Aspects of the molecular pharmacology of GABAB receptors

Hill, 1981, 3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain, Nature, 290, 149, 10.1038/290149a0 Curtis, 1974, Central effects of β-(p-chlorophenyl)-γ-aminobutyric acid, Brain Res, 70, 493, 10.1016/0006-8993(74)90257-1 Bowery, 1981, Bicuculline-insensitive GABA receptors on peripheral autonomic nerve terminals, Eur J Pharmacol, 71, 53, 10.1016/0014-2999(81)90386-1 Newberry, 1984, Direct hyperpolarizing action of baclofen on hippocampal pyramidal cells, Nature, 308, 450, 10.1038/308450a0 Dutar, 1988, A physiological role for GABAB receptors in the central nervous system, Nature, 332, 156, 10.1038/332156a0 Davies, 1990, Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus, J Physiol, 424, 513, 10.1113/jphysiol.1990.sp018080 Gustaffson, 1990, Basic features of long-term potentiation in the hippocampus, Semin Neurosci, 2, 321 Bowery, 1980, Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor, Nature, 283, 92, 10.1038/283092a0 Maguire, 1990, (−)Baclofen inhibits the K+ -evoked release of endogenous aspartate glutamate and GABA from, rat hippocampal synaptosomes, 1990 Del Rio, 1984, GABA inhibits the potassium-induced release of substance P from slices of rat spinal cord Price, 1987, The location of GABAB receptor binding sites in mammalian spinal cord, Synapse, 1, 530, 10.1002/syn.890010605 Barber, 1978, GABAergic terminals are presynaptic to primary afferent terminals in the substantia gelatinosa of the rat spinal cord, Brain Res, 141, 35, 10.1016/0006-8993(78)90615-7 Fox, 1978, Action of baclofen on mammalian synaptic transmission, Neuroscience, 3, 495, 10.1016/0306-4522(78)90016-7 Pittaluga, 1987, Studies on 3H GABA and endogenous GABA release in rat cerebral cortex suggest the presence of autoreceptors of the GABAB type, Eur J Pharmacol, 144, 45, 10.1016/0014-2999(87)90007-0 Minchin MCW, White R (1989) European Patent no. 345068 Swartzwelder, 1987, Seizure-like events in brain slices: suppression by interictal activity, Brain Res, 410, 362, 10.1016/0006-8993(87)90339-8 Feltz, 1987, Intracellular effectors and modulators of GABAA and GABAB receptors: a commentary, Biochimie, 69, 395, 10.1016/0300-9084(87)90031-9 Bowery, 1986, GABAB receptor activation inhibits the increase in nerve terminal Ca2+ induced by depolarization, Br J Pharmacol, 87, 37P Stirling, 1989, The effect of GABAB receptor agonists and antagonists on potassium-stimulated [Ca2+]i in rat brain synaptosomes, Neuropharmacology, 28, 699, 10.1016/0028-3908(89)90153-6 Bowery, 1989, GABA receptor characterization and localization in mammalian brain, 24 Harrison, 1990, Presynaptic GABAB receptors on rat hippocampal neurons, 207 Karlsson, 1988, Phaclofen: a GABAB blocker reduces long-duration inhibition in the neocortex, Eur J Pharmacol, 148, 485, 10.1016/0014-2999(88)90136-7 Soltesz, 1988, The GABAB antagonist phaclofen inhibits the late K+-dependent i.p.s.p. in cat and rat thalamic and hippocampal neurones, Brain Res, 448, 351, 10.1016/0006-8993(88)91275-9 Thalmann, 1988, Evidence that guanosine triphosphate (GTP)-binding proteins control a synaptic response in brain: Effect of pertussis toxin and GTPγS on the late inhibitory postsynaptic potential of hippocampal CA3 neurons, J Neurosci, 8, 4589, 10.1523/JNEUROSCI.08-12-04589.1988 Asano, 1985, Prevention of the agonist binding to γ-aminobutyric acid B receptors by guanine nucleotides and islet-activating protein, pertussis toxin, in bovine cerebral cortex, J Biol Chem, 260, 12653, 10.1016/S0021-9258(17)38921-4 Xu, 1986, Gamma aminobutyric acid B receptor-mediated inhibition of adenylate cyclase in cultured cerebellar granule cells: blockade by islet-activating protein, J Pharmac Exp Ther, 239, 568 Bowery, 1989, Neurochemistry and autoradiography of GABAB receptors in mammalian brain: second messenger system(s), 159 Hill, 1985, GABAB receptor modulation of adenylate cyclase activity in rat brain slices, Br J Pharmacol, 84, 249 Wojcik, 1989, Islet-activating protein inhibits the β-adrenergic receptor facilitation elicited by γ-aminobutyric acidB receptors, J Neurochem, 53, 753, 10.1111/j.1471-4159.1989.tb11769.x Bowery, 1987, GABAA and GABAB receptor site distribution in the rat central nervous system, Neuroscience, 20, 365, 10.1016/0306-4522(87)90098-4 Lloyd, 1985, Upregulation of γ-aminobutyric acid (GABAB) binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock, J Pharmac Exp Ther, 235, 191 Cross, 1988, Effects of chronic oral administration of the antidepressants desmethylimipramine and zimelidine on rat cortical GABAB binding sites: a comparison with 5HT2 binding site changes, Br J Pharmacol, 93, 331, 10.1111/j.1476-5381.1988.tb11438.x Pratt, 1990, Autoradiographic analysis of GABAB receptors in rat frontal cortex following chronic antidepressant administration, 319 Chu, 1990, Distribution and kinetics of GABAB binding sites in rat central nervous system: a quantitative autoradiographic study, Neuroscience, 34, 341, 10.1016/0306-4522(90)90144-S Bagetta, 1990, Tetanus toxin produces neuronal loss and a reduction in GABAA but not GABAB binding sites in rat hippocampus, Neurosci Lett, 109, 7, 10.1016/0304-3940(90)90529-I Bagetta, 1991, Hippocampal damage produced by tetanus toxin in rats can be prevented by lesioning CA1 pyramidal cell excitatory afferents, Neurosci Lett, 123, 32, 10.1016/0304-3940(91)90151-I Bagetta, 1990, Prevention by the NMDA receptor antagonist MK801 of neuronal loss produced by tetanus toxin in the rat hippocampus, Br J Pharmacol, 101, 776, 10.1111/j.1476-5381.1990.tb14156.x Bagetta, 1991, CGP 37849, a competitive NMDA receptor antagonist, prevents the behavioural and neurodegenerative effects of tetanus toxin in rat hippocampus, Mol Neuropharmacol Penn, 1989, Intrathecal baclofen for severe spinal spasticity, N Engl J Med, 320, 1517, 10.1056/NEJM198906083202303 Chapman, 1991, GABAergic mechanisms in the pulmonary system Bittiger, 1990, Biochemistry, electrophysiology and pharmacology of a new GABAB antagonist: CGP 35348, 47 Andrade, 1986, A G-protein couples serotonin and GABAB receptors to the same channels in hippocampus, Science, 234, 1261, 10.1126/science.2430334 Dutar, 1988, Pre- and post-synaptic GABAB receptors in the hippocampus have different pharmacological properties, Neuron, 1, 585, 10.1016/0896-6273(88)90108-0 Dolphin, 1990, GABAB-mediated inhibition of calcium currents: a possible role in presynaptic inhibition, 259 Ong, 1990, 3-aminopropanephosphinic acid is a potent agonist at peripheral and central presynaptic GABAB receptors, Brain Res, 526, 138, 10.1016/0006-8993(90)90260-I Ohmori, 1990, Solubilization and partial purification of GABAB receptor from bovine brain, Biochem Biophys Res Commun, 172, 22, 10.1016/S0006-291X(05)80167-6 Schofield, 1987, Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super family, Nature, 328, 221, 10.1038/328221a0 Sekiguchi, 1990, GABAB receptors expressed in Xenopus oocytes by guineapig cerebral mRNA are functionally coupled with Ca++- dependent Cl− channels and with K+ channels, through GTP-binding proteins, Mol Brain Res, 8, 301, 10.1016/0169-328X(90)90043-D Bonanno, 1989, GABAB autoreceptors in rat cortex synaptosomes: response under different depolarising and ionic conditions, Eur J Pharmacol, 172, 41, 10.1016/0922-4106(89)90043-6 Taniyama, 1990, Expression of the GABAB receptor in Xenopus oocytes and inhibition of the response by activation of protein kinase C, FEBS, 222