An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

Alam, 1999, Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene, J. Biol. Chem., 274, 26071, 10.1074/jbc.274.37.26071

Anderson, 1985, Determination of glutathione and glutathione disulfide in biological samples, Meth. Enzymol., 113, 548, 10.1016/S0076-6879(85)13073-9

Applegate, 1991, Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells, Cancer Res., 51, 974

Arndt, 1986, GCN4 protein, a positive transcription factor in yeast, binds general control promoters at all 5′ TGACTC 3′ sequences, Proc. Natl. Acad. Sci. USA, 83, 8516, 10.1073/pnas.83.22.8516

Barbosa-Tessmann, 1999, Activation of the unfolded protein response pathway induces human asparagine synthetase gene expression, J. Biol. Chem., 274, 31139, 10.1074/jbc.274.44.31139

Bertolotti, 2000, Dynamic interaction of BiP and the ER stress transducers in the unfolded protein response, Nat. Cell Biol., 2, 326, 10.1038/35014014

Brostrom, 1996, Inhibition of translational initiation by activators of the glucose-regulated stress protein and heat shock protein stress response systems. Role of the interferon-inducible double-stranded RNA-activated eukaryotic initiation factor 2α kinase, J. Biol. Chem., 271, 24995, 10.1074/jbc.271.40.24995

Cabibbo, 2000, ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum, J. Biol. Chem., 275, 4827, 10.1074/jbc.275.7.4827

Calfon, 2002, IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA, Nature, 415, 92, 10.1038/415092a

Casagrande, 2000, Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway, Mol. Cell, 5, 729, 10.1016/S1097-2765(00)80251-8

Cuozzo, 1999, Competition between glutathione and protein thiols for disulphide-bond formation, Nat. Cell Biol., 1, 130, 10.1038/11047

Delepine, 2000, EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome, Nat. Genet., 25, 406, 10.1038/78085

Dever, 2002, Gene-specific regulation by general translation factors, Cell, 108, 545, 10.1016/S0092-8674(02)00642-6

Fauchon, 2002, Sulfur sparing in the yeast proteome in response to sulfur demand, Mol. Cell, 9, 713, 10.1016/S1097-2765(02)00500-2

Fawcett, 1999, Complexes containing activating transcription factor (ATF)/cAMP- responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response, Biochem. J., 339, 135, 10.1042/0264-6021:3390135

Ferri, 2001, Organelle-specific initiation of cell death pathways, Nat. Cell Biol., 3, E255, 10.1038/ncb1101-e255

Frand, 1998, The ERO1 gene of yeast is required for oxidation of protein dithiols in the endoplasmic reticulum, Mol. Cell, 1, 161, 10.1016/S1097-2765(00)80017-9

Frerichs, 1998, Suppression of protein synthesis in brain during hibernation involves inhibition of protein initiation and elongation, Proc. Natl. Acad. Sci. USA, 95, 14511, 10.1073/pnas.95.24.14511

Friedlander, 2000, A regulatory link between ER-associated protein degradation and the unfolded-protein response, Nat. Cell Biol., 2, 379, 10.1038/35017001

Griffith, 1980, Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine, Anal. Biochem., 106, 207, 10.1016/0003-2697(80)90139-6

Harding, 2000, Regulated translation initiation controls stress-induced gene expression in mammalian cells, Mol. Cell, 6, 1099, 10.1016/S1097-2765(00)00108-8

Harding, 2000, Perk is essential for translational regulation and cell survival during the unfolded protein response, Mol. Cell, 5, 897, 10.1016/S1097-2765(00)80330-5

Harding, 2001, Diabetes Mellitus and excocrine pancreatic dysfunction in Perk−/− mice reveals a role for translational control in survival of secretory cells, Mol. Cell, 7, 1153, 10.1016/S1097-2765(01)00264-7

Hayes, 1999, Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress, Free Radic. Res., 31, 273, 10.1080/10715769900300851

Hayes, 2001, Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention, Cancer Lett., 174, 103, 10.1016/S0304-3835(01)00695-4

He, 2001, Identification of activating transcription factor 4 (ATF4) as a Nrf2 interacting protein: Implication for heme oxygenase-1 gene regulation, J. Biol. Chem., 276, 20858, 10.1074/jbc.M101198200

Hekimi, 2001, Why only time will tell, Mech. Ageing Dev., 122, 571, 10.1016/S0047-6374(01)00218-4

Held, 1996, Role of Fenton chemistry in thiol-induced toxicity and apoptosis, Radiat. Res., 145, 542, 10.2307/3579272

Hettmann, 2000, Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor, Dev. Biol., 222, 110, 10.1006/dbio.2000.9699

Hinnebusch, 1986, The general control of amino acid biosynthetic genes in the yeast Saccharomyces cerevisiae, CRC Crit. Rev. Biochem., 21, 277, 10.3109/10409238609113614

Hinnebusch, 1993, Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2, Mol. Microbiol., 10, 215, 10.1111/j.1365-2958.1993.tb01947.x

Hinnebusch, 1997, Translational regulation of yeast GCN4. A window on factors that control initiator-tRNA binding to the ribosome, J. Biol. Chem., 272, 21661, 10.1074/jbc.272.35.21661

Hinnebusch, 2000, Mechanism and regulation of initiator methionyl-tRNA binding to ribosomes, 185

Honda, 2002, Oxidative stress and life span determination in the nematode Caenorhabditis elegans, Ann. N Y Acad. Sci., 959, 466, 10.1111/j.1749-6632.2002.tb02117.x

Ishii, 1996, Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress, Biochem. Biophys. Res. Commun., 226, 456, 10.1006/bbrc.1996.1377

Kopito, 1997, ER quality control: the cytoplasmic connection, Cell, 88, 427, 10.1016/S0092-8674(00)81881-4

Korsmeyer, 1995, Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family, Biochim. Biophys. Acta, 1271, 63, 10.1016/0925-4439(95)00011-R

Lockhart, 1996, Expression monitoring by hybridization to high-density oligonucleotide arrays, Nat. Biotechnol., 14, 1675, 10.1038/nbt1296-1675

Mezghrani, 2001, Manipulation of oxidative protein folding and PDI redox state in mammalian cells, EMBO J., 20, 6288, 10.1093/emboj/20.22.6288

Natarajan, 2001, Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast, Mol. Cell. Biol., 21, 4347, 10.1128/MCB.21.13.4347-4368.2001

Ng, 2000, The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control, J. Cell Biol., 150, 77, 10.1083/jcb.150.1.77

Novoa, 2001, Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α, J. Cell Biol., 153, 1011, 10.1083/jcb.153.5.1011

Okada, 2002, Distinct roles of ATF6 and PERK in transcription during the mammalian unfolded protein response, Biochem. J., 366, 585, 10.1042/bj20020391

Plemper, 1999, Retrograde protein translocation: ERADication of secretory proteins in health and disease, Trends Biochem. Sci., 24, 266, 10.1016/S0968-0004(99)01420-6

Pollard, 1998, Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum, Mol. Cell, 1, 171, 10.1016/S1097-2765(00)80018-0

Qiu, 2002, Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2, Genes Dev., 16, 1271, 10.1101/gad.979402

Rao, 2002, Coupling endoplasmic reticulum stress to the cell death program: An Apaf-1-independent intrinsic pathway, J. Biol. Chem., 277, 21836, 10.1074/jbc.M202726200

Ron, 2000, PERK and translational control by stress in the endoplasmic reticulum, 547

Scheuner, 2001, Translational control is required for the unfolded protein response and in vivo glucose homeostasis, Mol. Cell, 7, 1165, 10.1016/S1097-2765(01)00265-9

Sevier, 2001, A flavoprotein oxidase defines a new endoplasmic reticulum pathway for biosynthetic disulphide bond formation, Nat. Cell Biol., 3, 874, 10.1038/ncb1001-874

Shen, 2001, Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development, Cell, 107, 893, 10.1016/S0092-8674(01)00612-2

Shigenaga, 1994, Oxidative damage and mitochondrial decay in aging, Proc. Natl. Acad. Sci. USA, 91, 10771, 10.1073/pnas.91.23.10771

Tan, 2001, Regulation of antioxidant metabolism by translation initiation factor 2α, J. Cell Biol., 152, 997, 10.1083/jcb.152.5.997

Tortorella, 1998, Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential, J. Cell Biol, 142, 365, 10.1083/jcb.142.2.365

Travers, 2000, Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation, Cell, 101, 249, 10.1016/S0092-8674(00)80835-1

Tu, 2002, The FAD and O2-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum, Mol. Cell, 10, 983, 10.1016/S1097-2765(02)00696-2

Tu, 2000, Biochemical basis of oxidative protein folding in the endoplasmic reticulum, Science, 290, 1571, 10.1126/science.290.5496.1571

Wardman, 1996, Fenton chemistry: an introduction, Radiat. Res., 145, 523, 10.2307/3579270

Zamzami, 1995, Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death, J. Exp. Med., 182, 367, 10.1084/jem.182.2.367

Zhang, 2002, The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas, Mol. Cell. Biol., 22, 3864, 10.1128/MCB.22.11.3864-3874.2002