COMPARISON OF THERAPY WITH SIMVASTATIN 80 MG AND ATORVASTATIN 80 MG IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLAEMIA

International Journal of Clinical Practice - Tập 53 Số 8 - Trang 609-611 - 1999
Anthony S. Wierzbicki1, P Lumb1, G Chik1, Martin Crook1
1Department of Chemical Pathology, St Thomas' Hospital, London

Tóm tắt

SUMMARYThis study compared the efficacy of simvastatin 80 mg and atorvastatin 80 mg in the treatment of 26 patients with familial hypercholesterolaemia over 12 weeks using an open crossover trial format. Both, similarly, reduced LDL by 47 ± 13% and 43 ± 16% and median triglycerides by 22% and 27% respectively. However, atorvastatin reduced HDL by 2 ± 24% compared with 8 ± 30% increase with simvastatin (p=0.05) affecting the LDL:HDL ratio achieved (4.478 ± 1.56 vs 3.74 ± 0.93, P=0.001). Atorvastatin raised median fibrinogen by 15% compared with a non‐significant 5% increase with simvastatin (p=0.05). Simvastatin reduced lipoprotein (a) by a median 20% compared with baseline (p=0.05) compared with 5% for atorvastatin. Side‐effects, mostly gastrointestinal, were seen in four patients (16%) with atorvastatin compared with one case of myalgia with simvastatin (4%). We conclude both drugs are equally effective in LDL reduction but that simvastatin is superior in raising HDL and causes fewer side‐effects. These results require confirmation in larger studies.

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Tài liệu tham khảo

10.1016/S0021-9150(98)00200-7

10.1093/qjmed/90.10.631

10.1093/qjmed/91.4.291

10.1093/qjmed/92.7.387

10.1161/01.ATV.15.5.678

Black DM, 1995, Atherosclerosis X, 307

10.1016/S0002-9149(97)00965-X

10.1016/S0002-9149(96)00742-4

10.1016/S0002-9149(99)00153-8

10.1001/jama.1996.03530260042029

10.1016/S0002-9149(98)00041-1

10.1001/jama.279.20.1643

10.1093/oxfordjournals.eurheartj.a060387

10.1161/01.ATV.19.6.1368

10.1016/S0268-9499(97)80100-2

10.1161/01.ATV.17.8.1527

10.1016/S0140-6736(05)78556-1

10.1016/S0140-6736(98)26019-3

Bertolotto A, 1999, More on the effect of atorvastatin on plasma fibrinogen levels in primary hypercholesterolemia, Atherosclerosis, 143, 455

Thông tin
Thông tin xuất bản

International Journal of Clinical Practice

Tập 53 Số 8

609-611

Thông tin tác giả