Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

Otte, 2016, Major depressive disorder, Nat Rev Dis Primers, 2, 16065, 10.1038/nrdp.2016.65 Bromet, 2011, Cross-national epidemiology of DSM-IV major depressive episode, BMC Med, 9, 90, 10.1186/1741-7015-9-90 Zeng, 2016, Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression, EBioMedicine, 14, 161, 10.1016/j.ebiom.2016.11.003 Sullivan, 2000, Genetic epidemiology of major depression: Review and meta-analysis, Am J Psychiatry, 157, 1552, 10.1176/appi.ajp.157.10.1552 Belmaker, 2008, Major depressive disorder, N Engl J Med, 358, 55, 10.1056/NEJMra073096 Ripke, 2013, A mega-analysis of genome-wide association studies for major depressive disorder, Mol Psychiatry, 18, 497, 10.1038/mp.2012.21 Hek, 2013, A genome-wide association study of depressive symptoms, Biol Psychiatry, 73, 667, 10.1016/j.biopsych.2012.09.033 Lubke, 2012, Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms, Biol Psychiatry, 72, 707, 10.1016/j.biopsych.2012.03.011 2015, Sparse whole genome sequencing identifies two loci for major depressive disorder, Nature, 523, 588, 10.1038/nature14659 Hyde, 2016, Identification of 15 genetic loci associated with risk of major depression in individuals of European descent, Nat Genet, 48, 1031, 10.1038/ng.3623 Mullins, 2017, Genetics of depression: Progress at Last, Curr Psychiatry Rep, 19, 43, 10.1007/s11920-017-0803-9 2015, Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways, Nat Neurosci, 18, 199, 10.1038/nn.3922 Jia, 2012, A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia, J Med Genet, 49, 96, 10.1136/jmedgenet-2011-100397 Zeng, 2017, A combined pathway and regional heritability analysis indicates NETRIN1 pathway is associated with major depressive disorder, Biol Psychiatry, 81, 336, 10.1016/j.biopsych.2016.04.017 Serafini, 1996, Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system, Cell, 87, 1001, 10.1016/S0092-8674(00)81795-X Castillo-Paterna, 2015, DCC functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity, EMBO Rep, 16, 851, 10.15252/embr.201439882 Manitt, 2013, DCC orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients, Transl Psychiatry, 3, e338, 10.1038/tp.2013.105 Ward, 2017, Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia, Transl Pschiatry, 7, 1264, 10.1038/s41398-017-0012-7 Reus, 2017, Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank, Sci Rep, 7, 42140, 10.1038/srep42140 Shen, 2017, Subcortical volume and white matter integrity abnormalities in major depressive disorder: Findings from UK Biobank imaging data, Sci Rep, 7, 5547, 10.1038/s41598-017-05507-6 Klimes-Dougan, 2010, Altered white matter microstructure in adolescents with major depression: A preliminary study, J Am Acad Child Adolesc Psychiatry, 49, 173 Korgaonkar, 2011, Loss of white matter integrity in major depressive disorder: Evidence using tract-based spatial statistical analysis of diffusion tensor imaging, Hum Brain Mapp, 32, 2161, 10.1002/hbm.21178 Wray, 2018, Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression, Nat Genet, 50, 635, 10.1038/s41588-018-0113-0 Yang, 2015, Genomic variant annotation and prioritization with ANNOVAR and wANNOVAR, Nat Protoc, 10, 1556, 10.1038/nprot.2015.105 Hagenaars, 2016, Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N= 112 151) and 24 GWAS consortia, Mol Psychiatry, 21, 1624, 10.1038/mp.2015.225 Bycroft, 2018, The UK Biobank resource with deep phenotyping and genomic data, Nature, 562, 203, 10.1038/s41586-018-0579-z Euesden, 2014, PRSice: Polygenic risk score software, Bioinformatics, 31, 1466, 10.1093/bioinformatics/btu848 Purcell, 2009, Common polygenic variation contributes to risk of schizophrenia and bipolar disorder, Nature, 460, 748, 10.1038/nature08185 Whalley, 2016, Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts, Transl Psychiatry, 6, e938, 10.1038/tp.2016.207 Alfaro-Almagro, 2018, Image processing and quality control for the first 10,000 brain imaging datasets from UK Biobank, Neuroimage, 166, 400, 10.1016/j.neuroimage.2017.10.034 Cox, 2016, Ageing and brain white matter structure in 3,513 UK Biobank participants, Nat Commun, 7, 13629, 10.1038/ncomms13629 Cabrera, 2012, Uncovering networks from genome-wide association studies via circular genomic permutation, G3 (Bethesda, Md.), 2, 1067, 10.1534/g3.112.002618 Wu, 2011, Whiter matter abnormalities in medication-naive subjects with a single short-duration episode of major depressive disorder, Psychiatry Res, 191, 80, 10.1016/j.pscychresns.2010.09.002 Cole, 2012, White matter abnormalities and illness severity in major depressive disorder, Br J Psychiatry, 201, 33, 10.1192/bjp.bp.111.100594 Bonnin, 2007, Serotonin modulates the response of embryonic thalamocortical axons to netrin-1, Nat Neurosci, 10, 588, 10.1038/nn1896 Whalley, 2013, Polygenic risk and white matter integrity in individuals at high risk of mood disorder, Biol Psychiatry, 74, 280, 10.1016/j.biopsych.2013.01.027 Ritchey, 2011, Neural correlates of emotional processing in depression: Changes with cognitive behavioural therapy and predictors of treatment response, J Psychiatr Res, 45, 577, 10.1016/j.jpsychires.2010.09.007 Braisted, 2000, Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection, J Neurosci, 20, 5792, 10.1523/JNEUROSCI.20-15-05792.2000 Clascá, 2016, Anatomy and development of multispecific thalamocortical axons: Implications for cortical dynamics and evolution, 69 Day, 2016, A robust example of collider bias in a genetic association study, Am J Hum Genet, 98, 392, 10.1016/j.ajhg.2015.12.019