CELL‐LINE SPECIFIC ACTIVATION OF SV40 TRANSCRIPTIONAL ENHANCER BY p40tax OF HTLV‐1

Wiley - Tập 79 Số 7 - Trang 800-804 - 1988
Jun‐ichi Fujisawa1, Motoharu Seiki2, M Toita2, Shoichiro Miyatake3, Ken‐ichi Arai3, Mitsuaki Yoshida2
1Department of Viral Oncology, Cancer Institute, Tokyo, Japan
2Department of Viral Oncology, Cancer Institute, Kami‐Ikebukuro, Toshima‐ku, Tokyo 170, Japan
3Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304‐1104, USA

Tóm tắt

A transcriptional trans‐activator P40tax of HTLV‐1 was reported to activate HTLV‐1 enhancer, but not SV40 or Rous sarcoma virus enhancer. However, in certain cell lines, we found that SV40 enhancer was activated by p40tax. These cell lines were mostly T cells, where the SV40 enhancer showed only low activity without p40tax. Since p40tax‐mediated activation of the LTR is not cell line‐specific, the activation of enhancers by p40tax depends on the combination of enhancer and cell type used for the test. Thus, apparent activation by p40tax depends on variable cellular components involved in transcriptional regulation.

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Tài liệu tham khảo

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Wiley

Tập 79 Số 7

800-804

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