Allergens and molecular diagnostics of shellfish allergy

Allergo Journal International - Tập 25 - Trang 210-218 - 2016
Andreas L. Lopata1,2,3,4,5, Jörg Kleine-Tebbe6, Sandip D. Kamath1,2,3
1Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Australia
2Centre for Biodiscovery and Molecular Development of Therapeutics, James Cook University, Townsville, Australia
3College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Australia
4Centre for Food and Allergy Research, Murdoch Childrens Research Institute, Melbourne, Australia
5Pharmacy and Medical Research College of Public Health, Medical and Veterinary Sciences, James Cook University (Townsville Campus), Townsville, Australia
6Allergy and Asthma Center Westend, Outpatient Clinic Hanf, Ackermann and Kleine-Tebbe, Berlin, Germany

Tóm tắt

Shellfish belongs to “The Big 8” food groups causing allergy, which often does not outgrow during childhood. Shellfish is one of the main food allergens in adults and constitutes a diverse group of species subdivided into crustaceans and mollusks, which seem to include similar but also different allergens. Several pan-allergens are characterized in detail, including tropomyosin and arginine kinase, responsible for clinical cross-reactivity with other invertebrate allergen sources, embracing mites, insects, and parasites. Currently, at least seven different shellfish allergens have been identified, mostly from crustaceans. However, only three recombinant allergens are available for IgE-based routine diagnostic, including tropomyosin, arginine kinase, and sarcoplasmic Ca2+-binding protein. Other allergens include myosin light chain, troponin C, triosephosphate isomerase, and actin. This review summarizes the current advances on the molecular characterization of shellfish allergens, clinical cross-reactivity, and current diagnostic approaches for the management of this life-threatening disease.

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Allergo Journal International

Tập 25

210-218

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