Annexin II and Regulation of Cell Surface Fibrinolysis

Annals of the New York Academy of Sciences - Tập 902 Số 1 - Trang 265-271 - 2000
Katherine A. Hajjar1, Suchitra S. Acharya1
1Departments of Pediatrics and Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA

Tóm tắt

Abstract: The regulated function of the fibrinolytic system is fundamental to the solubilization of fibrin‐containing thrombi and to a number of other biologic processes. In recent years, several receptors, which serve to localize proteolytic activity on the cell surface, have been identified on endothelial cells, blood cells, neuronal cells, and tumor cells. One such receptor is annexin II, a calcium‐ and phospholipid‐binding protein that serves as a profibrinolytic coreceptor for tissue plasminogen activator and plasminogen on endothelial cells. Accumulating evidence suggests that impaired cell surface fibrinolytic assembly could lead to progressive atherothrombotic disease. In addition, dysregulation of annexin II expression in acute promyelocytic leukemia is an important mechanism for the bleeding diathesis associated with this malignancy.

Từ khóa


Tài liệu tham khảo

Hajjar K.A. 1998. The molecular basis of fibrinolysis.InHematology of Infancy and Childhood. D.G. Nathan & S.H. Orkin Eds.: 1557–1573. W.B. Saunders Co. Philadelphia.

10.1083/jcb.94.3.631

10.1073/pnas.74.9.3903

10.1016/S0021-9258(18)67293-X

10.1172/JCI113262

Hajjar K.A., 1990, Identification and characterization of human endothelial cell membrane binding sites for tissue plasminogen activator and urokinase, J. Biol. Chem., 265, 2908, 10.1016/S0021-9258(19)39887-4

Hajjar K.A., 1991, The endothelial cell tissue plasminogen activator receptor: specific interaction with plasminogen, J. Biol. Chem., 266, 21962, 10.1016/S0021-9258(18)54731-1

Hajjar K.A., 1994, An endothelial cell receptor for plasminogen and tissue plasminogen activator: I, Identity with annexin II. J. Biol. Chem., 269, 21191

10.1016/0092-8674(86)90736-1

10.1016/0304-4157(94)90019-1

10.1146/annurev.bb.23.060194.001205

10.1002/jcb.240530311

10.1083/jcb.126.2.539

10.1091/mbc.7.6.883

10.1111/j.1600-0897.1996.tb00155.x

10.1128/JVI.69.8.4784-4791.1995

10.1099/0022-1317-77-9-2297

10.1074/jbc.271.35.21652

Cesarman G.M., 1994, An endothelial cell receptor for plasminogen/tissue plasminogen activator: II, Annexin II-mediated enhancement of t-PA-dependent plasminogen activation. J. Biol. Chem., 269, 21198

10.1074/jbc.273.8.4790

10.1021/bi981713l

10.1074/jbc.273.16.9987

10.1038/330132a0

10.1038/339303a0

Mudd H. H.L. Levy & F. Skovby. 1995. Disorders of transsulfuration.InThe Metabolic and Molecular Basis of Inherited Disease. C.R. Scriver A.L. Beaudet W.S. Sly & D. Valle Eds.: 1279–1327. McGraw‐Hill Inc. New York.

Mudd H., 1985, The natural history of homocystinuria due to cystathionine β‐synthase deficiency, Am. J. Hum. Gen., 37, 1

10.1172/JCI116532

Dombret H., 1993, Coagulation disorders associated with acute promyelocytic leukemia: corrective effect of all‐trans retinoic acid treatment, Leukemia, 7, 2

Dombret H., 1995, in vivo thrombin and plasmin activities in patients with acute promyelocytic leukemia (APL): Effect of all‐transretinoic acid (ATRA) therapy, Leukemia, 9, 19

10.1056/NEJM199904013401303

Thông tin
Thông tin xuất bản

Annals of the New York Academy of Sciences

Tập 902 Số 1

265-271

Thông tin tác giả