An Electron Microscopical Study of the Skin in 18 Cases of Xeroderma pigmentosum

Dermatology - Tập 146 Số 4 - Trang 211-221 - 1973
Claire Guerrier1, Marvin A. Lutzner1, V Devico1, M Pruniéras1
1Laboratoire de Recherches sur les Tumeurs de la Peau Humaine (Head: Prof. M. Prunieras), Fondation Ad. de Rothschild, Paris, and Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md., and Service de Dermatologie et de Vénéréologie (Head: Dr R. Rollier) Hôpital Averroès, Casablanca

Tóm tắt

The skin of 18 cases of xeroderma pigmentosum was examined electronmicroscopically. In all cases, the melanocytes were abnormal. They showed extensive melanosome polymorphism, the formation of large autophagic vacuoles; in eight cases, giant pigment granules of a unique character were present. There was passage of premelanosomes and giant pigment granules to keratinocytes. In a depigmented lesion, Langerhans’ cells were seen to be situated in the position normally occupied by melanocytes. Langerhans’ cells were also seen bearing large quantities of melanin.

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Dermatology

Tập 146 Số 4

211-221

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