Bilirubin accumulation and Cyp mRNA expression in selected brain regions of jaundiced Gunn rat pups
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Benaron DA, Bowen FW . Variation of initial serum bilirubin rise in newborn infants with type of illness. Lancet 1991;338:78–81.
Bhutani VK, Johnson L . 2005 Kernicterus: a preventable neonatal brain injury. J Arab Neonatal Forum 2005;2:12–24.
Calligaris SD, Bellarosa C, Giraudi P, Wennberg RP, Ostrow JD, Tiribelli C . Cytotoxicity is predicted by unbound and not total bilirubin concentration. Pediatr Res 2007;62:576–80.
Takahashi M, Sugiyama K, Shumiya S, Nagase S . Penetration of bilirubin into the brain in albumin-deficient and jaundiced rats (AJR) and Nagase analbuminemic rats (NAR). J Biochem 1984;96:1705–12.
Ahlfors CE, Wennberg RP . Bilirubin-albumin binding and neonatal jaundice. Semin Perinatol 2004;28:334–9.
Cannon C, Daood MJ, O’Day TL, Watchko JF . Sex-specific regional brain bilirubin content in hyperbilirubinemic Gunn rat pups. Biol Neonate 2006;90:40–5.
Aono S, Semba R, Sato H, Kashiwamata S . Mode of bilirubin deposition in the cerebellum of developing jaundiced Gunn rats. Biol Neonate 1989;55:119–23.
Daood MJ, Watchko JF . Calculated in vivo free bilirubin levels in the central nervous system of Gunn rat pups. Pediatr Res 2006;60:44–9.
Hansen TW . Pioneers in the scientific study of neonatal jaundice and kernicterus. Pediatrics 2000;106:E15.
Zelenka J, Lenícek M, Muchová L,et al. Highly sensitive method for quantitative determination of bilirubin in biological fluids and tissues. J Chromatogr B Analyt Technol Biomed Life Sci 2008;867:37–42.
Kapitulnik J, Gonzalez FJ . Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat. Mol Pharmacol 1993;43:722–5.
De Matteis F, Lord GA, Kee Lim C, Pons N . Bilirubin degradation by uncoupled cytochrome P450. Comparison with a chemical oxidation system and characterization of the products by high-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 2006;20:1209–17.
Pons N, Pipino S, De Matteis F . Interaction of polyhalogenated compounds of appropriate configuration with mammalian or bacterial CYP enzymes. Increased bilirubin and uroporphyrinogen oxidation in vitro. Biochem Pharmacol 2003;66:405–14.
Abu-Bakar A, Moore MR, Lang MA . Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5. Biochem Pharmacol 2005;70:1527–35.
Hankø E, Tommarello S, Watchko JF, Hansen TW . Administration of drugs known to inhibit P-glycoprotein increases brain bilirubin and alters the regional distribution of bilirubin in rat brain. Pediatr Res 2003;54:441–5.
Watchko JF, Daood MJ, Mahmood B, Vats K, Hart C, Ahdab-Barmada M . P-glycoprotein and bilirubin disposition. J Perinatol 2001;21:Suppl 1:S43–7; discussion S59–62.
Corich L, Aranda A, Carrassa L, Bellarosa C, Ostrow JD, Tiribelli C . The cytotoxic effect of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells is modulated by the expression level of MRP1 but not MDR1. Biochem J 2009;417:305–12.
Calligaris S, Cekic D, Roca-Burgos L,et al. Multidrug resistance associated protein 1 protects against bilirubin-induced cytotoxicity. FEBS Lett 2006;580:1355–9.
Falcão AS, Bellarosa C, Fernandes A,et al. Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin. Neuroscience 2007;144:878–88.
Strauss KA, Robinson DL, Vreman HJ, Puffenberger EG, Hart G, Morton DH . Management of hyperbilirubinemia and prevention of kernicterus in 20 patients with Crigler-Najjar disease. Eur J Pediatr 2006;165:306–19.
Ostrow JD, Pascolo L, Shapiro SM, Tiribelli C . New concepts in bilirubin encephalopathy. Eur J Clin Invest 2003;33:988–97.
Watchko JF . Kernicterus and the molecular mechanisms of bilirubin-induced CNS injury in newborns. Neuromolecular Med 2006;8:513–29.
Chowdhury JR, Kondapalli R, Chowdhury NR . Gunn rat: a model for inherited deficiency of bilirubin glucuronidation. Adv Vet Sci Comp Med 1993;37:149–73.
Conlee JW, Shapiro SM . Development of cerebellar hypoplasia in jaundiced Gunn rats: a quantitative light microscopic analysis. Acta Neuropathol 1997;93:450–60.
Keino H, Sato H, Semba R, Aono S, Aoki E, Kashiwamata S . Mode of prevention by phototherapy of cerebellar hypoplasia in a new Sprague-Dawley strain of jaundiced Gunn rats. Pediatr Neurosci 1985;12:145–50.
Schmid R, Hammaker L . Metabolism and disposition of c14-bilirubin in congenital nonhemolytic jaundice. J Clin Invest 1963;42:1720–34.
Kapitulnik J, Ostrow JD . Stimulation of bilirubin catabolism in jaundiced Gunn rats by an induced of microsomal mixed-function monooxygenases. Proc Natl Acad Sci USA 1978;75:682–5.
Zaccaro C, Sweitzer S, Pipino S,et al. Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice. Biochem Pharmacol 2001;61:843–9.
Ahlfors CE, Shapiro SM . Auditory brainstem response and unbound bilirubin in jaundiced (jj) Gunn rat pups. Biol Neonate 2001;80:158–62.
Zarattini P, Gazzin S, Stebel M. Improvement of a historical animal model for Crigler Najjar Type I syndrome: development of the normobilirubinemic JJ genotype as a true control for the Gunn jaundiced rat, 2011. Experimental Models: 110-114. ( http://www.felasa.eu/media/uploads/Proceedings_FELASA-ScandLAS-2010_small_SEC.pdf ).
Gazzin S, Berengeno AL, Strazielle N,et al. Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat. PLoS ONE 2011;6:e16165.