Association between the MTHFR A1298C polymorphism and risk of cancer: evidence from 265 case–control studies

Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088–1101

Blount BC, Mack MM, Wehr CM, MacGregor JT, Hiatt RA, Wang G, Wickramasinghe SN, Everson RB, Ames BN (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage; implications for cancer and neuronal damage. Proc Natl Acad Sci USA 94:3290–3295

Castro R, Rivera I, Ravasco P, Jakobs C, Blom HJ, Camilo ME, de Almeida IT (2003) 5,10-Methylenetetrahydrofolate reductase 677C > T and 1298A > C mutations are genetic determinants of elevated homocysteine. QJM 96:297–303

Choi S, Mason J (2000) Folate and carcinogenesis: an integrated scheme. J Nutr 130:129–132

Davey SG, Egger M (1997) Meta-analyses of randomized controlled trials. Lancet 350:1182

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188

Dong S, Liu Y, Chen J (2014) MTHFR gene polymorphism and risk of myeloid leukemia: a meta-analysis. Tumour Biol 35:8913–8919

Duthie S (1999) Folic acid deficiency and cancer: mechanisms of DNA instability. Br Med Bull 55:578–592

Egger M, Smith DG, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. Br Med J 315:629–634

Försti A, Angelini S, Festa F, Sanyal S, Zhang Z, Grzybowska E, Pamula J, Pekala W, Zientek H, Hemminki K, Kumar R (2004) Single nucleotide polymorphisms in breast cancer. Oncol Rep 11:917–922

Franco RF, Morelli V, Lourenço D, Maffei FH, Tavella MH, Piccinato CE, Thomazini IA, Zago MA (1999) A second mutation in the methylenetetrahydrofolate reductase gene and the risk of venous thrombotic disease. Br J Haematol 105:556–559

Friedman G, Goldschmidt N, Friedlander Y et al (1999) A common mutation A1298C in human methylenetethrahydrofolate reductase gene; association with plasma total homocysteine and folate concentrations. J Nutr 129:1656–1661

Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP et al (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10:111–113

Goyette P, Pai A, Milos R, Frosst P, Tran P, Chen Z, Chan M, Rozen R (1998) Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR). Mamm Genome 9:652–656

Higgins JPT, Green S (2008) Cochrane handbook for systematic reviews of interventions version 5.0.1. The Cochrane Collaboration, Oxford

Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analysis. Br Med J 327:557–560

Hirschhorn JN, Lohmueller K, Byrne E (2002) A comprehensive review of genetic association studies. Genet Med 4:45–61

Kim YI (1999) Folate and carcinogenesis. Evidence, mechanisms and implications. J Nutr Biochem 10:66–88

Klug SJ, Ressing M, Koenig J, Abba MC, Agorastos T, Brenna SM, Ciotti M, Das BR, Del Mistro A, Dybikowska A, Giuliano AR, Gudleviciene Z, Gyllensten U, Haws AL, Helland A, Herrington CS, Hildesheim A, Humbey O, Jee SH, Kim JW, Madeleine MM, Menczer J, Ngan HY, Nishikawa A, Niwa Y, Pegoraro R, Pillai MR, Ranzani G, Rezza G, Rosenthal AN, Roychoudhury S, Saranath D, Schmitt VM, Sengupta S, Settheetham-Ishida W, Shirasawa H, Snijders PJ, Stoler MH, Suárez-Rincón AE, Szarka K, Tachezy R, Ueda M, van der Zee AG, von Knebel Doeberitz M, Wu MT, Yamashita T, Zehbe I, Blettner M (2009) TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies. Lancet Oncol 10:772–784

Little J, Bradley L, Bray MS, Clyne M, Dorman J, Ellsworth DL, Hanson J, Khoury M, Lau J, O’Brien TR, Rothman N, Stroup D, Taioli E, Thomas D, Vainio H, Wacholder S, Weinberg C (2002) Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations. Am J Epidemiol 156:300–310

Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. Natl Cancer Inst 22:719–748

Matsuo K, Suzuki R, Hamajima N et al (2001) Association between polymorphisms of folate and methioninemetabolizing enzymes and susceptibility to malignant lymphoma. Blood 97:3205–3209

Parle-McDermott A, Mills JL, Mollay AM et al (2006) The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels. Mol Genet Metab 88:290–294

Potter JD, Slattery ML, Bostick RM, Gapstur SM (1993) Colon cancer: a review of epidemiology. Epidemiol Rev 15:499–545

Rai V (2014) Methylenetetrahydrofolate reductase A1298C polymorphism and breast cancer risk: a meta-analysis of 33 studies. Ann Med Health Sci Res 4:841–851

Steinmetz KA, Potter JD (1996) Vegetables, fruit and cancer prevention: a review. J Am Diet Assoc 96:1027–1039

Stover PJ (2004) Physiology of folate and vitamin B12 in health and disease. Nutr Rev 62:S3–S12

van der Put NM, Gabreëls F, Stevens EM, Smeitink JA, Trijbels FJ, Eskes TK, van den Heuvel LP, Blom HJ (1998) A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet 62:1044–1051

Wang X, Yue K, Hao L (2015) Meta-analysis of methylenetetrahydrofolate reductase polymorphism and lung cancer risk in Chinese. Int J Clin Exp Med 8:1521–1525

Wei Q, Shen H, Wang LE, Duphorne CM, Pillow PC, Guo Z, Qiao Y, Spitz MR (2003) Association between low dietary folate intake and suboptimal cellular DNA repair capacity. Cancer Epidemiol Biomark Prev 12:963–969

Weisberg I, Tran P, Christensen B, Sibani S, Rozen R (1998) A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64:169–172

Xia LZ, Liu Y, Xu XZ, Jiang PC, Ma G, Bu XF, Zhang YJ, Yu F, Xu KS, Li H (2014) Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer susceptibility. World J Gastroenterol 20:11429–11438