Autophagy: in sickness and in health

Seglen, 1992, Autophagy and other vacuolar protein degradation mechanisms, Experientia, 48, 158, 10.1007/BF01923509

Kim, 2000, Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells, Annu. Rev. Biochem., 69, 303, 10.1146/annurev.biochem.69.1.303

Dice, 2000, Vol. 11

Cuervo, A.M. Autophagy: many paths to the same end. Mol. Cell. Biochem. (in press).

Meijer, 2003, Amino acids as regulators and components of nonproteinogenic pathways, J. Nutr., 133, 2057S, 10.1093/jn/133.6.2057S

Lemasters, 2002, Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy, Antioxid. Redox Signal., 4, 769, 10.1089/152308602760598918

Bellu, 2003, Selective degradation of peroxisomes in yeasts, Microsc. Res. Tech., 61, 161, 10.1002/jemt.10325

Roberts, 2003, Piecemeal microautophagy of nucleus in Saccharomyces cerevisiae, Mol. Biol. Cell, 14, 129, 10.1091/mbc.E02-08-0483

Hennig, 2002, Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila, Genesis, 34, 107, 10.1002/gene.10139

Jacinto, 2003, Tor signalling in bugs, brain and brawn, Nat. Rev. Mol. Cell Biol., 4, 117, 10.1038/nrm1018

Melendez, 2003, Essential role of autophagy genes in dauer development and lifespan extension in C. elegans, Science, 301, 1387, 10.1126/science.1087782

Otto, 2003, Macroautophagy is required for multicellular development of the social amoeba Dictyostelium discoideum, J. Biol. Chem., 278, 17636, 10.1074/jbc.M212467200

Thumm, 2000, Structure and function of the yeast vacuole and its role in autophagy, Microsc. Res. Tech., 51, 563, 10.1002/1097-0029(20001215)51:6<563::AID-JEMT6>3.0.CO;2-8

Khalfan, 2002, Molecular machinery required for autophagy and the cytoplasm to vacuole targeting (Cvt) pathway in S. cerevisiae, Curr. Opin. Cell Biol., 14, 468, 10.1016/S0955-0674(02)00343-5

Noda, 2002, Yeast autophagosomes: de novo formation of a membrane structure, Trends Cell Biol., 12, 231, 10.1016/S0962-8924(02)02278-X

Sakai, 1998, Peroxisome degradation by microautophagy in Pichia pastoris: identification of specific steps and morphological intermediates, J. Cell Biol., 141, 625, 10.1083/jcb.141.3.625

Ohsumi, 2001, Molecular dissection of autophagy: two ubiquitin-like systems, Nat. Rev. Mol. Cell Biol., 2, 211, 10.1038/35056522

Fengsrud, 2000, Ultrastructural characterization of the delimiting membranes of isolated autophagosomes and amphisomes by freeze-fracture electron microscopy, Eur. J. Cell Biol., 79, 871, 10.1078/0171-9335-00125

Mizushima, 2002, Autophagosome formation in mammalian cells, Cell Struct. Funct., 27, 421, 10.1247/csf.27.421

Müller, 2000, Autophagic tubes: vacuolar invaginations involved in lateral membrane sorting and inverse vesicle budding, J. Cell Biol., 151, 519, 10.1083/jcb.151.3.519

Deter, 1967, Influence of glucagon, an inducer of cellular autophagy, on some physical properties of rat liver lysosomes, J. Cell Biol., 33, 437, 10.1083/jcb.33.2.437

Fuertes, 2003, Changes in the proteolytic activities of proteasomes and lysosomes in human fibroblasts produced by serum withdrawal, amino-acid deprivation and confluent conditions, Biochem. J., 375, 75, 10.1042/bj20030282

Klionsky, 2003, A unified nomenclature for yeast autophagy-related genes, Dev. Cell, 5, 539, 10.1016/S1534-5807(03)00296-X

Nemoto, 2003, The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification, J. Biol. Chem., 278, 39517, 10.1074/jbc.M300550200

Asanuma, 2003, MAP-LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis, FASEB J., 17, 1165, 10.1096/fj.02-0580fje

Walker, 1997, Cytokine-induced, nitric oxide-dependent, intracellular antirickettsial activity of mouse endothelial cells, Lab. Invest., 76, 129

Talloczy, 2002, Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway, Proc. Natl. Acad. Sci. U. S. A., 99, 190, 10.1073/pnas.012485299

Webb, 2003, Alpha-Synuclein is degraded by both autophagy and the proteasome, J. Biol. Chem., 278, 25009, 10.1074/jbc.M300227200

Bursch, 2000, Programmed cell death (PCD). Apoptosis, autophagic PCD, or others?, Ann. N. Y. Acad. Sci., 926, 1, 10.1111/j.1749-6632.2000.tb05594.x

Tolkovsky, 2002, Mitochondrial disappearance from cells: a clue to the role of autophagy in programmed cell death and disease?, Biochimie, 84, 233, 10.1016/S0300-9084(02)01371-8

Larsen, 2002, Autophagy in neurons: a review, Histol. Histopathol., 17, 897

Xue, 1999, Autophagy is activated by apoptotic signaling in sympathetic neurons: an alternative mechanism of death execution, Mol. Cell. Neurosci., 14, 180, 10.1006/mcne.1999.0780

Inbal, 2002, DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death, J. Cell Biol., 157, 455, 10.1083/jcb.200109094

Jia, 1997, Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells, Br. J. Haematol., 98, 673, 10.1046/j.1365-2141.1997.2623081.x

Ogier-Denis, 2003, Autophagy: a barrier or an adaptive response to cancer, Biochim. Biophys. Acta, 1603, 113

Paglin, 2001, A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles, Cancer Res., 61, 439

Toth, 2002, Cellular autophagic capacity changes during azaserine-induced tumour progression in the rat pancreas. Up-regulation in all premalignant stages and down-regulation with loss of cycloheximide sensitivity of segregation along with malignant transformation, Cell Tissue Res., 309, 409, 10.1007/s00441-001-0506-7

Liang, 1999, Induction of autophagy and inhibition of tumorigenesis by beclin 1, Nature, 402, 672, 10.1038/45257

Suzuki, 2002, The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy, J. Biochem. (Tokyo), 131, 647, 10.1093/oxfordjournals.jbchem.a003147

Nishino, 2003, Autophagic vacuolar myopathies, Curr. Neurol. Neurosci. Rep., 3, 64, 10.1007/s11910-003-0040-y

Tanaka, 2000, Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice, Nature, 406, 902, 10.1038/35022595

Saftig, 2001, Disease model: LAMP-2 enlightens Danon disease, Trends Mol. Med., 7, 37, 10.1016/S1471-4914(00)01868-2

Yamamoto, 2001, Infantile autophagic vacuolar myopathy is distinct from Danon disease, Neurology, 57, 903, 10.1212/WNL.57.5.903

Buj-Bello, 2002, The lipid phosphatase myotubularin is essential for skeletal muscle maintenance but not for myogenesis in mice, Proc. Natl. Acad. Sci. U. S. A., 99, 15060, 10.1073/pnas.212498399

Nixon, 2000, The endosomal–lysosomal system of neurons in Alzheimer's disease pathogenesis: a review, Neurochem. Res., 25, 1161, 10.1023/A:1007675508413

Liberski, 2002, How do neurons degenerate in prion diseases or transmissible spongiform encephalopathies (TSEs): neuronal autophagy revisited, Acta Neurobiol. Exp., 62, 141, 10.55782/ane-2002-1432

Kegel, 2000, Huntingtin expression stimulates endosomal–lysosomal activity, endosome tubulation, and autophagy, J. Neurosci., 20, 7268, 10.1523/JNEUROSCI.20-19-07268.2000

Stefanis, 2001, Expression of A53T mutant but not wild-type α-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death, J. Neurosci., 21, 9549, 10.1523/JNEUROSCI.21-24-09549.2001

Chang, 2002, Phosphorylation of eukaryotic initiation factor-2α (eIF2α) is associated with neuronal degeneration in Alzheimer's disease, Neuroreport, 13, 2429, 10.1097/00001756-200212200-00011

Petersen, 2001, Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration, Hum. Mol. Genet., 10, 1243, 10.1093/hmg/10.12.1243

Gomez-Santos, 2003, Dopamine induces autophagic cell death and α-synuclein increase in human neuroblastoma SH-SY5Y cells, J. Neurosci. Res., 73, 341, 10.1002/jnr.10663

Jellinger, 2000, Mechanisms of cell death in neurodegenerative disorders, J. Neural Transm. Suppl., 59, 95

Michalik, 2003, Pathogenesis of polyglutamine disorders: aggregation revisited, Hum. Mol. Genet., 12, R173, 10.1093/hmg/ddg295

Ravikumar, 2002, Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy, Hum. Mol. Genet., 11, 1107, 10.1093/hmg/11.9.1107

Qin, Z.H. et al. Autophagy regulates the processing of amino terminal huntingtin fragments. Hum. Mol. Genet. (in press).

Matthews, 1972, A light and electron microscopic study of the cellular response to axonal injury in the superior cervical ganglion of the rat, Proc. R. Soc. Lond. B. Biol. Sci., 181, 43, 10.1098/rspb.1972.0040

Dorn, 2002, Bacterial interaction with the autophagic pathway, Cell. Microbiol., 4, 1, 10.1046/j.1462-5822.2002.00164.x

Scott, 2003, Phagosome maturation: a few bugs in the system, J. Membr. Biol., 193, 137, 10.1007/s00232-002-2008-2

Swanson, 1995, Association of Legionella pneumophila with the macrophage endoplasmic reticulum, Infect. Immun., 63, 3609, 10.1128/IAI.63.9.3609-3620.1995

Coers, 2000, Identification of icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth, Mol. Microbiol., 38, 719, 10.1046/j.1365-2958.2000.02176.x

Suhy, 2000, Remodeling the endoplasmic reticulum by poliovirus infection and by individual viral proteins: an autophagy-like origin for virus-induced vesicles, J. Virol., 74, 8953, 10.1128/JVI.74.19.8953-8965.2000

Ward, 2002, Protein degradation in the aging organism, Prog. Mol. Subcell. Biol., 29, 35, 10.1007/978-3-642-56373-7_3

Cuervo, 2000, When lysosomes get old, Exp. Gerontol., 35, 119, 10.1016/S0531-5565(00)00075-9

Cuervo, 2000, Age-related decline in chaperone-mediated autophagy, J. Biol. Chem., 275, 31505, 10.1074/jbc.M002102200

Del Roso, 2003, Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysis, Exp. Gerontol., 38, 519, 10.1016/S0531-5565(03)00002-0

Terman, 1995, The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes, Gerontology, 41, 319, 10.1159/000213753

Bergamini, 2003, The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically, Biomed. Pharmacother., 57, 203, 10.1016/S0753-3322(03)00048-9

Susan, 2001, Starvation-induced lysosomal degradation of aldolase B requires glutamine 111 in a signal sequence for chaperone-mediated transport, J. Cell. Physiol., 187, 48, 10.1002/1097-4652(2001)9999:9999<00::AID-JCP1050>3.0.CO;2-I

Lenk, 1999, Ubiquitinated aldolase B accumulates during starvation-induced lysosomal proteolysis, J. Cell. Physiol., 178, 17, 10.1002/(SICI)1097-4652(199901)178:1<17::AID-JCP3>3.0.CO;2-R

Ogier-Denis, 2000, Glucose persistence on high-mannose oligosaccharides selectively inhibits the macroautophagic sequestration of N-linked glycoproteins, Biochem. J., 345, 459, 10.1042/0264-6021:3450459