Association of facial skin aging and vitamin D levels in middle-aged white women
Tóm tắt
To investigate the relationship between UV-induced skin photodamage and 25(OH) vitamin D levels, we performed a cross-sectional study in 45 female subjects aged >40. Menopausal status, smoking status, skin cancer history, oral supplement use, and season of blood draw were recorded and serum 25(OH)D measured. A single-blinded, dermatologist evaluated standardized digital facial images for overall photodamage, erythema/telangiectasias, hyperpigmentation, number of lentigines, and wrinkling. Adjusting for age and season of blood collection, women with lower photodamage scores were associated with a 5-fold increased odds of being vitamin D insufficient (OR 5.0, 95% CI: 1.1, 23). Low scores for specific photodamage parameters including erythema/telangiectasias, hyperpigmentation, and wrinkling were also significantly associated with vitamin D insufficiency. Our results suggest an association between skin aging and 25(OH)D levels.
Tài liệu tham khảo
Martires KJ, Fu P, Polster AM, Cooper KD, Baron ED (2009) Factors that affect skin aging. Archiv Dermatol 145(12):1375–1379
Holick MF (2007) Vitamin D deficiency. N Engl J Med 357(3):266–281
AAD. Position Statement on Vitamin D. http://www.aad.org/forms/policies/Uploads/PS/AAD_PS_Vitamin_D.pdf June 19, 2009, http://www.aad.org/forms/policies/Uploads/PS/AAD_PS_Vitamin_D.pdf
Janjua R, Munoz C, Gorell E et al (2009) A two-year, double-blind, randomized placebo-controlled trial of oral green tea polyphenols on the long-term clinical and histologic appearance of photoaging skin. Dermatol Surg 35(7):1057–1065
Pasco JA, Henry MJ, Nicholson GC, Brennan SL, Kotowicz MA (2009) Behavioural and physical characteristics associated with vitamin D status in women. Bone 44(6):1085–1091
Keisala T, Minasyan A, Lou YR et al (2009) Premature aging in vitamin D receptor mutant mice. J Steroid Biochem Mol Biol 115(3–5):91–97