Association between serum cell adhesion molecules with hs-CRP, uric acid and VEGF genetic polymorphisms in subjects with metabolic syndrome

Hamideh Ghazizadeh1, Majid Rezaei2, Amir Avan1, Mohammad Fazilati3, Alireza Pasdar4,5, Shima Tavallaie2, Elham Kazemi6, Seyed Mohammad Seyedi7, Gordon A. Ferns8, Mohsen Azimi‐Nezhad9,10
1Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
2Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, 99199-91766, Iran.
3Department of Biochemistry, Payame Noor University, Tehran, Iran
4Division of Applied Medicine, Medical School, University of Aberdeen, Aberdeen, UK
5Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
6Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
7Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
8Division of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, Sussex BN1 9PH, UK
9UMR INSERM U 1122, IGE-PCV “Interactions Gène-Environnement en Physiopathologie CardioVasculaire”, Université de Lorraine, Nancy, France
10Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Tóm tắt

Từ khóa


Tài liệu tham khảo

Eckel RH, Grundy SM, Zimmet PZ (2005) The metabolic syndrome. Lancet 365:1415–1428

Ford ES, Li C, Zhao G (2010) Prevalence and correlates of metabolic syndrome based on a harmonious definition among adults in the US. J Diabetes 2(3):180–193

Maki KC, Bays HE, Dicklin MR (2012) Treatment options for the management of hypertriglyceridemia: strategies based on the best-available evidence. J Clin Lipidol 6(5):413–426

Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA et al (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National heart, lung, and blood institute scientific statement. Circulation 112(17):2735–2752

Isomaa B, Almgren P, Tuomi T, Forsén B, Lahti K, Nissen M et al (2001) Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24(4):683–689

Zimmet P, Boyko E, Collier G, de Courten M (1999) Etiology of the metabolic syndrome: potential role of insulin resistance, leptin resistance, and other players. Ann N Y Acad Sci 892(1):25–44

Koh KK, Han SH, Quon MJ (2005) Inflammatory markers and the metabolic syndrome: insights from therapeutic interventions. J Am Coll Cardiol 46(11):1978–1985

Hsu L-A, Ko Y-L, Wu S, Teng M-S, Chou H-H, Chang C-J et al (2009) Association of soluble intercellular adhesion molecule-1 with insulin resistance and metabolic syndrome in Taiwanese. Metabolism 58(7):983–988

Yaykasli KO, Hatipoglu OF, Yaykasli E, Yildirim K, Kaya E, Ozsahin M et al (2015) Leptin induces ADAMTS-4, ADAMTS-5, and ADAMTS-9 genes expression by mitogen-activated protein kinases and NF-ĸB signaling pathways in human chondrocytes. Cell Biol Int 39(1):104–112

Barthel SR, Gavino JD, Descheny L, Dimitroff CJ (2007) Targeting selectins and selectin ligands in inflammation and cancer. Expert Opin Ther Targets 11(11):1473–1491

Kelly M, Hwang JM, Kubes P (2007) Modulating leukocyte recruitment in inflammation. J Allergy Clin Immunol 120(1):3–10

Simon SI, Green CE (2005) Molecular mechanics and dynamics of leukocyte recruitment during inflammation. Annu Rev Biomed Eng 7:151–185

Sackstein R (2005) The lymphocyte homing receptors: gatekeepers of the multistep paradigm. Curr Opin Hematol 12(6):444–450

Weber C, Fraemohs L, Dejana E (2007) The role of junctional adhesion molecules in vascular inflammation. Nat Rev Immunol 7(6):467

Fusté B, Mazzara R, Escolar G, Merino A, Ordinas A, Díaz-Ricart M (2004) Granulocyte colony-stimulating factor increases expression of adhesion receptors on endothelial cells through activation of p38 MAPK. Haematologica 89(5):578–585

Leeuwenberg J, Smeets E, Neefjes J, Shaffer M, Cinek T, Jeunhomme T et al (1992) E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro. Immunology 77(4):543

Ehrhardt C, Kneuer C, Bakowsky U (2004) Selectins—an emerging target for drug delivery. Adv Drug Deliv Rev 56(4):527–549

Krieglstein CF, Granger DN (2001) Adhesion molecules and their role in vascular disease. Am J Hypertens 14(S3):44S–54S

Miller MA, Cappuccio FP (2006) Cellular adhesion molecules and their relationship with measures of obesity and metabolic syndrome in a multiethnic population. Int J Obes 30(8):1176

Ley K (2003) The role of selectins in inflammation and disease. Trends Mol Med 9(6):263–268

Navarro JF, Mora C (2006) Diabetes, inflammation, proinflammatory cytokines, and diabetic nephropathy. Sci World J 6:908–917

Miller MA, Sagnella GA, Kerry SM, Strazzullo P, Cappuccio FP (2003) Ethnic differences in circulating soluble adhesion molecules: the Wandsworth Heart and Stroke Study. Clin Sci 104(6):591–598

Miller MA, Kerry SM, Cook DG, Cappuccio FP (2004) Cellular adhesion molecules and blood pressure: interaction with sex in a multi-ethnic population. J Hypertens 22(4):705–711

Yörük Ü, Yaykaşli K, Özhan H, Memişoğullari R, Karabacak A, Bulur S et al (2014) Association of omentin Val109Asp polymorphism with coronary artery disease. Anadolu Kardiyol Derg 14(6):511–514

Hwang S-J, Ballantyne CM, Sharrett AR, Smith LC, Davis CE, Gotto AM Jr et al (1997) Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the atherosclerosis risk in communities (ARIC) study. Circulation 96(12):4219–4225

Ponthieux A, Herbeth B, Droesch S, Haddy N, Lambert D, Visvikis S (2004) Biological determinants of serum ICAM-1, E-selectin, P-selectin and L-selectin levels in healthy subjects: the Stanislas study. Atherosclerosis 172(2):299–308

Ghazizadeh H, Fazilati M, Pasdar A, Avan A, Tayefi M, Ghasemi F et al (2017) Association of a vascular endothelial growth factor genetic variant with serum VEGF level in subjects with metabolic syndrome. Gene 598:27–31

Uslu M, Kaya E, Yaykaşlı KO, Oktay M, Inanmaz ME, Işık C et al (2015) Erythropoietin stimulates patellar tendon healing in rats. Knee 22(6):461–468

Kim I, Moon S-O, Kim SH, Kim HJ, Koh YS, Koh GY (2001) Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-κB activation in endothelial cells. J Biol Chem 276(10):7614–7620

Dąbek J, Kułach A, Gąsior Z (2010) Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB): a new potential therapeutic target in atherosclerosis? Pharmacol Rep 62(5):778–783

Hatipoglu OF, Yaykasli KO, Dogan M, Yaykasli E, Bender O, Yasar T et al (2015) NF-[kappa] B and MAPKs are involved in resistin-caused ADAMTS-5 induction in human chondrocytes. Clin Investig Med 38(4):E248

Kanellis J, Watanabe S, Li JH, Kang DH, Li P, Nakagawa T et al (2003) Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension 41(6):1287–1293

Kang D-H, Park S-K, Lee I-K, Johnson RJ (2005) Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol 16(12):3553–3562

Ahmadnezhad M, Arefhosseini SR, Parizadeh MR, Tavallaie S, Tayefi M, Darroudi S et al (2018) Association between serum uric acid, high sensitive C-reactive protein and pro-oxidant-antioxidant balance in patients with metabolic syndrome. BioFactors 44(3):263–271

Mirhafez SR, Zarifian A, Ebrahimi M, Ali RFA, Avan A, Tajfard M et al (2015) Relationship between serum cytokine and growth factor concentrations and coronary artery disease. Clin Biochem 48(9):575–580

Yaykasli KO, Yaykasli E, Ataoglu S, Ozsahin M, Memisogullari R, Celebi E et al (2013) The frequency of omentin Val109Asp polymorphism and the serum level of omentin in patients with Rheumatoid Arthritis. Acta Med Mediterr 29(3):521–526

Yamak N, Yaykasli KO, Yilmaz U, Eroz R, Uzunlar AK, Ankarali H et al (2014) Association between survivin gene polymorphisms and the susceptibility to colon cancer development in the Turkish population. Asian Pac J Cancer Prev 15(20):8963–8967

Ghazizadeh H, Avan A, Fazilati M, Azimi-Nezhad M, Tayefi M, Ghasemi F et al (2018) Association of rs6921438 A<G with serum vascular endothelial growth factor concentrations in patients with metabolic syndrome. Gene 667:70–75

Mirhafez SR, Avan A, Pasdar A, Kazemi E, Ghasemi F, Tajbakhsh A et al (2015) Association of tumor necrosis factor-α promoter G-308A gene polymorphism with increased triglyceride level of subjects with metabolic syndrome. Gene 568(1):81–84

Agarwal S, Shlipak MG, Kramer H, Jain A, Herrington DM (2012) The association of chronic kidney disease and metabolic syndrome with incident cardiovascular events: multiethnic study of atherosclerosis. Cardiol Res Pract 2012:806102

Gu D, Reynolds K, Wu X, Chen J, Duan X, Reynolds RF et al (2005) Prevalence of the metabolic syndrome and overweight among adults in China. The Lancet 365(9468):1398–1405

Tanaka H, Shiohira Y, Uezu Y, Higa A, Iseki K (2006) Metabolic syndrome and chronic kidney disease in Okinawa, Japan. Kidney Int 69(2):369–374

Chen J, Gu D, Chen C-S, Wu X, Hamm LL, Muntner P et al (2007) Association between the metabolic syndrome and chronic kidney disease in Chinese adults. Nephrol Dial Transplant 22(4):1100–1106

Zomorrodian D, Khajavi-Rad A, Avan A, Ebrahimi M, Nematy M, Azarpazhooh MR et al (2015) Metabolic syndrome components as markers to prognosticate the risk of developing chronic kidney disease: evidence-based study with 6492 individuals. J Epidemiol Community Health 69(6):594–598

Khan QA, Sola S, Khan BV (2006) The metabolic syndrome: inflammation and endothelial dysfunction. Hosp Phys 26:37

Mirhafez SR, Pasdar A, Avan A, Esmaily H, Moezzi A, Mohebati M et al (2015) Cytokine and growth factor profiling in patients with the metabolic syndrome. Br J Nutr 113(12):1911–1919

Debette S, Visvikis-Siest S, Chen M-H, Ndiaye N-C, Song C, Destefano A et al (2011) Identification of cis-and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels. Circ Res 109(5):554–563

Girman CJ, Rhodes T, Mercuri M, Pyörälä K, Kjekshus J, Pedersen TR et al (2004) The metabolic syndrome and risk of major coronary events in the Scandinavian Simvastatin survival study (4S) and the air force/texas coronary atherosclerosis prevention study (AFCAPS/TexCAPS). Am J Cardiol 93(2):136–141

Sutherland JP, McKinley B, Eckel RH (2004) The metabolic syndrome and inflammation. Metab Syndr Relat Disord 2(2):82–104

Zavaroni I, Mazza S, Fantuzzi M, Dall’Aglio E, Bonora E, Delsignore R et al (1993) Changes in insulin and lipid metabolism in males with asymptomatic hyperuricaemia. J Intern Med 234(1):25–30

Miller M, Cappuccio F (2006) Cellular adhesion molecules and their relationship with measures of obesity and metabolic syndrome in a multiethnic population. Int J Obes 30(8):1176

Wildman RP, Kaplan R, Manson JE, Rajkovic A, Connelly SA, Mackey RH et al (2011) Body size phenotypes and inflammation in the women’s health initiative observational study. Obesity 19(7):1482–1491

Kent JW, Comuzzie AG, Mahaney MC, Almasy L, Rainwater DL, VandeBerg JL et al (2004) Intercellular adhesion molecule-1 concentration is genetically correlated with insulin resistance, obesity, and HDL concentration in Mexican Americans. Diabetes 53(10):2691–2695

Szmitko PE, Wang C-H, Weisel RD, de Almeida JR, Anderson TJ, Verma S (2003) New markers of inflammation and endothelial cell activation: part I. Circulation 108(16):1917–1923

Corella D, Ortega-Azorín C, Sorlí JV, Covas MI, Carrasco P, Salas-Salvadó J et al (2012) Statistical and biological gene-lifestyle interactions of MC4R and FTO with diet and physical activity on obesity: new effects on alcohol consumption. PLoS ONE 7(12):e52344