Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology
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2006, Uncoupling of pathways that promote postmitotic life span and apoptosis from replicative immortality of Caenorhabditis elegans germ cells, Aging Cell., 5, 559, 10.1111/j.1474-9726.2006.00244.x
2001, C-elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein, Curr. Biol., 11, 1934, 10.1016/S0960-9822(01)00604-2
2000, MRT-2 checkpoint protein is required for germline immortality and telomere replication in C-elegans, Nature., 403, 159, 10.1038/35003120
2001, Assessment of sublethal endpoints for toxicity testing with the nematode Caenorhabditis elegans, Environ. Toxicol. Chem., 20, 833, 10.1002/etc.5620200419
2004, Assessing behavioral toxicity with Caenorhabditis elegans, Environ. Toxicol. Chem., 23, 1235, 10.1897/03-264
2007, Genetics of aging in Caenorhabditis elegans, PLoS Genet., 3, 1565
2007, The versatile worm: Genetic and genomic resources for Caenorhabditis elegans research, Nat. Rev. Genet., 8, 518, 10.1038/nrg2105
2000, Characterization of Ce-atl-1, an ATM-like gene from Caenorhabditis elegans, Mol. Gen. Genet., 264, 119, 10.1007/s004380000291
2008, Nucleotide excision repair and the degradation of RNA pol II by the Caenorhabditis elegans XPA and Rsp5 orthologues, RAD-3 and WWP-1, DNA Repair., 7, 267, 10.1016/j.dnarep.2007.10.004
American Society for Testing and Materials (ASTM), 2002, Standard guide for conducting laboratory soil toxicity tests with the nematode Caenorhabditis elegans. E 2172-01, Annual Book of ASTM Standards, Vol. 11.05.
2003, Effects of toxic environmental contaminants on voltage-gated calcium channel function: From past to present, J. Bioenerg. Biomembr., 35, 507, 10.1023/B:JOBB.0000008023.11211.13
1990, Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans, J. Exp. Zool., 253, 263, 10.1002/jez.1402530305
2008, Remarkable longevity and stress resistance of nematode PI3K-null mutants, Aging Cell., 7, 13, 10.1111/j.1474-9726.2007.00348.x
2007, Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal, Mech. Ageing Dev., 128, 196, 10.1016/j.mad.2006.11.025
2005, Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal, Aging Cell., 4, 257, 10.1111/j.1474-9726.2005.00168.x
2002, Using machine vision to analyze and classify Caenorhabditis elegans behavioral phenotypes quantitatively, J. Neurosci. Methods., 118, 9, 10.1016/S0165-0270(02)00117-6
1994, Organophosphate and carbamate poisoning, Arch. Intern. Med., 154, 1433, 10.1001/archinte.1994.00420130020005
2006, Chemosensation in C. elegans, WormBook.
2006, Male mating behavior, WormBook., 1
2004, Targeted gene alteration in Caenorhabditis elegans by gene conversion, Nat. Genet., 36, 1231, 10.1038/ng1459
2006, Caenorhabditis elegans carbohydrates in bacterial toxin resistance, Methods Enzymol., 417, 340, 10.1016/S0076-6879(06)17021-4
2007, Resistance is non-futile: Resistance to Cry5B in the nematode Caenorhabditis elegans, J. Invertebr. Pathol., 95, 198, 10.1016/j.jip.2007.04.002
2007, Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose, J. Biol. Chem., 282, 3302, 10.1074/jbc.M606621200
2006, Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity, J. Neurosci., 26, 2830, 10.1523/JNEUROSCI.3344-05.2006
1997, Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing, Genes Funct., 1, 149, 10.1046/j.1365-4624.1997.00012.x
2008, Manganese and C. elegans in Parkinson's disease, Parkinson's Disease: Pathogenic and Therapeutic Insights from Toxin and Genetic Models.
1986, Micromotility meter: An instrument designed to evaluate the action of drugs on motility of larval and adult nematodes, Parasitology., 93, 341
2004, Homologous gene targeting in Caenorhabditis elegans by biolistic transformation, Nucleic Acids Res., 32, e40, 10.1093/nar/gnh033
1999, The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons, Brain Res., 69, 273, 10.1016/S0169-328X(99)00119-9
1998, Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease, J. Neuropathol. Exp. Neurol., 57, 738, 10.1097/00005072-199808000-00003
1998, Mutations in the Caenorhabditis elegans dystrophin-like gene dys-1 lead to hyperactivity and suggest a link with cholinergic transmission, Neurogenetics., 2, 61, 10.1007/s100480050053
2000, Chronic systemic pesticide exposure reproduces features of Parkinson's disease, Nat. Neurosci., 3, 1301, 10.1038/81834
2007, Effects of toxaphene on soil organisms, Ecotoxicol. Environ. Saf., 68, 326, 10.1016/j.ecoenv.2007.05.009
2006, Role of metals in neuronal apoptosis: Challenges associated with neurodegeneration, Curr. Alzheimer Res., 3, 311, 10.2174/156720506778249399
2006, Heterologous expression of C. elegans ion channels in Xenopus oocytes, WormBook., 1
2001, Preliminary assessment of metal toxicity in the middle Tisza River (Hungary) flood plain, J Soils Sediments., 1, 203
2000, The neurobiology of duchenne muscular dystrophy: Learning lessons from muscle?, Trends Neurosci., 23, 92, 10.1016/S0166-2236(99)01510-6
2002, Combined functional genomic maps of the C. elegans DNA damage response, Science., 295, 127, 10.1126/science.1065986
2004, BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans, Curr. Biol., 14, 33, 10.1016/j.cub.2003.11.029
2003, The effects of metals and food availability on the behavior of Caenorhabditis elegans, Environ. Toxicol. Chem., 22, 3049, 10.1897/02-565
2003, Comparison of the sensitivity of three nematode species to copper and their utility in aquatic and soil toxicity tests, Environ. Toxicol. Chem., 22, 2768, 10.1897/02-573
2006, Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Abeta(1-42): Implications for Alzheimer's disease, Neurobiol. Aging., 27, 1239, 10.1016/j.neurobiolaging.2005.07.001
Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau, Neurobiol. Aging.
2004, Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings, Neurodegener. Dis., 1, 175, 10.1159/000080983
2006, Ionotropic glutamate receptors: Genetics, behavior and electrophysiology, WormBook., 1
2007, Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans, Exp. Gerontol., 42, 845, 10.1016/j.exger.2007.02.004
2008, Oxidative stress in Caenorhabditis elegans: Protective effects of the Omega class glutathione transferase (GSTO-1), FASEB J., 22, 343, 10.1096/fj.06-7426com
2006, High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans, Nat. Protoc., 1, 1906, 10.1038/nprot.2006.283
1999, Quality of life and Parkinson's disease: Translation and validation of the US Parkinson's Disease Questionnaire (PDQ-39), Qual. Life. Res., 8, 345, 10.1023/A:1008979705027
1996, Transgenic Caenorhabditis elegans strains as biosensors, Trends Biotechnol., 14, 125, 10.1016/0167-7799(96)10016-0
2005, Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans, J. Neurosci., 25, 3801, 10.1523/JNEUROSCI.5157-04.2005
2006, Blocking of striated muscle degeneration by serotonin in C. elegans, J. Muscle Res. Cell Motil., 27, 253, 10.1007/s10974-006-9070-9
2005, Revising the standard wisdom of C. elegans natural history: Ecology of longevity, Sci. Aging Knowledge Environ., 2005, pe30
C. elegans Sequencing Consortium, 1998, Genome sequence of the nematode C. elegans: A platform for investigating biology, Science., 282, 2012, 10.1126/science.282.5396.2012
2007, Biogenic amine neurotransmitters in C. elegans, WormBook., 1
2006, Wiring optimization can relate neuronal structure and function, Proc. Natl Acad. Sci. USA., 103, 4723, 10.1073/pnas.0506806103
2003, Caenorhabditis elegans mutants resistant to phosphine toxicity show increased longevity and cross-resistance to the synergistic action of oxygen, Toxicol. Sci., 73, 60, 10.1093/toxsci/kfg049
2004, Characterization of C. elegans ubiquitin C-terminal hydrolases, In East Asia Worm Meeting.
2005, Neuronal differentiation in C. elegans, Curr. Opin. Cell Biol., 17, 682, 10.1016/j.ceb.2005.10.004
2000, HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin, Mamm. Genome., 11, 1006, 10.1007/s003350010195
2005, Improvement of heavy metal stress and toxicity assays by coupling a transgenic reporter in a mutant nematode strain, Aquat. Toxicol., 74, 320, 10.1016/j.aquatox.2005.06.006
2000, Transgenic strains of the nematode Caenorhabditis elegans as biomonitors of metal contamination, Environ. Toxicol. Chem., 19, 2122, 10.1002/etc.5620190823
2006, Developmental modulation of nonhomologous end joining in Caenorhabditis elegans, Genetics., 173, 1301, 10.1534/genetics.106.058628
2004, The nematode Caenorhabditis elegans as a model of organophosphate-induced mammalian neurotoxicity, Toxicol. Appl. Pharmacol., 194, 248, 10.1016/j.taap.2003.09.013
2005, Programmed cell death, WormBook., 1
1988, Ultraviolet mutagenesis of radiation-sensitive (rad) mutants of the nematode Caenorhabditis elegans, Mutat. Res., 209, 99, 10.1016/0165-7992(88)90025-5
2006, Electrophysiological recordings from the pharynx, WormBook., 1
2006, Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models, Science., 313, 324, 10.1126/science.1129462
2007, Toxicogenomic analysis of cadmium responsive transcription in Caenorhabditis elegans reveals novel genes and pathways involved in heavy metal resistance, SOT Meeting March 25-29, 2007.
2007, Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity, Genome Biol., 8, R122, 10.1186/gb-2007-8-6-r122
2001, Caenorhabditis elegans as an environmental monitor using DNA microarray analysis, Environmental Hormones: the Scientific Basis of Endocrine Disruption., 948, 32
2007, FOXO transcription factors in the regulatory networks of longevity, J. Biochem., 141, 769, 10.1093/jb/mvm104
2002, Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity, Proc. Natl Acad. Sci. USA., 99, 2158, 10.1073/pnas.032671599
2004, Caenorhabditis elegans as model system for rapid toxicity assessment of pharmaceutical compounds, J. Pharmacol. Toxicol. Methods., 50, 209, 10.1016/j.vascn.2004.04.002
2006, The relative roles of three DNA repair pathways in preventing Caenorhabditis elegan mutation accumulation, Genetics., 174, 57, 10.1534/genetics.106.059840
2004, High mutation rate and predominance of insertions in the Caenorhabditis elegans nuclear genome, Nature., 430, 679, 10.1038/nature02697
2000, High direct estimate of the mutation rate in the mitochondrial genome of Caenorhabditis elegans, Science., 289, 2342, 10.1126/science.289.5488.2342
2005, Ionizing radiations in Caenorhabditis elegans induce poly (ADP-ribosyl) ation, a conserved DNA-damage response essential for survival, DNA Repair., 4, 814, 10.1016/j.dnarep.2005.04.015
2005, The Caenorhabditis elegans FancD2 ortholog is required for survival following DNA damage, Comp. Biochem. Physiol. B Biochem. Mol. Biol., 141, 453, 10.1016/j.cbpc.2005.05.010
1999, Comparison of lethality, reproduction, and behavior as toxicological endpoints in the nematode Caenorhabditis elegans, J. Toxicol. Environ. Health A., 58, 451, 10.1080/009841099157179
2006, Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species, J. Neurosci., 26, 6985, 10.1523/JNEUROSCI.0746-06.2006
2007, The ToxCast program for prioritizing toxicity testing of environmental chemicals, Toxicol. Sci., 95, 5, 10.1093/toxsci/kfl103
1993, A soil toxicity test using the nematode Caenorhabditis elegans and an effective method of recovery, Arch. Environ. Contam. Toxicol., 25, 145
2003, Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model, Neurobiol. Aging., 24, 415, 10.1016/S0197-4580(02)00225-7
2007, Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans, Nat. Bio. technol., 25, 663, 10.1038/nbt1305
2001, Toxicity of the dithiocarbamate fungicide mancozeb to the nontarget soil nematode, Caenorhabditis elegans, J. Biochem. Mol. Toxicol., 15, 15, 10.1002/1099-0461(2001)15:1<15::AID-JBT2>3.0.CO;2-Z
2007, Efficient and cell specific knock-down of gene function in targeted C. elegans neurons, Gene., 395, 170, 10.1016/j.gene.2007.03.002
1999, Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron, Proc. Natl Acad. Sci. USA., 96, 179, 10.1073/pnas.96.1.179
2002, Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity, Proc. Natl Acad. Sci. USA., 99, 17131, 10.1073/pnas.262544899
2006, Vector-based RNAi approaches for stable, inducible and genome-wide screens, Drug Discovery Today., 11, 975, 10.1016/j.drudis.2006.09.008
1998, Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans, Nature., 391, 806, 10.1038/35888
2007, Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans, Autophagy., 3, 569, 10.4161/auto.4776
2008, Suppression of in vivo beta-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein, J. Biol. Chem., 283, 784, 10.1074/jbc.M703339200
2002, aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation, Dev. Cell., 3, 85, 10.1016/S1534-5807(02)00189-2
2006, Changes in gene expression associated with exposure to environmental toxicants, SOT Meeting March 5-9, 2006, (Abstract No. 1178).
2006, DNA Repair and Mutagenesis.
2004, Mutations in chemosensory cilia cause resistance to paraquat in nematode Caenorhabditis elegans, J. Biol. Chem., 279, 20277, 10.1074/jbc.M313119200
2005, Uncoupling of longevity and paraquat resistance in mutants of the nematode Caenorhabditis elegans, Biosci. Biotechnol. Biochem., 69, 2015, 10.1271/bbb.69.2015
1984, Effects of 8-methoxypsoralen plus near-ultraviolet light on the nematode Caenorhabditis-elegans, Photochem. Photobiol., 39, 831, 10.1111/j.1751-1097.1984.tb08867.x
2008, Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans, Development., 135, 1129, 10.1242/dev.013995
2002, The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans, Biochem. J., 368, 263, 10.1042/bj20020669
2006, Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/insulin-like signaling, BMC Dev. Biol., 6, 45, 10.1186/1471-213X-6-45
2003, Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons, J. Neurosci., 23, 6181, 10.1523/JNEUROSCI.23-15-06181.2003
2000, A conserved checkpoint pathway mediates DNA damage-induced apoptosis and cell cycle arrest in C. elegans, Mol. Cell., 5, 435, 10.1016/S1097-2765(00)80438-4
2006, Cellular mechanisms of lead neurotoxicity, Med. Sci. Monit., 12, RA57
2004, Prednisone reduces muscle degeneration in dystrophin-deficient Caenorhabditis elegans, Neuromuscul. Disord., 14, 365, 10.1016/j.nmd.2004.02.011
2008, Toxicity testing in the 21st century: A vision and a strategy, Reprod. Toxicol., 25, 136, 10.1016/j.reprotox.2007.10.013
1999, In vitro interactions of Caenorhabditis elegans dystrophin with dystrobrevin and syntrophin, FEBS Lett., 461, 59, 10.1016/S0014-5793(99)01421-0
1999, Dystrobrevin- and dystrophin-like mutants display similar phenotypes in the nematode Caenorhabditis elegans, Neurogenetics., 2, 87, 10.1007/s100480050057
2002, Overexpression of dystrobrevin delays locomotion defects and muscle degeneration in a dystrophin-deficient Caenorhabditis elegans, Neuromuscul. Disord., 12, 371, 10.1016/S0960-8966(01)00330-3
2000, Genetic suppression of phenotypes arising from mutations in dystrophin-related genes in Caenorhabditis elegans, Curr. Biol., 10, 1092, 10.1016/S0960-9822(00)00691-6
2001, Molecular, genetic and physiological characterisation of dystrobrevin-like (dyb-1) mutants of Caenorhabditis elegans, J. Mol. Biol., 307, 107, 10.1006/jmbi.2000.4480
2008, The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis, Proc. Natl Acad. Sci. USA., 105, 145, 10.1073/pnas.0710685105
1994, Transgenerational, ultrastructural analysis on the antioxidative effects of tocopherol on early gametogenesis in Caenorhabditis elegans grown in 100% oxygen, Toxicol. Appl. Pharmacol., 124, 212, 10.1006/taap.1994.1025
2007, Does neurotransmission impairment accompany aluminium neurotoxicity?, J. Inorg. Biochem., 101, 1291, 10.1016/j.jinorgbio.2007.06.002
2006, Mechanosensation, WormBook., 1
1998, The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living, Neurology., 50, 1346, 10.1212/WNL.50.5.1346
2004, Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome C oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis, Hum. Mol. Genet., 13, 303
2005, Using transgenic Caenorhabditis elegans in soil toxicity testing, Arch. Environ. Contam. Toxicol., 48, 490, 10.1007/s00244-004-0031-2
1980, Unc-93(E1500)—A behavioral mutant of Caenorhabditis-elegans that defines a gene with a wild-type null phenotype, Genetics., 96, 147, 10.1093/genetics/96.1.147
2005, Glycolipids as receptors for Bacillus thuringiensis crystal toxin, Science., 307, 922, 10.1126/science.1104444
2003, Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions, J. Biol. Chem., 278, 45594, 10.1074/jbc.M308142200
2001, Bt toxin resistance from loss of a putative carbohydrate-modifying enzyme, Science., 293, 860, 10.1126/science.1062441
2003, The stn-1 syntrophin gene of C. elegans is functionally related to dystrophin and dystrobrevin, J. Mol. Biol., 332, 1037, 10.1016/j.jmb.2003.08.021
2002, Dystrobrevin requires a dystrophin-binding domain to function in Caenorhabditis elegans, Eur. J. Biochem., 269, 1607, 10.1046/j.1432-1327.2002.02780.x
2002, Genetic evidence for a dystrophin-glycoprotein complex (DGC) in Caenorhabditis elegans, Gene., 294, 77, 10.1016/S0378-1119(02)00762-X
2003, The ubiquinone-binding site of the Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase is a source of superoxide, J. Biol. Chem., 278, 47629, 10.1074/jbc.M306312200
2004, Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans model, Front. Biosci., 9, 3333, 10.2741/1485
2005, Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans, BMC Neurosci., 6, 54, 10.1186/1471-2202-6-54
1999, The toxicity of dithiocarbamate fungicides to soil nematodes, assessed using a stress-inducible transgenic strain of Caenorhabditis elegans, J. Biochem. Mol. Toxicol., 13, 324, 10.1002/(SICI)1099-0461(1999)13:6<324::AID-JBT6>3.0.CO;2-Q
2008, Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model, Proc. Natl Acad. Sci. USA., 105, 728, 10.1073/pnas.0711018105
2005, A systematic RNAi screen for longevity genes in C. elegans, Genes Dev., 19, 1544, 10.1101/gad.1308205
2004, WormBase: A multi-species resource for nematode biology and genomics, Nucleic Acids Res., 32, D411, 10.1093/nar/gkh066
1995, Nematode development is inhibited by methyl viologen and high oxygen concentrations at a rate inversely proportional to life span, J. Gerontol. A Biol. Sci. Med. Sci., 50, B322
2004, Mitochondrial oxidative stress can lead to nuclear hypermutability, Mech. Ageing Dev., 125, 417, 10.1016/j.mad.2004.02.007
1984, UV irradiation of wild-type and radiation-sensitive mutants of the nematode Caenorhabditis elegans—Fertilities, survival, and parental effects, Photochem. Photobiol., 39, 169, 10.1111/j.1751-1097.1984.tb03424.x
1985, Epistatic interactions of radiation-sensitive (Rad) mutants of Caenorhabditis elegans, Genetics., 109, 81, 10.1093/genetics/109.1.81
1982, Radiation-sensitive mutants of Caenorhabditis elegans, Genetics., 102, 159, 10.1093/genetics/102.2.159
1989, Excision repair of UV radiation-induced DNA damage in Caenorhabditis elegans, Genetics., 122, 379, 10.1093/genetics/122.2.379
1992, Inactivation of wild-type and rad mutant Caenorhabditis elegans by 8-methoxypsoralen and near ultraviolet radiation, Photochem. Photobiol., 55, 103, 10.1111/j.1751-1097.1992.tb04215.x
1998, Processing of DNA damage in the nematode Caenorhabditis elegans, DNA damage and Repair Volume 1: DNA Repair in Prokaryotes and Lower Eukaryotes., 557
1988, Radiation sensitivity and DNA repair in Caenorhabditis elegans strains with different mean life spans, Mutat. Res., 208, 77, 10.1016/S0165-7992(98)90003-3
2007, Inverse correlation between expression of the Wolfs Hirschhorn candidate gene Letm1 and mitochondrial volume in C. elegans and in mammalian cells, Hum. Mol. Genet., 16, 2061, 10.1093/hmg/ddm154
2008, Acrylamide-responsive genes in the nematode Caenorhabditis elegans, Toxicol. Sci., 101, 215, 10.1093/toxsci/kfm276
2007, The role of Caenorhabditis elegans insulin-like signaling in the behavioral avoidance of pathogenic Bacillus thuringiensis, FASEB J., 21, 1801, 10.1096/fj.06-6551com
1994, Programmed cell death in Caenorhabditis elegans, Curr. Opin. Genet. Dev., 4, 581, 10.1016/0959-437X(94)90076-F
2005, In vivo imaging of C. elegans ASH neurons: Cellular response and adaptation to chemical repellents, EMBO J., 24, 63, 10.1038/sj.emboj.7600493
2004, Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans, J. Neurosci., 24, 1217, 10.1523/JNEUROSCI.1569-03.2004
2002, Manganese-induced apoptosis in PC12 cells, Neurotoxicol. Teratol., 24, 639, 10.1016/S0892-0362(02)00215-5
1997, Investigations into using the nematode Caenorhabditis elegans for municipal and industrial wastewater toxicity testing, Arch. Environ. Contam. Toxicol., 33, 252, 10.1007/s002449900251
2005, Specification of the nervous system, WormBook., 1
1999, Conventional genetics, Practical Approach Series; C. elegans: A Practical Approach., 245
2003, Cdc42-interacting protein 4 binds to huntingtin: Neuropathologic and biological evidence for a role in Huntington's disease, Proc. Natl Acad. Sci. USA., 100, 2712, 10.1073/pnas.0437967100
2006, Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos, J. Cell Biol., 172, 999, 10.1083/jcb.200512136
1993, Oxygen-dependent perturbation of life span and aging rate in the nematode, J. Gerontol., 48, B57, 10.1093/geronj/48.2.B57
1999, Background on Caenorhabditis elegans, C. elegans: A Practical Approach., 1
2003, Worms, life, and death (Nobel lecture), Chem. biochem., 4, 697
2006, Computer-driven automatic identification of locomotion states in Caenorhabditis elegans, J. Neurosci. Methods., 157, 355, 10.1016/j.jneumeth.2006.05.002
2008, Effects of transgenic corn and Cry1Ab protein on the nematode, Caenorhabditis elegans, Ecotoxicol. Environ. Saf., 70, 334, 10.1016/j.ecoenv.2007.10.017
1997, Influence of particle size distribution and content of organic matter on the toxicity of copper in sediment bioassays using Caenorhabditis elegans (nematoda), Water Air Soil Pollut., 99, 689
1999, Growth and fertility of Caenorhabditis elegans (Nematoda) in unpolluted freshwater sediments: Response to particle size distribution and organic content, Environ. Toxicol. Chem., 18, 2921, 10.1002/etc.5620181238
2001, Toxicity of cadmium to Caenorhabditis elegans (Nematoda) in whole sediment and pore water—The ambiguous role of organic matter, Environ. Toxicol. Chem., 20, 2794, 10.1002/etc.5620201219
2007, Endocrine disruption in nematodes: Effects and mechanisms, Ecotoxicology., 16, 15, 10.1007/s10646-006-0108-y
2002, Ageing is reversed, and metabolism is reset to young levels in recovering dauer larvae of C. elegans, Exp. Gerontol., 37, 1015, 10.1016/S0531-5565(02)00063-3
2004, Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins, Proc. Natl Acad. Sci. USA., 101, 10995, 10.1073/pnas.0404073101
2004, Pore worms: Using Caenorhabditis elegans to study how bacterial toxins interact with their target host, Int. J. Med. Microbiol., 293, 599, 10.1078/1438-4221-00303
2008, Longevity and resistance to stress correlate with DNA repair capacity in Caenorhabditis elegans, Nucleic Acids Res., 36, 1380, 10.1093/nar/gkm1161
2005, RNA/DNA ratios as a sublethal endpoint for large-scale toxicity tests with the nematode Caenorhabditis elegans, Environ. Toxicol. Chem., 24, 1155, 10.1897/04-262R.1
2008, Proteomics of Caenorhabditis elegans over-expressing human alpha-synuclein analyzed by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry: Identification of actin and several ribosomal proteins as negative markers at early Parkinson's disease stages, Biomed. Chromatogr., 22, 232, 10.1002/bmc.931
2008, An RNAi screen for mitochondrial proteins required to maintain the morphology of the organelle in Caenorhabditis elegans, J. Biochem., 143, 449, 10.1093/jb/mvm245
2005, The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response, Genes Dev., 19, 2278, 10.1101/gad.1324805
2000, Suppressors of transforming growth factor-beta pathway mutants in the Caenorhabditis elegans dauer formation pathway, Genetics., 156, 1035, 10.1093/genetics/156.3.1035
2001, Enhancement of oxidative damage to cultured cells and Caenorhabditis elegans by mitochondrial electron transport inhibitors, IUBMB life., 51, 263, 10.1080/152165401753311816
1993, The radiation-sensitive mutant rad-8 of Caenorhabditis elegans is hypersensitive to the effects of oxygen on aging and development, Mech. Ageing Dev., 68, 1, 10.1016/0047-6374(93)90135-E
1990, A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans, Mutat. Res., 237, 165, 10.1016/0921-8734(90)90022-J
International Standards Organization (ISO), 2007
2006, A nematode model to elucidate mechanisms of developmental toxicity, SOT Meeting March 5-9, 2006.
2005, DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans, Nature., 433, 754, 10.1038/nature03316
2007, Neurotoxic potential of depleted uranium effects in primary cortical neuron cultures and in Caenorhabditis elegans, Toxicol. Sci., 99, 553, 10.1093/toxsci/kfm171
2002, Synaptogenesis: Insights from worm and fly, Curr. Opin. Neurobiol., 12, 71, 10.1016/S0959-4388(02)00292-1
2005, Synaptogenesis, WormBook., 1
2003, Advantages and disadvantages of Caenorhabditis elegans for aging research, Exp. Gerontol., 38, 1329, 10.1016/j.exger.2003.10.020
1988, Radiation effects on lifespan in Caenorhabditis elegans, J. Gerontol., 43, B137, 10.1093/geronj/43.5.B137
1991, Caenorhabditis elegans: A model system for space biology studies, Exp. Gerontol., 26, 299, 10.1016/0531-5565(91)90024-G
1996, Replication in UV-irradiated Caenorhabditis elegans embryos, Photochem. Photobiol., 63, 187, 10.1111/j.1751-1097.1996.tb03012.x
1999, Feeding is inhibited by sublethal concentrations of toxicants and by heat stress in the nematode Caenorhabditis elegans: Relationship to the cellular stress response, J. Exp. Zool., 284, 147, 10.1002/(SICI)1097-010X(19990701)284:2<147::AID-JEZ4>3.0.CO;2-Z
1996, Transgenic strains of the nematode C. elegans in biomonitoring and toxicology: Effects of captan and related compounds on the stress response, Toxicology., 109, 119, 10.1016/0300-483X(96)03316-1
2005, Gaba, WormBook., 1
2006, Finding function in novel targets: C-elegans as a model organism, Nat. Rev. Drug Discovery., 5, 387, 10.1038/nrd2031
2003, Genome-wide RNAi screening in Caenorhabditis elegans, Methods., 30, 313, 10.1016/S1046-2023(03)00050-1
2000, Biomarkers in terrestrial invertebrates for ecotoxicological soil risk assessment, Rev. Environ. Contam. Toxicol., 164, 93
2001, Novel DNA repair alkyltransferase from Caenorhabditis elegans, Environ. Mol. Mutagen., 38, 235, 10.1002/em.1077
2007, Activation of SKN-1 by novel kinases in Caenorhabditis elegans, Free Radic. Biol. Med., 43, 1560, 10.1016/j.freeradbiomed.2007.08.025
1987, UV photobiology of the nematode Caenorhabditis-elegans—Action spectra, absence of photoreactivation and effects of caffeine, Photochem. Photobiol., 46, 483, 10.1111/j.1751-1097.1987.tb04799.x
2000, Caenorhabditis elegans msh-5 is required for both normal and radiation-induced meiotic crossing over but not for completion of meiosis, Genetics., 156, 617, 10.1093/genetics/156.2.617
2005, The plasticity of aging: Insights from long-lived mutants, Cell., 120, 449, 10.1016/j.cell.2005.02.002
2001, A gene expression map for Caenorhabditis elegans, Science., 293, 2087, 10.1126/science.1061603
2007, Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan, Aging Cell., 6, 489, 10.1111/j.1474-9726.2007.00302.x
2005, Tales of cannibalism, suicide, and murder: Programmed cell death in C. elegans, Curr. Top. Dev. Biol., 65, 1
2006, Ecology of Caenorhabditis species, WormBook., 1
2005, Ubiquitin-mediated pathways in C. elegans, WormBook., 1
2003, The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities, J. Biol. Chem., 278, 12130, 10.1074/jbc.M212058200
1983, Age-correlated changes in the DNA template in the nematode Caenorhabditis elegans, Mech. Ageing Dev., 22, 253, 10.1016/0047-6374(83)90080-5
1977, Aging in nematode Caenorhabditis elegans—Major biological and environmental factors influencing lifespan, Mech. Ageing Dev., 6, 413, 10.1016/0047-6374(77)90043-4
2005, Effect of oxidative stress on translocation of DAF-16 in oxygen-sensitive mutants, mev-1 and gas-1 of Caenorhabditis elegans, Mech. Ageing Dev., 126, 637, 10.1016/j.mad.2004.11.011
1988, MPTP toxicity: Implications for research in Parkinson's disease, Annu. Rev. Neurosci., 11, 81, 10.1146/annurev.ne.11.030188.000501
2007, Protective effects of verapamil on mercury toxicity in C. elegans, SOT Meeting March 25-29, 2007 (Abstract No. 98).
2006, Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans, Hum. Mol. Genet., 15, 1483, 10.1093/hmg/ddl067
2007, SUT-1 enables tau-induced neurotoxicity in C. elegans, Hum. Mol. Genet., 16, 1959, 10.1093/hmg/ddm143
2003, Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy, Proc. Natl Acad. Sci. USA., 100, 9980, 10.1073/pnas.1533448100
2007, Molecular chaperones and the epigenetics of longevity and cancer resistance, Ann. N. Y. Acad. Sci., 1100, 75, 10.1196/annals.1395.006
2007, Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade, Biochem. Biophys. Res. Commun., 363, 438, 10.1016/j.bbrc.2007.08.190
2006, Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans, J. Biol. Chem., 281, 334, 10.1074/jbc.M504860200
2004, Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans, Genomics., 83, 600, 10.1016/j.ygeno.2003.10.008
2001, Development and application of bioluminescent Caenorhabditis elegans as multicellular eukaryotic biosensors, FEBS Lett., 493, 36, 10.1016/S0014-5793(01)02271-2
2003, Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein, J. Neurochem., 86, 165, 10.1046/j.1471-4159.2003.01809.x
1984, MPTP-induced Parkinsonism in human and non-human primates—Clinical and experimental aspects, Acta. Neurol. Scand. Suppl., 100, 49
2008, A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans, Nat. Genet., 40, 181, 10.1038/ng.2007.70
2002, The gene expression and deficiency phenotypes of Cockayne syndrome B protein in Caenorhabditis elegans, FEBS Lett., 522, 47, 10.1016/S0014-5793(02)02880-6
2006, Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans, RNA., 12, 589, 10.1261/rna.2231506
2004, A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint, Development., 131, 2565, 10.1242/dev.01136
2003, A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity, Nat. Genet., 33, 40, 10.1038/ng1056
2003, A stress-responsive glutathione S-transferase confers resistance to oxidative stress in Caenorhabditis elegans, Free Radic. Biol. Med., 34, 1405, 10.1016/S0891-5849(03)00102-3
2006, Developmental apoptosis in C. elegans: A complex CEDnario, Nat. Rev. Mol. Cell Biol., 7, 97, 10.1038/nrm1836
1995, Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene, Nature., 377, 351, 10.1038/377351a0
2004, A map of the interactome network of the metazoan C. elegans, Science., 303, 540, 10.1126/science.1091403
1997, HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling, Proc. Natl Acad. Sci. USA., 94, 12204, 10.1073/pnas.94.22.12204
2005, Caenorhabditis elegans gcs-1 confers resistance to arsenic-induced oxidative stress, Biometals., 18, 519, 10.1007/s10534-005-2996-3
2001, Transgenic invertebrate models of age-associated neurodegenerative diseases, Mech. Ageing Dev., 122, 1639, 10.1016/S0047-6374(01)00291-3
2003, Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model, Neurobiol. Aging., 24, 397, 10.1016/S0197-4580(02)00224-5
1997, Environmental risk factors and Parkinson's disease: A case-control study in Taiwan, Neurology., 48, 1583, 10.1212/WNL.48.6.1583
2006, Alzheimer's disease, the nematode Caenorhabditis elegans, and ginkgo biloba leaf extract, Life Sci., 78, 2066, 10.1016/j.lfs.2005.12.004
1994, A screen for nonconditional dauer-constitutive mutations in Caenorhabditis elegans, Genetics., 136, 879, 10.1093/genetics/136.3.879
2000, Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans, Genetics., 155, 1693, 10.1093/genetics/155.4.1693
2007, Identification of neuroprotective compounds of Caenorhabditis elegans dopaminergic neurons against 6-OHDA, J. Mol. Neurosci., 31, 127, 10.1385/JMN/31:02:127
2000, Apoptosis in neurodegenerative disorders, Nat. Rev. Mol. Cell. Biol., 1, 120, 10.1038/35040009
1900, Modes et formes de reproduction des nematodes, Arch. Zool. Exp. Gen., 8, 463
2004, Latrophilin is required for toxicity of black widow spider venom in Caenorhabditis elegans, Biochem. J., 378, 185, 10.1042/bj20031213
2007, Reversible AChE inhibitors in C. elegans vs. rats, mice, Biochem. Biophys. Res. Commun., 357, 200, 10.1016/j.bbrc.2007.03.122
2007, Cytochrome P450s and short-chain dehydrogenases mediate the toxicogenomic response of PCB52 in the nematode Caenorhabditis elegans, J. Mol. Biol., 370, 1, 10.1016/j.jmb.2007.04.058
2007, Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans, Genome Biol., 8, R70, 10.1186/gb-2007-8-5-r70
1998, The effects of benzo[a]pyrene (cough cough!) on C. elegans, Worm Breed. Gaz., 15, 43
1998, Lethal consequences of simulated solar radiation on the nematode Caenorhabditis elegans in the presence and absence of photosensitizers, Photochem. Photobiol., 68, 816, 10.1111/j.1751-1097.1998.tb05289.x
2003, A genetic analysis of axon guidance in the C. elegans pharynx, Dev. Biol., 260, 158, 10.1016/S0012-1606(03)00238-0
2007, C. elegans and volatile anesthetics, WormBook., 1
2007, Worm thermotaxis: A model system for analyzing thermosensation and neural plasticity, Curr. Opin. Neurobiol., 17, 712, 10.1016/j.conb.2007.11.010
1986, DNA glycosylase activities in the nematode Caenorhabditis elegans, Mutat. Res., 165, 101
2007, Caenorhabditis elegans as a model system to study aging of learning and memory, Mol. Neurobiol., 35, 85, 10.1007/BF02700625
1996, A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans, Genetics., 143, 1207, 10.1093/genetics/143.3.1207
1997, Use of stress-inducible transgenic nematodes as biomarkers of heavy metal pollution in water samples from an English river system, Arch. Environ. Contam. Toxicol., 32, 146, 10.1007/s002449900167
2005, A genetic screen in Caenorhabditis elegans for dopamine neuron insensitivity to 6-hydroxydopamine identifies dopamine transporter mutants impacting transporter biosynthesis and trafficking, J. Neurochem., 94, 774, 10.1111/j.1471-4159.2005.03205.x
2002, Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans, Proc. Natl Acad. Sci. USA., 99, 3264, 10.1073/pnas.042497999
National Research Council (NRC), 2000, Scientific Frontiers in Developmental Toxicology and Risk Assessment., 296
2006, Extra-long PCR, an identifier of DNA adducts in single nematodes (Caenorhabditis elegans), Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol., 144, 279, 10.1016/j.cbpc.2006.10.005
2008, The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans, Dev. Biol., 315, 418, 10.1016/j.ydbio.2007.12.044
2007, A mutation in CHN-1/CHIP suppresses muscle degeneration in Caenorhabditis elegans, Dev. Biol., 312, 193, 10.1016/j.ydbio.2007.09.033
1998, A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans, Genetics., 149, 1303, 10.1093/genetics/149.3.1303
2006, Using Caenorhabditis elegans as a model for aging and age-related diseases, Ann. N. Y. Acad. Sci., 1067, 120, 10.1196/annals.1354.015
2005, DNA repair, WormBook.
2005, Iron, neuroinflammation, and Alzheimer's disease, J. Alzheimers Dis., 8, 183, 10.3233/JAD-2005-8211
2004, A DNA repair gene of Caenorhabditis elegans: A homolog of human XPF, DNA Repair., 3, 1375, 10.1016/j.dnarep.2004.04.008
2002, The Caenorhabditis elegans XPA homolog of human XPA, Mol. Cells., 14, 50, 10.1016/S1016-8478(23)15073-4
2001, Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death, Proc. Natl Acad. Sci. USA., 98, 13318, 10.1073/pnas.231476398
2000, Utility of Caenorhabditis elegans for assessing heavy metal contamination in artificial soil, Arch. Environ. Contam. Toxicol., 39, 113, 10.1007/s002440010086
2008, Use of non-mammalian alternative models for neurotoxicological study, Neurotoxicology., 29, 545
2007, DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans, Nat. Genet., 39, 1403, 10.1038/ng.2007.1
1995, Reverse genetics: From gene sequence to mutant worm, Methods Cell Biol., 48, 59, 10.1016/S0091-679X(08)61383-7
1992, Targeted alterations of the Caenorhabditis-elegans genome by transgene instructed DNA double strand break repair following Tc1 excision, EMBO J., 11, 287, 10.1002/j.1460-2075.1992.tb05051.x
2003, Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi, Genes Dev., 17, 443, 10.1101/gad.1060703
2004, Genome-wide RNAi screens in Caenorhabditis elegans: Impact on cancer research, Oncogene., 23, 8340, 10.1038/sj.onc.1208010
2007, Behavior patterns in Duchenne muscular dystrophy: Report on the Parent Project Muscular Dystrophy Behavior Workshop 8–9 of December 2006, Philadelphia, USA, Neuromuscul. Disord., 17, 986, 10.1016/j.nmd.2007.06.465
2006, Techniques for analysis, sorting, and dispensing of C. elegans on the COPAS flow-sorting system, Methods Mol. Biol., 351, 275
2006, Axon guidance: Ephrins at WRK on the midline, Curr. Biol., 16, R954, 10.1016/j.cub.2006.10.021
2008, A comparative study on the relationship between various toxicological endpoints in Caenorhabditis elegans exposed to organophosphorus insecticides, Toxicol. Environ. Health., 71, 1043, 10.1080/15287390801989002
2007, Acetylcholine, WormBook., 1
1997, Synaptic Transmission.
1990, Caenorhabditis elegans: A new model system for the study of learning and memory, Behav. Brain Res., 37, 89, 10.1016/0166-4328(90)90074-O
1999, Evidence for a physical interaction between presenilin and Notch, Proc. Natl Acad. Sci. USA., 96, 3263, 10.1073/pnas.96.6.3263
2007, Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans, PLoS Biol., 5, e259, 10.1371/journal.pbio.0050259
2005, Expression profiling of five different xenobiotics using a Caenorhabditis elegans whole genome microarray, Chemosphere., 61, 229, 10.1016/j.chemosphere.2005.01.077
2005, Synaptic function, WormBook., 1
1997, C. elegans II.
2000, Parkinson's disease mortality and pesticide exposure in California 1984–1994, Int. J. Epidemiol., 29, 323, 10.1093/ije/29.2.323
2006, Assessment of stress-related gene expression in the heavy metal-exposed nematode Caenorhabditis elegans: A potential biomarker for metal-induced toxicity monitoring and environmental risk assessment, Environ. Toxicol. Chem., 25, 2946, 10.1897/05-676R.1
2007, Microfluidic system for on-chip high-throughput whole-animal sorting and screening at subcellular resolution, Proc. Natl Acad. Sci. USA., 104, 13891, 10.1073/pnas.0706513104
1985, Mutagenesis in Caenorhabditis elegans. II. A spectrum of mutational events induced with 1500 R of gamma-radiation, Genetics., 109, 493, 10.1093/genetics/109.3.493
1983, Mutagenesis in Caenorhabditis elegans I: A rapid eukaryotic mutagen test system using the reciprocal translocation eT1(III;V), Mutat. Res., 110, 39
1993, Site-selected insertion of the transposon Tc1 into a Caenorhabditis-elegans myosin light chain gene, Mol. Cell Biol., 13, 902, 10.1128/MCB.13.2.902
1989, Rad-2-dependent repair of radiation-induced chromosomal-aberrations in Caenorhabditis-elegans, Mutat. Res., 218, 25, 10.1016/0921-8777(89)90043-8
2005, Modeling impact of parathion and its metabolite paraoxon on the nematode Caenorhabditis elegans in soil, Environ. Toxicol. Chem., 24, 1387, 10.1897/04-318R.1
2007, LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins, Curr. Biol., 17, 592, 10.1016/j.cub.2007.01.074
2006, Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans, Cell Death Differ., 13, 2129, 10.1038/sj.cdd.4401976
1999, Sensing of cadmium and copper ions by externally exposed ADL, ASE, and ASH neurons elicits avoidance response in Caenorhabditis elegans, Neuroreport., 10, 753, 10.1097/00001756-199903170-00017
2004, Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans, EMBO J., 23, 473, 10.1038/sj.emboj.7600057
2003, Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain, J. Inorg. Biochem., 97, 151, 10.1016/S0162-0134(03)00258-7
2000, C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway, Neuron., 26, 619, 10.1016/S0896-6273(00)81199-X
2006, Neurophysiological methods in C. elegans: An introduction, WormBook., 1
2007, Caenorhabditis elegans as a model system for Parkinson's disease, Neurodegener. Dis., 4, 199, 10.1159/000101845
2007, Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126), Proc. Natl Acad. Sci. USA., 104, 834, 10.1073/pnas.0510527104
2004, Natural variation in the response of Caenorhabditis elegans towards Bacillus thuringiensis, Parasitology., 128, 433, 10.1017/S003118200300461X
2005, C-elegans ced-13 can promote apoptosis and is induced in response to DNA damage, Cell Death Differ., 12, 153, 10.1038/sj.cdd.4401539
1992, Parkinson's disease and exposure to agricultural work and pesticide chemicals, Neurology., 42, 1328, 10.1212/WNL.42.7.1328
2005, Characterization of Caenorhabditis elegans exonuclease-3 and evidence that a Mg2+-dependent variant exhibits a distinct mode of action on damaged DNA, Biochemistry., 44, 12835, 10.1021/bi050195t
2005, Identification of two apurinic/apyrimidinic endonucleases from Caenorhabditis elegans by cross-species complementation, DNA Repair., 4, 655, 10.1016/j.dnarep.2005.02.005
2002, Embryonic extracts derived from the nematode Caenorhabditis elegans remove uracil from DNA by the sequential action of uracil-DNA glycosylase and AP (apurinic/apyrimidinic) endonuclease, Biochem. J., 365, 547, 10.1042/bj20020375
2005, FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans, Cell., 121, 951, 10.1016/j.cell.2005.03.031
2007, Migration of neuronal cells along the anterior-posterior body axis of C. elegans: Wnts are in control, Curr. Opin. Genet. Dev., 17, 320, 10.1016/j.gde.2007.05.007
2003, Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions, PLoS Biol., 1, E12, 10.1371/journal.pbio.0000012
2002, Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi, Curr. Biol., 12, 1317, 10.1016/S0960-9822(02)01041-2
2007, An automated tracking system for Caenorhabditis elegans locomotor behavior and circadian studies application, J. Neurosci. Methods., 161, 273, 10.1016/j.jneumeth.2006.11.015
2007, Effects of seven organic pollutants on soil nematode Caenorhabditis elegans, Environ. Int., 33, 798, 10.1016/j.envint.2007.03.001
2005, A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress, Hum. Mol. Genet., 14, 3407, 10.1093/hmg/ddi371
2007, The nucleotide excision repair pathway is required for UV-C-induced apoptosis in Caenorhabditis elegans, Cell Death Differ., 14, 1129, 10.1038/sj.cdd.4402115
2004, Death and more: DNA damage response pathways in the nematode C. elegans, Cell Death Differ., 11, 21, 10.1038/sj.cdd.4401340
1991, Most ultraviolet-irradiation induced mutations in the nematode Caenorhabditis-elegans are chromosomal rearrangements, Mutat. Res., 249, 37, 10.1016/0027-5107(91)90131-7
2007, Altered DNA damage response in Caenorhabditis elegans with impaired poly(ADP-ribose) glycohydrolases genes expression, DNA Repair., 6, 329, 10.1016/j.dnarep.2006.10.027
1994, Transgenic hsp16-lacZ strains of the soil nematode Caenorhabditis elegans as biological monitors of environmental stress, Environmental Toxicology and Chemistry., 13, 1211, 10.1002/etc.5620130802
1983, Neuronal cell lineages in the nematode Caenorhabditis elegans, Cold Spring Harb. Symp. Quant. Biol., 48, 443
2003, Caenorhabditis elegans: The cell lineage and beyond (Nobel lecture), Chembiochem., 4, 688, 10.1002/cbic.200300577
1983, The embryonic cell lineage of the nematode Caenorhabditis elegans, Dev. Biol., 100, 64, 10.1016/0012-1606(83)90201-4
2002, The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans, Cell., 109, 861, 10.1016/S0092-8674(02)00793-6
1998, Characterization of a Caenorhabditis elegans recA-like gene Ce-rdh-1 involved in meiotic recombination, DNA Res., 5, 373, 10.1093/dnares/5.6.373
1998, Use of ion characteristics to predict relative toxicity of mono-, di- and trivalent metal ions: Caenorhabditis elegans LC50, Aquat. Toxicol., 42, 255, 10.1016/S0166-445X(97)00104-5
2000, Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: Environmental risk factors for Parkinson's disease?, Brain Res., 873, 225, 10.1016/S0006-8993(00)02496-3
2000, The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: Implications for Parkinson's disease, J. Neurosci., 20, 9207, 10.1523/JNEUROSCI.20-24-09207.2000
2002, Frequent germline mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans, Genetics., 161, 651, 10.1093/genetics/161.2.651
2005, RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans, Nucleic Acids Res., 33, 347, 10.1093/nar/gki183
1997, Ecotoxicological assessment of aquatic sediments with Caenorhabditis elegans (nematoda), Environ. Toxicol. Chem., 16, 245
2006, Prokaryotic nucleotide excision repair: The UvrABC system, Chem. Rev., 106, 233, 10.1021/cr040471u
2007, Caenorhabditis elegans expresses a functional ArsA, FEBS J., 274, 2566, 10.1111/j.1742-4658.2007.05791.x
2007, Nemo: A computational tool for analyzing nematode locomotion, BMC Neurosci., 8, 86, 10.1186/1471-2202-8-86
2008, Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans, Cell., 132, 1025, 10.1016/j.cell.2008.01.030
2008, Caenorhabditis elegans gene, Numr-1, assembles into nuclear stress granules after cadmium treatment, SOT Meeting March 16-20, 2008.
2004, Neurotoxicant-induced animal models of Parkinson's disease: Understanding the role of rotenone, maneb and paraquat in neurodegeneration, Cell Tissue Res., 318, 225, 10.1007/s00441-004-0937-z
1993, Oxidative stress and ageing in Caenorhabditis elegans, Biochem. J., 292, 605
2004, Genomic instability and cancer: Scanning the Caenorhabditis elegans genome for tumor suppressors, Oncogene., 23, 8366, 10.1038/sj.onc.1208011
2004, Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality, Proc. Natl Acad. Sci. USA., 101, 12992, 10.1073/pnas.0403131101
2008, C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging, PLoS Genet., 4, e1000027, 10.1371/journal.pgen.1000027
2006, Identification of gene expression changes in transgenic C. elegans overexpressing human alpha-synuclein, Neurobiol. Dis., 22, 477, 10.1016/j.nbd.2005.12.021
2005, Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans, J. Biol. Chem., 280, 42655, 10.1074/jbc.M505910200
2006, Long-lived C. elegans mitochondrial mutants as a model for human mitochondrial-associated diseases, Exp. Gerontol., 41, 974, 10.1016/j.exger.2006.06.060
2002, Moving around in a worm: Netrin UNC-6 and circumferential axon guidance in C. elegans, Trends Neurosci., 25, 423, 10.1016/S0166-2236(02)02206-3
2006, Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin, Hum. Mol. Genet., 15, 1025, 10.1093/hmg/ddl017
2008, Cadmium-induced germline apoptosis in Caenorhabditis elegans: The roles of HUS1, p53, and MAPK signaling pathways, Toxicol. Sci., 102, 345, 10.1093/toxsci/kfm220
2007, An evolutionarily conserved 16-kDa thioredoxin-related protein is an antioxidant which regulates the NF-kappaB signaling pathway, Free Radic. Biol. Med., 42, 247, 10.1016/j.freeradbiomed.2006.10.040
2007, ATP depletion is the major cause of MPP+ induced dopamine neuronal death and worm lethality in alpha-synuclein transgenic C. elegans, Neurosci. Bull., 23, 329, 10.1007/s12264-007-0049-3
2005, A mutation in a cuticle collagen causes hypersensitivity to the endocrine disrupting chemical, bisphenol A, in Caenorhabditis elegans, Mutat. Res., 570, 71, 10.1016/j.mrfmmm.2004.10.005
2003, Bacillus thuringiensis crystal proteins that target nematodes, Proc. Natl Acad. Sci. USA., 100, 2760, 10.1073/pnas.0538072100
2006, A Caenorhabditis elegans tissue model of radiation-induced reproductive cell death, Proc. Natl Acad. Sci. USA., 103, 9946, 10.1073/pnas.0603791103
1986, The structure of the nervous system of the nematode Caenorhabditis elegans, Philos. Trans. R. Soc. Lond. B Biol. Sci., 314, 1, 10.1098/rstb.1986.0056
2000, Caenorhabditis elegans as an alternative animal species, J. Toxicol. Environ. Health A., 61, 641, 10.1080/00984100050195125
1988, Using the nematode Caenorhabditis elegans to predict mammalian acute lethality to metallic salts, Toxicol. Ind. Health., 4, 469, 10.1177/074823378800400406
1990, Aquatic toxicity testing using the nematode, Caenorhabditis elegans, Environ. Toxicol. Chem., 9, 1285, 10.1002/etc.5620091007
1990, A promising indicator of neurobehavioral toxicity using the nematode Caenorhabditis elegans and computer tracking, Toxicol. Ind. Health., 6, 425, 10.1177/074823379000600306
1996, Differential changes in neurochemical markers of striatal dopamine nerve terminals in idiopathic Parkinson's disease, Neurology., 47, 718, 10.1212/WNL.47.3.718
2008, Investigating convergent actions of genes linked to familial Parkinson's disease, Neurodegener. Dis., 5, 182, 10.1159/000113697
2006, Understanding the molecular causes of Parkinson's disease, Trends Mol. Med., 12, 521, 10.1016/j.molmed.2006.09.007
2005, Transgenic C. elegans as a model in Alzheimer's research, Curr. Alzheimer Res., 2, 37, 10.2174/1567205052772768
2006, Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans, J. Neurosci., 26, 13102, 10.1523/JNEUROSCI.3448-06.2006
2007, Caenorhabditis elegans neuronal regeneration is influenced by life stage, ephrin signaling, and synaptic branching, Proc. Natl Acad. Sci. USA., 104, 15132, 10.1073/pnas.0707001104
1996, Properties of an oxygen-sensitive mutant mev-3 of the nematode Caenorhabditis elegans, Mutat. Res., 358, 1, 10.1016/0027-5107(96)00070-X
2002, Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span, Mech. Ageing Dev., 123, 1579, 10.1016/S0047-6374(02)00093-3
2007, A measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans, Genetics., 177, 2063, 10.1534/genetics.107.080788
Trace administration of vitamin E can retrieve and prevent UV-irradiation and metal exposure-induced memory deficits in nematode Caenorhabditis elegans, Neurobiol. Learn. Mem.
2006, Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity, Proc. Natl Acad. Sci. USA., 103, 9357, 10.1073/pnas.0603161103