Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

American Association for the Advancement of Science (AAAS) - Tập 226 Số 4676 - Trang 850-852 - 1984
R. P. Simon1, J. H. Swan1, T. Griffiths1, B.S. Meldrum1
1Department of Neurology, Institute of Psychiatry, De Crespigny Park, London, England SES 8AF

Tóm tắt

In rats ischemia of the forebrain induced by a 30-minute occlusion of the carotid artery, followed by 120 minutes of arterial reperfusion, produced ischemic lesions of selectively vulnerable pyramidal cells in both hippocampi. Focal microinfusion into the dorsal hippocampus of 2-amino-7-phosphonoheptanoic acid, an antagonist of excitation at the N -methyl-D-aspartate-preferring receptor, before ischemia was induced protected against the development of ischemic damage. It is proposed that excitatory neurotransmission plays an important role in selective neuronal loss due to cerebral ischemia.

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American Association for the Advancement of Science (AAAS)

Tập 226 Số 4676

850-852

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