Apparent glucose utilization in Walker 256 metastatic brain tumors
Tóm tắt
Regional rates of apparent glucose utilization (GU) in metastatic Walker 256 (WL-256) brain tumors produced by the intracarotid injection of WL-256 tumor cells in rats were measured using14C-deoxyglucose and quantitative auroradiography. Apparent glucose utilization was uniform within individual small and medium size tumors without necrosis, varied considerably among different tumors within this group, and did not correlate with tumor size or location. High values of GU in medium and large-size tumors correlated with viable-appearing tissue in contrast to necrotic tissue and were always 1.3 to 3 times higher than that of adjacent and contralateral nontumorous brain. The apparent net extraction of glucose (E n * ) in viable tumor regions was estimated to be several fold higher than that in remote brain tissue; analysis of this data for medium and large tumors indicates that the calculated values of GU and E n * overestimate the actual rates of utilization and net extraction of glucose. Local cerebral glucose utilization (LCGU) was higher than normal adjacent to small tumors and lower than normal adjacent to large tumors. The LCGU in many gray-matter structures remote from the intracerebral tumors was reduced and roughly proportional to the metastatic tumor burden. The comparatively high uptake of 2-deoxyglucose by viable tumor cells has diagnostic and localization value and suggests that appropriate glucose analogues could be developed to produce a tumor-selective inhibition of glycolysis and tumoricidal effect.
Tài liệu tham khảo
Warburg O: The Matabolism of Tumors. London, Constable and Co., 1930, pp 327.
citation_journal_title=Acta Neurochirurg; citation_title=Biochemical patterns in brain tumors. I. Enzymes of the glycolysis; citation_author=GL Viale; citation_volume=20; citation_publication_date=1969; citation_pages=263-272; citation_id=CR2
citation_title=Anerobic energy metabolism in brain tumors; citation_inbook_title=Recent Advances in Brain Tumor Research. Prog Exp Tumr Res 17; citation_publication_date=1972; citation_pages=163-191; citation_id=CR3; citation_author=WM Kirsh; citation_author=D Shultz; citation_author=J Buskirk; citation_author=P Nakane; citation_publisher=Karger
citation_title=Oxidative metabolism of brain tumors; citation_inbook_title=Recent Advances in Brain Tumor Research. Prog Exp Tumor Res 17; citation_publication_date=1972; citation_pages=192-209; citation_id=CR4; citation_author=N Allen; citation_publisher=Karger
citation_title=Biochemistry of brain tumors; citation_inbook_title=Handbook of Neurochemistry; citation_publication_date=1972; citation_pages=503-542; citation_id=CR5; citation_author=M Wollman; citation_publisher=Plenum Press
citation_title=Brain Metabolism and Cerebral Disorders; citation_publication_date=1951; citation_id=CR6; citation_author=HE Himwich; citation_publisher=Williams and Wilkens
citation_title=Biochemistry of the Central Nervous System; citation_publication_date=1966; citation_id=CR7; citation_author=HH McIlwain; citation_publisher=Churchill
citation_title=Brain Energy Metabolism; citation_publication_date=1978; citation_id=CR8; citation_author=BK Siesjo; citation_publisher=Wiley
citation_journal_title=Trans Am Neurol Assoc; citation_title=Glucose analogues as potential agents for brain tumor diagnosis and treatment; citation_author=W Wassenaar, CH Tator; citation_volume=98; citation_publication_date=1973; citation_pages=43-48; citation_id=CR9
citation_journal_title=Cancer Res; citation_title=Glucose analogs as potential diagnostic tracers for brain tumors; citation_author=W Wassenaar, CH Tator, HP Batty; citation_volume=35; citation_publication_date=1975; citation_pages=785-790; citation_id=CR10
citation_journal_title=Neurology; citation_title=Glucose utilization of cerebral gliomas measured by [18F]fluorodeoxyglucose and positron emission tomography; citation_author=G DiChiro, RL DeLaPaz, RA Brooks, L Sokoloff, PL Kornblith, BH Smith, NJ Patronas, CV Kufta, RM Kessler, GS Johnston, RG Manning, AP Wolf; citation_volume=32; citation_publication_date=1982; citation_pages=1323-1329; citation_id=CR11
citation_title=Glycolytic rate and histologic grade of human cerebral gliomas: a study with (F)fluoro-deoxyglucose and postron emission tomography; citation_inbook_title=Positron Emission Tomography of the Brain; citation_publication_date=1983; citation_pages=181-191; citation_id=CR12; citation_author=G DiChiro; citation_author=RA Brooks; citation_author=L Sokoloff; citation_author=NJ Patronas; citation_author=RL DeLaPaz; citation_author=BH Smith; citation_author=PL Kornblith; citation_publisher=Springer-Verlag
citation_journal_title=J Neurochem; citation_title=The ["C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure and normal values in the conscious and anesthetized albino rat; citation_author=L Sokoloff, M Reivich, C Kennedy, MH Rosiers, CS Patlak, KD Pettigrew, O Sakurada, M Shinohara; citation_volume=28; citation_publication_date=1977; citation_pages=897-916; citation_id=CR13
citation_journal_title=Ann Neurol; citation_title=Computerized densitometry and color coding of14C-deoxyglucose autoradiography; citation_author=C Goochee, W Rasband, L Sokoloff; citation_volume=7; citation_publication_date=1980; citation_pages=359-370; citation_id=CR14
citation_journal_title=J Neurooncol; citation_title=Local blood flow in Walker 256 metastatic brain tumors; citation_author=RG Blasberg, WR Shapiro, P Molnar, CS Patlak, JD Fenstermacher; citation_volume=2; citation_publication_date=1984; citation_pages=195-204; citation_id=CR15
citation_journal_title=Arch Pathol Lab Med; citation_title=Glucose antagonists in experimental cancer; citation_author=HB Sokoloff, WH Eddy, CC Saelholf, J Beach; citation_volume=59; citation_publication_date=1955; citation_pages=729-732; citation_id=CR16
citation_journal_title=Cancer Res; citation_title=Influence of glucose antimetabolites on the Walker tumor; citation_author=HA Ball, AN Wick, C Sanders; citation_volume=17; citation_publication_date=1957; citation_pages=235-239; citation_id=CR17
citation_journal_title=J Natl Cancer Inst; citation_title=Effects of glucose analogs (2-deoxy-D-glucose, 2-deoxy-D-galactose) on the experimental tumors; citation_author=J Laszlo, SR Humphreys, A Goldin; citation_volume=24; citation_publication_date=1960; citation_pages=267-281; citation_id=CR18
Cummulative drug screening data on D-glucose, 2-deoxy (NSC 015193); Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20205.
citation_journal_title=Cancer Res.; citation_title=Failure of 2-deoxy-Dglucose and 5-thio-D-glucose to kill hypoxic cells of two murine tumors; citation_author=IF Tannock, P Guttman, AM Rauth; citation_volume=43; citation_publication_date=1983; citation_pages=980-983; citation_id=CR20
citation_journal_title=Ann Neurol; citation_title=Metastatic tumor of the brain: development of an experimental model; citation_author=Y Ushio, NL Chernik, WR Shapiro, J Posner; citation_volume=2; citation_publication_date=1977; citation_pages=20-29; citation_id=CR21
citation_journal_title=Acta Neurol Scand Suppl; citation_title=The [14C] deoxyglucose method: four years later; citation_author=L Sokoloff; citation_volume=60; citation_publication_date=1979; citation_pages=640-649; citation_id=CR22
citation_journal_title=J Cereb Blood Flow Metab; citation_title=Glucose metabolic rates in transplanted astrocytic gliomas in rats; citation_author=MM, Graham, AM Spence, SM Larson; citation_volume=3; citation_issue=Supplement 1; citation_publication_date=1983; citation_pages=S41-S42; citation_id=CR23
citation_journal_title=J Cereb Blood Flow Metabol; citation_title=Local cerebral glucose utilization in hypoglycemia; citation_author=S Suda, M Shinohara, M Miyaoka, C Kennedy, L Sokoloff; citation_volume=1; citation_issue=Supplement 1; citation_publication_date=1981; citation_pages=S62-S62; citation_id=CR24
citation_title=Regional multiparametric assessment of brain tumors and brain infarcts; citation_inbook_title=Cerebral Vascular Disease IV; citation_publication_date=1982; citation_pages=86-90; citation_id=CR25; citation_author=W Paschen; citation_author=G Mies; citation_author=W Bodsch; citation_author=K-A Hossmann; citation_publisher=Excerpta Medica
citation_title=The radioactive deoxyglucose method; citation_inbook_title=Advances in Neurochemistry, Vol. 4; citation_publication_date=1982; citation_pages=1-82; citation_id=CR26; citation_author=L Sokoloff; citation_publisher=Plenum Publishing Corp.
citation_title=Transport of carbohydrates by animal cells; citation_inbook_title=Metabolic Pathways; Metabolic Transport; citation_publication_date=1972; citation_pages=358-454; citation_id=CR27; citation_author=PG LeFevre; citation_publisher=Academic Press
citation_journal_title=J Physiol (London); citation_title=Fascilitated transfer of glucose from blood into brain tissue; citation_author=C Crone; citation_volume=181; citation_publication_date=1965; citation_pages=103-113; citation_id=CR28
citation_journal_title=Biochem Biophys Acta; citation_title=Kinetics of blood-brain barrier transport of hexoses; citation_author=WM Pardridge, WH Oldendorf; citation_volume=382; citation_publication_date=1975; citation_pages=377-392; citation_id=CR29
citation_journal_title=Acta Physiol Scand; citation_title=Rapid steady-state analysis of blood-brain glucose transfer in rat; citation_author=A Gjedde; citation_volume=108; citation_publication_date=1980; citation_pages=331-339; citation_id=CR30
citation_journal_title=Cancer Treat Rep; citation_title=Regional blood flow, capillary permeability, and glucose utilization in two brain tumor models: preliminary observations and pharmacokinetic implications; citation_author=RG Blasberg, T Kobayashi, CS Patlak, M Shinohara, M Miyaoka, JM Rice, WR Shapiro; citation_volume=65; citation_issue=Supplement 2; citation_publication_date=1981; citation_pages=3-12; citation_id=CR31
citation_title=Clinical implications of quantitative autoradiographic measurements of regional blood flow, capillary permeability and glucose utilization in a metastatic brain tumor model; citation_inbook_title=Treatment of Neopplastic Lesions of the Nervous System; citation_publication_date=1982; citation_pages=135-141; citation_id=CR32; citation_author=RG Blasberg; citation_author=J Gazendam; citation_author=W Shapiro; citation_author=M Shinohara; citation_author=CS Patlak; citation_author=J Fenstermacher; citation_publisher=Pergamon Press Ltd
citation_journal_title=N Engl J Med; citation_title=Enzymology of cancer cells. II; citation_author=G Weber; citation_volume=296; citation_publication_date=1977; citation_pages=541-551; citation_id=CR33
citation_title=Glycolysis in neuroectodermal tumours; citation_inbook_title=Brain Tumours; citation_publication_date=1980; citation_pages=145-167; citation_id=CR34; citation_author=WR Timperly; citation_publisher=Butterworth
citation_journal_title=J Neurosurg; citation_title=Effects of methylprednisolone on peritumoral brain edema; citation_author=K Yamada, Y Ushio, T Hayakawa, N Arita, N Yamada, H Mogami; citation_volume=59; citation_publication_date=1983; citation_pages=612-619; citation_id=CR35
citation_journal_title=J Cereb Blood Flow Metabol.; citation_title=Simultaneous measurements of blood flow and relative glucose utilization in ASV induced brain tumors; citation_author=RG Blasberg, P Molnar, D Groothuis, CS Patlak, J Fenstermacher; citation_volume=1; citation_issue=Supplement 1; citation_publication_date=1981; citation_pages=568-568; citation_id=CR36
citation_journal_title=J Cereb Blood Flow Metabol.; citation_title=Local cerebral blood flow and glucose consumption of rats with experimental gliomas; citation_author=K-A Hossmann, I Niebuhr, M Tamara; citation_volume=2; citation_publication_date=1982; citation_pages=25-32; citation_id=CR37
citation_journal_title=Clin Neurosurg; citation_title=The metabolism of the glioblastoma: pathological correlates; citation_author=WM Kirsch, WS Tucker, K Tabuchi, LM Fink, J Buskirk, M Low; citation_volume=25; citation_publication_date=1978; citation_pages=310-325; citation_id=CR38
citation_journal_title=J Cereb Blood Flow Metabol.; citation_title=A theoretical derivation of the lumped constant for the 2-deoxyglucose method for measuring local glucose metabolism in the brain; citation_author=KD Pettigrew, L Sokoloff, CS Patlak; citation_volume=3; citation_issue=Supplement 1; citation_publication_date=1983; citation_pages=S89-S90; citation_id=CR39
citation_journal_title=J Neurochem; citation_title=The interaction of transport and metabolism on glucose utilization: reevaluation of the lumped constant; citation_author=PD Crane, WM Pardridge, LD Braun, AM Nyerges, WH Oldendorf; citation_volume=36; citation_publication_date=1981; citation_pages=1601-1604; citation_id=CR40
citation_journal_title=Brain Research Reviews; citation_title=Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogs in vivo: a re-examination; citation_author=A Gjedde; citation_volume=4; citation_publication_date=1982; citation_pages=237-274; citation_id=CR41
citation_journal_title=J Cereb Blood Flow Metabol.; citation_title=Comparative regional analysis of 2fluorodeoxyglucose and methylglucose uptake in brain of four stroke patients; citation_author=A Gjedde, K Wienhard, W-D Heiss, G Kloster, NH Diemer, K Herholz, G Pawlik; citation_volume=5; citation_publication_date=1985; citation_pages=163-178; citation_id=CR42
citation_journal_title=Ann Neurol; citation_title=In vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomas; citation_author=CG Rhodes, RJS Wise, JM Gibbs, RSJ Frackowiak, J Hatazawa, AJ Palmer, DGT Thomas, T Jones; citation_volume=14; citation_publication_date=1983; citation_pages=614-626; citation_id=CR43
citation_journal_title=Ann Neurol; citation_title=Issues in the in vivo measurement of glucose metabolism of human central nervous system tumors; citation_author=G Chiro, RA Brooks, NJ Patronas, D Bairamian, PL Kornblith, BH Smith, L Mansi, J Barker; citation_volume=15; citation_issue=suppl; citation_publication_date=1984; citation_pages=S138-5146; citation_id=CR44
citation_journal_title=J Neurochem; citation_title=The effects of 2-deoxy-D-glucose on metabolism of slices of cerebral cortex incubated in vitro; citation_author=DB Tower; citation_volume=3; citation_publication_date=1958; citation_pages=185-205; citation_id=CR45
citation_journal_title=Proc Soc Exp Biol (NY); citation_title=Animal responses to 2-deoxy-Dglucose administration; citation_author=BR Landau, HA Lubs; citation_volume=99; citation_publication_date=1958; citation_pages=124-127; citation_id=CR46
citation_journal_title=J Neurochem; citation_title=Enzymic and cerebral metabolic effects of 2-deoxy-D-glucose; citation_author=RW Horton, BS Meldrum, HS Bachelard; citation_volume=21; citation_publication_date=1973; citation_pages=507-520; citation_id=CR47
citation_journal_title=Science; citation_title=Barbiturate-enhanced detection of brain lesions by carbon-l4-labeled 2-deoxyglucose autoradiography; citation_author=KA Frey, BW Agranoff; citation_volume=219; citation_publication_date=1983; citation_pages=879-881; citation_id=CR48
citation_title=The Advanced Theory of Statistics; Vol. 1, Distribution Theory; citation_publication_date=1958; citation_id=CR49; citation_author=MG Kendall; citation_author=A Stuart; citation_publisher=Wagner Pub. Co.
citation_journal_title=Am J Physiol; citation_title=Measurement of local cerebral blood flow with Iodo ('4C)-antipyrine; citation_author=O Sakurada, C Kennedy, J Jehle, JD Brown, GL Carbin, L Sokoloff; citation_volume=234; citation_issue=1; citation_publication_date=1978; citation_pages=H59-H66; citation_id=CR50