Bilirubin accumulation and Cyp mRNA expression in selected brain regions of jaundiced Gunn rat pups

Pediatric Research - Tập 71 Số 6 - Trang 653-660 - 2012
Silvia Gazzin1, Jaroslav Zelenka2, Lucie Zdrahalova2, Renata Koníčková2, Carlos Coda Zabetta1, Pablo J. Giraudi1, Andrea L. Berengeno1, Alan Raseni3, María Celeste Robert1, Libor Vı́tek4, Claudio Tiribelli5
1Fondazione Italiana Fegato (Italian Liver Foundation), Trieste, Italy
2Institute of Clinical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
3S.C. Laboratorio Analisi Cliniche, IRCCS Burlo Garofolo, Trieste, Italy
4Department of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
5Department of Medical Sciences, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

Tóm tắt

Từ khóa


Tài liệu tham khảo

Benaron DA, Bowen FW . Variation of initial serum bilirubin rise in newborn infants with type of illness. Lancet 1991;338:78–81.

Bhutani VK, Johnson L . 2005 Kernicterus: a preventable neonatal brain injury. J Arab Neonatal Forum 2005;2:12–24.

Calligaris SD, Bellarosa C, Giraudi P, Wennberg RP, Ostrow JD, Tiribelli C . Cytotoxicity is predicted by unbound and not total bilirubin concentration. Pediatr Res 2007;62:576–80.

Takahashi M, Sugiyama K, Shumiya S, Nagase S . Penetration of bilirubin into the brain in albumin-deficient and jaundiced rats (AJR) and Nagase analbuminemic rats (NAR). J Biochem 1984;96:1705–12.

Ahlfors CE, Wennberg RP . Bilirubin-albumin binding and neonatal jaundice. Semin Perinatol 2004;28:334–9.

Cannon C, Daood MJ, O’Day TL, Watchko JF . Sex-specific regional brain bilirubin content in hyperbilirubinemic Gunn rat pups. Biol Neonate 2006;90:40–5.

Aono S, Semba R, Sato H, Kashiwamata S . Mode of bilirubin deposition in the cerebellum of developing jaundiced Gunn rats. Biol Neonate 1989;55:119–23.

Daood MJ, Watchko JF . Calculated in vivo free bilirubin levels in the central nervous system of Gunn rat pups. Pediatr Res 2006;60:44–9.

Hansen TW . Pioneers in the scientific study of neonatal jaundice and kernicterus. Pediatrics 2000;106:E15.

Zelenka J, Lenícek M, Muchová L,et al. Highly sensitive method for quantitative determination of bilirubin in biological fluids and tissues. J Chromatogr B Analyt Technol Biomed Life Sci 2008;867:37–42.

Kapitulnik J, Gonzalez FJ . Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat. Mol Pharmacol 1993;43:722–5.

De Matteis F, Lord GA, Kee Lim C, Pons N . Bilirubin degradation by uncoupled cytochrome P450. Comparison with a chemical oxidation system and characterization of the products by high-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 2006;20:1209–17.

Pons N, Pipino S, De Matteis F . Interaction of polyhalogenated compounds of appropriate configuration with mammalian or bacterial CYP enzymes. Increased bilirubin and uroporphyrinogen oxidation in vitro. Biochem Pharmacol 2003;66:405–14.

Abu-Bakar A, Moore MR, Lang MA . Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5. Biochem Pharmacol 2005;70:1527–35.

Hankø E, Tommarello S, Watchko JF, Hansen TW . Administration of drugs known to inhibit P-glycoprotein increases brain bilirubin and alters the regional distribution of bilirubin in rat brain. Pediatr Res 2003;54:441–5.

Watchko JF, Daood MJ, Mahmood B, Vats K, Hart C, Ahdab-Barmada M . P-glycoprotein and bilirubin disposition. J Perinatol 2001;21:Suppl 1:S43–7; discussion S59–62.

Corich L, Aranda A, Carrassa L, Bellarosa C, Ostrow JD, Tiribelli C . The cytotoxic effect of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells is modulated by the expression level of MRP1 but not MDR1. Biochem J 2009;417:305–12.

Calligaris S, Cekic D, Roca-Burgos L,et al. Multidrug resistance associated protein 1 protects against bilirubin-induced cytotoxicity. FEBS Lett 2006;580:1355–9.

Falcão AS, Bellarosa C, Fernandes A,et al. Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin. Neuroscience 2007;144:878–88.

Strauss KA, Robinson DL, Vreman HJ, Puffenberger EG, Hart G, Morton DH . Management of hyperbilirubinemia and prevention of kernicterus in 20 patients with Crigler-Najjar disease. Eur J Pediatr 2006;165:306–19.

Ostrow JD, Pascolo L, Shapiro SM, Tiribelli C . New concepts in bilirubin encephalopathy. Eur J Clin Invest 2003;33:988–97.

Watchko JF . Kernicterus and the molecular mechanisms of bilirubin-induced CNS injury in newborns. Neuromolecular Med 2006;8:513–29.

Chowdhury JR, Kondapalli R, Chowdhury NR . Gunn rat: a model for inherited deficiency of bilirubin glucuronidation. Adv Vet Sci Comp Med 1993;37:149–73.

Conlee JW, Shapiro SM . Development of cerebellar hypoplasia in jaundiced Gunn rats: a quantitative light microscopic analysis. Acta Neuropathol 1997;93:450–60.

Keino H, Sato H, Semba R, Aono S, Aoki E, Kashiwamata S . Mode of prevention by phototherapy of cerebellar hypoplasia in a new Sprague-Dawley strain of jaundiced Gunn rats. Pediatr Neurosci 1985;12:145–50.

Schmid R, Hammaker L . Metabolism and disposition of c14-bilirubin in congenital nonhemolytic jaundice. J Clin Invest 1963;42:1720–34.

Kapitulnik J, Ostrow JD . Stimulation of bilirubin catabolism in jaundiced Gunn rats by an induced of microsomal mixed-function monooxygenases. Proc Natl Acad Sci USA 1978;75:682–5.

Zaccaro C, Sweitzer S, Pipino S,et al. Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice. Biochem Pharmacol 2001;61:843–9.

Ahlfors CE, Shapiro SM . Auditory brainstem response and unbound bilirubin in jaundiced (jj) Gunn rat pups. Biol Neonate 2001;80:158–62.

Gunn CH . Hereditary acholuric jaundice in a new mutant strain of rats. J Hered 1938;29:137–9.

Zarattini P, Gazzin S, Stebel M. Improvement of a historical animal model for Crigler Najjar Type I syndrome: development of the normobilirubinemic JJ genotype as a true control for the Gunn jaundiced rat, 2011. Experimental Models: 110-114. ( http://www.felasa.eu/media/uploads/Proceedings_FELASA-ScandLAS-2010_small_SEC.pdf ).

Gazzin S, Berengeno AL, Strazielle N,et al. Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat. PLoS ONE 2011;6:e16165.

Gazzin S, Strazielle N, Schmitt C,et al. Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces. J Comp Neurol 2008;510:497–507.