skinned striated muscle, Am. J. Physiol., 254, C491, 10.1152/ajpcell.1988.254.4.C491
Debler, 1989, Effects of caffeine on amino acid transport in the brain, Neurochem. Int., 14, 55, 10.1016/0197-0186(89)90009-0
Debry, 1987, Effets du café sur le système nerveux, 101
De Freitas, 1979, Effects of caffeine in chronic psychiatric patients, Am. J. Psychiatry, 136, 1337, 10.1176/ajp.136.10.1337
De Gubareff, 1965, Effects of caffeine on mammalian atrial muscle and its interaction with adenosine and calcium, J. Pharmacol Exp. Ther., 148, 202
Delbecke, 1984, Caffeine: use and abuse in sports, Int. J. Sports Med., 5, 179, 10.1055/s-2008-1025901
Denaro, 1991, Effects of caffeine with repeated dosing, Eur. J. Clin. Pharmacol., 40, 273, 10.1007/BF00315208
Denaro, 1990, Dose-dependency of caffeine metabolism with repeated dosing, Clin. Pharmacol. Ther., 48, 277, 10.1038/clpt.1990.150
Denenberg, 1982, Effects of theophylline on behavioral state development in the newborn rabbit, J. Pharmacol. Exp. Ther., 221, 604
Desaulles, 1991, Caffeine-induced Ca2+ release inhibits GABAA responsiveness in rat identified native primary afferents, Eur. J. Pharmacol., 203, 137, 10.1016/0014-2999(91)90803-X
Desmond, 1980, Impaired elimination of caffeine in cirrhosis, Digest. Dis. Sci., 25, 193, 10.1007/BF01308138
DesRosiers, 1974, Relationship between local cerebral blood flow and glucose utilization in the rat, Neurology, 24, 389
Dews, 1984, Behavioral effects of caffeine, 86
Dews, 1984, 22, 163
Diamond, 1970, Visual threshold as a function of test area and caffeine administration, Psychon. Sci., 20, 109, 10.3758/BF03335627
Dodd, 1991, The effects of caffeine on graded exercise performance in caffeine naive versus habituated subjects, Eur. J. Appl. Physiol., 62, 424, 10.1007/BF00626615
Dorfman, 1970, Comparative stimulant effects and diuretic actions of caffeine and theobromine in man, Clin. Pharmacol. Ther., 11, 869, 10.1002/cpt1970116869
Dragunow, 1984, Adenosine modulation of amygdala kindling, Exp. Neurol., 84, 654, 10.1016/0014-4886(84)90212-7
Dragunow, 1985, Is adenosine an endogenous anticonvulsant?, Epilepsia, 26, 480, 10.1111/j.1528-1157.1985.tb05684.x
Dreisbach, 1943, Caffeine-withdrawal headache, J. Lab. Clin. Med., 28, 1212
Dunwiddie, 1981, Alkylxanthines elevate hippocampal excitability. Evidence for a role of endogenous adenosine, Naunyn-Schmiedeberg's Arch. Pharmacol., 316, 326, 10.1007/BF00501365
Dunwiddie, 1982, Sedative and anticonvulsant effects of adenosine analogs in mouse and rat, J. Pharmacol. Exp. Ther., 220, 70
Eaton, 1984, Consumption of coffee or tea and symptoms of anxiety, Am. J. Public Health, 74, 66, 10.2105/AJPH.74.1.66
Eddy, 1928, Tolerance and cross-tolerance in human subject to diuretic effect of caffeine, theobromine and theophylline, Pharmacol. Exp. Ther., 33, 167
Edelman, 1985, The effects of caffeine on psychological functioning, Nutr. Health, 4, 29, 10.1177/026010618500400105
Eichler, 1938
Eichler, 1976
Eichler, 1949, Kaffeewirkung bei sportlichen Übungen, Arch. Pharmakol. Exp. Pathol., 20b, 251
Eisner, 1985, The mechanism of the increase of tonic tension produced by caffeine in sheep cardiac Purkinje fibers, J. Physiol., 364, 313, 10.1113/jphysiol.1985.sp015747
Eitan, 1977, The effects of dibutyril cyclic AMP, theophylline and papaverine on the release of 3Hcatecholamines from rat brain striatal and cortical synaptosomes, Eur. J. Pharmacol., 46, 323, 10.1016/0014-2999(77)90226-6
Elkins, 1981, Acute effects of caffeine in normal prepubertal boys, Am. J. Psych., 138, 178, 10.1176/ajp.138.2.178
Enslen, 1980, Brain catecholamines and sleep states in offspring of caffeine-treated rats, Experientia, 36, 1105, 10.1007/BF01965996
Erikson, 1985, The effects of caffeine on memory for word lists, Physiol. Behav., 35, 47, 10.1016/0031-9384(85)90170-2
Erickson, 1987, Effects of caffeine, fructoseand glucose ingestion on muscle glycogen utilization during exercice, Med. Sci. Sports Exerc., 19, 579, 10.1249/00005768-198712000-00007
Essig, 1980, Effects of caffeine ingestion on utilization of muscle glycogen and lipid during the ergometer cycling, Int. J. Sports Med., 1, 86, 10.1055/s-2008-1034637
Essig, 1981, Effects of caffeine on glycogen and triglyceride concentration in the roleus and plantaris muscles of the exercising rat (Abstract), 513
Estler, 1982, Caffeine, 369
Evans, 1990, The acute effects of caffeine, cocaine and d-amphetamine on the repeated acquisition responding of pigeons, Pharmacol. Biochem. Behav., 35, 631, 10.1016/0091-3057(90)90300-7
Evreux, 1979, Les accidents neuropsychiques de l'idrocilamide: conséquence d'une inhibition du métabolisme de la caféine?, Lyon Med., 241, 89
Eysenck, 1967
Falk, 1989, The effect of caffeine ingestion on physical performance after prolonged exercice, Eur. J. Appl. Physiol., 59, 168, 10.1007/BF02386182
Falk, 1991, Synergism by caffeine and by cocaine of the motor control deficit produced by midazolam, Pharmacol. Biochem. Behav., 39, 525, 10.1016/0091-3057(91)90221-M
Fasolato, 1991, Intracellular Ca2+ pools in PC12 cells. Three intracellular pools are distinguished by their turnover and mechanisms of Ca2+ accumulation, storageand release, J. Biol. Chem., 266, 20159, 10.1016/S0021-9258(18)54904-8
Fastbom, 1990, Effects of long-term theophylline treatment on adenosine A 1-receptors in rat brain: autoradiographic evidence for increased receptor number and altered coupling to G-proteins, Brain Res., 507, 195, 10.1016/0006-8993(90)90272-D
Fawzy, 1983, Generational continuity in the use of substances: the impact of parenteral substance use on adolescent substance use, Addict. Behav., 8, 109, 10.1016/0306-4603(83)90003-5
Feldberg, 1954, Injections of drugs into the lateral ventricle of the cat, J. Physiol., 123, 148, 10.1113/jphysiol.1954.sp005040
Fennelly, 1991, Is caffeine withdrawal the mechanism of postoperative headache?, Anesth. Analg., 72, 449, 10.1213/00000539-199104000-00006
Fernstrom, 1984, Caffeine injection raises brain tryptophan level, but does not stimulate the rate of serotonin synthesis in rat brain, Life Sci., 35, 1241, 10.1016/0024-3205(84)90094-8
Fernstrom, 1984, Effects of caffeine on monoamine neurotransmitters in the central and peripheral nervous system, 107
File, 1988, Behavioral effects of acute and chronic administration of caffeine in the rat, Pharmacol. Biochem. Behav., 30, 809, 10.1016/0091-3057(88)90104-9
File, 1982, Interaction between effects of caffeine and lorazepam in performance tests and self-ratings, J. Clin. Psychopharmacol., 2, 102, 10.1097/00004714-198204000-00003
File, 1979, A test of anxiety that distinguishes between the actions of benzodiazepines and those of other minor tranquilisers and of stimulants, Pharmacol. Biochem. Behav., 11, 65, 10.1016/0091-3057(79)90298-3
Fink, 1968, EEG classification of psychoactive compounds in man: a review and theory of behavioral association, 497
Finn, 1986, Tolerance to caffeine-induced stimulation of locomotor activity in rats, J. Pharmacol. Exp. Ther., 238, 542
Finn, 1987, Pharmacologie specificity of tolerance to caffeine-induced stimulation of locomotor activity, Psychopharmacology, 93, 428, 10.1007/BF00207230
Finn, 1988, Tolerance and cross-tolerance to theophylline-induced stimulation of locomotor activity in rats, Life Sci., 42, 2475, 10.1016/0024-3205(88)90346-3
Finn, 1990, Depletion of catecholamines in the brain of rats differentially affects stimulation of locomotor activity by caffeine, d-amphetamineand methylphenidate, Neuropharmacology, 29, 625, 10.1016/0028-3908(90)90023-K
Fisher, 1986, Influence of caffeine on exercice performance in habitual caffeine users, Int. J. Sports Med., 7, 276, 10.1055/s-2008-1025774
Flinn, 1990, Caffeine ingestion prior to incremental cycling to exhaustion in recreational cyclists, Int. J. Sports Med., 11, 188, 10.1055/s-2007-1024789
Flory, 1943, The effects of benzedrine sulfate and caffeine citrate on the efficiency of college students, J. Appl. Psychol., 27, 121, 10.1037/h0060179
Foltz, 1943, The influence of amphetamine (Benzedrine) sulfate, d-desoxyephedrine hydrochloride (Pervitan) and caffeine upon work output and recovery when rapidly exhausting work is done by trained subjects, J. Lab. Clin. Med., 28, 603
Foote, 1978, Neurophysiological and pharmacodynamic studies on caffeine and on interactions between caffeine and nicotinic acid in the rat, Neuropharmacology, 17, 7, 10.1016/0028-3908(78)90167-3
Forde, 1976, Caffeine effects on reticular formation neurons in the decerebrate cat (Abstract), Soc. Neurosci. Abstr., 2, 867
Foreman, 1989, High doses of caffeine impair performance of a numerical version of the stroop task in men, Pharmacol. Biochem. Behav., 32, 399, 10.1016/0091-3057(89)90169-X
Forney, 1965, Effects of caffeine and alcohol on performance under stress of audiofeedback, Q.J. Stud. Alcohol, 26, 206, 10.15288/qjsa.1965.26.206
Forsythe, 1986, Effects of caffeine and caffeine deprivation on exercice performance and catecholamine levels in young women (Abstract), 3, 617
Fowles, 1977, The influence of introversion/extraversion on the skin conductance response, J. Res. Personality, 11, 129, 10.1016/0092-6566(77)90012-5
Francks, 1975, The effects of caffeine on human performance, alone and in combination with ethanol, Psychopharmacologia, 45, 177, 10.1007/BF00429058
Franklin, 1948, Observations on human behavior in experimental semistarvation and rehabilitation, J. Clin. Psychol., 4, 28, 10.1002/1097-4679(194801)4:1<28::AID-JCLP2270040103>3.0.CO;2-F
Fredholm, 1980, Are methylxanthine effects due to antagonism of endogenous adenosine?, Trends. Pharmacol. Sci., 2, 129
Fredholm, 1982, Adenosine actions and adenosine receptors after 1 week treatment with caffeine, Acta Physiol. Scand., 115, 283, 10.1111/j.1748-1716.1982.tb07078.x
Fredholm, 1985, On the mechanism of action of theophylline and caffeine, Acta Med. Scand., 217, 149, 10.1111/j.0954-6820.1985.tb01650.x
Fredholm, 1980, Modulation of neurotransmission by purine nucleotides and nucleosides, Biochem. Pharmacol., 29, 1635, 10.1016/0006-2952(80)90117-3
Fredholm, 1984, Changes in noradrenaline release and in beta receptor number in rat hippocampus following long term treatment with theophylline or l-PIA, Acta Physiol. Scand., 122, 55, 10.1111/j.1748-1716.1984.tb07481.x
Fröberg, 1969, Test performance and subjective feelings as modified by caffeine-containing and caffeine-free coffee, 15
Fujii, 1972, Pharmacological studies on doping drugs for race horses. II. Caffeine, Jpn. J. Vet. Sci., 34, 141, 10.1292/jvms1939.34.135
Fulco, 1989, The effect of caffeine (CAF) on endurance time exhaustion (ETX) at high altitude (HA) (Abstract), FASEB J., 3, A987
Furlong, 1975, Possible psychiatric significance of excessive coffee consumption, Can. Psychiatr. Assoc., 20, 577, 10.1177/070674377502000804
Galloway, 1983, Clonidine prevents methylxanthine stimulation of norepinephrine metabolism in rat brain, J. Neurochem., 40, 246, 10.1111/j.1471-4159.1983.tb12678.x
Ganslen, 1964, Effects of some tranquilizing, analeptic and vasodilating drugs on physical work capacity and orthostatic tolerance, Aerospace Med., 35, 630
Garfinkel, 1975, Methylphenidate and caffeine in the treatment of children with minimal brain dysfunction, Am. J. Psychiatry, 132, 723, 10.1176/ajp.132.7.723
Gerson, 1980, Motor effects of serotonin in the central nervous system, Life Sci., 27, 1435, 10.1016/0024-3205(80)90368-9
Geyer, 1975, Differential effects of caffeine, d-amphetamine and methylphenidate on individual raphe cell fluorescence: a microspectrofluorimetric demonstration, Brain Res., 85, 135, 10.1016/0006-8993(75)91019-7
Ghoneim, 1986, Pharmacokinetic and pharmacodynamic interactions between caffeine and diazepam, J. Clin. Psychopharmacol., 6, 75, 10.1097/00004714-198604000-00003
Gibson, 1981, Caffeine withdrawal elevates urinary MHPG excretion, N. Engl. J. Med., 304, 363, 10.1056/NEJM198102053040624
Giddins, 1934, Normal sleep pattern for children: factors which derange such a pattern (physical factors), J. Am. Med. Ass., 102, 525, 10.1001/jama.1934.02750070023007
Gilbert, 1976, Caffeine as a drug of abuse, 49
Gilbert, 1984, Caffeine consumption, 185
1895, Bull. Soc. Med. Hop. Paris, 12, 558
Gilliland, 1981, Ad lib caffeine consumption, symptoms of caffeinism and academic performance, Am. J. Psychiatry, 138, 512, 10.1176/ajp.138.4.512
Gilliland, 1939, The effects of coffee on certain mental and physiological functions, J. Gen. Psychol., 21, 339, 10.1080/00221309.1939.10544302
Goldberg, 1982, Caffeine down regulates β-adrenoceptors in rat forebrain, Neuroscience Lett., 31, 47, 10.1016/0304-3940(82)90052-0
Goldstein, 1964, Wakefulness caused by caffeine, Naunyn-Schmiedebergs Arch. Pharmakol. Exp. Pathol., 248, 269
Goldstein, 1965, Psychotropic effects of caffeine in man. I. Interindividual differences in sensitivity to caffeine-induced wakefulness, J. Pharmacol. Exp. Ther., 149, 156
Goldstein, 1965, Psychotropic effects of caffeine in man. II. Alertness, psychomotor coordination and mood, J. Pharmacol. Exp. Ther., 150, 146
Goldstein, 1969, Psychotropic effects of caffeine in man. III. A questionnaire survey of coffee drinking and its effects in a group of housewives, Clin. Pharmacol. Ther., 10, 477, 10.1002/cpt1969104477
Goldstein, 1969, Psychotropic effects of caffeine in man. IV. Quantitative and qualitative differences associated with habituation to coffee, Clin. Pharmacol. Ther., 10, 489, 10.1002/cpt1969104489
Goldstein, 1963, Quantitative electroencephalography in man as a measure of electrical stimulation, Ann. NY Acad. Sci., 107, 1045, 10.1111/j.1749-6632.1963.tb13348.x
Gottstein, 1972, The effects of intracarotid aminophylline on the cerebral circulation, Stroke, 3, 560, 10.1161/01.STR.3.5.560
Graham, 1978, Caffeine — its identity, dietary sources, intake and biological effects, Nutr. Rev., 36, 97, 10.1111/j.1753-4887.1978.tb03717.x
Grant, 1982, Methylxanthine activation of noradrenergic unit activity and reversal by clonidine, Eur. J. Pharmacol., 85, 105, 10.1016/0014-2999(82)90430-7
Greden, 1974, Anxiety or caffeinism: a diagnostic dilemna, Am. J. Psychiatry, 131, 1089
Greden, 1980, Caffeine and tobacco dependence, Vol. 2, 1645
Greden, 1981, Caffeinism and caffeine withdrawal, 274
Greden, 1978, Anxiety and depression associated with caffeinism among psychiatric outpatients, Am. J. Psychiatry, 135, 963, 10.1176/ajp.135.8.963
Greden, 1980, Caffeine-withdrawal headache: a clinical profile, Psychosomatics, 21, 411, 10.1016/S0033-3182(80)73670-8
Greden, 1980, Caffeine-withdrawal headache: a clinical profile, Psychosomatics, 21, 417, 10.1016/S0033-3182(80)73670-8
Green, 1986, Chronic caffeine ingestion sensitizes the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex, J. Clin. Invest., 77, 222, 10.1172/JCI112280
Greene, 1985, Effects of caffeine on hippocampal pyramidal cells in vitro, Br. J. Pharmacol., 85, 163, 10.1111/j.1476-5381.1985.tb08843.x
Gresham, 1963, Alcohol and caffeine: effect on inferred visceral dreaming, Science, 140, 1226, 10.1126/science.140.3572.1226
Griffiths, 1986, Human coffee drinking: reinforcing and physical dependence producing effects of caffeine, J. Pharmacol. Exp. Ther., 239, 416
Griffiths, 1989, Reinforcing effects of caffeine in coffee and capsules, J. Exp. Anal. Behav., 52, 127, 10.1901/jeab.1989.52-127
Griffiths, 1986, Human coffee drinking: manipulation of concentration and caffeine dose, J. Exp. Anal. Behav., 45, 133, 10.1901/jeab.1986.45-133
Griffiths, 1981, Predicting the dependence liability of stimulant drugs, Natl. Inst. Drug Abuse Res. Monogr., 37, 182
Griffiths, 1990, Low-dose caffeine physical dependence in humans, J. Pharmacol. Exp Ther., 255, 1123
Griffiths, 1988, Reinforcing effects of caffeine in humans, J. Pharmacol. Exp. Ther., 246, 21
Griffiths, 1988, Reinforcing properties of caffeine: studies in humans and laboratory animals, Pharmacol. Biochem. Behav., 29, 419, 10.1016/0091-3057(88)90180-3
Griffiths, 1988, Caffeine physical dependence: a review of human and laboratory animal studies, Psychopharmacology, 94, 437, 10.1007/BF00212836
Grome, 1983, The effects of quipazone, a putative serotonin agonist on local cerebral blood flow and glucose utilization in the ratand pial vascular diameter in the cat, J. Cereb. Blood Flow Metab., 3, S302
Grome, 1985, Differential effects of xanthine derivatives on local cerebral blood flow and glucose utilization in the conscious rat, 453
Grome, 1986, Differential effects of methylxanthines on local cerebral blood flow and glucose Utilization in the conscious rat, Naunyn-Schmiedeberg's Arch. Pharmacol., 333, 172, 10.1007/BF00506522
Gross, 1975, Caffeine in the treatment of children with minimal brain dysfunction or hyperkinetic syndrome, Psychosomatics, 16, 26, 10.1016/S0033-3182(75)71230-6
Guelliot, 1885, Du caféinisme chronique, Union Med. Sci. Nordest, 9, 181
Guillet, 1990, Neonatal caffeine exposure alters adenosine receptor control of locomotor activity in the developing rat, Dev. Pharmacol. Ther., 15, 94, 10.1159/000457627
Gumulka, 1971, Behavioral and biochemical effects following the stimulation of the nucleus raphe dorsalis in rats, J. Neurochem., 18, 533, 10.1111/j.1471-4159.1971.tb11983.x
Guthrie, 1967, Interaction between caffeine and adenosine on calcium exchangeability in mammalian atria, Arch. Int. Pharmacodyn., 170, 249
Hach, 1971, Vergleichende Untersuchungen über die zentralerregende Wirkung von Coffein und Chlorogensäure an weissen Mäuse, Arzneimittelforschung, 21, 23
Hadfield, 1989, Caffeine and regional brain monoamine utilization in mice, Life Sci., 45, 2637, 10.1016/0024-3205(89)90249-X
Haldi, 1946, Action of drugs on the efficiency of swimmers, Res. Q., 17, 96
Hasenfratz, 1991, Interactions of smoking and lunch with the effects of caffeine on cardiovascular functions and information processing, Hum. Psychopharmacol., 6, 277, 10.1002/hup.470060403
Haulica, 1973, Preliminary data on the possible hypnogenic role of adenosine, J. Neurochem., 21, 1019, 10.1111/j.1471-4159.1973.tb07549.x
Hawkins, 1988, Effects of chronic administration of caffeine on adenosine A1 and A2 receptors in rat brain, Brain Res. Bull., 21, 479, 10.1016/0361-9230(88)90162-1
Hearst, 1964, Drug effects on stimulus generalization in the monkey, Psychopharmacologia, 6, 57, 10.1007/BF00710915
Herz, 1968, Vergleichende Untersuchungen über zentrale Wirkungen von Xanthinederivaten in Hinblick und deren Stoffwechsel und Verteilung in Organismus, Arch. Pharmakol. Exp. Pathol., 261, 486, 10.1007/BF00537564
Hicks, 1983, Daily caffeine use and the sleep of college students, Bull. Psychon. Soc., 21, 24, 10.3758/BF03329943
Hicks, 1983, Type A.B. behavior and caffeine use in college students (Abstract), Psychological Rep., 52, 338a, 10.2466/pr0.1983.52.1.338
Hilakivi, 1989, Effects of caffeine on social behavior, exploration and locomotor activity:interactions with ethanol, Life Sci., 44, 543, 10.1016/0024-3205(89)90616-4
Hinkle, 1987, Use of caffeine to lengthen seizures in ECT, Am. J. Psychiatry, 144, 1143, 10.1176/ajp.144.9.1143
Hirsh, 1984, Central nervous system pharmacology of the dietary methylxanthines, 235
Hirsh, 1982, Effects of caffeine and amphetamine SO4 on single unit activity in caudate nucleus (Abstract), Soc. Neumsci. Abstr., 8, 898
Hirsh, 1983, Demonstration of caffeine tolerance in reticular formation neurons (Abstract), 42, 882
Hirsh, 1974, Caffeine effects on spontaneous activity of reticular formation neurons (Abstract), Soc. Neumsci. Abstr., 257
Hirsh, 1979, Use of a sleeptime method to study nicotinic acid attenuation of caffeine, amphetamine and pentylenetetrazol stimulation (Abstract), 38, 755
Hirsh, 1974, Spontaneous locomotor activity changes evoked by caffeine in mice (Abstract), 33, 466
Hoegholm, 1989, Benzodiazepine antagonism by aminophylline, Acta Anaesthesiol. Scand., 33, 164, 10.1111/j.1399-6576.1989.tb02882.x
Hollingworth, 1912, The influence of caffeine on mental and motor efficiency, Arch. Psychol., 3, 1
Hollins, 1980, Adenosine inhibition of aminobutyric release from slices of rat cerebral cortex, Br. J. Pharmacol., 69, 107, 10.1111/j.1476-5381.1980.tb10888.x
Holloway, 1985, Methylxanthine discrimination in the rat: possible benzodiazepine and adenosine mechanisms, Pharmacol. Biochem. Behav., 22, 815, 10.1016/0091-3057(85)90533-7
Holloway, 1983, Caffeine: effects on the behaviors of juvenile rats, Neurobehav. Toxicol. Teratol., 5, 127
Holloway, 1983, Caffeine and social investigation in the adult male rat, Neurobehav. Toxicol. Teratol., 5, 119
Holman, 1975, Neuroregulators and sleep mechanisms, Ann. Rev. Med., 26, 499, 10.1146/annurev.me.26.020175.002435
Holtzman, 1983, Complete, reversible, drug-specific tolerance to stimulation of locomotor activity by caffeine, Life Sci., 33, 779, 10.1016/0024-3205(83)90784-1
Holtzman, 1986, Discriminative stimulus properties of caffeine in the rat: noradrenergic mediation, J. Pharmacol. Exp. Ther., 239, 706
Holtzman, 1991, CGS 15943, a nonxanthine adenosine receptor antagonist: effects on locomotor activity of nontolerant and caffeine-tolerant rats, Life Sci., 49, 1563, 10.1016/0024-3205(91)90329-A
Holtzman, 1988, Tolerance to the behavioral effects of caffeine in rats, Pharmacol. Biochem. Behav., 29, 411, 10.1016/0091-3057(88)90179-7
Holtzman, 1991, Role of adenosine receptors in caffeine tolerance, J. Pharmacol. Exp. Ther., 256, 62
Horning, 1977, Use of saliva in therapeutic drug monitoring, Clin. Chem., 23, 157, 10.1093/clinchem/23.2.157
Horst, 1934, The effect of the habitual use of coffee or decaffeinated coffee upon blood pressure and certain motor reactions of normal young men, J. Pharmacol., 52, 322
Horst, 1934, The effect of caffeine, coffee and decaffeinated coffee upon blood pressure, pulse rate and certain motor reactions of normal young men, J. Pharmacol., 52, 307
Hughes, 1988, A survey of physician advice about caffeine, J. Substance Abuse, 1, 67, 10.1016/S0899-3289(88)80009-9
Hughes, 1986, Behavioral effects of prenatal exposure to caffeine in rats, Life Sci., 38, 861, 10.1016/0024-3205(86)90253-5
Hughes, 1990, Sex- and age-dependent effects of prenatal exposure to caffeine on open-field behavior, emergence latency and adrenal weights in rats, Life Sci., 47, 2075, 10.1016/0024-3205(90)90443-U
Hughes, 1976, Effects of caffeine, metamphetamine and methylphenidate on reactions to novelty and activity in rats, Neuropharmacology, 15, 673, 10.1016/0028-3908(76)90035-6
Hughes, 1990, The actipn of caffeine on inward barium current through voltage-dependent calcium channels in single rabbit ear artery cells, Pflügers Arch., 416, 462, 10.1007/BF00370755
Hughes, 1991, Caffeine self-administration, withdrawaland adverse effects among coffee drinkers, Arch. Gen. Psychiatry, 48, 611, 10.1001/archpsyc.1991.01810310029006
Hull, 1935, The influence of caffeine and other factors on certain phenomena of rote learning, J. Gen. Psychol., 13, 249, 10.1080/00221309.1935.9917886
Hunter, 1990, Effects of uric acid and caffeine on A1 adenosine receptor binding in developing rat brain, Pharmacol. Biochem. Behav., 35, 791, 10.1016/0091-3057(90)90360-T
Hyde, 1990, Response to ‘effects of caffeine on behavior of schizophrenic impatients’, Schizophrenia Bull., 16, 371, 10.1093/schbul/16.3.371
In der Beeck, 1961, Kaffeesucht und Koffeinismus: Zugleich ein literarischer Beitrag zur Definition der Sucht, Ther. Monatsschr., 7, 232
Ishay, 1979, Effects of caffeine and various xanthines on hornets and bees, Psychopharmacology, 65, 299, 10.1007/BF00492219
Ivy, 1979, Influence of caffeine and carbohydrate feeding on endurance performance, Med. Sci. Sports Exerc., 11, 6
Izquierdo, 1986, Interactions between methylxanthines and benzodiazepine binding sites, Trends Pharmacol. Sci., 5, 256, 10.1016/0165-6147(86)90341-X
Jacobson, 1987, Effects of caffeine on simple reaction time and movement time, Aviat. Space Environm. Med., 58, 1153
Jaffe, 1980, Drug addiction and drug abuse, 535
James, 1990, The influence of user status and anxious disposition on the hypertensive effects of caffeine, Int. J. Psychophysiol., 10, 171, 10.1016/0167-8760(90)90031-8
James, 1991
Janssen, 1978, The effects of a depressant and a stimulant drug on the contingent negative variation, Biol. Psychol., 6, 209, 10.1016/0301-0511(78)90023-6
Jefferson, 1988, Lithium tremor and caffeine intake: two cases of drinking less and shaking more, J. Clin. Psychiatr., 49, 72
Jhamandas, 1980, Regional release of [3H]adenosine derivatives from rat brain in vivo: Effect of excitatory amino acids, opiate antagonists and benzodiazepines, Can. J. Physiol. Pharmacol., 58, 1262, 10.1139/y80-193
Johnson, 1990, Benzodiazepines and caffeine: effect on daytime sleepiness, performance and mood, Psychopharmacology, 101, 160, 10.1007/BF02244120
Jokela, 1959, Caffeine poisoning, Acta Pharmacol. Toxicol., 15, 331, 10.1111/j.1600-0773.1959.tb00302.x
Josselyn, 1991, Behavioral effects of intrastriatal caffeine mediated by adenosinergic modulation of dopamine, Pharmacol. Biochem. Behav., 39, 97, 10.1016/0091-3057(91)90403-O
Jouvet, 1969, Biogenic amines and the states of sleep, Science, 163, 32, 10.1126/science.163.3862.32
Jouvet, 1957, Action de la caféine sur l'activité électrique cérébrale, C.R. Soc. Biol., 151, 1542
Kaplan, 1989, Relationship of plasma and brain concentrations of caffeine and metabolites to benzodiazepine receptor binding and locomotor activity, J. Pharmacol. Exp. Ther., 248, 1078
Kaplan, 1990, Caffeine-induced behavioural stimulation is dose- and concentration-dependent, Br. J. Pharmacol., 100, 435, 10.1111/j.1476-5381.1990.tb15824.x
Karacan, 1976, Dose-related sleep disturbances induced by coffee and caffeine, Clin. Pharmacol. Ther., 20, 682, 10.1002/cpt1976206682
Karacan, 1975, Dose response effects of coffee on objective (EEG) and subjective measures of sleep, 504
Karasawa, 1976, Effect of theophylline on monoamine metabolism in the rat brain, Eur. J. Pharmacol., 37, 97, 10.1016/0014-2999(76)90012-1
Katims, 1983, Xanthine stimulants and adenosine, 63
Katz, 1977, Dependence of ionophore- and caffeine-induced calcium release from sarcoplasmic reticulum vesicles on external and internal calcium ion concentrations, J. Biol. Chem., 252, 1938, 10.1016/S0021-9258(18)71848-6
Kelly, 1983, The effect of GABAergic agonist muscimol upon the relationship between cerebral blood flow and glucose utilization, Brain Res., 258, 338, 10.1016/0006-8993(83)91162-9
Kesslar, 1972, Vigilance performance related to extroversion-introversion and caffeine, J. Exp. Res. Person., 6, 5
Kirch, 1990, Effect of chronic caffeine administration on monoamine and monoamine metabolite concentrations in rat brain, Neuropharmacology, 29, 599, 10.1016/0028-3908(90)90073-Z
Klein, 1975, Paradoxical effects of caffeine, Percept. Motor Skills, 40, 126, 10.2466/pms.1975.40.1.126
Klein, 1991, Anxiogenic effects of n-CPP in patients with panic disorder: comparison to caffeine's anxiogenic effects, Biol. Psychiatry, 30, 973, 10.1016/0006-3223(91)90119-7
Kling, 1979, Caffeine elimination in late pregnancy, 38, 218
Knapik, 1983, Influence of caffeine on serum substrate changes during running in trained and untrained individuals, Biochem. Exerc., 13, 514
Koe, 1987, [3H]Ro15-1788 binding to benzodiazepine receptors in mouse brain in vivo: marked enhancement by GABA agonists and other CNS drags, Eur. J. Pharmacol., 142, 373, 10.1016/0014-2999(87)90076-8
Kostopoulos, 1977, Purinergic depression of neurons in different areas of the rat brain, Exp. Neurol., 55, 719, 10.1016/0014-4886(77)90296-5
Kozlowski, 1976, Effects of caffeine consumption on nicotine suppression, Psychopharmacology, 47, 165, 10.1007/BF00735816
Kuba, 1980, Release of calcium ions linked to the activation of potassium conductance in a caffeine treated sympathetic neurone, J. Physiol., 298, 251, 10.1113/jphysiol.1980.sp013079
Kuba, 1976, Rhythmic hyperpolarization and depolarization of sympathetic ganglion induced by caffeine, J. NeuroPhysiol., 39, 547, 10.1152/jn.1976.39.3.547
Kusanagi, 1974, Evaluation of doping drugs by treadmill exercise in dogs. I. Caffeine, Jpn. J. Vet. Sci., 36, 81, 10.1292/jvms1939.36.81
Kuschinsky, 1983, Coupling between functional metabolism and blood flow in the brain: state of the art, Microcirculation, 2, 357
Kuznicki, 1986, The effects of caffeine on caffeine users and non-users, Physioi. Behav., 37, 397, 10.1016/0031-9384(86)90197-6
Lajtha, 1989, The effect of caffeine on some mouse brain free amino acid levels, Neurochem. Res., 14, 317, 10.1007/BF01000033
Lake, 1991, Manic psychosis after coffee and phenylpropanolamine, Biol. Psychiatry, 30, 401, 10.1016/0006-3223(91)90296-X
Lake, 1990, Phenylpropanolamine increases plasma caffeine levels, Clin. Pharmacol. Ther., 47, 675, 10.1038/clpt.1990.93
Laska, 1983, Effect of caffeine on acetaminophen analgesia, Clin. Pharmacol. Ther., 33, 498, 10.1038/clpt.1983.68
Leathwood, 1982, Diet-induced mood changes in normal populations, J. Psychiatr. Res., 17, 147, 10.1016/0022-3956(82)90016-4
LeBlanc, 1985, Enhanced metabolic response to caffeine in exercice-trained human subjects, J. Appl. Physiol., 59, 832, 10.1152/jappl.1985.59.3.832
Lee, 1987, Differential biochemical mechanisms mediate locomotor stimulation effects by caffeine and nicotine in rats, Pharmacol. Biochem. Behav., 26, 427, 10.1016/0091-3057(87)90142-0
Lee, 1985, Anxiety and caffeine consumption in people with anxiety disorders, Psychiatry Res., 15, 211, 10.1016/0165-1781(85)90078-2
Lee, 1988, Anxiogenic effects of caffeine on panic and depressed patients, Am. J. Psychiatry, 145, 632, 10.1176/ajp.145.5.632
Le Guennec, 1987, Delay in caffeine elimination in breast-fed infant, Pediatrics, 79, 264
Lehman, 1957, Differential screening of phrenotropic agents in man, J. Clin. Psychopathol, 18, 222
Lery, 1976, Effets neuro-psychiques rares dus á Pidrocilamide, Nouv. Presse Med., 5, 583
Levene, 1982, Risk factors in the development of intraventricular hemorrhage in the preterm neonate, Arch. Dis. Child., 57, 410, 10.1136/adc.57.6.410
Leviton, 1983, Biological effects of caffeine. Behavioral effects, Food Technol., 37, 44
Levy, 1983, Caffeine metabolism and coffee attributed sleep disturbances, Clin. Pharmacol. Ther., 33, 770, 10.1038/clpt.1983.105
Lieberman, 1987, The effects of low doses of caffeine on human performance and mood, Psychopharmacology, 92, 308, 10.1007/BF00210835
Lin, 1990, Chronic caffeine exposure enhances adenosinergic inhibition of cerebral cortical neurons, Brain Res., 520, 322, 10.1016/0006-8993(90)91722-S
Lin, 1990, Chronic caffeine exposure reduces the excitant action of acetylcholine on cerebral cortical neurons, Brain Res., 524, 316, 10.1016/0006-8993(90)90707-I
Logan, 1986, Inherent differences in sensitivity to methylxanthines among inbred mice, Pharmacol. Biochem. Behav., 24, 1281, 10.1016/0091-3057(86)90185-1
Loke, 1988, Effects of caffeine on mood and memory, Physiol. Behav., 44, 367, 10.1016/0031-9384(88)90039-X
Loke, 1985, Caffeine and diazepam: separate and combined effects on mood, memory, and psychomotor performance, Psychopharmacology, 87, 344, 10.1007/BF00432719
Loke, 1984, Effects of caffeine and nicotine on open-field exploration, Psychol. Rep., 55, 447, 10.2466/pr0.1984.55.2.447
Loke, 1984, Effects of caffeine use and ingestion on protracted visual vigilance task, Psychopharmacology, 84, 54, 10.1007/BF00432024
Londos, 1980, Subclasses of external adenosine receptors, 77, 2551
Lopes, 1983, Effect of caffeine on skeletal muscle function before and after fatigue, J. Appl. Physiol., 54, 1303, 10.1152/jappl.1983.54.5.1303
Lopez, 1989, Interaction of caffeine with the GABAA receptor complex: alterations in receptor function but not ligand binding, Eur. J. Pharmacol., 172, 453, 10.1016/0922-4106(89)90028-X
Lovingood, 1967, Effects of d-amphetamine sulfate, caffeineand high temperature on human performanc, Res. Q. Am. Ass. Health Physic. Educ. Recr., 38, 64
Lowenstein, 1982, Effect of pentoxifylline on alpha- and beta-adrenoceptor sites in cerebral cortex, medial basal hypothalamusand pineal gland of the rat, Neuropharmacology, 21, 243, 10.1016/0028-3908(82)90194-0
Lucas, 1990, Effects of the acute administration of caffeine in patients with schizophrenia, Biol. Psychiatry, 28, 35, 10.1016/0006-3223(90)90429-6
Lumley, 1987, Ethanol and caffeine effects on daytime sleepiness/alertness, Sleep, 10, 306
Lupica, 1991, Chronic theophylline treatment in vivo increases high affinity adenosine A1 receptor binding and sensitivity to exogenous adenosine in the in vitro hippocampal slice, Brain Res., 542, 55, 10.1016/0006-8993(91)90997-A
Macintosh, 1981, Contractile response to caffeine of rested and fatigued skeletal muscle, Med. Sci. Sports Exerc., 13, 95, 10.1249/00005768-198101320-00132
MacKenzie, 1981, Effects of caffeine withdrawal on isopreterenol-stimulated cyclic adenosine monophosphate, Clin. Pharmacol. Ther., 30, 436, 10.1038/clpt.1981.185
Magnussen, 1977, The effect of intraarterial administered aminophylline on cerebral hemodynamics in man, Acta Neurol Scand., 55, 131, 10.1111/j.1600-0404.1977.tb05633.x
Mally, 1990, Theophylline down-regulates adenosine receptor function, Brain Res., 509, 141, 10.1016/0006-8993(90)90321-2
Marangos, 1985, Differential effects of caffeine on brain adenosine receptors and uptake sites, 191
Marangos, 1984, Effects of chronic caffeine on brain adenosine receptors: regional and ontogenetic studies, Life Sci., 34, 899, 10.1016/0024-3205(84)90207-8
Marangos, 1979, Putative endogenous ligands for the benzodiazepine receptor, Life Sci., 25, 1093, 10.1016/0024-3205(79)90130-9
Marangos, 1979, Purinergic inhibition of diazepam binding to rat brain (in vitro), Life Sci., 24, 851, 10.1016/0024-3205(79)90369-2
Marbach, 1964, Effets physiologiques de l'alcool et de la caféine au cours du sommeil chez l'homme, Arch. Sci. Physiol. Paris, 18, 163
Margaria, 1964, The effect of some drugs on the maximal capacity of athletic performance in man, Int. Z. Ang. Physiol. Einschl. Arbeitphysiol., 20, 281
Marley, 1972, Effects of catecholamines and adenosine derivatives given into the brain of fowls, Br. J. Pharmacol., 46, 619, 10.1111/j.1476-5381.1972.tb06888.x
Mathew, 1985, Caffeine consumption, withdrawal and cerebral blood flow, Headache, 25, 305, 10.1111/j.1526-4610.1985.hed2506305.x
Mathew, 1985, Caffeine induced changes in cerebral circulation, Stroke, 16, 814, 10.1161/01.STR.16.5.814
Mathew, 1990, Behavioral and cerebrovascular effects of caffeine in patients with anxiety disorders, Acta Psychiatr. Scand., 82, 17, 10.1111/j.1600-0447.1990.tb01348.x
Matilla, 1982, Caffeine antagonizes diazepam effects in man, Med. Biol., 60, 121
Mazzeo, 1991, Catecholamine responses to acute and chronic exercise, Med. Sci. Sports Exerc., 23, 839, 10.1249/00005768-199107000-00012
McCall, 1982, Blood-brain barrier transport of caffeine: dose-related restriction of adenine transport, Life Sci., 31, 2709, 10.1016/0024-3205(82)90715-9
McCulloch, 1982, Effect of apomorphine on the relationship between local cerebral glucose utilization and local cerebral blood flow (with an appendix on its statistical analysis), J. Cereb. Blood Flow Metab., 2, 487, 10.1038/jcbfm.1982.56
McGee, 1980, Caffeine poisoning in a 19-year-old female, J. Forensic Sci., 25, 29, 10.1520/JFS10932J
McGowan, 1988, Neonatal withdrawal symptoms after chronic maternal ingestion of caffeine, South Med. J., 81, 1092, 10.1097/00007611-198809000-00006
McKim, 1980, The effects of caffeine, theophylline and amphetamine on operant responding of the mouse, Psychopharmacology, 68, 135, 10.1007/BF00432130
McManamy, 1936, Caffeine intoxication. Report of case, symptoms of which amounted to psychosis, N. Engl. J. Med., 215, 616, 10.1056/NEJM193610012151403
McMillan, 1968, Some interactions between sympathomimetic amines and amine depleting agents on the schedule-controlled behavior of the pigeon and the squirrel monkey, J. Pharmacol. Exp. Ther., 163, 172
McPherson, 1991, The brain ryanodine receptor: a caffeine-sensitive calcium release channel, Neuron, 7, 17, 10.1016/0896-6273(91)90070-G
Mechner, 1963, Behavioral effects of caffeine, metamphetamine and metnylphenidate in the rat, J. Exp. Anal. Behav., 6, 331, 10.1901/jeab.1963.6-331
Medek, 1971, The effect of chlorprothixene and caffeine on the conditioned alimentary motor reflexes in cats, Act. Nerv. Super., 13, 210
Mekhail-Ishak, 1987, Effects of caffeine and cyclic adenosine 3′,5′-monophosphate on adenosine triphosphate-dependent calcium uptake by lysed brain synaptosomes, Brain Res., 426, 62, 10.1016/0006-8993(87)90425-2
Meliska, 1990, Tolerance and sensitization to chronic and subchronic oral caffeine: effects on wheelrunning in rats, Pharmacol. Biochem. Behav., 35, 477, 10.1016/0091-3057(90)90189-O
Meliska, 1985, Caffeine effects: interaction of drug and wheelrunning experience, Pharmacol. Biochem. Behav., 23, 633, 10.1016/0091-3057(85)90429-0
Meliska, 1984, Caffeine and nicotine: differential effects on ambulation, rearing and wheelrunning, Pharmacol. Biochem. Behav, 21, 871, 10.1016/S0091-3057(84)80067-2
Mendel, 1889, Die schädlichen Folgen des chronischen Kaffeemisbrauchs, Berl. Klin. Wochenschr., 26, 877
Ment, 1981, Alterations in cerebral blood flow in preterm infants with intraventricular hemorrhage, Pediatrics, 68, 763
Michaelis, 1979, Adenosine modulation of synaptosomal dopamine release, Life Sci., 24, 2083, 10.1016/0024-3205(79)90082-1
Mikkelsen, 1978, Caffeine and schizophrenia, J. Clin. Psychiatr., 39, 732
Milon, 1988, Physiological effects of coffee and its components, Vol. III, 151
Mironov, 1991, Caffeine affects Ca uptake and Ca release from intracellular stores: fura-2 measurements in isolated snail neurons, Neurosci. Lett., 123, 200, 10.1016/0304-3940(91)90930-R
Misra, 1984, Effect of caffeine on cocaine locomotor stimulant activity in rats, Pharmacol. Biochem. Behav., 24, 761, 10.1016/0091-3057(86)90587-3
Missak, 1987, Does the human body produce a substance similar to caffeine?, Med. Hypotheses, 24, 161, 10.1016/0306-9877(87)90099-5
Missak, 1989, Understanding the pathogenesis of the restless legs syndrome at the level of the dopamine receptor. Are we about to identify the neurochemical deficiency causing schizophrenia?, Med. Hypotheses, 28, 177, 10.1016/0306-9877(89)90048-0
Missak, 1991, Exploring the role of an endogenous caffeine-like substance in the pathogenesis of schizophrenia, Med. Hypotheses, 36, 157, 10.1016/0306-9877(91)90261-V
Mitchell, 1974, Drugs and placebos: effects of caffeine on cognitive performance, Psychol. Rep., 35, 875, 10.2466/pr0.1974.35.2.875
Moraidis, 1991, Caffeine-induced discharges in CA3 neurons of hippocampal slices of the guinea pig, Neurosci. Lett., 129, 51, 10.1016/0304-3940(91)90718-9
Morgan, 1989, Methylxanthine effects on caudate dopamine release as measured by in vivo electrochemistry, Life Sci., 45, 2025, 10.1016/0024-3205(89)90577-8
Morgan, 1989, Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC), Life Sci., 45, 719, 10.1016/0024-3205(89)90091-X
Morgan, 1990, Caffeine-induced seizures: apparent proconvulsant action of N-ethylcarboxamidoadenosine (NECA), Life Sci., 47, 1, 10.1016/0024-3205(90)90559-A
Morruzzi, 1949, Brain stem reticular formation and activation of the EEG, Electroencephalogr. Clin. Neurophysiol., 1, 455, 10.1016/0013-4694(49)90219-9
Moyer, 1952, The effect of theophylline with ethylene diamine (aminophylline) and caffeine on cerebral hemodynamics and cerebral fluid pressure in patients with hypertensive headache, Am. J. Med. Sci., 224, 377, 10.1097/00000441-195210000-00002
Müller-Limmroth, 1972, Der Einfluss von coffeinhaltigem und coffeinfreiem Kaffee auf den Schlaf des Menschen, Z. Ernährungswiss., 14, 46
Müller-Limmroth, 1973, Der Einfluss von coffeinhaltigem und coffeinfreiem Kaffee auf den Schlaf des Menschen, 375
Mullin, 1983, Study of the physiology of sleep. X. The effect of alcohol and caffeine (sic) on motility and body temperature during sleep, Am. J. Physiol., 106, 478, 10.1152/ajplegacy.1933.106.2.478
Mumford, 1990, Methylxanthines elevate reinforcement threshold for electrical brain stimulation: role of adenosine receptors and phosphodiesterase inhibition, Brain Res., 528, 32, 10.1016/0006-8993(90)90191-D
Mumford, 1991, Do adenosinergic substrates mediate methylxanthine effects upon reinforcement thresholds for electrical brain stimulation in the rat?, Brain Res., 550, 172, 10.1016/0006-8993(91)90425-U
Mumford, 1988, Caffeine elevates reinforcement threshold for electrical brain stimulation: tolerance and withdrawal changes, Brain Res., 459, 163, 10.1016/0006-8993(88)90298-3
Murray, 1982, Up-regulation of rat cortical adenosine receptors following chronic administration of theophylline, Eur. J. Pharmacol., 82, 113, 10.1016/0014-2999(82)90563-5
Murray, 1982, Inhibition of acetylcholine turnover rate in rat hippocampus and cortex by intraventricular injection of adenosine analogs, J. Pharmacol. Exp. Ther., 222, 550
Murray, 1985, Purinergic modulation of the seizure threshold for pentylenetetrazol in the rat, Neuropharmacology, 24, 761, 10.1016/0028-3908(85)90010-3
Natsuno, 1972, Influence of caffeine upon spontaneous motor activity in mice, Jpn. J. Vet. Sci., 34, 243, 10.1292/jvms1939.34.243
Nehlig, 1986, Comparative effects of acute and chronic administration of caffeine on local cerebral glucose utilization in the conscious rat, Eur. J. Pharmacol., 129, 93, 10.1016/0014-2999(86)90340-7
Nehlig, 1987, Caffeine-diazepam interaction and local cerebral glucose utilization in the conscious rat, Brain Res., 419, 272, 10.1016/0006-8993(87)90593-2
Nehlig, 1990, Influence de l'administration de caféine et/ou de l-phénylisopropyladénosine sur l'activité locomotrice et le couplage entre le débit sanguin et le métabolisme cérébral chez le rat, Circ. Métab. Cerveau, 7, 99
Nehlig, 1984, Effects of acute administration of caffeine on local cerebral glucose utilization in the rat, Eur. J. Pharmacol., 101, 91, 10.1016/0014-2999(84)90034-7
Nehlig, 1987, Influence d'une administration chronique et aiguë de caféine sur l'utilisation cérébrale locale de glucose et sur l'activité locomotrice du rat, Cire. Métab. Cerveau., 4, 67
Nehlig, 1988, Comparative effects of caffeine and l-phenylisopropyladenosine on local cerebral glucose utilization in the rat, Eur. J. Pharmacol., 157, 1, 10.1016/0014-2999(88)90464-5
Nehlig, 1990, Effects of caffeine, l-phenylisopropyladenosine and their combination on local cerebral blood flow in the rat, Eur. J. Pharmacol., 179, 271, 10.1016/0014-2999(90)90165-3
Neil, 1978, Caffeinism complicating hypersomnic depressive episodes, Compr. Psychiatry, 19, 377, 10.1016/0010-440X(78)90021-4
Neims, 1983, Caffeine: metabolism and biochemical mechanisms of action, 1
Niemand, 1986, Adenosine in the inhibition of diazepam sedation by aminophylline, Acta Anaesthesiol. Scand., 30, 493, 10.1111/j.1399-6576.1986.tb02462.x
Nuotto, 1982, Coffee and caffeine and alcohol effects on psychomotor functions, Clin. Pharmacol. Ther., 31, 68, 10.1038/clpt.1982.11
Oborne, 1983, Interaction of alcohol and caffeine on human reaction time, Aviat. Space Environm. Med., 54, 528
Oettinger, 1985, Effects of tunnel maze complexity on caffeinic hyperactivity in the rat, Pharmacol. Biochem. Behav., 23, 85, 10.1016/0091-3057(85)90134-0
Okada, 1980, Inhibitory action of adenosine and adenosine analogs on neurotransmission in the olfactory cortex slice of guinea pig: structure-activity relationships, Eur. J. Pharmacol., 61, 137, 10.1016/0014-2999(80)90156-9
Okuma, 1982, Model of insomnia by methylphenidate and caffeine and use in the evaluation of temazepam, Psychopharmacology, 76, 201, 10.1007/BF00432545
Oliviera, 1990, Effect of caffeine administration on latent learning ability of male rats in a simple maze task, Brazil. J. Med. Biol. Res., 23, 975
O'Neill, 1990, The role of [Ca2+]i and [Ca2+] sensitization in the caffeine contracture of rat myocytes: measurements of [Ca2+]i and [caffeine]i, J. Physiol., 425, 55, 10.1113/jphysiol.1990.sp018092
Orlikov, 1991, Caffeine-induced anxiety and increase of kynurenine concentration in plasma of healthy subjects: a pilot study, Biol. Psychiatry, 29, 391, 10.1016/0006-3223(91)90225-B
Paalzow, 1974, Theophylline increased sensitivity to nociceptive stimulation and regional turnover of rat brain 5-HT, noradrenaline and dopamine, Acta Pharmacol. Toxicol., 34, 157, 10.1111/j.1600-0773.1974.tb03494.x
Parek, 1989, Theophylline-induced seizures (Abstract), Ann. Neurol., 26, 457
Parsons, 1978, Effect of smoking on caffeine clearance, Clin. Pharmacol. Ther., 24, 40, 10.1002/cpt197824140
Parsons, 1981, Prolonged half-life of caffeine in healthy term newborn infants, J. Pediatrics, 98, 640, 10.1016/S0022-3476(81)80784-6
Parsons, 1982, Delayed elimination of caffeine by women in the last 2 weeks of pregnancy, Can. Med. Assoc. J., 127, 377
Patwardhan, 1980, Impaired elimination of caffeine by oral contraceptive steroids, J. Lab. Clin. Med., 95, 603
Pearlman, 1989, Caffeine pharmacokinetics in preterm infants older than 2 weeks, Dev. Pharmacol. Ther., 12, 65, 10.1159/000480966
Pedata, 1983, Effects of methylxanthines on acetylcholine release from electrically stimulated cortical slices (Abstract), Br. J. Pharmacol., 80, 471P
Pedata, 1984, Biphasic effect of methylxanthines on acetylcholine release from electrically stimulated brain slices, Br. J. Pharmacol., 83, 69, 10.1111/j.1476-5381.1984.tb10120.x
Pelleg, 1990, The pharmacology of adenosine, Pharmacotherapy, 10, 157
Pellow, 1985, Validation of open/closed arm entries in an elevated plus-maze as a measure of anxiety in the rat, J. Neurosci. Methods, 14, 149, 10.1016/0165-0270(85)90031-7
Perkins, 1975, Effect of caffeine upon maximal muscular endurance of females, Med. Sci. Sports, 7, 221
Perrotin, 1988, Survenue de crises convulsives sous theophylline à doses thérapeutiques, Presse Med., 17, 1206
Perry, 1973, The effect of heredity on attitude towards alcohol, cigarettes and coffee, J. Appl. Physiol., 58, 275
Perry, 1973, Heredity, personality traits, product attitude and product consumption: an exploratory study, J. Marketing Res., 10, 376, 10.2307/3149384
Peters, 1967, Caffeine-induced hemorrhagic automutilation, Arch. Int. Pharmacodyn., 169, 139
Petitjohn, 1979, Effects of alcohol and caffeine on wheel running activity in the mongolian gerbil, Pharmacol. Biochem. Behav., 10, 339, 10.1016/0091-3057(79)90194-1
Pfeiffer, 1962, Caffeine-induced ulcerogenesis in the rat, Can. J. Biochem. Physiol., 40, 1473, 10.1139/o62-168
Phillis, 1980, Benzodiazepines inhibit adenosine uptake into rat brain synaptosomes, Brain Res., 195, 494, 10.1016/0006-8993(80)90087-6
Phillis, 1975, Adenosine as a putative transmitter in the cerebral cortex. Studies with potentiators and antagonists, Life Sci., 17, 1085, 10.1016/0024-3205(75)90329-X
Phillis, 1980, Effects of diazepam on adenosine and acetylcholine release from rat cerebral cortex: further evidence for a purinergic mechanism in the action of diazepam, Br. J. Pharmacol., 70, 341, 10.1111/j.1476-5381.1980.tb07942.x
Phillis, 1983, The role of adenosine and its nucleotides in central synaptic transmission, Prog. Neurobiol., 16, 187, 10.1016/0301-0082(81)90014-9
Phillis, 1980, The effect of morphine on purine and acetylcholine deaminase, dipyridamole and aminophylline on acetylcholine release from electrically stimulated brain slices, Pharmacol. Biochem. Behav., 13, 421, 10.1016/0091-3057(80)90249-X
Podboy, 1977, Caffeine reduction and behavior changes in the severely retarded, Ment. Retard., 15, 40
Pole, 1981, Caffeine antagonizes several central effects of diazepam, Life Sci., 28, 2265, 10.1016/0024-3205(81)90579-8
Pollock, 1981, Effects of caffeine on resting EEG and response to sine wave modulated light, Electroencephalogr. Clin. Neurophysiol., 51, 470, 10.1016/0013-4694(81)90223-6
Pons, 1988, Attentional effects of caffeine in man: comparison with drugs acting upon performance, Psychiatry Res., 23, 329, 10.1016/0165-1781(88)90023-6
Popoli, 1988, Anticonvulsant activity of carbamazepine and N6-l-phenylisopropyladenosine in rabbits. Relationship to adenosine receptors in the central nervous system, Pharmacol. Biochem. Behav., 29, 533, 10.1016/0091-3057(88)90016-0
Popoli, 1991, Akinesia due to catecholamine depletion in mice is prevented by caffeine. Further evidence for an involvement of adenosinergic system in the control of motility, J. Pharm. Pharmacol., 43, 280, 10.1111/j.2042-7158.1991.tb06685.x
Popoli, 1987, An EEG and behavioural study of the excitatory properties of caffeine in rabbits, Arch. Int. Pharmacodyn. Ther., 290, 5
Portoles, 1985, Caffeine-induced changes in the composition of the free amino acid pool of the cerebral cortex, Neurochem. Res., 10, 887, 10.1007/BF00964626
Powers, 1983, Effects of caffeine ingestion and metabolism and performance during graded exercice, Eur. J. Appl. Physiol., 50, 301, 10.1007/BF00423236
Powers, 1985, Caffeine and endurance performance, Sports Med., 2, 165, 10.2165/00007256-198502030-00002
Primavera, 1975, An investigation of personality and caffeine use, Br. J. Addict., 70, 213, 10.1111/j.1360-0443.1975.tb00029.x
Pryds, 1991, Aminophylline reduces cerebral blood flow in stable, preterm infants without affecting the visual evoked potential, Eur. J. Pediatrics, 150, 366, 10.1007/BF01955942
Puglisi, 1977, Molecular and cellular sites of action of caffeine, 285
Puiroud, 1988, Dynamic cerebral and systemic circulatory effects of adenosine, theophylline and dipyridamole, Brain Res., 453, 287, 10.1016/0006-8993(88)90169-2
Radulovacki, 1982, N6(l-Phenylisopropyl)adenosine (l-PIA) increases slow-wave sleep (S2) and decreases wakefulness in rats, Brain Res., 246, 178, 10.1016/0006-8993(82)90161-5
Radulovacki, 1980, Caffeine produces REM sleep rebound in rats, Brain Res., 201, 497, 10.1016/0006-8993(80)91060-4
Raichle, 1985, Dynamic measurements of local cerebral blood flow and metabolism using positron emission tomography, 159
Rainey, 1985, Headache related to chronic caffeine addiction, Text. Dent. J., 102, 29
Rall, 1980, Central nervous system stimulants. The xanthines, 592
Rall, 1982, The 1982 Theodore Weicker Memorial Award Oration: Evolution of the mechanism of action of methylxanthines: from calcium mobilizers to antagonists of adenosine receptors, Pharmacologist, 24, 277
Ramkumar, 1988, Multiple components of the A1 adenosine receptor-adenylate cyclase system are regulated in rat cerebral cortex by chronic caffeine ingestion, J. Clin. Invest., 82, 242, 10.1172/JCI113577
Rapoport, 1984, Behavioral effects of caffeine in children. Relationship between dietary choice and effects of caffeine challenge, Arch. Gen. Psychiatry, 41, 1073, 10.1001/archpsyc.1983.01790220063010
Rapoport, 1981, Behavioral and automatic effects of caffeine in normal boys, Dei. Pharmacol. Ther., 3, 74, 10.1159/000457425
Rapoport, 1981, Behavioural and cognitive effects of caffeine in boys and adult males, J. Nerv. Ment. Dis., 169, 726, 10.1097/00005053-198111000-00007
Reichard, 1977, The effects of caffeine on reaction time in hyperkinetic and normal children, Am. J. Psychiatry, 134, 144, 10.1176/ajp.134.2.144
Regina, 1974, Effects of caffeine on alertness in stimulated automobile driving, J. Appl. Psychol., 59, 483, 10.1037/h0037225
Reith, 1987, Effects of caffeine on monoaminergic systems in mouse brain, Acta Biochim. Biophys. Hung., 22, 149
Reivich, 1974, Blood flow metabolism couple, 125
Rennie, 1976, A sparing effect of increased free fatty acids on muscle glycogen content in exercising rats, Biochem. J., 156, 647, 10.1042/bj1560647
Revelle, 1980, The interactive effect of personality, time of dayand caffeine: a test of the arousal model, J. Exp. Psychol. Gen., 109, 1, 10.1037/0096-3445.109.1.1
Richards, 1985, Theophylline-associated seizures in children, Ann. Allergy, 54, 276
Ritchie, 1975, Central nervous system stimulants. II. The xanthines, 358
Rivers, 1907, The action of caffeine on the capacity for muscular work, J. Physiol., 36, 33, 10.1113/jphysiol.1907.sp001215
Roache, 1987, Interactions of diazepam and caffeine: behavioral and subjective dose effects in humans, Pharmacol. Biochem. Behav., 26, 801, 10.1016/0091-3057(87)90614-9
Robertson, 1978, Effects of caffeine on plasma renin activity, catecholamines and blood pressure, N. Engl. J. Med., 298, 181, 10.1056/NEJM197801262980403
Robertson, 1981, Tolerance to the humoral and hemodynamic effects of caffeine in man, J. Clin. Invest., 67, 1111, 10.1172/JCI110124
Roca, 1988, Chronic caffeine or theophylline exposure reduces γ-aminobutyric acid/benzodiazepine receptor site interactions, Mol. Pharmacol., 30, 481
Rodrigues, 1990, Effects of caffeine on the rate of perceived exertion, Brazil. J. Med. Biol. Res., 23, 965
Roller, 1981, Caffeinism: subjective quantitative aspect of withdrawal syndrome, Med. J. Aust., 1, 146, 10.5694/j.1326-5377.1981.tb135407.x
Rosenthal, 1977, Alerting effects of caffeine after endorphin levels in blood but not in brain, Nature, 270, 618
Rossier, 1977, Foot-shock induced stress increases beta-endorphin levels in blood but not brain, Nature, 270, 618, 10.1038/270618a0
Rossignol, 1985, Caffeine-containing beverages and premenstrual syndrome in young women, Am. J. Public Health, 75, 1335, 10.2105/AJPH.75.11.1335
Roussinov, 1976, Comparative study of the effect of caffeine, strychnine and echinopsin on learning and memory in albino rats, Acta Physiol. Pharmacol. Bulg., 2, 66
Rowland, 1980
Rubtsov, 1988, Caffeine interaction with the Ca-release channels of heavy sarcoplasmic reticulum. Evidence that 170 kD Ca-binding protein is a caffeine receptor to the Ca-channels, Biochem. Biophys. Res. Comm., 154, 462, 10.1016/0006-291X(88)90709-7
Sakata, 1973, Stereotyped and aggressive behavior induced by sustained high dose of theophylline in rats, Jpn. J. Pharmacol., 23, 781, 10.1254/jjp.23.781
Sakata, 1973, Further aspects of aggressive behavior induced by sustained high dose of theophylline in rats, Jpn. J. Pharmacol., 23, 787, 10.1254/jjp.23.787
Sakata, 1975, Changes of brain serotonin and muricide behavior following chronic administration of theophylline in rats, Physiol. Behav., 15, 449, 10.1016/0031-9384(75)90258-9
Saliba, 1989, Caffeine and cerebral blood flow velocity in preterm infants, Dev. Pharmacol. Ther., 13, 134, 10.1159/000457595
Sanders, 1988, Chronic theophylline exposure increases agonist and antagonist binding to A1 adenosine receptors in rat brain, Neuropharmacology, 27, 757, 10.1016/0028-3908(88)90086-X
Sandow, 1966, Caffeine potentiation of twitch tension of sartorius muscle, Biochem. Z., 345, 232
Sanger, 1980, The effects of caffeine on timing behavior in rodents: comparisons with chlordiazepoxide, Psychopharmacology, 68, 305, 10.1007/BF00428121
Santos, 1991, Effect of coffee in alcoholics, Ann. Int. Med., 115, 499, 10.7326/0003-4819-115-6-499_1
Satinder, 1971, Genotype-dependent effects of d-amphetamine sulphate and escape-avoidance behavior of rats, J. Comp. Physiol. Psychol., 76, 359, 10.1037/h0031385
Sattin, 1970, The effect of adenosine and adenine nucleotides on the cyclic adenosine 3′,5′-phosphate content of guinea pig cerebral cortex slices, Mol. Pharmacol., 6, 13
Sawyer, 1982, Caffeine and human behavior: arousal, anxietyand performance effects, J. Behav. Med., 5, 415, 10.1007/BF00845371
Schaff, 1962, Influence de l'alcool et de la caféine sur la motilité spontanée, la fréquence cardiaque, la fréquence respiratoire et la température rectale au cours du sommeil, J. Physiol., 54, 411
Schlieper, 1981, Effect of therapeutic plasma concentrations of theophylline on behavior, cognitive processingand affect in chidren with asthma, J. Pediatrics, 118, 449, 10.1016/S0022-3476(05)82167-5
Schlosberg, 1981, Acute effects of caffeine injection on neutral amino acids and brain monoamine level in rats, Life Sci., 29, 173, 10.1016/0024-3205(81)90286-1
Schnackenberg, 1973, Caffeine as a substitute for Schedule II Stimulants in hyperkinetic children, Am. J. Psychiatry, 130, 796, 10.1176/ajp.130.7.796
Schwertz, 1965, Effets physiologiques de la caféine et du méprobamate au cours du sommeil chez l'homme, Arch. Sci. Physiol. Paris, 19, 425
Scott, 1946, Further study of some 1-substituted theobromine compounds, J. Pharmacol. Exp. Ther., 86, 113
Seashore, 1953, The effects of analeptic drugs in relieving fatigue, Psychological Monographs, 67, 1, 10.1037/h0093659
Severson, 1979, Regulation of lipid metabolism in adipose tissue and heart, Can. J. Physiol. Pharmacol., 57, 923, 10.1139/y79-142
Shallek, 1959, Effects of drugs on spontaneous and activated EEG of cat, Arch. Int. Pharmacodyn., 120, 319
Shanahan, 1986, Potentiation of performance-induced anxiety by caffeine in coffee, Psychol. Rep., 59, 83, 10.2466/pr0.1986.59.1.83
Shapira, 1987, Facilitation of ECT by caffeine pretreatment, Am. J. Psychiatry, 144, 1199, 10.1176/ajp.144.9.1199
Shapira, 1985, Potentiation of seizure length and clinical response to electroconvulsive therapy by caffeine pretreatment: a case control study, Convulsive Therapy, 1, 58
Shaul, 1984, Caffeine toxicity as a cause of acute psychosis in anorexia nervosa, J. Pediatrics, 105, 493, 10.1016/S0022-3476(84)80037-2
Shenkin, 1951, Effects of various drugs upon cerebral circulation and metabolism in man, J. Appl. Physiol., 3, 465, 10.1152/jappl.1951.3.8.465
Shirlow, 1985, A study of caffeine consumption and symptoms: indigestion, palpitations, tremor, headache and insomnia, Int. J. Epidemiol., 14, 239, 10.1093/ije/14.2.239
Shorofsky, 1977, Caffeine-withdrawal headache and fasting, NY State J. Med., 77, 217
Sinton, 1989, The influence of chronic caffeine administration on sleep parameters in the cat, Pharmacol. Biochem. Behav., 32, 459, 10.1016/0091-3057(89)90179-2
Sinton, 1981, Increased sleep time in the offspring of caffeine-treated dams from two inbred strains of mice, Neurosci. Lett., 24, 169, 10.1016/0304-3940(81)90243-3
Skinner, 1937, Effects of caffeine and theophylline on activity of rats in relation to brain xanthine concentrations, Psychol. Rec., 10, 340
Smellie, 1979, The dextro and levorotatory isomers of N6-phenylisopropyladenosine: stereospecific effects on cyclic AMP formation and evoked synaptic responses in brain slices, Life Sci., 25, 1739, 10.1016/0024-3205(79)90477-6
Smith, 1990, Effects of caffeine given before and after lunch on sustained attention, Neuropsychobiology, 23, 160, 10.1159/000119444
Smith, 1983, Extraversion and multiple levels of caffeine-induced arousal: effects on overhabituation and dishabituation, Psychophysiol., 20, 29, 10.1111/j.1469-8986.1983.tb00896.x
Smith, 1983, Detection of intracellular Ca2+ transients in sympathetic neurons using arsenazo III, Nature, 304, 350, 10.1038/304350a0
Snyder, 1984, Adenosine as a mediator of the behavioral effects of xanthines, 129
Snyder, 1981, Adenosine receptors and behavioral actions of methylxanthines, 78, 3260
Sokoloff, 1978, Local cerebral energy metabolism: its relationship to local functional activity and blood flow, 171
Sours, 1983, Case reports of anorexia nervosa and caffeinism, Am. J. Psychiatry, 140, 235, 10.1176/ajp.140.2.235
Spindel, 1984, Neuroendocrine effects of caffeine in rat and man, 119
Spealman, 1988, Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism, Psychopharmacology, 95, 19, 10.1007/BF00212759
Srasser, 1971, Vergleichende Untersuchungen über der Wirkung von Koffein und Chlorogensäure auf die Psychomotorik des Menschen, Arzneinmittelforschung, 25, 209
Stahle, 1990, Theophylline concentration in the extracellular space of rat brain: measurement by microdialysis and relation to behavior, Eur. J. Pharmacol., 185, 187, 10.1016/0014-2999(90)90639-N
Statland, 1980, Serum caffeine half-lifes. Healthy subjects vs patients having alcoholic hepatic disease, Am. J. Clin. Pathol., 73, 390, 10.1093/ajcp/73.3.390
Stauderman, 1991, The role of caffeine-sensitive Ca2+ stores in agonist- and inositol 1,4,5-triphosphate-induced Ca2+ release from bovine adrenal chromaffin cells, Biochem. J., 278, 643, 10.1042/bj2780643
Stavric, 1988, Methylxanthine toxicity to humans. 2. Caffeine, Food Chem. Toxicol, 26, 645, 10.1016/0278-6915(88)90236-0
Stavric, 1990, Caffeine metabolism: a problem in extrapolating results from animal studies to humans, Acta Pharm. Jugosl., 40, 475
Stephenson, 1977, Physiologic and psychotropic effects of caffeine on man, J. Am. Diet. Ass., 71, 240, 10.1016/S0002-8223(21)40969-7
Stillner, 1978, Caffeine-induced delirium during prolonged competitive stress, Am. J. Psychiatry, 135, 855, 10.1176/ajp.135.7.855
Stern, 1989, Reinforcing and subjective effects of caffeine in normal human volunteers, Psychopharmacology, 98, 81, 10.1007/BF00442010
Stoner, 1988, Preferential effects of caffeine on limbic and cortical dopamine systems, Bio. J. Psychiatry, 23, 761, 10.1016/0006-3223(88)90064-9
Stradomsky, 1970, Untersuchungen über Schlafbewegungen nach caffeinhaltigem and caffeinfreiem Bohnenkaffee, Med. Klin., 65, 1372
Stransky, 1932, Zur Frage des Coffeinismus, Wien Med. Woschenschr., 82, 395
Stripling, 1974, Nicotine and caffeine: Disruption of the long-term store of memory and proactive facilitation of learning in mice, Psychopharmacology, 38, 187, 10.1007/BF00421371
Strömberg, 1973, Behavioural and biochemical interaction between caffeine and l-dopa, J. Pharm. Pharmacol., 25, 302, 10.1111/j.2042-7158.1973.tb10012.x
Strubelt, 1969, The influence of reserpine, propranolol and adrenal medullectomy on the hyperglycemic actions of theophylline and caffeine, Arch. Int. Pharmacodyn., 169, 215
Sulc, 1974, Neurophysiological effects of small doses of caffeine in man, Activ. Nerv. Sup., 16, 217
Svensson, 1980, Mood effects of diazepam and caffeine, Psychopharmacology, 67, 73, 10.1007/BF00427598
Swift, 1989, The effects of age on the response to caffeine, Psychopharmacology, 94, 29, 10.1007/BF00735876
Switzer, 1935, The influence of caffeine upon ‘inhibition of delay’, J. Comp. Psychol., 19, 155, 10.1037/h0063122
Switzer, 1935, The effect of caffeine on experimental extinction of conditioned reactions, J. Gen. Psychol., 12, 78, 10.1080/00221309.1935.9920089
Szot, 1987, Theophylline-induced upregulation of A1-adenosine receptors associated with reduced sensitivity to convulsants, Neuropharmacology, 26, 1173, 10.1016/0028-3908(87)90264-4
Tanaka, 1990, Maternal caffeine ingestion increases the tyrosine level in neonatal rat cerebrum, Biol. Neonate, 57, 133, 10.1159/000243173
Tarnopolsky, 1989, Physiological responses to caffeine during endurance training in habitual caffeine users, Med. Sci. Sports Exerc., 21, 418, 10.1249/00005768-198908000-00013
Teschemacher, 1968, Permeation of purine derivatives into the cerebrospinal fluid of dogs, Experientia, 24, 54, 10.1007/BF02136789
Thithapandha, 1972, Effects of caffeine and theophylline on activity of rats in relation to brain xanthine concentrations, 139, 582
Thornthon, 1939, The effects of benzedrine and caffeine upon performance in certain psychomotor tasks, J. Abnorm. Soc. Psychol., 34, 96, 10.1037/h0062063
Toner, 1982, Metabolic and cardiovascular responses to exercice with caffeine, Ergonomics, 25, 1175, 10.1080/00140138208925074
Trotta, 1980, Inhibition by caffeine of calcium uptake by brain microsomal vesicles, J. Pharm. Pharmacol., 214, 670
Truitt, 1971, The xanthines, 533
Uhde, 1988, Caffeine: practical facts for the psychiatrist, 73
Uhde, 1990, Caffeine provocation of panic: a focus on biological mechanisms, 219
Uhde, 1989, Caffeine model of panic, 410
Uhde, 1984, Caffeine and behavior: relationship to psychopathology and underlying mechanisms, Psychopharmacol. Bull., 20, 426
Uhde, 1984, Fear and anxiety: relationship to noradrenergic function, Psychopathology, 17, 8, 10.1159/000284127
Uzunov, 1973, Cyclic AMP phosphodiesterase in cloned astrocytoma cells: norepinephrine induces a specific enzyme form, Science, 180, 304, 10.1126/science.180.4083.304
Uzunov, 1972, Separation of multiple molecular forms of cyclic adenosine 3′,5′-monophosphate phosphodiesterase in rat cerebellum by polyacrylamide gel electrophoresis, Biochim. Biophys. Acta, 284, 220, 10.1016/0005-2744(72)90060-5
Valdman, 1967, Pharmacology of the brain, 20, 1
Valzelli, 1973, Behavioral and neurochemical effects of caffeine in normal and aggressive mice, Pharmacol. Biochem. Behav., 1, 251, 10.1016/0091-3057(73)90112-3
Van Calker, 1979, Adenosine regulates, via two different types of receptors, the accumulation of cyclic AMP in cultured cells, J. Neurochem., 33, 999, 10.1111/j.1471-4159.1979.tb05236.x
Van Dusseldorp, 1990, Headache caused by caffeine withdrawal among moderate coffee drinkers switched from ordinary to decaffeinated coffee: a 12 week double blind trial, Br. Med. J., 300, 1558, 10.1136/bmj.300.6739.1558
Van Handel, 1983, Caffeine, 128
Vernikos-Danellis, 1968, The effect of in vitro and in vivo caffeine, theophylline and hydrocortisone on the phosphodiesterase activity of the pituitary, median eminence, heart and cerebral cortex of the rat, 128, 1016
Victor, 1981, Somatic manifestations of caffeinism, J. Clin. Psychiatry, 42, 185
Virus, 1990, A comparison of the effects of caffeine, 8-cyclopentyltheophylline, and alloxazine on sleep in rats. Possible roles of central nervous system adenosine receptors, Neuropsychopharmacology, 3, 243
Von Borstel, 1983, Caffeine withdrawal enhances sensitivity to physiological level of adenosine in vivo (Abstract), 41, 1669
Wachtel, 1982, Characteristic behavioral alterations in rats induced by rolipram and other selective adenosine cyclic 3′,5′-monophosphate phosphodiesterase inhibitors, Psychopharmacology, 77, 309, 10.1007/BF00432761
Wakade, 1990, Ca2+ mobilized by caffeine from the inositol 1,4,5-triphosphate-insensitive pool of Ca2+ in somatic regions of sympathetic neurons does not evoke [3H]norepinephrine release, J. Neurochem., 55, 1806, 10.1111/j.1471-4159.1990.tb04972.x
Waldeck, 1971, Some effects of caffeine and aminophylline on the turnover of catecholamines in the brain, J. Pharm. Pharmacol., 23, 824, 10.1111/j.2042-7158.1971.tb10198.x
Waldeck, 1974, Ethanol and caffeine: a complex interaction with respect to locomotor activity and central catecholamines, Psychopharmacologia, 36, 209, 10.1007/BF00421803
Waldeck, 1975, On the interaction between caffeine and barbiturates with respect to locomotor activity and brain catecholamines, Acta Pharmacol. Toxicol., 36, 172, 10.1111/j.1600-0773.1975.tb00783.x
Waldeck, 1975, Effect of caffeine on locomotor activity and central catecholamine mechanisms: a study with special reference to drug interaction, Acta Pharmacol. Toxicol., 36, 1
Walsh, 1990, Effect of caffeine on physiological sleep tendency and ability to sustain wakefulness at night, Psychopharmacology, 101, 271, 10.1007/BF02244139
Wanner, 1965, Pharmakologische Wirkungen auf die Laufleistung der Ratte bei verschiedene Leistungsbelohnungen und verschiedenen Leistunganforderungen, Psychopharmacologia, 7, 182, 10.1007/BF00411217
Warbritton, 1980, Increased sensitivity to intracerebroventricular infusion of serotonin and deaminated indoles after lesioning rat with dihydroxytryptamine, Brain Res., 177, 355, 10.1016/0006-8993(80)90470-9
Webb, 1978, Effects of caffeine on DRL performance in the mouse, Pharmacol. Biochem. Behav., 9, 7, 10.1016/0091-3057(78)90004-7
Weber, 1968, The mechanism of the action of caffeine on sarcoplasmic reticulum, J. Gen. Physiol., 52, 761, 10.1085/jgp.52.5.760
Weber, 1968, The relationship between caffeine contracture of intact muscle and the effect of caffeine on reticulum, J. Gen. Physiol., 52, 751, 10.1085/jgp.52.5.750
Wechsler, 1950, The effects of intravenously administered aminophylline on cerebral circulation and metabolism in man, J. Clin. Invest., 29, 28, 10.1172/JCI102230
Weil, 1983
Weir, 1987, A high carbohydrate diet negates the metabolic effects of caffeine during exercice, Med. Sci. Sports Exerc., 19, 100, 10.1249/00005768-198704000-00006
Weir, 1983, Interaction between methylxanthines and the benzodiazepine receptor, Arch. Int. Pharmacodyn. Ther., 265, 42
Weiss, 1977, Selective cyclic nucleotide phosphodiesterase inhibitors as potential therapeutic agents, Annu. Rev. Pharmacol. Toxicol., 17, 441, 10.1146/annurev.pa.17.040177.002301
Weiss, 1962, Enhancement of human performance by caffeine and the amphetamines, Pharmacol. Rev., 14, 1
Wells, 1984, Caffeine: implications of recent research for clinical practice, Am. J. Orthopsychiatry, 54, 375, 10.1111/j.1939-0025.1984.tb01504.x
Wendt, 1968, Effects of caffeine on Ca-activated force production in skinned cardiac and skeletal muscle fibres of the rat, J. Gen. Physiol., 52, 750
Wenzel, 1962, Effects of centrally acting drugs on human motor and psychomotor performance, J. Pharm. Sci., 51, 634, 10.1002/jps.2600510706
Westfall, 1968, Sensitivity changes in the dog heart to norepinephrine, calcium and aminophylline resulting from pretreatment with reserpine, J. Pharmacol. Exp. Ther., 159, 98
White, 1980, Anxiety and muscle tension as consequences of caffeine withdrawal, Science, 209, 1547, 10.1126/science.7433978
Wilcox, 1985, Effects of caffeine and exercice on body fat levels in the rat, Int. J. Sports Med., 6, 322, 10.1055/s-2008-1025863
Wilkin, 1986, The caffeine withdrawal flush: report of a case of ‘weekend flushing’, Milit. Med., 151, 123, 10.1093/milmed/151.2.123
Winn, 1981, The role of adenosine in the regulation of cerebral blood flow, J. Cereb. Blood Flow Metab., 1, 239, 10.1038/jcbfm.1981.29
Winstead, 1976, Coffee consumption among psychiatric inpatients, Am. J. Psychiatry, 133, 1147
Winter, 1981, Caffeine-induced stimulus control, Pharmacol. Biochem. Behav., 15, 157, 10.1016/0091-3057(81)90170-2
Wolpaw, 1978, Effects of ethanol, caffeine and placebo on the auditory evoked response, Electroencephalogr. Clin. NeuroPhysiol., 44, 568, 10.1016/0013-4694(78)90124-4
Wu, 1984, Up-regulation of brain [3H]diazepam binding sites in chronic caffeine-treated rats, Brain Res., 294, 186, 10.1016/0006-8993(84)91329-5
Wu, 1983, Caffeine upregulates adenosine receptors in the rat central nervous system (Abstract), 42, 883
Wu, 1988, Up-regulation of brain [3H]diazepam binding sites in chronic caffeine treated rats, Gen. Pharmacol., 17, 501, 10.1016/0306-3623(86)90203-X
Würzner, 1982, Prenatal effects of caffeine on sleep profile in rats, 309
Yanick, 1987, The dose-response effects of caffeine on sleep in rats, Brain Res., 403, 177, 10.1016/0006-8993(87)90141-7
Yarbrough, 1981, In vivo behavioral assessment of central nervous system purinergic receptors, Eur. J. Pharmacol., 76, 137, 10.1016/0014-2999(81)90495-7
Yasuhara, 1990, Rapid development of functional tolerance to caffeine-induced seizures in rats, 188, 185
Yokogoshi, 1988, Phenylalanine inhibits caffeine-induced increase in brain serotonin concentrations in rats, Agric. Biol. Chem., 52, 3173, 10.1271/bbb1961.52.3173
Yokogoshi, 1987, The effects of caffeine and caffeine-containing beverages on the disposition of brain serotonin in rats, Agric. Biol Chem., 51, 3281, 10.1271/bbb1961.51.3281
York, 1982, The effect of diazepam on adenosine uptake and adenosine-stimulated adenylate cyclase in guinea-pig brain, Can. J. Physiol. Pharmacol., 60, 302, 10.1139/y82-041
Zacchetti, 1991, Intracellular Ca2+ pools in PC12 cells. A unique, rapidly exchanging pool is sensitive to both inositol 1,4,5-triphosphate and caffeine-ryanodine, J. Biol Chem., 266, 20152, 10.1016/S0021-9258(18)54903-6
Zazlove, 1991, Changes in behaviors of inpatients after a ban on the sale of caffeinated drinks, Hosp. Comm. Psychiatry, 42, 84
Zazlove, 1991, Effect of caffeine intake on psychotic in-patients, Br. J. Psychiatry, 159, 565, 10.1192/bjp.159.4.565
Zhang, 1990, The effects of chronic caffeine administration on peripheral adenosine receptors, J. Pharmacol Exp. Ther., 254, 757
Zielke, 1987, Chronic exposure to subcutaneously implanted methylxanthines. Differential elevation of A1-adenosine receptors in mouse cerebellar and cerebral cortical memebranes, Biochem. Pharmacol, 15, 2533, 10.1016/0006-2952(87)90527-2
Zimbardo, 1958, Effect of caffeine and chlorpromazine on the sexual behavior of male rats, Science, 127, 85, 10.1126/science.127.3289.84
Zimmerberg, 1991, The effect of postnatal caffeine exposure on growth, activity and learning in rats, Pharmacol Biochem. Behav., 39, 883, 10.1016/0091-3057(91)90048-7