Breakthrough Moments: Yoshiki Sasai’s Discoveries in the Third Dimension

Eiraku, 2008, Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals, Cell Stem Cell, 3, 519, 10.1016/j.stem.2008.09.002 Kadoshima, 2013, Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex, Proc. Natl. Acad. Sci. USA, 110, 20284, 10.1073/pnas.1315710110 Lancaster, 2013, Cerebral organoids model human brain development and microcephaly, Nature, 501, 373, 10.1038/nature12517 Mariani, 2012, Modeling human cortical development in vitro using induced pluripotent stem cells, Proc. Natl. Acad. Sci. USA, 109, 12770, 10.1073/pnas.1202944109 Mariani, 2015, FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders, Cell, 162, 375, 10.1016/j.cell.2015.06.034 Muguruma, 2015, Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells, Cell Rep., 10, 537, 10.1016/j.celrep.2014.12.051 Ozone, 2016, Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells, Nat. Commun., 7, 10351, 10.1038/ncomms10351 Sakaguchi, 2015, Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue, Nat. Commun., 6, 8896, 10.1038/ncomms9896 Sasai, 2013, Next-generation regenerative medicine: organogenesis from stem cells in 3D culture, Cell Stem Cell, 12, 520, 10.1016/j.stem.2013.04.009 Watanabe, 2005, Directed differentiation of telencephalic precursors from embryonic stem cells, Nat. Neurosci., 8, 288, 10.1038/nn1402