Antipyretics

Ablondi, 1952, An antimalarial alkaloid from hydrangea. II. Isolation, J. org. Chem., 17, 14, 10.1021/jo01135a003 Adams, 1963, Some biological properties of “ibufenac”, a new anti-rheumatic drug, Nature, Lond., 200, 271, 10.1038/200271b0 Adams, 1967, Some biological properties of 2-(4-isobutylphenyl)propionic acid, J. pharm. Sci., 56, 1686, 10.1002/jps.2600561238 Adams, 1968, Some aspects of the pharmacology of ibufenac, a non-steroidal antiinflammatory agent, J. Pharm. Pharmac., 20, 305, 10.1111/j.2042-7158.1968.tb09744.x Adler, 1969, The effect of salicylate on pyrogen-induced fever in man, Clin. Sci., 37, 91 Allison, 1965, DNA: Reaction with chloroquine, Science, 149, 1111, 10.1126/science.149.3688.1111 Almirante, 1965, Derivatives of imidazole. I. Synthesis and reactions of imidazo[1,2-a]pyridines with analgesic, antiinflammatory, antipyretic and anticonvulsant activity, J. med. Chem., 8, 305, 10.1021/jm00327a007 Almirante, 1966, Derivatives of imidazole. II. Synthesis and reactions of imidazo[1,2-a]pyrimidines and other bi- and tricyclic imidazo derivatives with analgesic, antiinflammatory, antipyretic and anticonvulsant activity, J. med. Chem., 9, 29, 10.1021/jm00319a007 Arden, 1966, Antimalarial therapy and early retinal changes in patients with rheumatoid arthritis, Br. med. J., i, 270, 10.1136/bmj.1.5482.270 Arrigoni-Martelli, 1979, Screening and assessment of antiinflammatory drugs, Meth. Find. exp. clin. Pharmacol., 1, 157 Atkins, 1960, Pathogenis of fever, Physiol. Rev., 40, 580, 10.1152/physrev.1960.40.3.580 Atkins, 1983, Fever—new perspective on an old phenomenon, New Engl. J. Med., 308, 958, 10.1056/NEJM198304213081610 Atkins, 1955, Studies on the antipyretic action of cortisone in pyrogen-induced fever, J. exp. Med., 101, 353, 10.1084/jem.101.4.353 Atkins, 1972, Fever, New Engl. J. Med., 286, 27, 10.1056/NEJM197201062860109 Atkinson, 1974, 2-(2,4-Dichlorophenoxy)phenylacetic acid (fenclofenac): one of a novel series of antiinflammatory compounds with low ulcerogenic potential, J. Pharm. Pharmac., 26, 357, 10.1111/j.2042-7158.1974.tb09289.x Baker, 1952, An antimalarial alkaloid from hydrangea. XII. Synthesis of 3-[β-keto-γ-(3-hydroxy-2-piperidyl)propyl]-4-quinazolone, the alkaloid, J. org. Chem., 17, 132, 10.1021/jo01135a013 Baracos, 1983, Stimulation of muscle protein degradation and prostaglandin E2, New Engl. J. Med., 308, 553, 10.1056/NEJM198303103081002 Bavin, 1955, Anti-inflammatory compounds. Part I. The activity of a series of new compounds compared with phenylbutazone and cortisone, J. Pharm. Pharmac., 7, 1022, 10.1111/j.2042-7158.1955.tb12113.x Bavin, 1952, The analgesic and antipyretic properties of some derivatives of salicylamide, J. Pharm. Pharmac., 4, 872, 10.1111/j.2042-7158.1952.tb13220.x Beaver, 1965, Mild analgesics: A review of their clinical pharmacology (Part I), Am. J. med. Sci., 250, 577, 10.1097/00000441-196511000-00011 Beaver, 1966, Mild analgesics: A review of their clinical pharmacology (Part II), Am. J. med. Sci., 251, 576, 10.1097/00000441-196605000-00012 Beisel, 1983, Mediators of fever and muscle proteolysis, New Engl. J. Med., 308, 586, 10.1056/NEJM198303103081009 Berger, 1973, The pharmacological properties of seclazone (7-chloro-3,3a-dihydro-2H,9H-isoxazolo[3,2-b][1,3]benzoxazin-9-one). A new antiinflammatory agent, Pharmacology, 9, 164, 10.1159/000136381 Berliner, 1948, Studies on the chemotherapy of the human malarial. VI. The physiological disposition, antimalarial activity, and toxicity of several derivatives of 4-aminoquinoline, J. clin. Invest., 27, 98, 10.1172/JCI101980 Berman, 1968 Bianchi, 1972, Pharmacological investigations of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370). Part I: Antiinflammatory, analgesic and antipyretic properties, Arzneimittel-Forsch., 22, 183 Bigger, 1980, Antiarrhythmic drugs, 768 Bligh, 1982, Thermoregulation: Its change during infection with endotoxin-producing micro-organisms, Vol. 60, 25 Bodel, 1972, Anti-inflammatory effects of estradiol on human blood, J. Lab. clin. Med., 80, 373 Boots Pure Drug Company Ltd (1967) South African Patent 62/294. Borovsky, 1960, Antipyretic activity of acetylsalicyclic acid and salicylamide suspension in pediatrics. A comparative clinical evaluation in two hundred six cases, Am. J. Dis. Child., 100, 47/23, 10.1001/archpedi.1960.04020040025007 Braverman, 1983, Thyroid storm, 67 Breckenridge, 1973, Immediate decrease by hydrocortisone of the plasma half-life of antipyrine, Br. J. Pharmac., 47, 434, 10.1111/j.1476-5381.1973.tb08344.x Brieger, 1882, Ueber die antipyretische Wirkung des Chinolinum tartaricum, Z. klin. Med., 4, 296 Brown, 1974, Nonsteroidal antiinflammatory agents. I. 2,4-Diphenylthiazole-5-acetic acid and related compounds, J. med. Chem., 17, 1177, 10.1021/jm00257a010 Brown, 1968, Diaryloxazole and diarylthiazolealkanoic acids: Two novel series of non-steroidal antiinflammatory agents, Nature, Lond., 219, 164, 10.1038/219164a0 Bruce-Chwatt, 1982, Qinghaosu: a new antimalarial, Br. med. J., 284, 767, 10.1136/bmj.284.6318.767 Bruce-Chwatt, 1982, Chemoprophylaxis of malaria in Africa: the spent “magic bullet”, Br. med. J., 285, 674, 10.1136/bmj.285.6343.674 Buller, 1957, The comparative antipyretic activity of acetylsalicyclic acid and salicylamide in fever-induced rats, J. Pharm. Pharmac., 9, 128, 10.1111/j.2042-7158.1957.tb12265.x Burger, 1960, Analgesics in rheumatoid diseases and fever, 352 Buskirk, 1964, Heat exchange in men and women following intravenous injection of endotoxin, J. appl. Physiol., 19, 907, 10.1152/jappl.1964.19.5.907 Buss, 1876, On the antipyretic action of cresotinic acid, Klin. Wschr., 13, 445 Buttinoni, 1973, Pharmacological study on a new analgesic-antiinflammatory drug: α-[4-(1-oxo-2-isoindolinyl-phenyl]-propionic acid or K4277, Arzneimittel-Forsch., 23, 1100 Buu-Höi, 1970, Synthesis and pharmacological properties of substituted cinnamohydroxamic acids, J. med. Chem., 13, 211, 10.1021/jm00296a010 Buu-Höi, 1969, 4-Allyloxy-3-chlorophenylacetic acid, a new type of analgesic, antipyretic and antiphlogistic drug, Naturwissenschaften, 56, 330, 10.1007/BF00602182 Cahn, 1886, Das Antifebrin, ein neues Fiebermittel, Centrabl. klin. Med., 7, 561 Casadio, 1972, Terpene compounds as drugs. X. 4-Prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2,370): a new antiinflammatory drug, with low ulcerogenic effects, derived from a series of terpenyl pyrazolidinediones, Arzneimittel-Forsch., 22, 171 Cashin, 1968, The assay of antipyretic drugs in mice, using intracerebral injection of pyretogenins, Br. J. Pharmac., 34, 148, 10.1111/j.1476-5381.1968.tb07958.x Cashin, 1977, Pharmacology of benzoxaprofen(2-[4-chlorophenyl]-α-methyl-5-benzoxazole acetic acid), LRCL 3794, a new compound with antiinflammatory activity apparently unrelated to inhibition of prostaglandin synthesis, J. Pharm. Pharmac., 29, 330, 10.1111/j.2042-7158.1977.tb11330.x Casterlin, 1982, The pyrogenic responses of invertebrates, Vol. 60, 669 Chai, 1971, The site of action of leukocytic pyrogen and antipyresis of sodium acetylsalicylate in monkeys, Neuropharmacology, 10, 715, 10.1016/0028-3908(71)90086-4 Cheng, 1976, Structural similarity between febrifugine and chloroquine, J. theor. Biol., 59, 497, 10.1016/0022-5193(76)90186-7 Chien, 1970, Structural modification of febrifugine. Some methylenedioxy analogs, J. med. Chem., 13, 867, 10.1021/jm00299a018 Chou, 1948, Antimalarial constituents in Chinese drug, Ch'ang San, Dichroa febrifuga Lour. J. Am. chem. Soc., 70, 1765, 10.1021/ja01185a028 Chowers, 1968, Local effect of cortisol in the preoptic area on temperature regulation, Am. J. Physiol., 214, 538, 10.1152/ajplegacy.1968.214.3.538 Clark, 1978, 2-(Substituted phenyl)oxazolo[4,5-b]pyridines and 2-(substituted phenyl)oxazolo[5,4-b]pyridines as non-acidic antiinflammatory agents, J. med. Chem., 21, 1158, 10.1021/jm00209a014 Clark, 1979, Minireview. Mechanisms of antipyretic action, Gen. Pharmacol., 10, 71, 10.1016/0306-3623(79)90038-7 Clark, 1975, The antipyretic effect of indomethacin, J. Physiol., Lond., 248, 625, 10.1113/jphysiol.1975.sp010992 Clarke, 1958, Phenolic compounds in chemotherapy of rheumatic fever, Am. J. med. Sci., 235, 7, 10.1097/00000441-195801000-00002 Clarke, 1953, Phenolic compounds in the treatment of rheumatic fevers. I. A study of gentisic acid derivatives, Circulation, 7, 247, 10.1161/01.CIR.7.2.247 Clowes, 1983, Muscle proteolysis induced by a circulating peptide in patients with sepsis or trauma, New Engl. J. Med., 308, 545, 10.1056/NEJM198303103081001 Coatney, 1952, The use of antibiotics in the treatment of malaria, Ann. N.Y. Acad. Sci., 55, 1075, 10.1111/j.1749-6632.1952.tb22668.x Coatney, 1953, Survey of antimalarial agents: Chemotherapy of Plasmodium gallinaceum infections; Toxicity; Correlation of structure and action Colgan, 1957, The comparative antipyretic effect of N-acetyl-p-aminophenol and acetylsalicylic acid, J. Pediat., 50, 552, 10.1016/S0022-3476(57)80219-4 Collier, 1956, Antipyretic and analgesic properties of two hydroxyisophthalic acids, Br. J. Pharmac. Chemother., 11, 20, 10.1111/j.1476-5381.1956.tb01021.x Colot, 1974, Antiinflammatory and antiarthritic properties of 5-chloro-3-methylbenz[b]thiofen-2-acetic acid, Archs int. Pharmacodyn. Thér., 208, 328 Committee of Revision, 1979, Pyrogen test, 902 Coombs, 1973, Synthesis and antiinflammatory activity of 1-alkyl-4-aryl-2(1H)-quinazolinones and quinazolinethiones, J. med. Chem., 16, 1237, 10.1021/jm00269a006 Cooper, 1964, Temperature during fever regulation in man, Clin. Sci., 27, 345 Court, 1984, Poisoning after overdose with non-steroidal anti-inflammatory drugs, Adverse Drug Reactions Acute Poisoning Rev., 3, 1 Cox, 1977, Pharmacologic control of temperature regulation, A. Rev. Pharmacol. Toxicol., 17, 341, 10.1146/annurev.pa.17.040177.002013 Cranston, 1966, Temperature regulation, Br. med. J., ii, 69, 10.1136/bmj.2.5505.69 Cranston, 1981, The effects of intracerebroventricular cycloheximide on protein synthesis and fever in rabbits, Br. J. Pharmac., 73, 6, 10.1111/j.1476-5381.1981.tb16763.x Cranston, 1975, A dissociation between fever and prostaglandin concentration in cerebrospinal fluid, J. Physiol., Lond., 253, 583, 10.1113/jphysiol.1975.sp011208 Cranston, 1971, Influence of the duration of experimental fever on salicylate antipyresis in the rabbit, Br. J. Pharmac., 41, 344, 10.1111/j.1476-5381.1971.tb08035.x Davidson, 1964, The Principles and Practice of Medicine, 545 Davies, 1976, The anti-inflammatory and analgesic effects of Norvedan, a novel non-steroidal agent, Archs int. Pharmacodyn. Thér., 221, 274 Dawson, 1930, Cinchona alkaloids and bark in malaria, Int. Clin., 2, 121 Dillard, 1970, Studies on steroid fever. II. Pyrogenic and antipyrogenic activity in vitro of some endogenous steroids of man, J. clin. Invest., 49, 2418, 10.1172/JCI106461 Dinarello, 1978, Pathogenesis of fever in man, New Engl. J. Med., 298, 607, 10.1056/NEJM197803162981107 Dinarello, 1982, Exogenous pyrogens, Vol. 60, 98 Dinarello, 1974, Demonstration and characterization of two distinct leukocytic pyrogens, J. exp. Med., 139, 1369, 10.1084/jem.139.6.1369 DiPasquale, 1973, The antiinflammatory effects of 4-hydroxy-2-methyl-3-phenylcarbamoyl-2H-1,2-benzothiazine-1,1-dioxide (W-7477), Archs int. Pharmacodyn. Thér., 203, 92 Dobner, 1930, Amatin, ein neues, die Diaphorese nicht anregendes Antipyretikum, Munch. med. Wschr., 77, 1103 Donath, 1881, Physiologische und physiologisch-chemische Wirkungen des Chinolins, Ber. dt. chem. Ges., 14, 178, 10.1002/cber.18810140148 Donath, 1881, Beiträge zu den physiologischen Wirkungen und den chemischen Reactionen des Chinolins, Ber. dt. chem. Ges., 14, 1769, 10.1002/cber.18810140246 Dorfman, 1975, Chemistry and pharmacology of naproxen, Arzneimittel-Forsch., 25, 278 Douglas, 1972, Metabolic fate of 7-chloro-3,3a-dihydro-2H,9H-isoxazolo[3,2-b][1,3]benzoxazin-9-one W-2354, 31, 578 Douglas, 1952, The hypothermic and antipyretic effect of preparations of ACTH, Lancet, i, 342, 10.1016/S0140-6736(52)91850-3 Dunwell, 1975, 2-Aryl-5-benzoxazolealkonoic acid derivatives with notable antiinflammatory activity, J. med. Chem., 18, 53, 10.1021/jm00235a012 Edeson, 1955, Treatment of acute malaria with a synthetic alkaloid of the quinazolone series (1698L), Trans. R. Soc. trop. Med. Hyg., 49, 543, 10.1016/0035-9203(55)90025-0 Edgcomb, 1950, Primaquine, SN 13272, a new curative agent in vivax malaria: a preliminary report, J. natn. Malar. Soc., 9, 285 Ehrlich, 1886, Experimentelles und Klinisches über Thallin, Dt. med. Wschr., 12, 849, 10.1055/s-0028-1140274 Eisenman, 1982, Electrophysiology of the anterior hypothalamus: thermoregulation and fever, Vol. 60, 187 Fairley, 1945, Chemotherapeutic suppression and prophylaxis in malaria. An experimental investigation undertaken by medical research teams in Australia, Trans. R. Soc. trop. Med. Hyg., 38, 311, 10.1016/0035-9203(45)90038-1 Falk, 1890, Ueber Nebenwirkungen und Intoxicationen bei der Anwendung neurerer Arzneimittel. 2. Thallin, Ther. Mh., 4, 211 Feldberg, 1975, The Ferrier Lecture 1974. Body temperature and fever: changes in our views during the last decade, 191, 199 Feldberg, 1978, Prostaglandin and body temperature, Vol. 50, 617 Feldberg, 1971, Further studies on prostaglandin E1 fever in cats, J. Physiol., Lond., 219, 739, 10.1113/jphysiol.1971.sp009686 Feri, 1911, Zur Wirkung der Antipyretica, Archs int. Pharmacodyn Thér., 21, 27 Filehne, 1882, Ueber neue Mittel, welche die fieberhafte Temperatur zur Norm bringen, Berl. klin. Wschr., 19, 681 Filehne, 1883, Weiteres uber Kairin und analoge Körper, Berl. klin. Wschr., 20, 77 Filehne, 1883, Ueber den Unterschied in der Wirkung zwischen dem “Kairin” und dem “Kairin M”, Berl. klin. Wschr., 20, 238 Fischer, 1883 Flower, 1972, Inhibition of prostaglandin synthetase in brain explains the antipyretic activity of paracetamol (4-acetamidophenol), Nature, Lond., 240, 410, 10.1038/240410a0 Fogel, 1966, The osmotic fragility of erythrocytes in experimental malaria, Am. J. trop. Med. Hyg., 15, 269, 10.4269/ajtmh.1966.15.269 Foy, 1950, The correlation between blackwater fever, malaria, quinine and atebrin, Ann. trop. Med. Parasit., 44, 309, 10.1080/00034983.1950.11685454 Foy, 1945, Survival of transferred red cells in blackwater fever circulation and of blackwater fever red cells in normal circulation, Trans. R. Soc. trop. Med. Hyg., 38, 271, 10.1016/0035-9203(45)90043-5 Fróes, 1934, Il “blu di metilene” nella terapia della malaria, Riv. Malar., 13, 484 Fujimura, 1973, Pharmacological studies on some new quinazoline derivatives. (1). Antiiflammatory and some other properties, Jap. J. Pharmac., 23, 190, 10.1016/S0021-5198(19)61881-0 Fujimura, 1974, Pharmacological studies on H27 and H88, the new quinazoline-2,4-dione derivatives. I. Antiinflammatory, analgesic, and antipyretic activities, Nippon Yakurigaku Zasshi, 70, 673, 10.1254/fpj.70.673 Gaddum, 1959, Pharmacology, 169 Gaddum, 1959, Pharmacology, 450 Gander, 1968, Mechanism of the antipyretic action glucocorticoids, Endocrinology, 82, 195, 10.1210/endo-82-1-195 Gazzard, 1976, Why do people use paracetamol for suicide?, Br. med. J., i, 212, 10.1136/bmj.1.6003.212 Giemsa, 1914, Erfahrungen mit weiteren dem Chinin nähestehenden Alkaloiden und einigen ihrer Derivative bei Malaria (Chinidin, Hydrochinidin, Cinchonin, Hydrocinchonin, Cuprein, Chinäthylin und Chinpropylin), Arch. Schiffs-u. Tropenhyg., 18, 12 Girndt, 1929, Über der Angriffspunkt von Antipyreticis: Chinin und chininähnlichen Stoffen, Arch. exp. Path. Pharmak., 140, 91, 10.1007/BF01997490 Glenn, 1967, Pharmacology of 2,3-bis-(p-methoxyphenyl)indole(indoxole), J. Pharmac. exp. Ther., 155, 157 Glyn, 1981, Hypothermic and antipyretic effects of centrally administered ACTH (1–24) and α-melanotropin, Peptides, 2, 177, 10.1016/S0196-9781(81)80032-0 Goldblatt, 1935, Properties of human seminal fluid, J. Physiol., Lond., 84, 208, 10.1113/jphysiol.1935.sp003269 Goodman, 1956, Drugs used in the chemotherapy of malaria, 1189 Grimaux, 1894, Sur les homologues de la quinine; leur action physiologique et thérapeutique, C.r. hebd. Séanc. Acad. Sci., Paris, 118, 1303 Gross, 1948 Gruber, 1974, Antipyresis with fenprofen, J. clin. Pharmac., 14, 215, 10.1002/j.1552-4604.1974.tb01400.x Gruber, 1972, Antipyretic effect of fenoprofen, J. med. exp. Clin., 3, 242 Guerra, 1943, The mechanism of aspirin antipyresis in monkey, J. Pharmac. exp. Ther., 79, 55 Guttmann, 1883, Ueber die antifebrile Wirkung des Kairin, Berl. klin. Wschr., 20, 465 Guttmann, 1891, Ueber die Wirkung des Methyleneblau bei Malaria, Berl. klin. Wschr., 28, 953 Hannah, 1978, Novel analgesic-antiinflammatory salicylates, J. med. Chem., 21, 1093, 10.1021/jm00209a001 Hanson, 1980, Failure of rabbit neutrophils to secrete endogenous pyrogen when stimulated with staphylococci, J. exp. Med., 151, 1360, 10.1084/jem.151.6.1360 Hanzlik, 1927 Harrison, 1975, Control of the malignant hyperpyretic syndrome in MHS swine by dantrolene sodium, Br. J. Anaesth., 47, 62, 10.1093/bja/47.1.62 Harrison, 1970, Nonsteroidal antiinflammatory agents. I. 6-Substituted 2-naphthylacetic acids, J. med. Chem., 13, 203, 10.1021/jm00296a008 Hellon, 1975, Monoamines, pyrogens and cations: their actions on central control of body temperature, Pharmac. Rev., 26, 289 Hellon, 1983, Mechanism of fever, Pharmac. Ther., 19, 211, 10.1016/0163-7258(82)90063-8 Hench, 1949, The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticotrophic rheumatoid arthritis, 24, 181 Henderson, 1949, γ-Dichroine, the antimalarial alkaloid of Ch'ang Shan, J. Pharmac. exp. Ther., 95, 191 Hesse, 1930, Zur biologischen Werthestimmung der Analgetika und ihrer Kombinationen, Arch. exp. Path. Pharmak., 158, 233, 10.1007/BF01861235 Hewitt, 1952, An antimalarial alkaloid from Hydrangea. XIII. The effects of various synthetic quinazolones against Plasmodium lophurae in ducks, Am. J. trop. Med. Hyg., 1, 768, 10.4269/ajtmh.1952.1.768 Hirschfelder, 1915, Effects of drugs upon the vessels of the pia mater and retina, J. Pharmac. exp. Ther., 6, 597 Hueper, 1948, Cinchophen (atophan); a critical review, Medicine, Baltimore, 27, 43, 10.1097/00005792-194802000-00002 Hunsicker, 1969, The pharmacology of the antimalarials, Archs intern. Med., 123, 645, 10.1001/archinte.1969.00300160035006 Hunter, 1973, Study of antipyretic therapy in current use, Archs Dis. Childh., 48, 313, 10.1136/adc.48.4.313 Jang, 1944, Present status of studies on Chinese antimalarial drugs, Chinese med. J., 62, 185 Jang, 1948, Pharmacology of Ch'ang Shan (Dichroafebrifuga), a Chinese antimalarial herb, Nature, Lond., 161, 400, 10.1038/161400b0 Jang, 1946, Ch'ang Shan, a Chinese antimalarial herb, Science, 103, 59, 10.1126/science.103.2663.59-b Jess, 1916, Eine neue experimentelle Retinitis (Chinolinretinitis), Zentbl. Biochem. Biophys., 18, 546 Jick, 1974, Drugs—remarkably nontoxic, New Engl. J. Med., 291, 824, 10.1056/NEJM197410172911605 Jick, 1982, Adverse effects of salicylic acid, 239 Jones, 1978, Synthetic and analgesic-antiinflammatory activity of some 4- and 5-substituted heteroarylsalicylic acids, J. med. Chem., 21, 1100, 10.1021/jm00209a002 Juby, 1972, Antiiinlammatory activity of some indan-1-carboxylic acids and related compounds, J. med. Chem., 15, 1297, 10.1021/jm00282a024 Julou, 1967, Properties anti-inflammatoires de l'acide (méthyl-10-phénothiazinyl-2)acétique (16091 R.P.), C.r. hebd. Séanc. Acad. Sci. Paris, 265, 1007 Julou, 1971, Study of the pharmacological properties of a new anti-inflammatory drug: 2-(3-benzoylphenyl)-propionic acid (19583 R.P.), J. Pharmacol., Fr., 2, 259 Kass, 1950, Effect of ACTH on induced fever, New Engl. J. Med., 243, 693, 10.1056/NEJM195011022431803 Kasting, 1982, Fever and its role in disease: rationale for antipyretics, Vol. 60, 5 Kawai, 1971, Antiinflammatory, analgesic and antipyretic activity of 6-chloro-5-cyclohexylinden-1-carboxylic acid (TAI-284), Jap. J. Pharmac., 21, 621, 10.1254/jjp.21.621 Keene, 1961, Observations on the pyrogenic response and its application to the bioassay of endotoxin, J. clin. Invest., 40, 295, 10.1172/JCI104256 Kim, 1982, The chemistry of non-steroidal antipyretic agents: structure-activity relationships, Vol. 60, 317 Knorr, 1884, Ueber die Constitution des Chinizin Derivativen, Ber. dt. chem. Ges., 17, 2032, 10.1002/cber.18840170298 Kobayashi, 1968, Fever responses to bacterial pyrogens in guinea pigs and application for screening of antipyretic agents, Jap. J. Pharmac., 18, 80, 10.1254/jjp.18.80 Kobert, 1887, Ueber die Beeinflussung der peripheren Gefässe durch pharmakologische Agentien, Arch. exp. Pharmak., 22, 77, 10.1007/BF02000607 Koch-Weser, 1976, Acetaminophen, New Engl. J. Med., 295, 1297, 10.1056/NEJM197612022952306 Koepfli, 1947, An alkaloid with high antimalarial activity from Dichroa febrifuga, J. Am. chem. Soc., 69, 1837, 10.1021/ja01199a513 Koepfli, 1949, Alkaloid of Dichroa febrifuga. I. Isolation and degradation studies, J. Am. chem. Soc., 71, 1048, 10.1021/ja01171a080 Kopanaris, 1911, Die Wirkung von Chinin, Salvarsan und Atoxyl auf die Proteosoma (Plasmodium praecox-) Infektion des Kanarienvogels, Arch. Schiffs-u. Tropenhyg., 15, 586 Krehl, 1897, Wie entsteht die Temperatursteigerung des fiebernden Organismus?, Arch. exp. Path. Pharmak., 38, 284, 10.1007/BF01824602 Kreier, 1972, Destruction of erythrocytes in monkeys (Macaca mulatta) infected with Plasmodium cynomolgi, Am. J. vet. Res., 33, 409 Kuehl, 1948, Alkaloids of Dichroa febrifuga Lour, J. Am. chem. Soc., 70, 2091, 10.1021/ja01186a031 Lambelin, 1970, Pharmacology of a new analgesic, antipyretic and antiinflammatory agent, 4-allyloxy-3-chlorophenylacetic acid, Arzneimittel-Forsch., 20, 610 Laqueur, 1924, Optochin, 469 Laqueur, 1924, Ergebn. inn. Med. Kiderheilk, 23, 467 Laser, 1946, A method of testing the antimalarial properties of compounds in vitro, Nature, Lond., 157, 301, 10.1038/157301a0 Laser, 1948, Haemolytic system in the blood of malaria-infected monkeys, Nature, Lond., 161, 560, 10.1038/161560a0 Laser, 1950, The isolation of a haemolytic substance from animal tissues and its biological properties, J. physiol. Lond., 110, 338, 10.1113/jphysiol.1949.sp004443 Laser, 1945, Crystalline haemolytic substance from normal blood, Nature, Lond., 156, 507, 10.1038/156507a0 Laser, 1975, Malaria, quinine and red cell lysis, Parasitology, 71, 167, 10.1017/S003118200004662X Lee, 1968, Synthesis and pharmacology of p-methoxycinnamic acid derivatives, J. med. Chem., 11, 1262, 10.1021/jm00312a609 Lerner, 1955, Isolation of homogeneous melanocyte stimulating hormone from hog pituitary gland, J. Am. chem. Soc., 77, 1066, 10.1021/ja01609a098 Lin, 1972, The antipyretic effect of sodium acetylsalicylate on pyrogen-induced fever in rabbits, J. Pharmac. exp. Ther., 180, 603 Lipton, 1980, Central administration of peptides alters thermoregulation in the rabbit, Peptides, 1, 15, 10.1016/0196-9781(80)90029-7 Lipton, 1981, ACTH and α-melanotropin in central temperature control, 40, 2760 Liu, 1979, Structure and reaction of arteannuin, Hua Hsueh Hsueh Pao. (Acta chim. sin.), 37, 129 Lombardino, 1974, Enolic acids with antiinflammatory activity, Vol. 1, 129 Lombardino, 1972, Sudoxicam and related N-heterocyclic carboxamides of 4-hydroxy-2H-1,2-benzothiazine-1,1-dioxide. Potent nonsteroidal inflammatory agents, J. med. Chem., 15, 848, 10.1021/jm00278a016 Lombardino, 1975, Acidic antiinflammatory agents—correlation of some physical, pharmacological and clinical data, Arzneimittel-Forsch., 25, 1629 Lombardino, 1973, Potent anti-inflammatory N-heterocyclic 3-carboxamides of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-1,1-dioxide, J. med. Chem., 16, 493, 10.1021/jm00263a017 Mackerras, 1949, Some observations on the action of quinine, atebrin and plasmoquin on Plasmodium vivax, Trans. R. Soc. trop. Med. Hyg., 42, 443, 10.1016/0035-9203(49)90050-4 MacPherson, 1959, The effect of fever on temperature regulation in man, Clin. Sci., 18, 281 Marazzi-Uberti, 1966, α-Isopropyl-α-(2-dimethylaminoethyl)-1-naphthylacetamide(naphthypramide, DA 992): a new antiinflammatory agent. I. Antiinflammatory activity and acute toxicity, Archs int. Pharmacodyn. Thér., 162, 378 Marmo, 1974, Experimentation of an anti-reactional, antalgic and antipyretic drug (2-phenyl-4-chlorophenylthiazol-5-yl acetic acid), Gazz. med. ital., Milano, 133, 337 Martel, 1974, Antiinflammatory properties of furobufen, Can. J. Physiol. Pharmacol., 52, 669, 10.1139/y74-085 McKendrick, 1874, On the physiological action of chinoline and pyridine bases, 23, 290 Meredith, 1981, The epidemiology of acute acetaminophen poisoning in England and Wales, Archs. intern. Med., 141, 397, 10.1001/archinte.1981.00340030129024 Merkel, 1884, Kairin als Antipyreticum, Dt. Arch. klin. Med., 34, 100 Messer, 1967, Synthése des acides (méthyl-10-phenothiazinyl)acétiques, C.r. hebd. Séanc. Acad. Sci.(C.), Paris, 265, 758 Messer, 1969, Acidic derivatives of phenothiazin, Arzheimittel-Forsch., 19, 1193 Meyer, 1948, The antirheumatic effect of sodium gentisate, Science, 108, 281, 10.1126/science.108.2802.281 Mielke, 1976, Hemostasis, antipyretics, and mild analgesics. Acetaminophen vs. aspirin, J. Am. med. Ass., 235, 613, 10.1001/jama.1976.03260320021016 Milne, 1963, The toxicity of salicylates, 248 Milton, 1976, Modern views on the pathogenesis of fever and the modes of action of antipyretic drugs, J. Pharm. Pharmac., 28, 393, 10.1111/j.2042-7158.1976.tb04186.x Milton, 1982, Prostaglandins in fever and the mode of action of antipyretic drugs, Vol. 60, 257 Milton, 1982, Protein synthesis and fever, Vol. 60, 305 Milton, 1968, The effect of 4-acetamidophenol in reducing fever produced by the intracerebral injection of 5-hydroxytryptamine and pyrogen in the conscious cat, Br. J. Pharmac., 34, 215 Milton, 1970, A possible role for prostaglandin E1 as a modulator for temperature regulation in the central nervous system of the cat, J. Physiol., Lond., 207, 76 Milton, 1971, Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits, J. Physiol., Lond., 218, 325, 10.1113/jphysiol.1971.sp009620 Morton, 1950, The haemolytic acid present in horse brain, Biochem. J., 47, 327, 10.1042/bj0470327 Mühlens, 1926, Die Behandlung der naturlichen menschlichen Malaria—infection mit Plasmochin, Arch. Schiffs-u. Tropenhyg., 30 Mühlens, 1926, Beih, 3, 25 Murphy, 1982, Peripheral administration of α-MSH reduces fever in older and younger rabbits, Peptides, 3, 775, 10.1016/0196-9781(82)90014-6 Murphy, 1974, Further purification of rabbit leukocyte pyrogen, J. lab. clin. Med., 83, 310 Murry, 1983, Antipyretic potency of centrally administered α-melanocyte stimulating hormone, Science, 221, 192, 10.1126/science.6602381 Myers, 1974, Fever produced by endotoxin injected into the hypothalamus of the monkey and its antagonism by salicylate, J. Physiol., Lond., 243, 167, 10.1113/jphysiol.1974.sp010748 Nakamura, 1970, Pharmacological studies of a new antiinflammatory drug, 1-pheylsulfonyl-5,5-diphenylhydantoin (PG-796) in experimental animals. I. Antiinflammatory, analgesic and antipyretic activity, Arzneimittel-Forsch., 20, 1032 Nannini, 1973, New analgesic-antiinflammatory drugs, Arzheimittel-Forsch., 23, 1090 Nickander, 1971, Antiinflammatory and analgesic effects of fenoprofen, 30, 563 Nicolaier, 1908, Ueber Wirkung von Chinolincarbonsäuren und ihrer Derivate auf die Ausscheidung von Harnsäure, Dt. Arch. klin. Med., 93, 331 Niemegeers, 1975, The antipyretic effect of suprofen in rats with yeast-induced fever, Arzneimittel-Forsch., 25, 1519 Niemegeers, 1964, Effect of various drugs on carrageenin-induced oedema in the rat hind paw, J. Pharm. Pharmac., 16, 810, 10.1111/j.2042-7158.1964.tb07414.x Noguchi, 1971, 6-Chloro-5-cyclohexylinden-1-carboxylic acid (TAI-284), a new antiinflammatory agent, Chem. pharm. Bull., Tokyo, 19, 646, 10.1248/cpb.19.646 Nuss, 1976, The antiphlogistic, antinociceptive and antipyretic properties of fenclorac, Agents Actions, 6, 735, 10.1007/BF02026097 Openshaw, 1953, The quinazoline alkaloids, 101, 10.1016/S1876-0813(08)60140-2 Orme, 1982, Plasma concentrations and therapeutic effect of anti-inflammatory and anti-rheumatic drugs, Pharmac. Ther., 16, 167, 10.1016/0163-7258(82)90052-3 Pala, 1966, Synthesis and pharmacological evaluation of α-substituted 1-naphthylacetic acids, J. med. Chem., 9, 603, 10.1021/jm00322a037 Pala, 1965, Structure-activity relationships in antiinflammatory and analgesic compounds chemically related to α-isopropyl-2-(2-dimethyl-aminoethyl)-1- naphthylacetamide, J. med. Chem., 8, 698, 10.1021/jm00329a033 Pelletier, 1820, Recherches chimiques sur les quinquinas, Annls Chim. Phys., 15, 289 Pelletier, 1820, Suite des recherches chimique sur les quinquinas, Annls Chim. Phys., 15, 337 Perlow, 1975, A primate model for the study of human fever, J. infect. Dis., 132, 157, 10.1093/infdis/132.2.157 Pertwee, 1982, Therapeutic agents affecting body temperature, Vol. 60, 377 Peters, 1973, Antimalarial drugs and their actions, Post-grad. med. J., 49, 573, 10.1136/pgmj.49.574.573 Pircio, 1972, Pharmacology of a new non-steroidal antiinflammatory agent 5-cyclohexylindan-1-carboxylic acid, Archs int. Pharmacodyn. Thér., 199, 151 Ramey, 1976, The effect of aspirin and indomethacin on the TRH response in man, J. clin. Endocr. Metab., 43, 107, 10.1210/jcem-43-1-107 Randall, 1976, Analgesic and antiinflammatory activity of 6-chloro-α-methyl-carbazole-2-acetic acid (C-5720), Archs int. Pharmacodyn. Thér., 220, 94 Rehns, 1901, D'une nécrose typique de la papille rénale determinée par la tétrahydroquinoléine et certains de ses dérivés, Archs int. Pharmacodyn. Thér., 8, 199 Reid, 1951, Sodium γ-resorcylate in rheumatic fever, Br. med. J., 2, 321, 10.1136/bmj.2.4727.321 Reisner, 1977, Pharmacological properties of 2,3-dihydro-9H-isoxazolo[3,2-b]quinazolin-9-one (W-2429), Arzneimittel-Forsch., 27, 766 Reisner, 1977, Sythhesis and anti-inflammatory activity of 3,3a-dihydro-2H,9H-isoxazolo[3,2-b][1,3]benzoxazin-9-ones and related compounds, Arzneimittel-Forsch., 27, 760 Reynolds, 1982, The pyrogenic responses of non-mammalian vertebrates, Vol. 60, 649 Richter, 1891, Experimentaluntersuchungen über Antipyrese und Pyrese, nervöse und künstliche Hyperthermie, Arch. path. Anat., 123, 118, 10.1007/BF01881933 Rieckmann, 1971, Effects of tetracycline against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum, Am. J. trop. Med. Hyg., 20, 811, 10.4269/ajtmh.1971.20.811 Riess, 1883, Ueber die antipyretische Wirkung des Kairin, Berl. klin. Wschr., 20, 817 Riley, 1960, The effect of Plasmodium berghei malaria on mouse liver mitochondria, Biochem. J., 76, 41, 10.1042/bj0760041 Riley, 1961, A factor in the serum of malaria-infected animals capable of inhibiting the in vitro oxidative metabolism of normal liver mitochondria, Ann. trop. Med. Parasit., 55, 489, 10.1080/00034983.1961.11686078 Roehl, 1926, Die Wirkung des Plasmochins auf die Vogelmalaria, Arch. Schiffs-u. Tropenhyg., 30 Roehl, 1926, Beih, 3, 11 Rohde, 1920, Pyridin, chinolin, chinin, chininderivate, Bd. 20, 1 Rollo, 1965, Drugs used in the chemotherapy of malaria, 1107 Rollo, 1980, Drugs used in the chemotherapy of malaria, 1038 Rooks, 1979, The analgesic and antiinflammatory profile of (±)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid (DPP), 38, 1115 Rosendorff, 1968, Effects of salicylate on human temperature regulation, Clin. Sci., 35, 81 Roszkowski, 1971, Antiinflammatory and analgesic properties of d-2(6′-methoxy-2′-naphtyl)propionic acid (Naproxen), J. Pharmac. exp. Ther., 179, 114 Russell, 1960, Antimalarials, 814 Russell, 1943, Malaria and its influence on world health, Bull. N.Y. Acad. Med., 19, 599 Schellenberg, 1961, The influence of antimalarial drugs on nucleic acid synthesis in Plasmodium gallinaceum and Plasmodium berghei, Biochem. Pharmac., 6, 143, 10.1016/0006-2952(61)90158-7 Schlievert, 1978, Effects of antipyretics on group A streptococcal pyrogenic exotoxin fever production and ability to enhance lethal endotoxin shock, 114, 376 Schmid, 1983, Total synthesis of qinghaosu, J. Am. chem. Soc., 105, 624, 10.1021/ja00341a054 Schmidt, 1949, Development of resistance to chlorguanide (Paludrine) during treatment of infections with Plasmodium cynomolgi, J. Pharmac. exp. Ther., 95, 382 Schulemann, 1932, Synthese des Plasmochin, Klin. Wschr., 11, 381, 10.1007/BF01759885 Senda, 1972, Pyrimidine derivatives and related compounds. 15. Synthesis and analgesic and antiinflammatory activities of 1,3-substituted-5-amino-6-methyluracil derivatives, J. med. Chem., 15, 471, 10.1021/jm00275a008 Shannon, 1948, Studies on the chemotherapy of the human malarias. I. Method for the quantitative assay of suppressive antimalarial action in vivax malaria, J. clin. Invest., 27, 66, 10.1172/JCI101975 Shen, 1967, Antiinflammatory arylacetic acid derivatives, Chim. Ther., 2, 459 Shen, 1977, Clinical and biological studies on indomethacin, sulindac and their analogs, Adv. Drug Res., 12, 89, 10.1016/B978-0-12-013312-3.50007-8 Shen, 1963, Nonsteroid antiinflammatory agents, J. Am. Chem. Soc., 85, 488, 10.1021/ja00887a038 Siegert, 1976, Mechanism of fever induction in rabbits, Infect. Immunity, 14, 1130, 10.1128/IAI.14.5.1130-1137.1976 Similä, 1977, Oral antipyretic therapy. Evaluation of mefenamic acid (short communication), Arzheimittel-Forsch., 27, 687 Sioli, 1926, Prüfung des Plasmochins bei der Impfmalaria der Paralytiker, Arch. Schiffs-u. Tropenhyg., 30 Sioli, 1926, Beih, 3, 19 Skraup, 1885, Über das Parachinanisol, Mh. Chem., 6, 760 Smith, 1916, The comparative pharmacologic action of ethylhydrocuprein (optochin) and quinine, J. Pharmac. exp. Ther., 8, 53 Smith, 1963, Salicylates and intermediary metabolism, 47 Snell, 1957, Properties of human endogenous pyrogen, Clin. Sci., 16, 615 Sobański, 1974, Carrageenin hyperthermia in rats, Experientia, 30, 1326, 10.1007/BF01945211 Sofia, 1974, Pharmacology of a new non-steroidal anti-inflammatory agent 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one(W-2395), Eur. J. Pharmacol., 26, 51, 10.1016/0014-2999(74)90073-9 Sollmann, 1942, 601 Steele, 1972, Oral antipyretic therapy: evaluation of aspirin acetaminophen combination, Am. J. Dis. Child, 123, 204, 10.1001/archpedi.1972.02110090074006 Stenzl, 1950, 3-Amino-5-pyrazolones, Helv. Chim. Acta, 33, 1183, 10.1002/hlca.19500330509 Stitt, 1979, Fever versus hyperthermia, 38, 39 Stockman, 1912, The therapeutic action of cresotinic acid, J. Pharmac. exp. Ther., 4, 97 Stone, 1977, Pharmacology and toxicology of diflunisal, Br. J. clin. Pharmacol., 4, 19S, 10.1111/j.1365-2125.1977.tb04510.x Stühlinger, 1899, Ueber die Einwirkung einiger antipyretischer Mittel auf den Wärmehaushalt gesunder und kranker Thiere, Arch. exp. Path. Pharmak., 43, 166, 10.1007/BF01961150 Sweeney, 1979, Antimalarials, 333 Swingle, 1975, Antiinflammatory activity of α-methyl-3-phenyl-7-benzofuranacetic acid (R-803), Archs int. Pharmacodyn. Thér., 214, 240 Szmuskovicz, 1966, Synthesis and antiinflammatory activity of 2,3-bis(p-methoxyphenyl)indole and related compounds, J. med. Chem., 9, 527, 10.1021/jm00322a020 Takesue, 1976, The antiinflammatory profile of praquazone, Archs int. Pharmacodyn. Thér., 221, 122 Talbott, 1967 Thompson, 1972, Vol. 12 Tiku, 1983, Polymorphonuclear leukocyte derived interleukin-1 activity, Arthritis Rheum., 26 Trenholme, 1975, Mefloquine (WR 142, 490) in the treatment of human malaria, Science, 190, 792, 10.1126/science.1105787 Tricerri, 1979, Synthesis and preliminary pharmacological data on zidometacin, a new anti-inflammatory compound, Eur. J. med. Chem., 14, 181 Tsukada, 1978, Pharmacological study of 6,11-dihydro-11-oxodibenz[b,e]oxepin-3-acetic acid (oxepinac): a new anti-inflammatory drug, Arzneimittel-Forsch., 28, 428 U.S. Bureau of the Census, 1980, Statistical Abstract of the United States: 1980 Unterhalt, 1970, Untersuchungen an neueren Antiphlogistica, Arch. Pharm. Berl., 303, 445, 10.1002/ardp.19703030509 Van Arman, 1978, Antiarthritics, Vol. 5, 1 Van Arman, 1975, Anti-inflammatory activity of thiabendazole and its relation to parasitic disease, Tex. Rep. Biol. Med., 33, 303 Van Arman, 1974, Antiinflammatory drugs and the behavior of leucocytes, 159 Van Arman, 1974, Experimental gouty synovitis caused by bacterial endotoxin adsorbed onto urate crystals, Arthritis Rheum., 17, 439, 10.1002/art.1780170415 Van Arman, 1976, Pharmacology of sulindac, 9 Vane, 1971, Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs, Nature New Biol., 231, 232, 10.1038/newbio231232a0 Vaughn, 1980, Fever and survival in a mammal: effects of central antipyresis, 115 Vignec, 1958, Antipyretic effectiveness of salicylamide and acetylsalicyclic acid in infants. A comparative study, J. Am. med. Ass., 167, 1821, 10.1001/jama.1958.02990320015005 Vital Statistic of the United States, 1950, Use categories E853.1, E950.1, E980.1, E970E, 970C, E872, depending upon which category was used in a particular year, for aspirin and other salicylates, Vol. II von Euler, 1961, Physiology and pharmacology of temperature regulation, Pharmac. Rev., 13, 361 von Euler, 1936, On the specific vasodilating and plain muscle stimulating substance from accessory genital glands in man and certain animals (prostaglandin and vesiglandin), J. Physiol. Lond., 88, 213, 10.1113/jphysiol.1936.sp003433 von Jaksch, 1884, Ueber die therapeutische Wirkung einiger neuer Chinolinbasen, Z. klin. Med., 8, 442 von Mering, 1884, Ueber das Schicksal des Kairin im menschlichen Organismus, Z. klin. Med., 7, 149 von Mering, 1893, Ueber die Function des Magens, Ther. Mh., 7, 201 von Öttingen, 1933, The Therapeutic Agents of the Quinoline Group Watnick, 1971, Antiinflammatory and analgesic properties of clonixin[2-(2-methyl-3-chloroanilino)nicotinic acid], Archs int. Pharmacodyn. Thér., 190, 78 Willies, 1980, The site of action of corticosteroid antipyresis in the rabbit, J. Physiol. Lond., 300, 1, 10.1113/jphysiol.1980.sp013146 Winder, 1962, Anti-inflammatory, antipyretic and antinociceptive of N-(2,3-xylyl)antranilic acid(mefenamic acid), J. Pharmac. exp. Ther., 138, 405 Winter, 1965, Antiinflammatory testing method: Comparative evaluation of indomethacin and other agents, Int. Congr. Ser., 82, 190 Winter, 1965, Reaction thresholds to pressure in edematous hind paws of rats and responses to analgesic drugs, J. Pharmac. exp. Ther., 150, 165 Winter, 1962, Carrageeenan-induced edema in hind paw of the rat as an assay for antiinflammatory drugs, 111, 544 Winter, 1963, Antiinflammatory and antipyretic properties of indomethacin, 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid, J. Pharmac. exp. Ther., 141, 369 Woo, 1963, Pharmacologically aive component in Scrophularia root, p-methoxycinnamic acid. I. Identification of p-methoxycinnamic acid and its antipyretic action, Yakhak Hoe Chi, 7, 55 Woodward, 1944, Thiophane derivatives, J. Am. chem. Soc., 66, 849 Woodward, 1945, The total synthesis of quinine, J. Am. chem. Soc., 67, 860, 10.1021/ja01221a051 1983, 745 World Health Organization, 1963, Terminology of Malaria and Malaria Eradication Yaffe, 1981, Comparative efficacy of aspirin and acetaminophen in the reduction of fever in children, Archs intern. Med., 141, 286, 10.1001/archinte.1981.00340030018005 Zimmer, 1981, Central and peripheral injections of ACTH (1–24) reduce fever in adrenalectomized rabbits, Peptides, 2, 413, 10.1016/S0196-9781(81)80097-6 Zuckerman, 1964, Autoimmunization and other types of indirect damage to host cells as factors in certain protozoan diseases. Parasitological review, Expl Parasit., 15, 138, 10.1016/0014-4894(64)90014-1