Bone tissue and its mineralization in aged estrogen-depleted rats after long-term intermittent treatment with parathyroid hormone (PTH) analog SDZ PTS 893 or human PTH(1-34)

Andreassen, 1996, The influence of growth hormone on cancellous and cortical bone of the vertebral body in aged rats, J Bone Miner Res, 11, 1094, 10.1002/jbmr.5650110808 Boyde, 1995, Mineral density quantification of the human cortical iliac crest by backscattered electron image analysis, Bone, 16, 619, 10.1016/8756-3282(95)00119-X Boyde, 1999, The mineralisation density of iliac crest bone from children with osteogenesis imperfecta, Calcif Tissue Int, 64, 185, 10.1007/s002239900600 Delmas, 1995, The anabolic effect of human PTH (1-34) on bone formation is blunted when bone resorption is inhibited by the bisphosphonate tiludronate, Bone, 16, 603, 10.1016/8756-3282(95)00113-R Dobnig, 1995, Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells, Endocrinology, 136, 3632, 10.1210/en.136.8.3632 Ejersted, 1995, Parathyroid hormone (1-34) increases vertebral bone mass, compressive strength, and quality in old rats, Bone, 17, 507, 10.1016/8756-3282(95)00371-1 Ejersted, 1994, Human parathyroid hormone(1-34) increases bone formation and strength of cortical bone in aged rats, Eur J Endocrinol, 130, 201, 10.1530/eje.0.1300201 Ejersted, 1993, Human parathyroid hormone (1-34) and (1-84) increase the mechanical strength and thickness of cortical bone in rats, J Bone Miner Res, 8, 1097, 10.1002/jbmr.5650080910 Erben, 1990, Role of vitamin D metabolites in the prevention of the osteopenia induced by ovariectomy in the axial and appendicular skeleton of the rat, Z Ernahrungswiss, 29, 229, 10.1007/BF02023080 Gamse, 1997, SDZ PTS 893, J Bone Miner Res, 12, S317 Gasser, J. A. Modulation of strain sensing: A new approach for the treatment of osteoporosis. In: Lyritis G. P., Ed. Muscoskeletal Interactions. Volume 2. Athens, Greece: Hylonome; 1999; 77–82. Gasser, 1997, Quantitative assessment of bone mass and geometry by pQCT in rats in vivo and site specificity of changes at different skeletal sites, J Jpn Soc Bone Morphometry, 7, 107 Gasser, 1997, SDZ PTS 893, a PTH analog with improved therapeutic window in skeletally mature rats (abstract T537), J Bone Miner Res, 12, S236 Gram, 1994, A novel approach for high level production of a recombinant human parathyroid hormone fragment in Escherichia coli, Biotechnology NY, 12, 1017, 10.1038/nbt1094-1017 Grote, 1995, Intervertebral variation in trabecular microarchitecture throughout the normal spine in relation to age, Bone, 16, 301, 10.1016/8756-3282(94)00042-5 Gunness, 1993, Anabolic effect of parathyroid hormone on cancellous and cortical bone histology, Bone, 14, 277, 10.1016/8756-3282(93)90152-Z Gunness-Hey, 1984, Increased trabecular bone mass in rats treated with human synthetic parathyroid hormone, Metab Bone Dis Rel Res, 5, 177, 10.1016/0221-8747(84)90026-2 Hahn, 1992, Trabecular bone pattern factor, a new parameter for simple quantification of bone microarchitecture, Bone, 13, 327, 10.1016/8756-3282(92)90078-B Hock, 1989, Comparison of the anabolic effects of synthetic parathyroid hormone, related protein (PTHrP) 1-34 and PTH 1-34 on bone in rats, Endocrinology, 125, 2022, 10.1210/endo-125-4-2022 Hock, 1988, Human parathyroid hormone (1-34) increases bone mass in ovariectomized and orchidectomized rats, Endocrinology, 122, 2899, 10.1210/endo-122-6-2899 Hodsman, 1997, A randomized controlled trial to compare the efficacy of cyclical parathyroid hormone versus cyclical parathyroid hormone and sequential calcitonin to improve bone mass in postmenopausal women with osteoporosis, J Clin Endocrinol Metab, 82, 620, 10.1210/jc.82.2.620 Hodsman, 1993, Early histomorphometric changes in response to parathyroid hormone therapy in osteoporosis, Bone, 14, 523, 10.1016/8756-3282(93)90190-L Ibbotson, 1992, Contrasting effects of parathyroid hormone and insulin, like growth factor I in an aged ovariectomized rat model of postmenopausal osteoporosis, J Bone Miner Res, 7, 425, 10.1002/jbmr.5650070410 Inoue, 1985, Bone changes with long term administration of low dose 1-34 human PTH on adult beagles, Nippon Seikeigeka Gakkai Zasshi, 59, 409 Jilka, R. L., Weinstein, R. S., Bellido, T., Roberson, P., Parfitt, A. M., and Manolagas, S. C. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone J Clin Invest 104:439–446; 1999. Jowsey, J. Variations in bone mineralisation with age and disease. In: Frost, H. M., Ed. Bone Dynamics. Boston: Little, Brown; 1964; 461–479. Jowsey, 1966, Studies of haversian systems in man and some animals, J Anat, 100, 857 Kimmel, 1993, The effect of recombinant human (1-84) or synthetic human (1-34) parathyroid hormone on the skeleton of adult osteopenic ovariectomized rats, Endocrinology, 132, 1577, 10.1210/en.132.4.1577 Kneissel, 1997, Cancellous bone structure in the growing and aging lumbar spine in a historic Nubian population, Calcif Tissue Int, 61, 95, 10.1007/s002239900302 Lafage, 1995, Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs, J Clin Invest, 95, 2127, 10.1172/JCI117901 Leaffer, 1995, Modulation of osteogenic cell ultrastructure by RS 23581, an analog of human parathyroid hormone (PTH) related peptide (1-34), and bovine PTH (1-34), Endocrinology, 136, 3624, 10.1210/en.136.8.3624 Li, 1999, Parathyroid hormone stimulates cancellous bone formation at skeletal sites regardless of marrow composition in ovariectomized rats, Bone, 24, 95, 10.1016/S8756-3282(98)00167-7 Lindsay, 1997, Randomised controlled study of effect of parathyroid hormone on vertebral, bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis, Lancet, 350, 550, 10.1016/S0140-6736(97)02342-8 Liu, 1990, Human parathyroid hormone (1-34) prevents bone loss and augments bone formation in sexually mature ovariectomized rats, J Bone Miner Res, 5, 973, 10.1002/jbmr.5650050911 Liu, 1991, Preexisting bone loss associated with ovariectomy in rats is reversed by parathyroid hormone, J Bone Miner Res, 6, 1071, 10.1002/jbmr.5650061008 Ma, 1995, Human parathyroid hormone (1-38) restores cancellous bone to the immobilized, osteopenic proximal tibial metaphysis in rats, J Bone Miner Res, 10, 496, 10.1002/jbmr.5650100322 Meng, 1996, Temporal expression of the anabolic action of PTH in cancellous bone of ovariectomized rats, J Bone Miner Res, 11, 421, 10.1002/jbmr.5650110402 Miller, 1993, Long-term osteopenic changes in cancellous bone structure in ovariectomized rats, Anat Rec, 236, 433, 10.1002/ar.1092360303 Mosekilde, 1990, Consequences of the remodelling process for vertebral trabecular bone structure, Bone Miner, 10, 13, 10.1016/0169-6009(90)90046-I Mosekilde, 1994, The effect on vertebral bone mass and strength of long-term treatment with antiresorptive agents (estrogen and calcitonin), human parathyroid hormone-(1-38), and combination therapy, assessed in aged ovariectomized rats, Endocrinology, 134, 2126, 10.1210/en.134.5.2126 Mosekilde, 1991, The anabolic effects of human parathyroid hormone (hPTH) on rat vertebral body mass are also reflected in the quality of bone, assessed by biomechanical testing, Endocrinology, 129, 421, 10.1210/endo-129-1-421 Narita, 1995, Effect of intermittent administration of human PTH on experimental osteopenia in adult rat, Nippon Seikeigeka Gakkai Zasshi, 69, 1027 Neer, M., Slovik, D. M., Daly, M., Potts, T., Jr., and Nussbaum, S. R. Treatment of postmenopausal osteoporosis with daily parathyroid hormone plus calcitriol. Osteopor Int 3:204–205; 1993. Neer, R. M., Slovik D., and Doppelt, S. The use of parathyroid hormone plus 1.25 dihydroxyvitamin D to increase trabecular bone in osteoporotic men and postmenopausal women. In: Christiansen, C., Johanson, J. S., and Riis, B. J., Eds. Osteoporosis. Copenhagen: Osteopress; 1987; 829–835. Nishida, 1994, Increased bone formation by intermittent parathyroid hormone administration is due to the stimulation of proliferation and differentiation of osteoprogenitor cells in bone marrow, Bone, 15, 717, 10.1016/8756-3282(94)90322-0 Parfitt, 1987, Bone and plasma calcium homeostasis, Bone, 8, 1 Parfitt, 1987, Bone Histomorphometry, J Bone Miner Res, 2, 595, 10.1002/jbmr.5650020617 Qi, 1995, A comparison of the anabolic effects of parathyroid hormone at skeletal sites with moderate and severe osteopenia in aged ovariectomized rats, J Bone Miner Res, 10, 948, 10.1002/jbmr.5650100616 Reeve, 1991, hPTH 1-34 treatment of osteoporosis with added hormone replacement therapy, Osteopor Int, 1, 162, 10.1007/BF01625448 Reeve, J., Davies, U. M., Hesp, R., McNally, E., and Katz, D. Treatment of osteoporosis with human parathyroid peptide and observations on effect of sodium fluoride Br Med J 301:314–318; 1990. Reeve, J., Meunier, P. J., Parsons, J. A., Bernat, M., Bijvoet, O. L., Courpron, P., Edouard, C., Klenerman, L., Neer, R. M., Renier, J. C., Slovik, D., Vismans, F. J., and Potts, J. T., Jr. Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: A multicentre trial. Br Med J 280:1340–1344; 1980. Roschger, 1997, Mineralisation of cancellous bone after alendronate and sodium fluoride treatment, Bone, 20, 393, 10.1016/S8756-3282(97)00018-5 Roschger, P., Plenk, H., Jr., Klaushofer, K., and Eschberger, J. A new scanning electron microscopy approach to the quantification of bone mineral distribution: Backscattered electron image grey, levels correlated to calcium K alpha-line intensities. Scann Microsc 9:75–88; 1995. Simmons, 1998, Parathyroid hormone (1-34) increased total body bone mass in aged female rats, J Pharmacol Exp Ther, 286, 341 Tam, 1982, Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action, Endocrinology, 110, 506, 10.1210/endo-110-2-506 Thomsen, 1999, Long-term therapy of ovx-induced osteopenia with PTH analog SDZ PTS 893 and bone maintenance in retired breeder rats, Bone, 25, 561, 10.1016/S8756-3282(99)00212-4 Whitfield, 1995, Restoration of severely depleted femoral trabecular bone in ovariectomized rats by parathyroid hormone-(1-34), Calcif Tissue Int, 56, 227, 10.1007/BF00298615 Wronski, 1989, Time course of vertebral osteopenia in ovariectomied rats, Bone, 10, 295, 10.1016/8756-3282(89)90067-7 Wronski, 1989, Long-term effects of ovariectomy and aging on the rat skeleton, Calcif Tissue Int, 45, 360, 10.1007/BF02556007 Wronski, 1993, Parathyroid hormone is more effective than estrogen or bisphosphonates for restoration of lost bone mass in ovariectomized rats, Endocrinology, 132, 823, 10.1210/en.132.2.823