Berberine modulates gut microbiota to attenuate cerebral ferroptosis induced by ischemia-reperfusion in mice

European Journal of Pharmacology - Tập 953 - Trang 175782 - 2023
Xinyu Wang1, Jiamin Zhang1,2, Sisi Wang1,2, Zhengyang Song1, Hongxia Sun1,2, Fangquan Wu1,2, Xiaohui Lin1,2, Keke Jin1,2, Xiaofeng Jin1,2, Wantie Wang1, Qiongqiong Lin3, Fangyan Wang1,2
1School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, China
2The research institute of microbiota and host inflammation-related diseases, Wenzhou Medical University, Wenzhou, 325035, China
3Department of Pathology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China

Tài liệu tham khảo

Aoyama, 2015, Glutathione in cellular redox homeostasis: association with the excitatory amino acid carrier 1 (EAAC1), Molecules, 20, 8742, 10.3390/molecules20058742

Brigelius-Flohé, 2013, Glutathione peroxidases, Biochim. Biophys. Acta, 1830, 3289, 10.1016/j.bbagen.2012.11.020

Chen, 2021, Ferritin reduction is essential for cerebral ischemia-induced hippocampal neuronal death through p53/SLC7A11-mediated ferroptosis, Brain Res., 1752, 10.1016/j.brainres.2020.147216

Chen, 2016, Pretreatment of rats with increased bioavailable berberine attenuates cerebral ischemia-reperfusion injury via down regulation of adenosine-5'monophosphate kinase activity, Eur. J. Pharmacol., 779, 80, 10.1016/j.ejphar.2016.03.015

Cryan, 2019, The microbiota-gut-brain Axis, Physiol. Rev., 99, 1877, 10.1152/physrev.00018.2018

Doshi, 2021, Triiodothyronine aggravates global cerebral ischemia-reperfusion injury in mice, Biol. Pharm. Bull., 44, 1824, 10.1248/bpb.b21-00424

Dumitrescu, 2018, Oxidative stress and the microbiota-gut-brain Axis, Oxid. Med. Cell. Longev., 2018, 10.1155/2018/2406594

Fan, 2019, Pharmacological effects of berberine on mood disorders, J. Cell Mol. Med., 23, 21, 10.1111/jcmm.13930

Fang, 2021, Berberine ameliorates ovariectomy-induced anxiety-like behaviors by enrichment in equol generating gut microbiota, Pharmacol. Res., 165, 10.1016/j.phrs.2021.105439

Fontagné, 2008, Lipid peroxidative stress and antioxidant defence status during ontogeny of rainbow trout (Oncorhynchus mykiss), Br. J. Nutr., 100, 102, 10.1017/S0007114507876215

Gao, 2009, Butyrate improves insulin sensitivity and increases energy expenditure in mice, Diabetes, 58, 1509, 10.2337/db08-1637

Gong, 2021, Isothiocyanate Iberin inhibits cell proliferation and induces cell apoptosis in the progression of ovarian cancer by mediating ROS accumulation and GPX1 expression, Biomed. Pharmacother., 142, 10.1016/j.biopha.2021.111533

González, 2020, Long-term coffee consumption is associated with fecal microbial composition in humans, Nutrients, 12, 10.3390/nu12051287

Guan, 2021, Galangin attenuated cerebral ischemia-reperfusion injury by inhibition of ferroptosis through activating the SLC7A11/GPX4 axis in gerbils, Life Sci., 264, 10.1016/j.lfs.2020.118660

Guo, 2021, Carthamin yellow improves cerebral ischemia-reperfusion injury by attenuating inflammation and ferroptosis in rats, Int. J. Mol. Med., 47, 10.3892/ijmm.2021.4885

Habtemariam, 2020, Berberine pharmacology and the gut microbiota: a hidden therapeutic link, Pharmacol. Res., 155, 10.1016/j.phrs.2020.104722

Hasanein, 2017, Effects of isoquinoline alkaloid berberine on lipid peroxidation, antioxidant defense system, and liver damage induced by lead acetate in rats, Redox Rep., 22, 42, 10.1080/13510002.2016.1140406

Hsieh, 2007, Protective effects of berberine against low-density lipoprotein (LDL) oxidation and oxidized LDL-induced cytotoxicity on endothelial cells, J. Agric. Food Chem., 55, 10437, 10.1021/jf071868c

Jiang, 2015, Ferroptosis as a p53-mediated activity during tumour suppression, Nature, 520, 57, 10.1038/nature14344

Jin, 2019, Neuroprotective effects of irisin against cerebral ischemia/reperfusion injury via Notch signaling pathway, Biomed. Pharmacother., 120, 10.1016/j.biopha.2019.109452

Lan, 2020, Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats, J Integr Med, 18, 344, 10.1016/j.joim.2020.01.008

Lee, 2006, Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo. Berberine improves neointima formation in a rat model, Atherosclerosis, 186, 29, 10.1016/j.atherosclerosis.2005.06.048

Lewerenz, 2013, The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities, Antioxidants Redox Signal., 18, 522, 10.1089/ars.2011.4391

Li, 2020, Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-κB pathway, Pharmacol. Res., 152, 10.1016/j.phrs.2019.104603

Li, 2021, Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke, Pharmacol. Res., 174, 10.1016/j.phrs.2021.105933

Li, 2014, Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy, Eur. J. Pharmacol., 728, 67, 10.1016/j.ejphar.2014.01.061

Li, 2021, Protective effects of andrographolide against cerebral ischemia-reperfusion injury in mice, Int. J. Mol. Med., 48, 10.3892/ijmm.2021.5019

Lin, 2018, Berberine: pathways to protect neurons, Phytother Res., 32, 1501, 10.1002/ptr.6107

Liu, 2019, Berberine protects against ischemia-reperfusion injury: a review of evidence from animal models and clinical studies, Pharmacol. Res., 148, 10.1016/j.phrs.2019.104385

Magtanong, 2018, Ferroptosis and brain injury, Dev. Neurosci., 40, 382, 10.1159/000496922

Philpott, 2014, Special delivery: distributing iron in the cytosol of mammalian cells, Front. Pharmacol., 5, 173, 10.3389/fphar.2014.00173

Ren, 2021, Crosstalk between oxidative stress and ferroptosis/oxytosis in ischemic stroke: possible targets and molecular mechanisms, Oxid. Med. Cell. Longev., 2021, 10.1155/2021/6643382

Saliu, 2021, Abatement of neurobehavioral and neurochemical dysfunctions in cerebral ischemia/reperfusion injury by Tetrapleura tetraptera fruit extract, J. Ethnopharmacol., 264, 10.1016/j.jep.2020.113284

Shou, 2022, Therapeutic efficacies of berberine against neurological disorders: an update of pharmacological effects and mechanisms, Cells, 11, 10.3390/cells11050796

Singh, 2016, Microbiota dysbiosis controls the neuroinflammatory response after stroke, J. Neurosci., 36, 7428, 10.1523/JNEUROSCI.1114-16.2016

Stockwell, 2017, Ferroptosis: a regulated cell death nexus linking metabolism, redox Biology, and disease, Cell, 171, 273, 10.1016/j.cell.2017.09.021

Tonnus, 2017, The in vivo evidence for regulated necrosis, Immunol. Rev., 277, 128, 10.1111/imr.12551

Tuo, 2017, Tau-mediated iron export prevents ferroptotic damage after ischemic stroke, Mol. Psychiatr., 22, 1520, 10.1038/mp.2017.171

Vongsfak, 2021, The alterations in mitochondrial Dynamics following cerebral ischemia/reperfusion injury, Antioxidants, 10, 10.3390/antiox10091384

Wang, 2021, Gut microbiota from mice with cerebral ischemia-reperfusion injury affects the brain in healthy mice, Aging (Albany NY), 13, 10058, 10.18632/aging.202763

Wang, 2017, The metabolism of berberine and its contribution to the pharmacological effects, Drug Metab. Rev., 49, 139, 10.1080/03602532.2017.1306544

Wang, 2021, Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota, Signal Transduct. Targeted Ther., 6, 77, 10.1038/s41392-020-00456-5

Wei, 2020, Expression and prognostic potential of GPX1 in human cancers based on data mining, Ann. Transl. Med., 8, 124, 10.21037/atm.2020.02.36

Wu, 2020, Effect of berberine on atherosclerosis and gut microbiota modulation and their correlation in high-fat diet-fed ApoE-/- mice, Front. Pharmacol., 11, 223, 10.3389/fphar.2020.00223

Xiang, 2022, miR-204-5p is sponged by TUG1 to aggravate neuron damage induced by focal cerebral ischemia and reperfusion injury through upregulating COX2, Cell Death Dis., 8, 89, 10.1038/s41420-022-00885-x

Yan, 2021, Neuroprotective and anti-Inflammatory effect of pterostilbene against cerebral ischemia/reperfusion injury via suppression of COX-2, Front. Pharmacol., 12, 10.3389/fphar.2021.770329

Yang, 2018, Berberine ameliorates MCAO induced cerebral ischemia/reperfusion injury via activation of the BDNF-TrkB-PI3K/akt signaling pathway, Neurochem. Res., 43, 702, 10.1007/s11064-018-2472-4

Yang, 2016, Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis, Proc. Natl. Acad. Sci. U. S. A., 113, E4966, 10.1073/pnas.1603244113

Yu, 2021, Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases, Cell Death Dis., 7, 193, 10.1038/s41420-021-00579-w

Zhang, 2020, Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study), Nat. Commun., 11, 5015, 10.1038/s41467-020-18414-8

Zhao, 2021, Molecular mechanisms of ferroptosis and its roles in hematologic Malignancies, Front. Oncol., 11, 10.3389/fonc.2021.743006

Zhao, 2021, Berberine exerts neuroprotective activities against cerebral ischemia/reperfusion injury through up-regulating PPAR-γ to suppress NF-κB-mediated pyroptosis, Brain Res. Bull., 177, 22, 10.1016/j.brainresbull.2021.09.005

Zhu, 2020, The molecular mechanisms of regulating oxidative stress-induced ferroptosis and therapeutic Strategy in Tumors, Oxid. Med. Cell. Longev., 2020, 10.1155/2020/8810785

Zhu, 2018, Berberine attenuates ischemia-reperfusion injury through inhibiting HMGB1 release and NF-κB nuclear translocation, Acta Pharmacol. Sin., 39, 1706, 10.1038/s41401-018-0160-1

Zille, 2017, Neuronal death after hemorrhagic stroke in vitro and in vivo Shares features of ferroptosis and necroptosis, Stroke, 48, 1033, 10.1161/STROKEAHA.116.015609