Antihypercholesterolaemic effect of ginger rhizome (Zingiber officinale) in rats

El-Sayed M. ElRokh1, Nemat A. Yassin2, Siham M. El‐Shenawy2, Bassant M. M. Ibrahim2
1Department of Pharmacology, Faculty of Medicine, Cairo University, Cairo, Egypt
2National Research Centre

Tóm tắt

Từ khóa


Tài liệu tham khảo

Afshari AT, Shirpoor A, Farshid A, Saadatian R, Rasmi Y, Saboory E et al (2007) The effect of ginger on diabetic nephropathy, plasma antioxidant capacity and lipid peroxidation in rats. Food Chem 101:148–153

Belinky PA, Aviram M, Fuhrman B, Rosenblat M, Vaya J (1998) The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation. Atherosclerosis 137:49–61

Benzie IFF, Szeto YT (1999) Total antioxidant capacity of teas by the ferric reducing/antioxidant power assay. J Agric Food Chem 47:633–636

Bhandari U, Sharma JN, Zafar R (1998) The protective action of ethanolic ginger extract in cholesterol-fed rabbits. J Ethnopharmacol 61:167–171

Bhandari U, Kanojiah R, Pillai KK (2005) Effect of ethanol extract of Zingiber officinale on dyslipidaemia in diabetic rats. J Ethnopharmacol 97(2):227–230

Budhiraja RD, Sudhir S (1987) Review of biological activity of withanolides. J Sci Ind Res 46:488–491

Durrington P (2003) Dyslipidaemia. Lancet 362(9385):717–731

Elam MB, Hunninghake DB, Davis KB, Garg R, Johnson C, Egan D, Kostis JB, Sheps DS, Brinton EA (2000) Effect of niacin on lipid and lipoprotein levels and glycaemic control in patients with diabetes and peripheral arterial disease. The ADMIT Study: a randomized trial. JAMA 284:1263–1270

Flegg HM (1973) An investigation for the determination of serum cholesterol by an enzyme method. Ann Clin Biochem 10:79–84

Freidwald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifugation. Clin Chem 18:499–502

Gardia G, Gressorial D, Impedovo G, Lillo A, Regina G (1990) Plasma lipids as a risk factor in peripheral vascular disease. Angelology 41(1):19–22

Gimeno-Orna JA, Faure-Nogueras E, Sancho-Serrano MA (2005) Usefulness of total cholesterol/HDL-cholesterol ratio in the management of diabetic dyslipidaemia. Diabetes Med 22(1):26–31

Govindarajan VS (1982) Ginger: chemistry, technology and quality evaluation. Part I. Crit Rev Food Sci Nutr 17:1–69

Gruenwald J, Brendler T, Jaenicke C (2000) PDR for herbal medicines, 2nd edn. Medical Economics Company, Inc, Montvale, NJ

Langner E, Greifenberg S, Gruenwald J (1998) Ginger: history and use. Adv Ther 15:25–44

Liu N, Huo G, Zhang L, Zhang X (2003) Effect of Zingiber officinale Rosc on lipid peroxidation in hyperlipidemia rats. Wei Sheng Yan Jiu 32(1):22–23

Mary JM, John PK (2000) Agents used in hyperlipidaemia. In: Katzung BG (ed) Basic and clinical pharmacology, 8th edn. McGraw Hill Comp, New York, pp 581–595

Murcia M, Egea I, Romojaro F, Parras P, Jimenez A, Martinez-Tome M (2004) Antioxidant evaluation in dessert spices compared with common food additives. Influence of irradiation procedure. J Agric Food Chem 52:1872–1881

Ness GC, Zhao Z, Lopez D (1996) Inhibitor of cholesterol biosynthesis increase hepatic low density lipoprotein receptor protein degradation. Arch Biochem Biophys 325:242–248

Ney DM, Lasekan JB, Shinnick FL (1988) Soluble oat fibre tends to normalize lipoprotein composition in cholesterol fed rats. J Nutr 118(12):1455–1462

NIH Guide for the Care and Use of Laboratory Animals. (a) DHEW Publication No. (NIH) 8-23, revised 1978 and (b) NIH Publication No. 85-23, revised 1985. US Department of Health, Education and Welfare

Paget GE, Barnes JM (1964) Toxicity test. In: Laurence DR, Bacharach AL (eds) Evaluation of drug activities: pharmacometrics. Academic Press, London, pp 135–166

Platel K, Srinivasan K (2000) Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats. Nahrung 1:42–46

Reddy AA, Lokesh BR (1992) Studies of spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes. Mol Cell Biochem 111:117–124

Samra G (2001) Healthy hearts and hypoglycemic. Hypoglycemic Health Newslett 17(2):3–6

Sharma RD (1980) Effect of hydroxy acids on hypercholesterolemia in rats. Atherosclerosis 37:463–468

Soni KB, Rajan A, Kuttan R (1992) Reversal of aflatoxin induced liver damage by turmeric and curcumin. Cancer Lett 66:115–121

Srinivasan K, Sambaiah K (1991) The effect of spices on cholesterol 7a-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. Int J Vit Nutr Res 61(4):364–369

Tanabe M, Chen YD, Saits K, Kano Y (1993) Cholesterol biosynthesis inhibitory component from Zingiber officinale Roscoe. Chem Pharm Bull 41:710

Wahlefeld AW (1974) Enzymatic determination of triglycerides. In: Bergmeyer HU (ed) Methods of enzymatic analysis, vol 5. Academic Press, New York, pp 1831–1835

Watanabe (1958) Volatile components of mulberry leave. J Seri Sci Japan 20:448–452

Wieland H, Seidel D (1983) A simple specific method for precipitation of low density lipoproteins. J Lipid Res 24(7):904–909

Yen G, Chang Y, Su S (2003) Antioxidant activity and active compounds of rice koji fermented with Aspergillus candidus. Food Chem 83:49–52