Assessment of possible protective roles of selenium, zinc, and cis‐Stilbene oxide against acute T‐2 toxin poisoning: A preliminary report

Wiley - Tập 5 Số 4 - Trang 133-135 - 1997
Hassan Yazdanpanah1, F. Roshanzamir2, Bijan Shafaghi1, Mehrdad Faizi1, Mehrdad Elhami1, Ali Rajabzadeh Ghatari1
1Department of Pharmacology and Toxicology, School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Iran
2Department of Pharmacology, Faculty of Medicine, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Iran

Tóm tắt

AbstractThe efficacy of two free radical scavengers, selenium and zinc, and a microsomal epoxide hydrolase–inducing agent, cis‐stilbene oxide on the acute toxicity of T‐2 toxin, a potent cytotoxic trichothecene, was investigated. Mice were pretreated daily for 3 consecutive days with either zinc sulfate (4.4 mg/kg, intraperitoneally [i.p.]), sodium selenite (1, 2, and 3 mg/kg i.p.) or cis‐stilbene oxide (50 mg/kg i.p.). A full 24‐hr after the final dosing with these agents, mice were given T‐2 toxin (2, 2.5, or 3 mg/kg i.p.). The acute lethal toxicity of T‐2 toxin (2.5 mg/kg) was reduced by administration of only sodium selenite (3 mg/kg) and cis‐stilbene oxide (50 mg/kg). No significant effect on weight gain was observed. Nat. Toxins 5:133–135, 1997. © 1997 Wiley‐Liss, Inc.

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