AmpC β-Lactamases

Clinical Microbiology Reviews - Tập 22 Số 1 - Trang 161-182 - 2009
George A. Jacoby1
1Lahey Clinic, Burlington, Massachusetts

Tóm tắt

SUMMARYAmpC β-lactamases are clinically important cephalosporinases encoded on the chromosomes of many of the Enterobacteriaceae and a few other organisms, where they mediate resistance to cephalothin, cefazolin, cefoxitin, most penicillins, and β-lactamase inhibitor-β-lactam combinations. In many bacteria, AmpC enzymes are inducible and can be expressed at high levels by mutation. Overexpression confers resistance to broad-spectrum cephalosporins including cefotaxime, ceftazidime, and ceftriaxone and is a problem especially in infections due to Enterobacter aerogenes and Enterobacter cloacae, where an isolate initially susceptible to these agents may become resistant upon therapy. Transmissible plasmids have acquired genes for AmpC enzymes, which consequently can now appear in bacteria lacking or poorly expressing a chromosomal blaAmpCgene, such as Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. Resistance due to plasmid-mediated AmpC enzymes is less common than extended-spectrum β-lactamase production in most parts of the world but may be both harder to detect and broader in spectrum. AmpC enzymes encoded by both chromosomal and plasmid genes are also evolving to hydrolyze broad-spectrum cephalosporins more efficiently. Techniques to identify AmpC β-lactamase-producing isolates are available but are still evolving and are not yet optimized for the clinical laboratory, which probably now underestimates this resistance mechanism. Carbapenems can usually be used to treat infections due to AmpC-producing bacteria, but carbapenem resistance can arise in some organisms by mutations that reduce influx (outer membrane porin loss) or enhance efflux (efflux pump activation).

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Tài liệu tham khảo

Abraham, E. P., and E. Chain. 1940. An enzyme from bacteria able to destroy penicillin. Nature146:837.

Adler, H., L. Fenner, P. Walter, D. Hohler, E. Schultheiss, S. Oezcan, and R. Frei. 2008. Plasmid-mediated AmpC β-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes: prevalence at a Swiss university hospital and occurrence of the different molecular types in Switzerland. J. Antimicrob. Chemother.61:457-458.

10.1086/520214

10.1016/j.ijantimicag.2008.04.019

10.1128/jb.179.6.2006-2013.1997

10.1128/AAC.48.2.533-537.2004

10.1098/rstb.1980.0049

10.1128/AAC.47.3.1165-1168.2003

10.1093/jac/45.6.877

10.1093/jac/dkh077

10.1093/jac/46.5.695

10.1093/jac/dkh151

10.1093/jac/41.1.115

10.1093/genetics/164.1.23

10.1128/AAC.46.5.1190-1198.2002

10.1128/AAC.42.9.2352

10.1128/AAC.48.3.1040-1042.2004

10.1111/j.1574-6968.2001.tb10519.x

10.1128/JCM.43.5.2261-2265.2005

10.1007/BF01650718

10.1128/AAC.43.8.1924

10.1128/AAC.40.1.221

10.1128/AAC.40.8.1926

10.1128/jb.171.1.308-313.1989

10.1128/AAC.49.10.4240-4246.2005

10.1093/jac/dkm070

10.1371/journal.pone.0000947

10.1042/bj2090229

10.1128/JCM.02470-06

10.1128/AAC.45.10.2965-2968.2001

10.1128/jb.155.3.1297-1305.1983

10.1128/AAC.16.4.427

10.1128/jb.150.2.528-534.1982

10.1128/AAC.49.8.3562-3565.2005

10.1128/JCM.43.7.3110-3113.2005

10.1128/JCM.43.8.4168-4171.2005

10.1128/JCM.42.5.2203-2206.2004

Evaluation of two new Etest strips for AmpC detection 2006

10.1128/AAC.44.2.428-432.2000

10.1093/jac/44.5.607

10.1128/AAC.41.3.563

10.1128/AAC.01684-07

Brenwald, N. P., J. Andrews, and A. P. Fraise. 2006. Activity of mecillinam against AmpC β-lactamase-producing Escherichia coli. J. Antimicrob. Chemother.58:223-224.

10.1093/jac/dki278

10.1128/AAC.43.7.1743

10.1128/jb.116.1.123-130.1973

10.1128/AAC.39.6.1211

10.1128/AAC.37.4.851

10.1093/jac/46.6.895

10.1128/AAC.46.5.1269-1272.2002

Caroff, N., E. Espaze, I. Berard, H. Richet, and A. Reynaud. 1999. Mutations in the ampC promoter of Escherichia coli isolates resistant to oxyiminocephalosporins without extended spectrum β-lactamase production. FEMS Microbiol. Lett.173:459-465.

10.1093/jac/45.6.783

10.1093/jac/46.1.133

10.1021/ja056806m

10.1128/AAC.00167-07

10.1126/science.1099776

10.1128/AAC.01083-07

10.7326/0003-4819-115-8-585

10.1093/jac/28.4.499

10.1111/j.1432-1033.1987.tb13362.x

10.1093/jac/dkg407

10.1093/jac/dkm284

10.1001/archinte.162.2.185

10.1128/JCM.43.8.4163-4167.2005

10.1128/JCM.41.2.772-777.2003

10.1128/JCM.38.5.1791-1796.2000

10.1021/bi9908787

10.1093/jac/17.1.51

10.1128/AAC.50.2.618-624.2006

10.1016/j.diagmicrobio.2007.07.018

10.1128/jcm.31.1.123-127.1993

10.1128/AAC.45.12.3595-3598.2001

10.1016/j.ijantimicag.2006.07.025

10.1089/mdr.2005.11.371

10.1007/s10096-008-0532-4

10.1016/j.ijid.2006.07.008

10.1128/AAC.48.7.2652-2658.2004

10.1128/AAC.00619-06

Dubus, A., P. Ledent, J. Lamotte-Brasseur, and J. M. Frère. 1996. The roles of residues Tyr150, Glu272, and His314 in class C β-lactamases. Proteins25:473-485.

10.1001/jama.284.24.3151

10.3201/eid1406.071168

10.1128/AAC.00043-08

Evaluation of a new Etest strip for AmpC detection using a large collection of genotypically characterized strains 2008

10.1017/S0016672300011769

10.1128/jb.90.1.54-62.1965

10.1038/sj.jp.7211550

10.1093/infdis/134.3.290

10.1111/j.1432-1033.1997.00186.x

10.1056/NEJM200004273421703

Fihman, V., M. Rottman, Y. Benzerara, F. Delisle, R. Labia, A. Philippon, and G. Arlet. 2002. BUT-1: a new member in the chromosomal inducible class C β-lactamases family from a clinical isolate of Buttiauxella sp. FEMS Microbiol. Lett.213:103-111.

10.1093/jac/36.3.537

10.1099/mic.0.27629-0

10.1093/jac/47.2.207

10.1016/S0732-8893(01)00278-4

10.1016/S0378-1097(03)00253-2

10.1128/AAC.45.12.3509-3516.2001

10.1042/bj2920697

10.1093/jac/39.1.85

10.1042/bj2550123

10.1042/bj2550119

10.1042/bj2500753

10.1128/AAC.30.3.453

10.1128/jcm.35.2.508-510.1997

Gazouli, M., L. S. Tzouvelekis, A. C. Vatopoulos, and E. Tzelepi. 1998. Transferable class C β-lactamases in Escherichia coli strains isolated in Greek hospitals and characterization of two enzyme variants (LAT-3 and LAT-4) closely related to Citrobacter freundii AmpC β-lactamase. J. Antimicrob. Chemother.42:419-425.

10.1128/AAC.48.8.2845-2852.2004

10.1128/AAC.44.6.1470-1478.2000

10.1128/AAC.44.11.3220-3223.2000

10.1007/s10096-007-0370-9

10.1128/AAC.38.9.2150

10.1126/science.1066803

10.1093/jac/dki453

10.1128/AAC.48.8.3179-3181.2004

10.1086/379668

10.1128/AAC.00810-07

10.1093/jac/dkn257

10.1016/j.drup.2004.02.003

10.1128/AAC.00877-08

Hanson, N. D., and C. C. Sanders. 1999. Regulation of inducible AmpC β-lactamase expression among Enterobacteriaceae. Curr. Pharm. Des.5:881-894.

10.1093/jac/44.3.377

10.1007/BF02111340

10.1128/jb.179.19.6112-6121.1997

10.1111/j.1469-0691.2005.01320.x

10.1128/AAC.48.5.1670-1675.2004

10.1128/AAC.43.4.937

10.1093/jac/46.2.273

10.1093/jac/dki025

10.1093/jac/47.6.745

10.1093/jac/dkg406

10.1002/j.1460-2075.1986.tb04704.x

10.1093/jac/dkl414

10.1093/jac/25.suppl_A.49

10.1016/j.ijantimicag.2006.03.027

10.1016/j.ijantimicag.2006.03.020

10.1128/AAC.37.5.984

10.1093/jac/dkh240

10.1128/JCM.43.6.2608-2612.2005

10.1128/AAC.49.7.2941-2948.2005

10.1128/AAC.46.9.3045-3049.2002

10.1016/S0092-8674(00)81928-5

10.1002/j.1460-2075.1994.tb06792.x

10.1128/AAC.48.8.3203-3206.2004

10.1128/AAC.43.7.1759

10.1128/JCM.00062-06

10.1073/pnas.78.8.4897

10.1038/290221a0

10.1016/0092-8674(83)90067-3

10.1016/j.diagmicrobio.2008.01.017

10.1042/bj2390581

10.1128/AAC.35.11.2294

10.1128/AAC.49.11.4733-4738.2005

10.1128/AAC.50.5.1780-1787.2006

10.1128/AAC.00285-06

10.1128/JCM.43.6.2955-2958.2005

10.1093/jac/dkh462

10.1128/AAC.50.4.1590-1593.2006

10.1128/AAC.45.9.2628-2630.2001

Kazmierczak, A., X. Cordin, J. M. Duez, E. Siebor, A. Pechinot, and J. Sirot. 1990. Differences between clavulanic acid and sulbactam in induction and inhibition of cephalosporinases in enterobacteria. J. Int. Med. Res.18(Suppl. 4):67D-77D.

10.1111/j.1365-2958.2006.05146.x

10.1007/BF00172490

10.1007/BF02185845

10.1042/bj2010621

10.1016/S1074-5521(96)90182-9

10.1128/AAC.43.2.424

10.1128/AAC.49.11.4567-4575.2005

10.1128/AAC.44.3.561-567.2000

10.1128/AAC.50.4.1282-1286.2006

10.1128/AAC.49.5.1957-1964.2005

10.1128/AAC.35.6.1093

10.1016/j.diagmicrobio.2005.07.004

10.1089/mdr.2006.12.44

10.1016/j.ijantimicag.2006.09.006

10.1046/j.1365-2672.2003.02040.x

10.1128/AAC.00633-07

10.1128/JCM.00073-07

10.1128/AAC.46.1.216-219.2002

10.1089/107662904323047745

10.1016/j.bbrc.2004.11.065

10.1111/j.1432-1033.1986.tb09601.x

10.1111/j.1365-2958.1993.tb01731.x

10.1128/jb.101.1.218-231.1970

10.1128/AAC.43.4.882

10.1128/AAC.48.11.4136-4143.2004

10.1093/jac/dkn049

10.1007/BF02013107

10.1128/AAC.36.9.2046

10.1086/338782

10.1093/jac/dkl043

10.1016/j.tim.2006.07.008

10.1093/infdis/155.4.775

10.1073/pnas.90.23.11257

10.1093/jac/dkg133

10.1128/AAC.41.11.2352

10.1093/jac/dkm538

10.1128/AAC.48.10.4050-4053.2004

10.1111/j.1574-6968.2008.01126.x

10.1128/AAC.48.3.716-720.2004

10.1128/AAC.01633-05

10.1111/j.1574-6968.2006.00148.x

10.1093/jac/dkm227

10.1093/jac/dkg098

10.1128/AAC.44.9.2534-2536.2000

10.1128/AAC.40.2.342

10.1128/AAC.43.7.1669

10.1042/bj2650131

10.1128/AAC.19.1.185

10.1128/AAC.42.1.176

10.1128/AAC.18.5.687

10.1073/pnas.95.7.3943

10.1111/j.1742-4658.2008.06324.x

Migliavacca, R., E. Nucleo, M. M. D'Andrea, M. Spalla, T. Giani, and L. Pagani. 2007. Acquired AmpC type beta-lactamases: an emerging problem in Italian long-term care and rehabilitation facilities. New Microbiol.30:295-298.

10.1128/AAC.18.6.853

10.1128/AAC.18.1.77

10.1016/j.ijantimicag.2004.03.006

10.1128/AAC.48.8.3172-3174.2004

10.1186/1471-2180-7-25

10.1128/AAC.46.12.3837-3842.2002

10.1128/JCM.00756-06

10.1016/0014-5793(93)80692-N

10.1128/AAC.00172-08

Abstr. 48th Intersci. Conf. Antimicrob. Agents Chemother. 2008

10.1128/AAC.49.1.358-365.2005

10.7164/antibiotics.34.1164

10.1093/jac/40.6.823

Naas, T., D. Aubert, N. Fortineau, and P. Nordmann. 2002. Cloning and sequencing of the β-lactamase gene and surrounding DNA sequences of Citrobacter braakii,Citrobacter murliniae,Citrobacter werkmanii,Escherichia fergusonii and Enterobacter cancerogenus. FEMS Microbiol. Lett.215:81-87.

10.1128/AAC.01152-06

10.1093/jac/dkh446

10.1128/AAC.45.8.2324-2330.2001

Nadjar, D., M. Rouveau, C. Verdet, J. Donay, J. Herrmann, P. H. Lagrange, A. Philippon, and G. Arlet. 2000. Outbreak of Klebsiella pneumoniae producing transferable AmpC-type β-lactamase (ACC-1) originating from Hafnia alvei. FEMS Microbiol. Lett.187:35-40.

10.1007/s10156-006-0483-6

10.1128/AAC.48.4.1151-1158.2004

10.1128/JCM.42.10.4799-4802.2004

10.1093/jac/dkm018

10.1093/jac/17.4.441

10.1128/AAC.34.2.337

10.1093/jac/dkg247

10.2217/17460913.2.3.297

10.1128/jb.101.3.659-668.1970

10.1074/jbc.270.11.5729

10.1086/340742

10.1371/journal.pbio.0030248

10.1128/AAC.49.5.2095-2097.2005

10.1073/pnas.80.24.7556

10.1002/j.1460-2075.1982.tb01331.x

10.1128/AAC.01513-05

10.1128/AAC.48.10.3720-3728.2004

10.1128/AAC.45.2.480-484.2001

10.1016/j.ijid.2007.01.005

10.1128/AAC.00389-07

10.1128/AAC.34.11.2200

10.1128/AAC.00364-07

10.3201/eid1407.070826

10.1128/JCM.40.6.2153-2162.2002

10.1128/AAC.45.8.2287-2298.2001

10.1016/S0732-8893(97)00064-3

10.1128/AAC.46.1.1-11.2002

10.1111/j.1469-0691.2004.01018.x

10.1128/AAC.49.8.3311-3316.2005

10.3201/eid1303.060447

10.1128/AAC.41.1.35

10.1128/JCM.41.10.4578-4582.2003

10.1128/AAC.43.4.769

10.1128/AAC.49.1.447-450.2005

10.1128/AAC.44.4.891-897.2000

10.1093/jac/dkl217

10.1128/AAC.50.3.962-967.2006

10.1021/bi0109358

10.1128/AAC.44.11.3158-3162.2000

10.1128/AAC.00622-08

10.1128/AAC.50.5.1633-1641.2006

10.1128/AAC.45.11.3189-3194.2001

10.1128/AAC.35.6.1174

10.1128/AAC.46.7.2262-2265.2002

10.1128/AAC.38.9.2078

10.1099/13500872-141-12-3015

10.1093/jac/49.3.557

10.1128/AAC.48.11.4177-4182.2004

10.1093/jac/dkg204

10.1128/AAC.01639-05

10.1128/AAC.37.11.2391

10.1111/j.1574-6968.2002.tb11164.x

10.1128/JCM.00918-06

10.1042/bj0960739

10.1016/j.diagmicrobio.2005.05.005

Sanders, C. C. 1993. Cefepime: the next generation? Clin. Infect. Dis.17:369-379.

Reference deleted.

10.1093/infdis/154.5.792

10.1093/clinids/23.3.454

10.1093/clinids/10.4.721

10.1016/j.ijantimicag.2004.08.020

10.1128/AAC.01458-05

10.1128/AAC.00341-08

10.1111/j.1699-0463.1992.tb04024.x

10.1128/AAC.48.2.612-614.2004

10.1128/AAC.36.5.1049

Seoane, A., and J. M. Garcia Lobo. 1991. Cloning of chromosomal β-lactamase genes from Yersinia enterocolitica. J. Gen. Microbiol.137:141-146.

10.1093/jac/dkh389

10.1093/jac/dkh365

10.1128/AAC.47.7.2138-2144.2003

10.1128/AAC.38.8.1711

10.1093/jac/dkn023

10.1128/JCM.02322-06

10.1016/j.diagmicrobio.2006.08.023

10.1093/jac/36.3.483

10.1128/AAC.43.5.1206

10.1128/JCM.39.8.2864-2872.2001

10.1179/joc.2005.17.2.143

10.1093/jac/dkg156

Stock, I., T. Grueger, and B. Wiedemann. 2003. Natural antibiotic susceptibility of strains of Serratia marcescens and the S. liquefaciens complex: S. liquefaciens sensu stricto, S. proteamaculans and S. grimesii. Int. J. Antimicrob. Agents22:35-47.

10.1080/1120009X.2000.11782319

10.1099/0022-1317-51-1-56

10.1016/j.diagmicrobio.2004.10.008

10.1179/joc.2003.15.5.428

10.1128/AAC.45.8.2245-2255.2001

10.1016/S0928-8244(03)00179-2

10.1093/jac/dki116

10.1136/jcp.2007.053470

10.1128/AAC.21.5.711

10.1128/AAC.49.4.1354-1358.2005

10.3201/eid0702.010238

10.1128/AAC.36.9.1877

10.1128/AAC.37.6.1375

10.1016/S0014-5793(03)01508-4

10.1128/MMBR.00048-05

10.1111/j.1574-6968.2007.00672.x

10.1093/jac/dkn364

10.1099/00222615-40-6-403

10.1093/jac/31.5.645

Tzouvelekis, L. S., E. Tzelepi, A. F. Mentis, A. C. Vatopoulos, and A. Tsakris. 1992. Imipenem resistance in Enterobacter aerogenes is associated with derepression of chromosomal cephalosporinases and impaired permeability. FEMS Microbiol. Lett.74:195-199.

10.1093/jac/dkh235

10.1093/jac/dkm317

10.1128/AAC.27.3.393

10.1128/AAC.48.8.2905-2910.2004

10.1128/AAC.50.2.534-541.2006

10.1093/jac/36.1.41

10.1093/jac/40.2.171

10.1139/w02-039

10.1128/AAC.34.1.156

10.1016/j.bbrc.2003.12.171

10.3201/eid1311.061438

10.3201/eid1109.050182

10.1128/AAC.44.10.2777-2783.2000

10.1086/324742

Woodford, N., S. Reddy, E. J. Fagan, R. L. Hill, K. L. Hopkins, M. E. Kaufmann, J. Kistler, M. F. Palepou, R. Pike, M. E. Ward, J. Cheesbrough, and D. M. Livermore. 2007. Wide geographic spread of diverse acquired AmpC β-lactamases among Escherichia coli and Klebsiella spp. in the UK and Ireland. J. Antimicrob. Chemother.59:102-105.

10.1128/AAC.43.6.1350

10.1128/JCM.43.6.2551-2558.2005

10.1128/AAC.50.5.1861-1864.2006

10.1128/JCM.42.11.5337-5340.2004

10.1128/JCM.42.7.3329-3332.2004

Yatsuyanagi, J., S. Saito, T. Konno, S. Harata, N. Suzuki, J. Kato, and K. Amano. 2006. Nosocomial outbreak of ceftazidime-resistant Serratia marcescens strains that produce a chromosomal AmpC variant with N235K substitution. Jpn. J. Infect. Dis.59:153-159.

10.1128/AAC.46.12.3817-3822.2002

10.1128/AAC.47.11.3442-3447.2003

10.1128/AAC.01461-06

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Clinical Microbiology Reviews

Tập 22 Số 1

161-182

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