Autophagy: A Critical Regulator of Cellular Metabolism and Homeostasis

Elsevier BV - Tập 36 Số 1 - Trang 7-16 - 2013
Stefan W. Ryter1, Suzanne M. Cloonan2, Augustine M.K. Choi2
1Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
2Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA

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Bachar-Wikstrom, 2013, Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes, Diabetes, 62, 1227, 10.2337/db12-1474

Bodas, 2012, Therapeutic strategies to correct proteostasis-imbalance in chronic obstructive lung diseases, Curr. Mol. Med., 12, 807, 10.2174/156652412801318809

Boya, 2005, Inhibition of macroautophagy triggers apoptosis, Mol. Cell. Biol., 25, 1025, 10.1128/MCB.25.3.1025-1040.2005

Campbell, 2011, Hormonally active vitamin D3 (1alpha, 25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection, J. Biol. Chem., 286, 18890, 10.1074/jbc.M110.206110

Chan, 2012, Regulation and function of uncoordinated-51 like kinase proteins, Antioxid. Redox Signal., 17, 775, 10.1089/ars.2011.4396

Checroun, 2006, Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication, Proc. Natl. Acad. Sci. USA, 103, 14578, 10.1073/pnas.0601838103

Chen, 2008, Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease, PLoS One, 3, e3316, 10.1371/journal.pone.0003316

Choi, 2013, Autophagy in human health and disease, N. Engl. J. Med., 368, 651, 10.1056/NEJMra1205406

Clausen, 2010, p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy, Autophagy, 6, 330, 10.4161/auto.6.3.11226

Dagda, 2009, Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission, J. Biol. Chem., 284, 13843, 10.1074/jbc.M808515200

Deretic, 2009, Autophagy, immunity, and microbial adaptations, Cell Host Microbe., 5, 527, 10.1016/j.chom.2009.05.016

Elliott, 1998, Lung polymers in Z alpha1-antitrypsin deficiency-related emphysema, Am. J. Respir. Cell Mol. Biol., 18, 670, 10.1165/ajrcmb.18.5.3065

Ganley, 2009, ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy, J. Biol. Chem., 284, 12297, 10.1074/jbc.M900573200

Geisler, 2010, PINK1/Parkin-me- diated mitophagy is dependent on VDAC1 and p62/SQSTM1, Nat. Cell Biol., 12, 119, 10.1038/ncb2012

Gonzalez, 2011, The emerging role of autophagy in the pathophysiology of diabetes mellitus, Autophagy, 7, 2, 10.4161/auto.7.1.13044

Granell, 2008, Sequestration of mutated alpha1- antitrypsin into inclusion bodies is a cell-protective mechanism to maintain endoplasmic reticulum function, Mol. Biol. Cell, 19, 572, 10.1091/mbc.e07-06-0587

Gutierrez, 2005, Autophagy induction favours the generation and maturation of the Coxiella- replicative vacuoles, Cell. Microbiol., 7, 981, 10.1111/j.1462-5822.2005.00527.x

Hara, 2006, Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice, Nature, 44, 885, 10.1038/nature04724

He, 2010, The Beclin 1 interactome, Curr. Opin. Cell Biol., 22, 140, 10.1016/j.ceb.2010.01.001

He, 2012, Exercise-induced BCL2- regulated autophagy is required for muscle glucose homeostasis, Nature, 481, 511, 10.1038/nature10758

Hidvegi, 2010, An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis, Science, 329, 229, 10.1126/science.1190354

Hosokawa, 2009, Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy, Mol. Biol. Cell, 20, 1981, 10.1091/mbc.e08-12-1248

Hsu, 2000, alpha-synuclein promotes mitochondrial deficit and oxidative stress, Am. J. Pathol., 157, 401, 10.1016/S0002-9440(10)64553-1

Ichimura, 2010, Selective degradation of p62 by autophagy, Semin. Immunopathol., 32, 431, 10.1007/s00281-010-0220-1

Inoki, 2003, TSC2 mediates cellular energy response to control cell growth and survival, Cell, 115, 577, 10.1016/S0092-8674(03)00929-2

Imarisio, 2008, Huntington’s disease: from pathology and genetics to potential therapies, Biochem. J., 412, 191, 10.1042/BJ20071619

Itakura, 2008, Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG, Mol. Biol. Cell, 19, 5360, 10.1091/mbc.e08-01-0080

Jellinger, 2010, Basic mechanisms of neurodegeneration: a critical update, J. Cell. Mol. Med., 14, 457, 10.1111/j.1582-4934.2010.01010.x

Johansen, 2011, Selective autophagy mediated by autophagic adapter proteins, Autophagy, 7, 279, 10.4161/auto.7.3.14487

Jung, 2010, Role of autophagy in diabetes and mitochondria, Ann. N Y Acad. Sci., 1201, 79, 10.1111/j.1749-6632.2010.05614.x

Jung, 2009, ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery, Mol. Biol. Cell, 20, 1992, 10.1091/mbc.e08-12-1249

Jung, 2010, mTOR regulation of autophagy, FEBS Lett., 584, 1287, 10.1016/j.febslet.2010.01.017

Kabeya, 2000, LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing, EMBO J., 19, 5720, 10.1093/emboj/19.21.5720

Kabeya, 2004, LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation, J. Cell Sci., 117, 2805, 10.1242/jcs.01131

Kamimoto, 2006, Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity, J. Biol. Chem., 281, 4467, 10.1074/jbc.M509409200

Kaushik, 2011, Chaperone-mediated autophagy at a glance, J. Cell Sci., 124, 495, 10.1242/jcs.073874

Kaushik, 2011, Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance, Cell Metab., 14, 173, 10.1016/j.cmet.2011.06.008

Kawaguchi, 2003, The deacetylase HDAC6 regulates aggreso- me formation and cell viability in response to misfolded protein stress, Cell, 115, 727, 10.1016/S0092-8674(03)00939-5

Ke, 2011, Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro, J. Clin. Invest., 121, 3756, 10.1172/JCI41474

Kim, 2011, AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1, Nat. Cell Biol., 13, 132, 10.1038/ncb2152

Kirkin, 2009, A role for NBR1 in autophagosomal degradation of ubiquitinated substrates, Mol. Cell, 33, 505, 10.1016/j.molcel.2009.01.020

Komatsu, 2006, Loss of autophagy in the central nervous system causes neurodegeneration in mice, Nature, 441, 880, 10.1038/nature04723

Kroemer, 2010, Autophagy and the integrated stress response, Mol. Cell, 40, 280, 10.1016/j.molcel.2010.09.023

Kyei, 2009, Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages., J. Cell Biol., 186, 255, 10.1083/jcb.200903070

Lamark, 2012, Aggrephagy: selective disposal of protein aggregates by macroautophagy, Int. J. Cell Biol., 2012, 736, 10.1155/2012/736905

Lee, 2010, HDAC6 controls autophagosome maturation essential for ubiquitinselective quality-control autophagy, EMBO J., 29, 969, 10.1038/emboj.2009.405

Levine, 2008, Autophagy in the pathogenesis of disease, Cell, 132, 27, 10.1016/j.cell.2007.12.018

Levine, 2011, Autophagy in immunity and inflammation, Nature, 469, 323, 10.1038/nature09782

Li, 2011, Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment, J. Virol., 85, 6319, 10.1128/JVI.02627-10

Liang, 1999, Induction of autophagy and inhibition of tumorigenesis by beclin 1, Nature, 402, 672, 10.1038/45257

Liu, 2013, Regulation of lipid stores and metabolism by lipophagy, Cell Death Differ., 20, 3, 10.1038/cdd.2012.63

Liu, 2012, Mitochondrial outermembrane protein FUNDC1 mediates hypoxia-induced mito- phagy in mammalian cells, Nat. Cell Biol., 14, 177, 10.1038/ncb2422

Luciani, 2010, Defective CFTR induces aggre- some formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition, Nat. Cell Biol., 12, 863, 10.1038/ncb2090

Ma, 2010, Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer’s disease, Neuropathol. Appl. Neurobiol., 36, 312, 10.1111/j.1365-2990.2010.01067.x

Maiuri, 2007, Selfeating and self-killing: crosstalk between autophagy and apoptosis, Nat. Rev. Mol. Cell Biol., 8, 741, 10.1038/nrm2239

Marciniak, 2010, Alpha1-antitrypsin deficiency and autophagy, N. Engl. J. Med., 363, 1863, 10.1056/NEJMcibr1008007

Martinez-Vicente, 2010, Cargo recognition failure is responsible for inefficient autophagy in Huntington’s disease, Nat. Neurosci., 13, 567, 10.1038/nn.2528

Metcalf, 2012, Autophagy and misfolded proteins in neurodegeneration, Exp. Neurol., 238, 22, 10.1016/j.expneurol.2010.11.003

Mihaylova, 2011, The AMPK signalling pathway coordinates cell growth, autophagy and metabolism, Nat. Cell Biol., 13, 1016, 10.1038/ncb2329

Min, 2011, Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema, J. Mol. Med. (Berl.), 89, 577, 10.1007/s00109-011-0732-8

Mizushima, 2010, The role of the Atg1/ULK1 complex in autophagy regulation, Curr. Opin. Cell Biol., 22, 132, 10.1016/j.ceb.2009.12.004

Mizushima, 2011, Autophagy: renovation of cells and tissues, Cell, 147, 728, 10.1016/j.cell.2011.10.026

Mizushima, 2008, Autophagy fights disease through cellular self-digestion, Nature, 451, 1069, 10.1038/nature06639

Mizushima, 2010, Methods in mammalian autophagy research, Cell, 140, 313, 10.1016/j.cell.2010.01.028

Mornex, 1986, Expression of the alpha-1-antitry- psin gene in mononuclear phagocytes of normal and alpha-1- antitrypsin-deficient individuals, J. Clin. Invest., 77, 1952, 10.1172/JCI112524

Morris, 2005, Genetics of Parkinson’s disease, Ann. Med., 37, 86, 10.1080/07853890510007269

Nakahira, 2011, Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome, Nat. Immunol., 12, 222, 10.1038/ni.1980

Narendra, 2008, Parkin is recruited selectively to impaired mitochondria and promotes their autophagy, J. Cell Biol., 183, 795, 10.1083/jcb.200809125

Orvedahl, 2011, Imagebased genome-wide siRNA screen identifies selective autophagy factors, Nature, 480, 113, 10.1038/nature10546

Pattingre, 2005, Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy, Cell, 122, 927, 10.1016/j.cell.2005.07.002

Pickford, 2008, The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice, J. Clin. Invest., 118, 2190

Ranes, 2005, A review of alpha-1 antitrypsin deficiency, Semin. Respir. Crit. Care Med., 26, 154, 10.1055/s-2005-869536

Ravikumar, 2002, Aggregate- prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy., Hum. Mol. Genet., 11, 107, 10.1093/hmg/11.9.1107

Ravikumar, 2004, Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease, Nat. Genet., 36, 585, 10.1038/ng1362

Ravikumar, 2010, Regulation of mammalian autophagy in physiology and pathophysiology, Physiol. Rev., 90, 1383, 10.1152/physrev.00030.2009

Rubinsztein, 2012, Autophagy modulation as a potential therapeutic target for diverse diseases, Nat. Rev. Drug Discov., 11, 709, 10.1038/nrd3802

Santambrogio, 2011, Chasing the elusive mammalian microautophagy, Autophagy, 7, 652, 10.4161/auto.7.6.15287

Satoo, 2009, The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipi- dation during autophagy, EMBO J., 28, 1341, 10.1038/emboj.2009.80

Schaeffer, 2012, Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy, Brain, 135, 2169, 10.1093/brain/aws143

Schreiber, 2013, Substrate recognition in selective autophagy and the ubiquitin-proteasome system. Biochim. Biophys., Acta

Shaid, 2013, Ubiquitina- tion and selective autophagy, Cell Death Differ., 20, 21, 10.1038/cdd.2012.72

Shibata, 2006, Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1, J. Biol. Chem., 281, 14474, 10.1074/jbc.M600364200

Singh, 2009, Autophagy regulates lipid metabolism, Nature, 458, 1131, 10.1038/nature07976

Singh, 2009, Autophagy regulates adipose mass and differentiation in mice, J. Clin. Invest., 119, 3329

Spencer, 2009, Beclin1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in α-synuclein models of Parkinson’s and Lewy body diseases, J. Neurosci., 29, 13578, 10.1523/JNEUROSCI.4390-09.2009

Starr, 2012, Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle, Cell Host Microbe, 11, 33, 10.1016/j.chom.2011.12.002

Thurston, 2009, The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria, Nat. Immunol., 10, 1215, 10.1038/ni.1800

Tian, 2011, Autophagy required for hepatitis B virus replication in transgenic mice, J. Virol., 85, 13453, 10.1128/JVI.06064-11

Trancikova, 2012, Mitochondrial dysfunction in genetic animal models of Parkinson’s disease, Antioxid. Redox Signal., 216, 896, 10.1089/ars.2011.4200

Vander Haar, 2007, Insulin signalling to mTOR mediated by the Akt/ PKB substrate PRAS40, Nat. Cell Biol., 9, 316, 10.1038/ncb1547

Vives-Bauza, 2010, PINK1-dependent recruitment of Parkin to mitochondria in mito- phagy, Proc. Natl. Acad. Sci. USA, 107, 378, 10.1073/pnas.0911187107

Wang, 2012, Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation, Science, 338, 956, 10.1126/science.1225967

Wild, 2011, Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth, Science, 333, 228, 10.1126/science.1205405

Winslow, 2010, α-Synuclein impairs macroautophagy: implications for Parkinson’s disease., J. Cell Biol., 190, 1023, 10.1083/jcb.201003122

Wong, 2010, Autophagy gone awry in neurodegenerative diseases, Nat. Neurosci., 13, 805, 10.1038/nn.2575

Wong, 2013, The ULK1 complex: sensing nutrient signals for autophagy activation, Autophagy, 9, 124, 10.4161/auto.23323

Yamamoto, 2011, The elimination of accumulated and aggregated proteins: a role for aggrephagy in neurodegeneration, Neurobiol. Dis., 43, 17, 10.1016/j.nbd.2010.08.015

Yamamoto, 2012, Atg9 vesicles are an important membrane source during early steps of autophagosome formation, J. Cell Biol., 198, 219, 10.1083/jcb.201202061

Yang, 2010, Eaten alive: a history of macroautophagy, Nat. Cell Biol., 12, 814, 10.1038/ncb0910-814

Yang, 2010, Mammalian autophagy: core molecular machinery and signaling regulation, Curr. Opin. Cell Biol., 22, 124, 10.1016/j.ceb.2009.11.014

Yang, 2010, Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance, Cell Metab., 11, 467, 10.1016/j.cmet.2010.04.005

Yano, 2011, Intracellular recognition of pathogens and autophagy as an innate immune host defence, J. Biochem., 150, 143, 10.1093/jb/mvr083

Youle, 2011, Mechanisms of mitophagy, Nat. Rev. Mol. Cell Biol., 12, 9, 10.1038/nrm3028

Young, 2006, Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes, J. Cell Sci., 119, 38883900, 10.1242/jcs.03172

Yu, 2005, Macroautophagy-a novel Beta-amyloid pep- tide-generating pathway activated in Alzheimer’s disease, J. Cell Biol., 171, 87, 10.1083/jcb.200505082

Zhang, 2008, Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia, J. Biol. Chem., 283, 10892, 10.1074/jbc.M800102200

Zhou, 2010, Rapamycin induces autophagy and exacerbates metabolism associated complications in a mouse model of type 1 diabetes, Indian J. Exp. Biol., 48, 31