Application of gellan gum in pharmacy and medicine
Tóm tắt
Từ khóa
Tài liệu tham khảo
Agnihotri, 2006, Controlled release of cephalexin through gellan gum beads: effect of formulation parameters on entrapment efficiency, size, and drug release, European Journal of Pharmaceutics and Biopharmaceutics, 63, 249, 10.1016/j.ejpb.2005.12.008
Ahuja, 2013, Evaluation of carboxymethyl gellan gum as a mucoadhesive polymer, International Journal of Biological Macromolecules, 53, 114, 10.1016/j.ijbiomac.2012.10.033
Ahuja, 2010, Application of response surface methodology to formulation of ionotropically gelled gum cordia/gellan beads, Carbohydrate Polymers, 80, 161, 10.1016/j.carbpol.2009.11.005
Alhaique, 1996, Gellan in sustained release formulations: preparation of gel capsules and release studies, Biomaterials, 17, 1981, 10.1016/0142-9612(96)00017-8
Alupei, 2006, Composite membranes based on gellan and, poly(N-vinylimidazole). Synthesis and characterization, European Polymer Journal, 42, 908, 10.1016/j.eurpolymj.2005.09.033
Asghar, 2009, Colon specific delivery of indomethacin: effect of incorporating pH sensitive polymers in xanthan gum matrix bases, AAPS PharmSciTech, 10, 418, 10.1208/s12249-009-9223-4
Assifaoui, 2013, Silica-coated calcium pectinate beads for colonic drug delivery, Acta Biomaterialia, 6, 6218, 10.1016/j.actbio.2012.11.031
Babu, 2010, Formulation of controlled release gellan gum macro beads of amoxicillin, Current Drug Delivery, 7, 36, 10.2174/156720110790396445
Bajaj, 2007, Gellan gum: fermentative production, downstream processing and applications, Food Technology and Biotechnology, 45, 341
Balasubramaniam, 2003, In vitro and in vivo evaluation of the Gelrite® gellan gum-based ocular delivery system for indomethacin, Acta Pharmaceutica, 53, 251
Banerjee, 2011, Compressive textural attributes, opacity and syneresis of gels prepared from gellan, agar and their mixtures, Journal of Food Engineering, 102, 287, 10.1016/j.jfoodeng.2010.08.025
Barbani, 2012, Hydroxyapatite/gelatin/gellan sponges as nanocomposite scaffolds for bone reconstruction, Journal of Materials Science: Materials in Medicine, 23, 51
Bayarri, 2002, Influence of low sucrose concentrations on the compression resistance of gellan gum gels, Food Hydrocolloids, 16, 593, 10.1016/S0268-005X(02)00021-8
Bayarri, 2001, Diffusion of sucrose and aspartame in kappa-carrageenan and gellan gum gels, Food Hydrocolloids, 15, 67, 10.1016/S0268-005X(00)00052-7
Cao, 2009, In situ gel based on gellan gum as new carrier for nasal administration of mometasone furoate, International Journal of Pharmaceutics, 365, 109, 10.1016/j.ijpharm.2008.08.042
Cao, 2007, Preparation of ion-activated in situ gel systems of scopolamine hydrobromide and evaluation of its antimotion sickness efficacy, Acta Pharmacologica Sinica, 28, 584, 10.1111/j.1745-7254.2007.00540.x
Carlfors, 1998, Rheological evaluation of Gelriteö in situ gels for ophthalmic use, European Journal of Pharmaceutical Sciences, 6, 113, 10.1016/S0928-0987(97)00074-2
Cencetti, 2012, Preparation and characterization of antimicrobial wound dressings based on silver, gellan, PVA and borax, Carbohydrate Polymers, 90, 1362, 10.1016/j.carbpol.2012.07.005
Cencetti, 2011, Preparation and characterization of a new gellan gum and sulphated hyaluronic acid hydrogel designed for epidural scar prevention, Journal of Materials Science Materials in Medicine, 22, 263, 10.1007/s10856-010-4217-z
Chandrasekaran, 1992, Roles of potassium ions acetyl and l-glyceryl groups in native gellan double helix: an X-ray study, Carbohydrate Research, 224, 1, 10.1016/0008-6215(92)84088-A
Chandrasekaran, 1988, Cation interaction in gellan: an X-ray study of the potassium salt, Carbohydrate Research, 181, 23, 10.1016/0008-6215(88)84020-5
Chang, 2012, In vitro properties of gellan gum sponge as the dental filling to maintain alveolar space, Carbohydrate Polymers, 88, 684, 10.1016/j.carbpol.2012.01.017
Chang, 2010, Gellan gum films for effective guided bone regeneration, Journal of Medical and Biological Engineering, 30, 99
Colombo, 1995, Drug diffusion front movement is important in drug release control from swellable matrix tablets, Journal of Pharmaceutical Sciences, 84, 991, 10.1002/jps.2600840816
Colombo, 1985, Compressed polymeric mini-matrices for drug release control, Journal of Controlled Release, 1, 283, 10.1016/0168-3659(85)90004-5
Coutinho, 2012, Microfabricated photocrosslinkable polyelectrolyte-complex of chitosan and methacrylated gellan gum, Journal of Materials Chemistry, 22, 17262, 10.1039/c2jm31374j
Coutinho, 2010, Modified gellan gum hydrogels with tunable physical and mechanical properties, Biomaterials, 31, 7494, 10.1016/j.biomaterials.2010.06.035
Dai, 2010, Critical behavior at sol–gel transition in gellan gum aqueous solutions with KCl and CaCl2 of different concentrations, Carbohydrate Polymers, 81, 207, 10.1016/j.carbpol.2010.02.013
D‘Arrigo, 2012, Self-assembled gellan-based nanohydrogels as a tool for prednisolone delivery, Soft Matter, 8, 11557, 10.1039/c2sm26178b
Dickstein, 2001, Comparison of aqueous and gellan ophthalmic timolol with placebo on the 24-hour heart rate response in patients on treatment for glaucoma, American Journal of Ophthalmology, 132, 626, 10.1016/S0002-9394(01)01181-3
Dumitriu, 2002
El-Kamel, 2006, Environmentally responsive ophthalmic gel formulation of carteolol hydrochloride, Drug Delivery, 13, 55, 10.1080/10717540500309073
El-Kamel, 2006, Thermally reversible in situ gelling carbamazepine liquid suppository, Drug Delivery, 13, 143, 10.1080/10717540500316003
Emeje, 2010, Evaluation of the fluid uptake kinetics and drug release from gellan gum tablets containing metronidazole, International Journal of Biological Macromolecules, 47, 158, 10.1016/j.ijbiomac.2010.05.005
Evageliou, 2011, Effect of salts and sugars on the clarity of gellan gels, International Journal of Food Science and Technology, 46, 1001, 10.1111/j.1365-2621.2011.02575.x
Evageliou, 2010, Compression of gellan gels. Part II: effect of sugars, Food Hydrocolloids, 24, 392, 10.1016/j.foodhyd.2009.11.005
Ferrero, 2010, Towards elucidation of the drug release mechanism from compressed hydrophilic matrices made of cellulose ethers. II. Evaluation of a possible swelling-controlled drug release mechanism using dimensionless analysis, Journal of Controlled Release, 141, 223, 10.1016/j.jconrel.2009.09.011
Flores-Huicoche, 2013, Sol–gel transition temperatures of high acyl gellan with monovalent and divalent cations from rheological measurements, Food Hydrocolloids, 31, 299, 10.1016/j.foodhyd.2012.11.007
Francois, 1986, Microbial polysaccharides with actual potential industrial applications, Biotechnology Advances, 4, 245, 10.1016/0734-9750(86)90311-3
Franklin-Ude, 2007, Evaluation of gellan gum as a mini-matrix for sustained release of ephedrine hydrochloride granules, Journal of Pharmacology and Toxicology, 2, 646, 10.3923/jpt.2007.646.652
Funami, 2009, Molecular structures of gellan gum imaged with atomic force microscopy (AFM) in relation to the rheological behavior in aqueous systems in the presence of sodium chloride, Food Hydrocolloids, 23, 548, 10.1016/j.foodhyd.2008.02.014
García, 2011, Influence of gellan gum concentration on the dynamic viscoelasticity and transient flow of fluid gels, Biochemical Engineering Journal, 55, 73, 10.1016/j.bej.2011.02.017
Gong, 2009, An improved injectable polysaccharide hydrogel: modified gellan gum for long-term cartilage regeneration in vitro, Journal of Materials Chemistry, 19, 1968, 10.1039/b818090c
Goyal, 2011, Gellan gum blended PEI nanocomposites as gene delivery agents: evidences from in vitro and in vivo studies, European Journal of Pharmaceutics and Biopharmaceutics, 79, 3, 10.1016/j.ejpb.2011.01.009
Grasdalen, 1987, Gelation of gellan gum, Carbohydrate Polymers, 7, 371, 10.1016/0144-8617(87)90004-X
Gunning, 1993, Two topical carbonic anhydrase inhibitors sezolamide and dorzolamide in Gelrite vehicle: a multiple-dose efficacy study, Graefe's Archive for Clinical and Experimental Ophthalmology, 231, 384, 10.1007/BF00919645
Gurtler, 1995, Long-acting soluble bioadhesive ophthalmic drug insert (BODI) containing gentamicin for veterinary use: optimization and clinical investigation, Journal of Controlled Release, 33, 231, 10.1016/0168-3659(94)00096-D
Shin, 2014, Advance article. Gellan-gum microgel-reinforced cell-laden gelatin hydrogels, Journal of Materials Chemistry B, 10.1039/C3TB20984A
Hamcerencu, 2008, Synthesis and characterization of new unsaturated esters of gellan gum, Carbohydrate Polymers, 71, 92, 10.1016/j.carbpol.2007.05.021
Hîncu, 2007, Studies regarding preparation and evaluation from ophthalmic therapeutic system of in situ gel forming systems with piroxicam, Farmacia, 55, 557
Horinaka, 2004, Effect of pH on the conformation of gellan chains in aqueous systems, Biophysical Chemistry, 111, 223, 10.1016/j.bpc.2004.06.003
Huang, 2003, Effect of calcium concentration on textural properties of high and low acyl mixed gellan gels, Carbohydrate Polymers, 54, 517, 10.1016/j.carbpol.2003.08.006
Ikeda, 2004, Atomic force microscopy studies on cation-induced network formation of gellan, Food Hydrocolloids, 18, 727, 10.1016/j.foodhyd.2003.11.009
Illum, 2012, Nasal drug delivery – recent developments and future prospects, Journal of Controlled Release, 161, 254, 10.1016/j.jconrel.2012.01.024
Imeson, 2010, Food Stabilizers, Thickeners and Gelling Agents, 145
Izumi, 1996, Phase diagrams and molecular structures of sodium-salt-type gellan gum, Carbohydrate Polymers, 30, 121, 10.1016/S0144-8617(96)00063-X
Jahromi, 2011, Degradation of polysaccharide hydrogels seeded with bone marrow stromal cells, Journal of the Mechanical Behavior of Biomedical Materials, 4, 1157, 10.1016/j.jmbbm.2011.03.025
Jampen, 2000, Gellan polymer solution properties: dilute and concentrated regimes, Food Research International, 33, 579, 10.1016/S0963-9969(00)00094-6
Jansson, 2005, The influence of gellan gum on the transfer of fluorescein dextran across rat nasal epithelium in vivo, European Journal of Pharmaceutics and Biopharmaceutics, 59, 557, 10.1016/j.ejpb.2004.10.001
Jansson, 1983, Structural studies of gellan gum, an extracellular polysaccharide elaborated by Pseudomonas elodea, Carbohydrate Research, 124, 135, 10.1016/0008-6215(83)88361-X
Kajjari, 2012, Novel pH- and temperature-responsive blend hydrogel microspheres of sodium alginate and PNIPAAm-g-GG for controlled release of isoniazid, AAPS PharmSciTech, 13, 1147, 10.1208/s12249-012-9838-8
Kalam, 2008, Gelrite-based in vitro gelation ophthalmic drug delivery system of gatifloxacin, Journal of Dispersion Science and Technology, 29, 89, 10.1080/01932690701688482
Kaneko, 1979, Agar like polysaccharide produced by a pseudomonas species: taxonomical studies, Abstracts of the 79th Annual Melting of American Society for Microbiology, 25, 1
Kang, 1982, Agar-like polysaccharide produced by a Pseudomonas species: production and basic properties, Applied and Environmental Microbiology, 43, 1086, 10.1128/AEM.43.5.1086-1091.1982
Kasapis, 2006, The morphology of the gellan network in a high-sugar environment, Food Hydrocolloids, 20, 132, 10.1016/j.foodhyd.2005.03.004
Kedzierewicz, 1999, Effect of the formulation on the in vitro release of propranolol from gellan beads, International Journal of Pharmaceutics, 178, 129, 10.1016/S0378-5173(98)00351-2
Kesavan, 2010, Preparation and in vitro antibacterial evaluation of gatifloxacin mucoadhesive gellan system, DARU, 18, 237
Kubo, 2003, Oral sustained delivery of paracetamol from in situ-gelling gellan and sodium alginate formulations, International Journal of Pharmaceutics, 258, 55, 10.1016/S0378-5173(03)00163-7
Kulkarni, 2012, pH-Responsive interpenetrating network hydrogel beads of poly(acrylamide)-g-carrageenan and sodium alginate for intestinal targeted drug delivery: synthesis, in vitro and in vivo evaluation, Journal of Colloid and Interface Science, 367, 509, 10.1016/j.jcis.2011.10.025
Kulkarni, 2011, Interpenetrating polymer network microcapsules of gellan gum and egg albumin entrapped with diltiazem–resin complex for controlled release application, Carbohydrate Polymers, 83, 1001, 10.1016/j.carbpol.2010.09.017
Kumar, 2009, Effect of gelrite concentration on the release through ocular inserts of ciprofloxacin hydrochloride, Journal of Pharmaceutical Research, 2, 487
Leahy, 2001, Viscoelastic properties of the nucleus pulposus of the intervertebral disc in compression, Journal of Materials Science: Materials in Medicine, 12, 689
Lee, 2010, Preparation, characterization and biological properties of gellan gum films with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide cross-linker, Carbohydrate Polymers, 82, 920, 10.1016/j.carbpol.2010.06.019
Lee, 2012, Photocrosslinkable gellan gum film as an anti-adhesion barrier, Carbohydrate Polymers, 90, 1132, 10.1016/j.carbpol.2012.06.064
Liu, 2010, In situ gelling gelrite/alginate formulations as vehicles for ophthalmic drug delivery, AAPS PharmSciTech, 11, 610, 10.1208/s12249-010-9413-0
Mahajan, 2009, In situ gelling system based on thiolated gellan gum as new carrier for nasal administration of dimenhydrinate, International Journal of Pharmaceutics Science and Nanotechnology, 2, 544, 10.37285/ijpsn.2009.2.2.8
Mahajan, 2009, GEllan gum based microparticles of metoclopramide hydrochloride for intranasal delivery: development and evaluation, Chemical and Pharmaceutical Bulletin, 57, 388, 10.1248/cpb.57.388
Maiti, 2011, Al+3 ion cross-linked and cetalated gellan hydrogel network beads for prolonged release of glipizide, Carbohydrate Polymers, 85, 164, 10.1016/j.carbpol.2011.02.010
Mao, 1999, Effect of pH buffers on mechanical properties of gellan gels, Journal of Texture Studies, 30, 151, 10.1111/j.1745-4603.1999.tb00208.x
Mao, 1999, Texture properties of gellan gels as affected by temperature, Journal of Texture Studies, 30, 409, 10.1111/j.1745-4603.1999.tb00228.x
Mao, 2000, Texture properties of high and low acyl mixed gellan gels, Carbohydrate Polymers, 41, 331, 10.1016/S0144-8617(99)00108-3
Matricardi, 2009, Preparation and characterization of novel gellan gum hydrogels suitable for modified drug release, Molecules, 14, 3376, 10.3390/molecules14093376
Matsukawa, 2007, Gelation mechanism and network structure of mixed solution of low- and high-acyl gellan studied by dynamic viscoelasticity, CD and NMR measurements, Food Hydrocolloids, 21, 1355, 10.1016/j.foodhyd.2006.10.013
Mazen, 1999, Conformational transition of native and modified gellan, International Journal of Biological Macromolecules, 26, 109, 10.1016/S0141-8130(99)00070-7
Meseguer, 1996, Gamma scintigraphic comparison of eyedrops containing pilocarpine in healthy volunteers, Journal of Ocular Pharmacology and Therapeutics, 12, 481, 10.1089/jop.1996.12.481
Milas, 1990, On the physicochemical properties of gellan gum, Biopolymers, 30, 451, 10.1002/bip.360300322
Miyamoto, 2001, Preparation of gellan sulfate as an artificial ligand for removal of extra domain A containing fibronectin, International Journal of Biological Macromolecules, 28, 381, 10.1016/S0141-8130(01)00135-0
Miyamoto, 2002, Immobilized gellan sulfate surface for cell adhesion and multiplication: development of cell-hybrid biomaterials using self-produced fibronectin, International Journal of Biological Macromolecules, 30, 75, 10.1016/S0141-8130(02)00013-2
Miyamoto, 2010, Gellan sulfate selectively suppresses the activation of hemocoagulation factors XI and XII, Materials Science and Engineering C, 30, 364, 10.1016/j.msec.2009.11.015
Miyazaki, 1999, In situ-gelling gellan formulations as vehicles for oral drug delivery, Journal of Controlled Release, 60, 287, 10.1016/S0168-3659(99)00084-X
Miyazaki, 2001, Comparison of in situ gelling formulations for the oral delivery of cimetidine, International Journal of Pharmaceutics, 220, 161, 10.1016/S0378-5173(01)00669-X
Miyoshi, 1995, Effects of salts on the gel-sol transition of gellan gum by differential scanning calorimetry and thermal scanning rheology, Thermochimica Acta, 267, 269, 10.1016/0040-6031(95)02485-9
Miyoshi, 1996, Rheological and thermal studies of gelsol transition in gellan gum aqueous solutions, Carbohydrate Polymers, 30, 109, 10.1016/S0144-8617(96)00093-8
Morris, 1996, Conformational and rheological transitions of welan, rhamsan and acylated gellan, Carbohydrate Polymers, 30, 165, 10.1016/S0144-8617(96)00059-8
Morris, 2012, Gelation of gellan – a review, Food Hydrocolloids, 28, 373, 10.1016/j.foodhyd.2012.01.004
Mundargi, 2007, Evaluation and controlled release characteristics of modified xanthan films for transdermal delivery of atenolol, Drug Development and Industrial Pharmacy, 33, 79, 10.1080/03639040600975030
Mundargi, 2007, Evaluation of acrylamide-grafted-xanthan gum copolymer matrix tablets for oral controlled delivery of antihypertensive drugs, Carbohydrate Polymers, 69, 130, 10.1016/j.carbpol.2006.09.007
Mundargi, 2010, Novel thermo-responsive semi-interpenetrating network microspheres of gellan gum-poly(N-isopropylacrylamide) for controlled release of atenolol, Journal of Applied Polymer Science, 116, 1832, 10.1002/app.31551
Nakamura, 1996, In vitro and in vivo nasal mucoadhesion of some water-soluble polymers, International Journal of Pharmaceutics, 134, 173, 10.1016/0378-5173(95)04416-7
Nakamura, 1996, Dynamic mechanical properties of aqueous gellan solutions in the sol–gel transition region, Carbohydrate Polymers, 30, 101, 10.1016/S0144-8617(96)00081-1
Nampoothiri, 2003, Fermentative production of gellan using Sphingomonas paucimobilis, Process Biochemistry, 38, 1513, 10.1016/S0032-9592(02)00321-7
Narkar, 2010, Stomach-specific controlled release gellan beads of acid-soluble drug prepared by ionotropic gelation method, AAPS PharmSciTech, 11, 267, 10.1208/s12249-010-9384-1
Norton, 2011, Acid gelation of low acyl gellan gum relevant to self-structuring in the human stomach, Food Hydrocolloids, 25, 1105, 10.1016/j.foodhyd.2010.10.007
Ogawa, 2002, Conformational transition of gellan gum of sodium, lithium, and potassium types in aqueous solutions, Food Hydrocolloids, 16, 1, 10.1016/S0268-005X(01)00024-8
Ohtsuka, 1996, The network structure of gellan gum hydrogels based on the structural parameters by the analysis of the restricted diffusion of water, Carbohydrate Polymers, 30, 135, 10.1016/S0144-8617(96)00104-X
Oliveira, 2009, Performance of new gellan gum hydrogels combined with human articular chondrocytes for cartilage regeneration when subcutaneously implanted in nude mice, Journal of Tissue Engineering and Regenerative Medicine, 3, 493, 10.1002/term.184
Oliveira, 2010, Gellan gum: a new biomaterial for cartilage tissue engineering applications, Journal of Biomedical Materials Research Part A, 93, 852, 10.1002/jbm.a.32574
Oliveira, 2010, Gellan gum injectable hydrogels for cartilage tissue engineering applications: in vitro studies and preliminary in vivo evaluation, Tissue Engineering A, 16, 343, 10.1089/ten.tea.2009.0117
Oliveira, 2010, Injectable gellan gum hydrogels with autologous cells for the treatment of rabbit articular cartilage defects, Journal of Orthopaedic Research, 28, 1193, 10.1002/jor.21114
Patil, 2012, A review on ionotropic gelation method: novel approach for controlled gastroretentive gelispheres, International Journal of Pharmacy and Pharmaceutical Sciences, 4, 27
Pereira, 2011, Development of gellan gum-based microparticles/hydrogel matrices for application in the intervertebral disc regeneration, Tissue Engineering Part C, 17, 961, 10.1089/ten.tec.2011.0115
Pérez-Campos, 2012, Gelation and microstructure of dilute gellan solutions with calcium ions, Food Hydrocolloids, 28, 291, 10.1016/j.foodhyd.2012.01.008
Picone, 2011, Influence of pH on formation and properties of gellan gels, Carbohydrate Polymers, 84, 662, 10.1016/j.carbpol.2010.12.045
Prajapati, 2013, An insight into the emerging exopolysaccharide gellan gum as a novel polymer, Carbohydrate Polymers, 93, 670, 10.1016/j.carbpol.2013.01.030
Quigley, 1992, Use of deacetylated gellan gum (Gelrite) for the production of sulphamethizole containing beads, Journal of Microencapsulation, 9, 1, 10.3109/02652049209021217
Quinn, 1993, The conformational properties of gellan gum hydrogels, Polymer Gels and Networks, 1, 93, 10.1016/0966-7822(93)90014-9
Rajinikanth, 2007, Development and evaluation of a novel floating in situ gelling system of amoxicillin for eradication of Helicobacter pylori, International Journal of Pharmaceutics, 335, 114, 10.1016/j.ijpharm.2006.11.008
Rasul, 2010, Design, development and in vitro evaluation of metoprolol tartrate tablets containing xanthan-tragacanth, Acta Poloniae Pharmaceutica, 67, 517
Rathbone, 2003
Rehm, 2010, Bacterial polymers: biosynthesis, modifications and applications, Nature Reviews Microbiology, 8, 578, 10.1038/nrmicro2354
Remuñán-López, 1998, Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery, Journal of Controlled Release, 55, 143, 10.1016/S0168-3659(98)00044-3
Rozier, 1989, Gelrite®: a novel, ion-activated, in-situ gelling polymer for ophthalmic vehicles. Effect on bioavailability of timolol, International Journal of Pharmaceutics, 57, 163, 10.1016/0378-5173(89)90305-0
Rozier, 1997, Functionality testing of gellan gum, a polymeric excipient material for ophthalmic dosage forms, International Journal of Pharmaceutics, 153, 191, 10.1016/S0378-5173(97)00109-9
Rupenthal, 2011, Comparison of ion-activated in situ gelling systems for ocular drug delivery. Part 1: physicochemical characterisation and in vitro release, International Journal of Pharmaceutics, 411, 69, 10.1016/j.ijpharm.2011.03.042
Rupenthal, 2011, Comparison of ion-activated in situ gelling systems for ocular drug delivery. Part 2: precorneal retention and in vivo pharmacodynamic study, International Journal of Pharmaceutics, 411, 78, 10.1016/j.ijpharm.2011.03.043
Santos, 2004, Compaction compression and drug release characteristics of xanthan gum pellets of different compositions, European Journal of Pharmaceutical Sciences, 21, 271, 10.1016/j.ejps.2003.10.016
Santucci, 1996, Gellan for the formulation of sustained delivery beads, Journal of Controlled Release, 42, 157, 10.1016/0168-3659(96)01373-9
Sanzgiri, 1993, Gellan-based systems for ophthalmic sustained delivery of methylprednisolone, Journal of Controlled Release, 26, 195, 10.1016/0168-3659(93)90186-9
Sezer, 1995, Controlled release of piroxicam from chitosan beads, International Journal of Pharmaceutics, 121, 113, 10.1016/0378-5173(94)00413-Y
Shah, 2010, Formulation of sildenafil citrate loaded nasal microsphers: an in vitro, ex vivo characterization, International Journal of Drug Delivery, 2, 213, 10.5138/ijdd.2010.0975.0215.02031
Shalviri, 2010, Novel modified starch–xanthan gum hydrogels for controlled drug delivery: synthesis and characterization, Carbohydrate Polymers, 79, 898, 10.1016/j.carbpol.2009.10.016
Shedden, 2001, Plasma timolol concentrations of timolol maleate: timolol gel-forming solution (TIMOPTIC-XE) once daily versus timolol maleate ophthalmic solution twice daily, Documenta Ophthalmologica, 103, 73, 10.1023/A:1017962731813
Shimazaki, 1995, Influence of Ca2+-ion upon viscoelastic properties of gellan gum aqueous solutions, Polymer Gels and Networks, 3, 295, 10.1016/0966-7822(95)00004-5
Shimizu, 2012, Diffusion of probe polymer in gellan gum solutions during gelation process studied by gradient NMR, Food Hydrocolloids, 26, 28, 10.1016/j.foodhyd.2011.04.001
Shin, 2012, The mechanical properties and cytotoxicity of cell-laden double-network hydrogels based on photocrosslinkable gelatin and gellan gum biomacromolecules, Biomaterials, 33, 3143, 10.1016/j.biomaterials.2011.12.050
Shiraishi, 1993, Controlled release of indomethacin by chitosan-polyelectrolyte complex: optimization and in vivo/in vitro evaluation, Journal of Controlled Release, 25, 217, 10.1016/0168-3659(93)90080-O
Shiyani, 2009, Development and evaluation of novel immediate release tablets of metoclopramide HCl by direct compression using treated gellan gum as a disintegration-accelerating agent, Journal of Pharmaceutical Research, 2, 1460
Silva-Correia, 2012, Angiogenic potential of gellan gum-based hydrogels for application in nucleus pulposus regeneration: in vivo study, Tissue Engineering Part A, 18, 1203, 10.1089/ten.tea.2011.0632
Silva-Correia, 2011, Gellan gum-based hydrogels for intervertebral disc tissue-engineering applications, Journal of Tissue Engineering and Regenerative Medicine, 5, e97, 10.1002/term.363
Singh, 2009, l-Carnosine multifunctional dipeptide buffer for sustained-duration topical ophthalmic formulations, Journal of Pharmacy and Pharmacology, 61, 733, 10.1211/jpp.61.06.0005
Smith, 2007, An initial evaluation of gellan gum as a material for tissue engineering applications, Journal of Biomaterials Applications, 22, 241, 10.1177/0885328207076522
Smrdel, 2008, The influence of selected parameters on the size and shape of alginate beads prepared by ionotropic gelation, Scientia Pharmaceutica, 76, 77, 10.3797/scipharm.0611-07
Smrdel, 2008, Shape optimization and characterization of polysaccharide beads prepared by ionotropic gelation, Journal of Microencapsulation, 25, 90, 10.1080/02652040701776109
Sujja, 1999, Development and evaluation of a multiple unit oral sustained release dosage form for S (+)-ibuprofen: preparation and release kinetics, International Journal of Pharmaceutics, 193, 73, 10.1016/S0378-5173(99)00320-8
Sullad, 2011, Microspheres of carboxymethyl guar gum for in vitro release of abacavir sulfate: preparation and characterization, Journal of Applied Polymer Science, 122, 452, 10.1002/app.34173
Sultana, 2006, Ion-activated, Gelrite-based in situ ophthalmic gels of pefloxacin mesylate: comparison with conventional eye drops, Drug Delivery, 13, 215, 10.1080/10717540500309164
Tako, 2009, Molecular origin for rheological characteristics of native gellan gum, Colloid and Polymer Science, 287, 1445, 10.1007/s00396-009-2112-2
Talukdar, 1995, Swelling and drug release behaviour of xanthan gum matrix tablets, International Journal of Pharmaceutics, 120, 63, 10.1016/0378-5173(94)00410-7
Tang, 2012, An improved complex gel of modified gellan gum and carboxymethyl chitosan for chondrocytes encapsulation, Carbohydrate Polymers, 88, 46, 10.1016/j.carbpol.2011.11.058
Tang, 1996, Compression strength and deformation of gellan gels formed with mono- and divalent cations, Carbohydrate Polymers, 29, 11, 10.1016/0144-8617(95)00124-7
Tang, 1997, Gelling properties of gellan solutions containing monovalent and divalent cations, Journal of Food Science, 62, 688, 10.1111/j.1365-2621.1997.tb15436.x
Tayel, 2013, Promising ion-sensitive in situ ocular nanoemulsion gels of terbinafine hydrochloride: design, in vitro characterization and in vivo estimation of the ocular irritation and drug pharmacokinetics in the aqueous humor of rabbits, International Journal of Pharmaceutics, 443, 293, 10.1016/j.ijpharm.2012.12.049
Teratsubo, 2002, Measurement of stress and strain during tensile testing of gellan gum gels: effect of deformation speed, Carbohydrate Polymers, 47, 1, 10.1016/S0144-8617(00)00338-6
Thakur, 2011, Modern delivery systems for ocular drug formulations: a comparative overview w.r.t conventional dosage form, International Journal of Research in Pharmaceutical and Biomedical Sciences, 2, 8
Totosaus, 2009, Textural properties and microstructure of low-fat and sodium-reduced meat batters formulated with gellan gum and dicationic salts, LWT – Food Science and Technology, 42, 563, 10.1016/j.lwt.2008.07.016
Tripathi, 2010, Formulation and in vitro evaluation of pH sensitive oil entrapped polymeric blended gellan gum buoyant beads of clarithromycin, DARU, 18, 247
Ugwoke, 2005, Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives, Advanced Drug Delivery Reviews, 57, 1640, 10.1016/j.addr.2005.07.009
Vendruscolo, 2005, Xanthan and galactomannan (from M. scabrella) matrix tablets for oral controlled delivery of theophylline, International Journal of Pharmaceutics, 296, 1, 10.1016/j.ijpharm.2005.02.007
Verma, 2011, Rifabutin-loaded floating gellan gum beads: effect of calcium and polymer concentration on incorporation efficiency and drug release, Tropical Journal of Pharmaceutical Research, 10, 61, 10.4314/tjpr.v10i1.66542
Vijan, 2012, Microwave assisted synthesis and characterization of acrylamide grafted gellan, application in drug delivery, Carbohydrate Polymers, 90, 496, 10.1016/j.carbpol.2012.05.071
Wang, 2008, A novel gellan gel-based microcarrier for anchorage-dependent cell delivery, Acta Biomaterialia, 4, 1226, 10.1016/j.actbio.2008.03.008
Toti, 2004, Acrylamide-grafted-acacia gum polymer matrix tablets as erosion-controlled drug delivery systems, Journal of Applied Polymer Science, 93, 2245, 10.1002/app.20768
Wen, 2008, Direct electrochemistry and biocatalytic activity of hemoglobin entrapped into gellan gum and room temperature ionic liquid composite system, Electrochimica Acta, 54, 744, 10.1016/j.electacta.2008.06.077
Whittaker, 1997, Development of composite structures in the gellan polysaccharide/sugar system, Carbohydrate Polymers, 33, 39, 10.1016/S0144-8617(97)00027-1
Yadav, 2014, Gellan-thioglycolic acid conjugate: synthesis, characterization and evaluation as mucoadhesive polymer, Carbohydrate Polymers, 99, 601, 10.1016/j.carbpol.2013.08.068
