Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography

Journal of Applied Physiology - Tập 85 Số 1 - Trang 115-122 - 1998
N. Mitsiopoulos1, Richard Baumgartner2, S. B. Heymsfield3, W. R. Lyons4, Dympna Gallagher3, Robert Ross1
1School of Physical and Health Education, Queen's University, Kingston, Ontario, Canada K7L 3N6
2Clinical Nutrition Program, University of New Mexico, School of Medicine, Albuquerque, New Mexico 87131
3St-Luke’s-Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, New York 10025; and
4Department of Anatomy, Queen's University, Kingston, Ontario, Canada K7L 3N6

Tóm tắt

Magnetic resonance imaging (MRI) and computerized tomography (CT) are promising reference methods for quantifying whole body and regional skeletal muscle mass. Earlier MRI and CT validation studies used data-acquisition techniques and data-analysis procedures now outdated, evaluated anatomic rather than adipose tissue-free skeletal muscle (ATFSM), studied only the relatively large thigh, or found unduly large estimation errors. The aim of the present study was to compare arm and leg ATFSM cross-sectional area estimates (cm2) by using standard MRI and CT acquisition and image-analysis methods with corresponding cadaver estimates. A second objective was to validate MRI and CT measurements of adipose tissue embedded within muscle (interstitial adipose tissue) and surrounding muscle (subcutaneous adipose tissue). ATFSM area ( n = 119) by MRI [38.9 ± 22.3 (SD) cm2], CT (39.7 ± 22.8 cm2), and cadaver (39.5 ± 23.0 cm2) were not different ( P > 0.001), and both MRI and CT estimates of ATFSM were highly correlated with corresponding cadaver values [MRI: r = 0.99, SE of estimate (SEE) 3.9 cm2, P < 0.001; and CT: r = 0.99, SEE = 3.8 cm2, P < 0.001]. Similarly good results were observed between MRI- and CT-measured vs. cadaver-measured interstitial and subcutaneous adipose tissue. For MRI-ATFSM the intraobserver correlation for duplicate measurements in vivo was 0.99 [SEE = 8.7 cm2(2.9%), P < 0.001]. These findings strongly support the use of MRI and CT as reference methods for appendicular skeletal muscle, interstitial and subcutaneous adipose tissue measurement in vivo.

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Thông tin
Thông tin xuất bản

Journal of Applied Physiology

Tập 85 Số 1

115-122

Thông tin tác giả