CYP2C19*17 is associated with decreased breast cancer risk

Springer Science and Business Media LLC - Tập 115 Số 2 - Trang 391-396 - 2009
Christina Justenhoven1,2, Ute Hamann3, Christiane Barbara Pierl4, Christian Baisch5, Volker Harth6, Sylvia Rabstein6, Anne‐Lise Børresen‐Dale6, Beate Pesch6, Thomas Brüning6, Stefan Winter7,1,2, Yon‐Dschun Ko5, Hiltrud Brauch1,2
1Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen ( Geschwister-Scholl-Platz 72074 Tübingen - Germany)
2Molecular Mechanisms of Origin and Treatment of Breast Cancer, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (Stuttgart - Germany)
3Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ) (Heidelberg - Germany)
4Institute for Occupational Epidemiology and Risk Assessment (IERA), EVONIK Industries (Essen - Germany)
5Department of Internal Medicine (Bonn - Germany)
6BGFA Forschungsinstitut für Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung (Bochum - Germany)
7Department of Mathematics (Stuttgart - Germany)

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Key TJ, Allen NE, Spencer EA, Travis RC (2002) The effect of diet on risk of cancer. Lancet 360:861–868. doi: 10.1016/S0140-6736(02)09958-0

Folkerd EJ, Martin LA, Kendall A, Dowsett M (2006) The relationship between factors affecting endogenous oestradiol levels in postmenopausal women and breast cancer. J Steroid Biochem Mol Biol 102:250–255. doi: 10.1016/j.jsbmb.2006.09.024

Justenhoven C, Hamann U, Schubert F, Zapatka M, Pierl CB, Rabstein S et al (2008) Breast cancer: a candidate gene approach across the estrogen metabolic pathway. Breast Cancer Res Treat 108:137–149

Cheng ZN, Shu Y, Liu ZQ, Wang LS, Ou-Yang DS, Zhou HH (2001) Role of cytochrome P450 in estradiol metabolism in vitro. Acta Pharmacol Sin 22:148–154

Cribb AE, Knight MJ, Dryer D, Guernsey J, Hender K, Tesch M et al (2006) Role of polymorphic human cytochrome P450 enzymes in estrone oxidation. Cancer Epidemiol Biomarkers Prev 15:551–558. doi: 10.1158/1055-9965.EPI-05-0801

Furuta T, Ohashi K, Kamata T, Takashima M, Kosuge K, Kawasaki T et al (1998) Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med 129:1027–1030

Furuta T, Shirai N, Watanabe F, Honda S, Takeuchi K, Iida T et al (2002) Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole. Clin Pharmacol Ther 72:453–460. doi: 10.1067/mcp.2002.127637

Furuta T, Shirai N, Sugimoto M, Ohashi K, Ishizaki T (2004) Pharmacogenomics of proton pump inhibitors. Pharmacogenomics 5:181–202. doi: 10.1517/phgs.5.2.181.27483

Kawamura M, Ohara S, Koike T, Iijima K, Suzuki J, Kayaba S et al (2003) The effects of lansoprazole on erosive reflux oesophagitis are influenced by CYP2C19 polymorphism. Aliment Pharmacol Ther 17:965–973. doi: 10.1046/j.1365-2036.2003.01539.x

Kirchheiner J, Nickchen K, Bauer M, Wong ML, Licinio J, Roots I et al (2004) Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response. Mol Psychiatry 9:442–473. doi: 10.1038/sj.mp.4001494

Schroth W, Antoniadou L, Fritz P, Schwab M, Muerdter T, Zanger UM et al (2007) Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes. J Clin Oncol 25:5187–5193. doi: 10.1200/JCO.2007.12.2705

De Morais SM, Goldstein JA, Xie HG, Huang SL, Lu YQ, Xia H et al (1995) Genetic analysis of the S-mephenytoin polymorphism in a Chinese population. Clin Pharmacol Ther 58:404–411. doi: 10.1016/0009-9236(95)90053-5

Wedlund PJ (2000) The CYP2C19 enzyme polymorphism. Pharmacology 61:174–183. doi: 10.1159/000028398

De Morais SM, Wilkinson GR, Blaisdell J, Meyer UA, Nakamura K, Goldstein JA (1994) Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol 46:594–598

Roddam PL, Rollinson S, Kane E, Roman E, Moorman A, Cartwright R et al (2000) Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia. Pharmacogenetics 10:605–615. doi: 10.1097/00008571-200010000-00004

Sim SC, Risinger C, Dahl ML, Aklillu E, Christensen M, Bertilsson L et al (2006) A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants. Clin Pharmacol Ther 79:103–113. doi: 10.1016/j.clpt.2005.10.002

Justenhoven C, Hamann U, Pesch B, Harth V, Rabstein S, Baisch C et al (2004) ERCC2 genotypes and a corresponding haplotype are linked with breast cancer risk in a German population. Cancer Epidemiol Biomarkers Prev 13:2059–2064

Justenhoven C, Pierl CB, Haas S, Fischer HP, Baisch C, Hamann U et al (2007) The CYP1B1_1358_GG genotype is associated with estrogen receptor-negative breast cancer. Breast Cancer Res Treat. doi: 10.1007/s10549-007-9762-x

Pesch B, Ko Y, Brauch H, Hamann U, Harth V, Rabstein S et al (2005) Factors modifying the association between hormone-replacement therapy and breast cancer risk. Eur J Epidemiol 20:699–711. doi: 10.1007/s10654-005-0032-0

Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263–265. doi: 10.1093/bioinformatics/bth457

Kurzawski M, Gawronska-Szklarz B, Wrzesniewska J, Siuda A, Starzynska T, Drozdzik M (2006) Effect of CYP2C19*17 gene variant on Helicobacter pylori eradication in peptic ulcer patients. Eur J Clin Pharmacol 62:877–880. doi: 10.1007/s00228-006-0183-2

Beral V (2003) Breast cancer and hormone-replacement therapy in the million women study. Lancet 362:419–427. doi: 10.1016/S0140-6736(03)14596-5

Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML et al Writing Group for the Women’s Health Initiative Investigators (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women’s health initiative randomized controlled trial. JAMA 288:321–333. doi: 10.1001/jama.288.3.321