Bp-Bs, a Novel T-cell Engaging Bispecific Antibody with Biparatopic Her2 Binding, Has Potent Anti-tumor Activities

Molecular Therapy - Oncolytics - Tập 14 - Trang 66-73 - 2019
Jiayu Liu1, Xiaoqiong Wu1, Limin Lin1, Haitao Pan1, Yanlan Wang1, Yumei Li1, Yining Zhao1, Zhong Wang1
1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China

Tài liệu tham khảo

Greally, 2018, HER2: An emerging target in colorectal cancer, Curr. Probl. Cancer, 42, 560, 10.1016/j.currproblcancer.2018.07.001

Nahta, 2006, Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer, Nat. Clin. Pract. Oncol., 3, 269, 10.1038/ncponc0509

Wu, 2018, A Single Domain-Based Anti-Her2 Antibody Has Potent Antitumor Activities, Transl. Oncol., 11, 366, 10.1016/j.tranon.2018.01.024

Zhu, 2014, Site-specific antibody-drug conjugation through an engineered glycotransferase and a chemically reactive sugar, MAbs, 6, 1190, 10.4161/mabs.29889

Baselga, 2012, Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer, N. Engl. J. Med., 366, 109, 10.1056/NEJMoa1113216

Blumenthal, 2013, First FDA approval of dual anti-HER2 regimen: pertuzumab in combination with trastuzumab and docetaxel for HER2-positive metastatic breast cancer, Clin. Cancer Res., 19, 4911, 10.1158/1078-0432.CCR-13-1212

Huang, 2018, Structural and functional characterization of MBS301, an afucosylated bispecific anti-HER2 antibody, MAbs, 10, 864, 10.1080/19420862.2018.1486946

Croset, 2014, 139 GBR1302: a BEAT® bispecific antibody for the treatment of HER2 positive cancers, Eur. J. Cancer, 50, 48, 10.1016/S0959-8049(14)70265-5

Deng, 2018, A Bispecific Antibody Based on Pertuzumab Fab Has Potent Antitumor Activity, J. Immunother., 41, 1, 10.1097/CJI.0000000000000200

Skrlj, 2010, Single-chain Fv antibody fragments retain binding properties of the monoclonal antibody raised against peptide P1 of the human prion protein, Appl. Biochem. Biotechnol., 160, 1808, 10.1007/s12010-009-8699-4

Jones, 2009, Evolving novel anti-HER2 strategies, Lancet Oncol., 10, 1179, 10.1016/S1470-2045(09)70315-8

Riccio, 2017, Superior Suppression of ErbB2-positive Tumor Cells by a Novel Human Triparatopic Tribody, J. Immunother., 40, 117, 10.1097/CJI.0000000000000152

Ritter, 2007, Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network, Clin. Cancer Res., 13, 4909, 10.1158/1078-0432.CCR-07-0701

Brack, 2014, A bispecific HER2-targeting FynomAb with superior antitumor activity and novel mode of action, Mol. Cancer Ther., 13, 2030, 10.1158/1535-7163.MCT-14-0046-T

LoRusso, 2016, Inhibition of the PI3K/AKT/mTOR Pathway in Solid Tumors, J. Clin. Oncol., 34, 3803, 10.1200/JCO.2014.59.0018

LoRusso, 2011, Trastuzumab emtansine: a unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer, Clin. Cancer Res., 17, 6437, 10.1158/1078-0432.CCR-11-0762

Burris, 2011, Trastuzumab emtansine (T-DM1): a novel agent for targeting HER2+ breast cancer, Clin. Breast Cancer, 11, 275, 10.1016/j.clbc.2011.03.018

Schoonjans, 2000, Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives, J. Immunol., 165, 7050, 10.4049/jimmunol.165.12.7050

Rozan, 2013, Single-domain antibody-based and linker-free bispecific antibodies targeting FcγRIII induce potent antitumor activity without recruiting regulatory T cells, Mol. Cancer Ther., 12, 1481, 10.1158/1535-7163.MCT-12-1012

Li, 2015, A novel bispecific antibody, S-Fab, induces potent cancer cell killing, J. Immunother., 38, 350, 10.1097/CJI.0000000000000099

Swain, 2015, Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer, N. Engl. J. Med., 372, 724, 10.1056/NEJMoa1413513

Swain, 2013, Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study, Lancet Oncol., 14, 461, 10.1016/S1470-2045(13)70130-X

Even-Desrumeaux, 2012, Single-domain antibodies: a versatile and rich source of binders for breast cancer diagnostic approaches, Mol. Biosyst., 8, 2385, 10.1039/c2mb25063b

Pan, 2018, Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy, Int. J. Nanomedicine, 13, 3189, 10.2147/IJN.S164542