Akt in cancer: Mediator and more
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Bellacosa, 2005, Activation of AKT kinases in cancer: implications for therapeutic targeting, Adv. Cancer Res., 94, 29, 10.1016/S0065-230X(05)94002-5
Liu, 2018, 4268
Ward, 2011, Sat-Nav for T cells: role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes, Immunol. Lett., 138, 15, 10.1016/j.imlet.2011.02.007
Altomare, 2005, Perturbations of the AKT signalling pathway in human cancer, Oncogene., 24, 7455, 10.1038/sj.onc.1209085
Bellacosa, 1993, Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications, Oncogene, 8, 745
Datta, 1995, AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation, Mol. Cell Biol. [Internet], 15, 2304, 10.1128/MCB.15.4.2304
Alessi, 1998, 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro, Curr. Biol., 8, 69, 10.1016/S0960-9822(98)70037-5
Alessi, 1996, Mechanism of activation of protein kinase B by insulin and IGF-1, EMBO J., 15, 6541, 10.1002/j.1460-2075.1996.tb01045.x
Alessi, 1997, Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα, Curr. Biol., 7, 261, 10.1016/S0960-9822(06)00122-9
Balendran, 1999, PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2, Curr. Biol., 9, 393, 10.1016/S0960-9822(99)80186-9
Franke, 1997, Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3, 4-bisphosphate, Science, 275, 665, 10.1126/science.275.5300.665
Liu, 2014, Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus, Nature, 508, 541, 10.1038/nature13079
Delcommenne, 1998, Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase, Proc. Natl. Acad. Sci., 95, 11211, 10.1073/pnas.95.19.11211
Yano, 1998, Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway, Nature, 396, 584, 10.1038/25147
Li, 2018, SIRT7 promotes thyroid tumourigenesis through phosphorylation and activation of Akt and p70S6K1 via DBC1/SIRT1 axis, Oncogene, 1
Gao, 2014, Akt: a new activation mechanism, Vol. 24, 785
Wang, 1999, Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD, Science, 284, 339, 10.1126/science.284.5412.339
Datta, 1997, Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery, Cell, 91, 231, 10.1016/S0092-8674(00)80405-5
Scheid, 1998, Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of bad phosphorylation, Proc. Natl. Acad. Sci. [Internet], 95, 7439, 10.1073/pnas.95.13.7439
Cardone, 1998, Regulation of cell death protease caspase-9 by phosphorylation, Science (80), 282, 1318, 10.1126/science.282.5392.1318
Meier, 1997, Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bβ, J. Biol. Chem., 272, 30491, 10.1074/jbc.272.48.30491
Cichy, 1998, Protein kinase B/Akt mediates effects of insulin on hepatic insulin- like growth factor-binding protein-1 gene expression through a conserved insulin response sequence, J. Biol. Chem., 273, 6482, 10.1074/jbc.273.11.6482
Liao, 1998, Activation of protein kinase B/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene, J. Biol. Chem., 273, 27320, 10.1074/jbc.273.42.27320
Rena, 1999, Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B, J. Biol. Chem., 274, 17179, 10.1074/jbc.274.24.17179
Nakae, 1999, Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway, J. Biol. Chem., 274, 15982, 10.1074/jbc.274.23.15982
Brunet, 1999, Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor, Cell, 96, 857, 10.1016/S0092-8674(00)80595-4
Du, 1998, CREB is a regulatory target for the protein kinase Akt/PKB, J. Biol. Chem., 273, 32377, 10.1074/jbc.273.49.32377
Tao, 1998, Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism, Neuron, 20, 709, 10.1016/S0896-6273(00)81010-7
Ozes, 1999, NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase, Nature, 401, 82, 10.1038/43466
Zong, 1999, The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosis, Genes Dev., 13, 382, 10.1101/gad.13.4.382
Pap, 1998, Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway, J. Biol. Chem., 273, 19929, 10.1074/jbc.273.32.19929
Dimmeler, 1999, Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation, Nature, 399, 601, 10.1038/21224
Fulton, 1999, Regulation of endothelium-derived nitric oxide production by the protein kinase Akt, Nature, 399, 597, 10.1038/21218
Deprez, 1997, Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signalling cascades, J. Biol. Chem., 272, 17269, 10.1074/jbc.272.28.17269
Wijkander, 1997, Regulation of protein kinase B in rat adipocytes by insulin, vanadate, and peroxovanadate membrane translocation in response to peroxovanadate, J. Biol. Chem., 272, 21520, 10.1074/jbc.272.34.21520
Kang, 1999, Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit, J. Biol. Chem., 274, 13085, 10.1074/jbc.274.19.13085
He, 2018, Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis, Cell Res., 28, 934, 10.1038/s41422-018-0079-6
Ramos, 2018, Phosphorylation of E-box binding USF-1 by PI3K/AKT enhances its transcriptional activation of the WBP2 oncogene in breast cancer cells, FASEB J., 10.1096/fj.201801167RR
Maurer, 2006, Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1, Mol. Cell, 21, 749, 10.1016/j.molcel.2006.02.009
Qi, 2006, Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function, J. Biol. Chem., 281, 813, 10.1074/jbc.M505546200
Kim, 2001, Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1, Mol. Cell. Biol., 21, 893, 10.1128/MCB.21.3.893-901.2001
Kovacina, 2003, Identification of a proline-rich Akt substrate as a 14-3-3 binding partner, J. Biol. Chem., 278, 10189, 10.1074/jbc.M210837200
Viglietto, 2002, Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27 Kip1 by PKB/Akt-mediated phosphorylation in breast cancer, Nat. Med., 8, 1136, 10.1038/nm762
Mayo, 2001, A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus, Proc. Natl. Acad. Sci., 98, 11598, 10.1073/pnas.181181198
Gao, 2001, TSC1 and TSC2 tumour suppressors antagonize insulin signalling in cell growth, Genes Dev., 15, 1383, 10.1101/gad.901101
Zhou, 2001, Cytoplasmic localization of p21 Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells, Nat. Cell Biol., 3, 245, 10.1038/35060032
Wen, 2000, HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway, Cancer Res., 60, 6841
Zimmermann, 1999, Phosphorylation and regulation of Raf by Akt (protein kinase B), Science, 286, 1741, 10.1126/science.286.5445.1741
Altiok, 1999, Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-kinase/AKT in breast cancer cells, J. Biol. Chem., 274, 32274, 10.1074/jbc.274.45.32274
del Peso, 1997, Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt, Science., 278, 687, 10.1126/science.278.5338.687
Kohn, 1996, Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation, J. Biol. Chem., 271, 31372, 10.1074/jbc.271.49.31372
Kauffmann-Zeh, 1997, Suppression of c-Myc-induced apoptosis by Ras signalling through PI (3) K and PKB, Nature, 385, 544, 10.1038/385544a0
Carracedo, 2008, Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer, J. Clin. Invest., 118, 3065
Valentino, 2014, Co-targeting the PI3K and RAS pathways for the treatment of neuroendocrine tumours, Clin. Cancer Res., 10.1158/1078-0432.CCR-13-1897
She, 2018, Identification of the C-reactive protein interaction network using a bioinformatics approach provides insights into the molecular pathogenesis of hepatocellular carcinoma, Cell. Physiol. Biochem., 48, 741, 10.1159/000491903
Broustas, 2012, Rad9 contributes to prostate tumour progression by promoting cell migration and anoikis resistance, J. Biol. Chem., 12
Valenti, 2018, Ectopic expression of the osteogenic master gene RUNX2 in melanoma, World J. Stem Cells, 10, 78, 10.4252/wjsc.v10.i7.78
Fan, 2018, Reciprocal feedback regulation of ST3GAL1 and GFRA1 signalling in breast cancer cells, Cancer Lett., 434, 184, 10.1016/j.canlet.2018.07.026
Cerami, 2012, The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data, Cancer Discov., 2, 401, 10.1158/2159-8290.CD-12-0095
Zhang, 2018, Telomerase reverse transcriptase induced thyroid carcinoma cell proliferation through PTEN/AKT signalling pathway, Mol. Med. Rep., 18, 1345, 10.1007/s00109-018-1696-8
Stemke-Hale, 2008, An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer, Cancer Res., 68, 6084, 10.1158/0008-5472.CAN-07-6854
Bacus, 2002, AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumour aggressiveness by enhancing cell survival, Oncogene, 21, 3532, 10.1038/sj.onc.1205438
Costa, 2018, Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review, Breast Cancer Res. Treat., 10.1007/s10549-018-4697-y
Bahrami, 2017, The potential value of the PI3K/Akt/mTOR signalling pathway for assessing prognosis in cervical cancer and as a target for therapy, J. Cell. Biochem., 118, 4163, 10.1002/jcb.26118
Cheng, 1992, Testa JR. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas, Proc. Natl. Acad. Sci., 89, 9267, 10.1073/pnas.89.19.9267
David, 2004, Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage, Clin. Cancer Res., 10, 6865, 10.1158/1078-0432.CCR-04-0174
Carlisle, 2007, Nicotine activates cell-signalling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells, Pulm. Pharmacol. Ther., 20, 629, 10.1016/j.pupt.2006.07.001
Tabernero, 2005, A phase I study with tumour molecular pharmacodynamic (MPD) evaluation of dose and schedule of the oral mTOR-inhibitor Everolimus (RAD001) in patients (pts) with advanced solid tumours, J. Clin. Oncol., 23, 3007, 10.1200/jco.2005.23.16_suppl.3007
Steelman, 2008, Akt as a therapeutic target in cancer, Expert Opin. Ther. Targets, 12, 1139, 10.1517/14728222.12.9.1139
Murakami, 2007, Expression of phosphorylated Akt (pAkt) in gastric carcinoma predicts prognosis and efficacy of chemotherapy, Gastric Cancer, 10, 45, 10.1007/s10120-006-0410-7
Horiguchi, 2003, Elevated Akt activation and its impact on clinicopathological features of renal cell carcinoma, J. Urol., 169, 710, 10.1016/S0022-5347(05)63998-5
Schiffer, 2005, Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis, Hepatology, 41, 307, 10.1002/hep.20538
Sartelet, 2007, Activation of the PI3K/Akt pathway in neuroblastoma
Itoh, 2002, Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumour progression in human colorectal carcinoma, Cancer, 94, 3127, 10.1002/cncr.10591
Manning, 2007, 129
Staal, 1987, Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma, Proc. Natl. Acad. Sci., 84, 5034, 10.1073/pnas.84.14.5034
Knobbe, 2003, Genetic alterations and aberrant expression of genes related to the phosphatidyl‐lnositol‐3′‐kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas, Brain Pathol., 13, 507, 10.1111/j.1750-3639.2003.tb00481.x
Bellacosa, 1995, Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas, Int. J. Cancer, 64, 280, 10.1002/ijc.2910640412
Cheng, 1996, Amplification of AKT2 in human pancreatic cancer cells and inhibition of AK12 expression and tumourigenicity by antisense RNA, Proc. Natl Acad. Sci. U. S. A., 93, 3641
Nakatani, 1999, Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines, J. Biol. Chem., 274, 21528, 10.1074/jbc.274.31.21528
Xu, 2004, Akt2 expression correlates with prognosis of human hepatocellular carcinoma, Oncol. Rep., 11, 25
Roy, 2002, AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis, Carcinogenesis., 23, 201, 10.1093/carcin/23.1.201
Parsons, 2005, Colorectal cancer: mutations in a signalling pathway, Nature, 436, 792, 10.1038/436792a
Slattery, 2018, The PI3K/AKT signalling pathway: associations of miRNAs with dysregulated gene expression in colorectal cancer, Mol. Carcinog., 57, 243, 10.1002/mc.22752
Hay, 2005, The Akt-mTOR tango and its relevance to cancer, Cancer Cell, 8, 179, 10.1016/j.ccr.2005.08.008
Vandamme, 2019, Hotspot DAXX, PTCH2 and CYFIP2 mutations in pancreatic neuroendocrine neoplasms, Endocr. Relat. Cancer, 1
Mundi, 2016, AKT in cancer: new molecular insights and advances in drug development, Br. J. Clin. Pharmacol., 82, 943, 10.1111/bcp.13021
Askham, 2010, AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K, Oncogene., 29, 150, 10.1038/onc.2009.315
Carpten, 2007, A transforming mutation in the pleckstrin homology domain of AKT1 in cancer, Nature., 448, 439, 10.1038/nature05933
Malanga, 2008, Activating E17K mutation in the gene encoding the protein kinase AKT in a subset of squamous cell carcinoma of the lung, Cell Cycle, 7, 665, 10.4161/cc.7.5.5485
Mohamedali, 2008, AKT1 (E17K) mutation in pancreatic cancer, Technol. Cancer Res. Treat., 7, 407, 10.1177/153303460800700509
Shoji, 2009, The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas, Br. J. Cancer, 101, 145, 10.1038/sj.bjc.6605109
Zilberman, 2009, AKT1 E17 K pleckstrin homology domain mutation in urothelial carcinoma, Cancer Genet. Cytogenet., 191, 34, 10.1016/j.cancergencyto.2009.01.009
Yang, 2009, The E3 ligase TRAF6 regulates Akt ubiquitination and activation, Science., 325, 1134, 10.1126/science.1175065
Parikh, 2012, Disruption of PH–kinase domain interactions leads to oncogenic activation of AKT in human cancers, Proc. Natl. Acad. Sci., 109, 19368, 10.1073/pnas.1204384109
Downward, 2003, Targeting RAS signalling pathways in cancer therapy, Nat. Rev. Cancer, 3, 11, 10.1038/nrc969
Liu, 2018, M 6 A mRNA methylation regulates AKT activity to promote the proliferation and tumourigenicity of endometrial cancer, Nat. Cell Biol., 20, 1074, 10.1038/s41556-018-0174-4
Nakakido, 2015, Dysregulation of AKT pathway by SMYD2-mediated lysine methylation on PTEN, Neoplasia., 17, 367, 10.1016/j.neo.2015.03.002
Chan, 2014, Posttranslational regulation of Akt in human cancer, Cell Biosci., 4, 59, 10.1186/2045-3701-4-59
Yang, 2010, Regulation of Akt signalling activation by ubiquitination, Cell Cycle, 9, 486, 10.4161/cc.9.3.10508
Chan, 2012, The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumourigenesis, Cell, 149, 1098, 10.1016/j.cell.2012.02.065
Bellacosa, 1998, Akt activation by growth factors is a multiple-step process: the role of the PH domain, Oncogene, 17, 313, 10.1038/sj.onc.1201947
Cai, 2013, The microRNA-302-367 cluster suppresses the proliferation of cervical carcinoma cells through the novel target AKT1, Rna, 19, 85, 10.1261/rna.035295.112
Cui, 2013, micro RNA‐133a regulates the cell cycle and proliferation of breast cancer cells by targeting epidermal growth factor receptor through the EGFR/A kt signalling pathway, FEBS J., 280, 3962, 10.1111/febs.12398
Guo, 2008, The noncoding RNA, miR‐126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3‐kinase signalling and is frequently lost in colon cancers, Genes Chromosomes Cancer, 47, 939, 10.1002/gcc.20596
Ren, 2018, Wang M. microRNA-212-induced protection of the heart against myocardial infarction occurs via the interplay between AQP9 and PI3K/Akt signalling pathway, Exp. Cell Res., 370, 531, 10.1016/j.yexcr.2018.07.018
Li, 2018, MicroRNA758 inhibits malignant progression of retinoblastoma by directly targeting PAX6, Oncol. Rep., 40, 1777
Meng, 2007, MicroRNA-21 regulates expression of the PTEN tumour suppressor gene in human hepatocellular cancer, Gastroenterology, 133, 647, 10.1053/j.gastro.2007.05.022
Bar, 2010, Dikstein R. miR-22 forms a regulatory loop in PTEN/AKT pathway and modulates signalling kinetics, PLoS One, 5, 10.1371/journal.pone.0010859
Li, 2018, Huang SX. miR-182-5p promotes growth in oral squamous cell carcinoma by inhibiting CAMK2N1, Cell. Physiol. Biochem., 49, 1329, 10.1159/000493411
Sachdeva, 2011, MicroRNA-101-mediated Akt activation and estrogen-independent growth, Oncogene, 30, 822, 10.1038/onc.2010.463
Wong, 2010, MiR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signalling, Clin. Cancer Res.
Hamano, 2011, Overexpression of miR-200c induces chemoresistance in esophageal cancers mediated through activation of the Akt signalling pathway, Clin. Cancer Res., 10.1158/1078-0432.CCR-10-2532
Zhang, 2013, Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop, Oncogen, 32, 61, 10.1038/onc.2012.28
Small, 2010, Regulation of PI3-kinase/Akt signalling by muscle-enriched microRNA-486, Proc. Natl. Acad. Sci., 10.1073/pnas.1000300107
Sanchez Calle, 2018, Emerging roles of long non‐coding RNA in cancer, Cancer Sci., 109, 2093, 10.1111/cas.13642
Xue, 2016, LncRNA GAS5 inhibits proliferation and progression of prostate cancer by targeting miR-103 through AKT/mTOR signalling pathway, Tumour Biol., 37, 16187, 10.1007/s13277-016-5429-8
Hu, 2014, A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer, Cancer Cell, 26, 344, 10.1016/j.ccr.2014.07.009
Xia, 2015, Long noncoding RNA FER1L4 suppresses cancer cell growth by acting as a competing endogenous RNA and regulating PTEN expression, Sci. Rep., 5, 13445, 10.1038/srep13445
Wang, 2017, LncRNA AB073614 regulates proliferation and metastasis of colorectal cancer cells via the PI3K/AKT signalling pathway, Biomed. Pharmacother., 93, 1230, 10.1016/j.biopha.2017.07.024
Sun, 2017, Down-regulation of long non-coding RNA RP11-708H21. 4 is associated with poor prognosis for colorectal cancer and promotes tumourigenesis through regulating AKT/mTOR pathway, Oncotarget, 8, 27929, 10.18632/oncotarget.15846
Liu, 2016, Long noncoding RNA H19-derived miR-675 enhances proliferation and invasion via RUNX1 in gastric cancer cells, Oncol. Res. Featur. Preclin. Clin. Cancer Ther., 23, 99
Zhuang, 2014, The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumour suppressor RUNX1, Biochem. Biophys. Res. Commun., 448, 315, 10.1016/j.bbrc.2013.12.126
Wang, 2016, Long noncoding RNA H19 contributes to gallbladder cancer cell proliferation by modulated miR-194-5p targeting AKT2, Tumour Biol., 37, 9721, 10.1007/s13277-016-4852-1
Huang, 2017, LncRNA AK023391 promotes tumourigenesis and invasion of gastric cancer through activation of the PI3K/Akt signalling pathway, J. Exp. Clin. Cancer Res., 36, 194, 10.1186/s13046-017-0666-2
Liu, 2018, Cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy, J. Hematol. Oncol., 11, 77, 10.1186/s13045-018-0619-z
Liu, 2018, LncRNA TP73-AS1 promotes cell proliferation and inhibits cell apoptosis in clear cell renal cell carcinoma through repressing KISS1 expression and inactivation of PI3K/Akt/mTOR signalling pathway, Cell. Physiol. Biochem., 48, 371, 10.1159/000491767
Li, 2018, Long noncoding RNA HR1 participates in the expression of SREBP1c through phosphorylation of the PDK1/AKT/FoxO1 pathway, Mol. Med. Rep., 18, 2850
Chen, 2018, Long non-coding RNAs: crucial regulators of gastrointestinal cancer cell proliferation, Cell Death Discov., 4, 50, 10.1038/s41420-018-0051-8
Koirala, 2017, LncRNA AK023948 is a positive regulator of AKT, Nat. Commun., 8, 14422, 10.1038/ncomms14422
Chen, 2017, LncRNA-uc002mbe. 2 interacting with hnRNPA2B1 mediates AKT deactivation and p21 up-regulation induced by trichostatin in liver cancer cells, Front. Pharmacol., 8, 669, 10.3389/fphar.2017.00669
Li, 2005, Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin β1 to control cell migration, Dev. Cell, 9, 663, 10.1016/j.devcel.2005.09.012
Enomoto, 2005, Akt/PKB regulates actin organization and cell motility via Girdin/APE, Dev. Cell, 9, 389, 10.1016/j.devcel.2005.08.001
Zhou, 2003, Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration, Mol. Cell. Biol., 23, 8058, 10.1128/MCB.23.22.8058-8069.2003
Koundouros, 2018, Phosphoinositide 3-kinase/Akt signalling and redox metabolism in cancer, Front. Oncol., 8
Lawlor, 2001, PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?, J. Cell. Sci., 114, 2903, 10.1242/jcs.114.16.2903
Stahl, 2002, The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2, J. Immunol., 168, 5024, 10.4049/jimmunol.168.10.5024
Spokoini, 2010, Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis, Mol. Endocrinol., 24, 1136, 10.1210/me.2009-0466
Ekert, 2006, Cell death provoked by loss of interleukin-3 signalling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma, Blood., 108, 1461, 10.1182/blood-2006-03-014209
Hardwick, 2013, Multiple functions of BCL-2 family proteins, Cold Spring Harb. Perspect. Biol., 5, 10.1101/cshperspect.a008722
Rahmani, 2009, The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways, Blood., 114, 4507, 10.1182/blood-2008-09-177881
Widmann, 1998, Caspase-dependent cleavage of signalling proteins during apoptosis A turn-off mechanism for anti-apoptotic signals, J. Biol. Chem., 273, 7141, 10.1074/jbc.273.12.7141
Wee, 2006, Akt versus p53 in a network of oncogenes and tumour suppressor genes regulating cell survival and death, Biophys. J., 91, 857, 10.1529/biophysj.105.077693
Singh, 2013, Human oncoprotein MDM2 activates the Akt signalling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells, Cell Death Differ., 20, 558, 10.1038/cdd.2012.153
Gomes, 2014, Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels, Haematologica, 10.3324/haematol.2013.096438
Shan, 2000, Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation, Mol. Cell. Biol., 20, 6945, 10.1128/MCB.20.18.6945-6957.2000
Fang, 2010, The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway, Cell, 143, 711, 10.1016/j.cell.2010.10.010
Taha, 1999, Opposite Translational Control of glut1 and glut4 glucose transporter mrnas in response to insulin role of mammalian target of rapamycin, protein kinase b, and phosphatidylinositol 3-kinase in glut1 mRNA TRANSLATION, J. Biol. Chem., 274, 33085, 10.1074/jbc.274.46.33085
Gottlob, 2001, Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase, Genes Dev., 15, 1406, 10.1101/gad.889901
Rathmell, 2003, Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival, Mol. Cell. Biol., 23, 7315, 10.1128/MCB.23.20.7315-7328.2003
Wu, 2013, AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1, Mol. Cell, 49, 1167, 10.1016/j.molcel.2013.01.035
Waldhart, 2017, Phosphorylation of TXNIP by AKT mediates acute influx of glucose in response to insulin, Cell Rep., 19, 2005, 10.1016/j.celrep.2017.05.041
Liu, 2016, Effects of inhibiting PI3K-Akt-mTOR pathway on lipid metabolism homeostasis in goose primary hepatocytes, Animal, 10, 1319, 10.1017/S1751731116000380
Amemiya-Kudo, 2002, Transcriptional activities of nuclear SREBP-1a,-1c, and-2 to different target promoters of lipogenic and cholesterogenic genes, J. Lipid Res., 43, 1220, 10.1194/jlr.M100417-JLR200
Krycer, 2010, The Akt–SREBP nexus: cell signalling meets lipid metabolism, Trends Endocrinol. Metab., 21, 268, 10.1016/j.tem.2010.01.001
Horton, 2003, Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes, Proc. Natl. Acad. Sci., 100, 12027, 10.1073/pnas.1534923100
Yin, 2017, TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signalling pathway, Oncogenesis, 6, e347, 10.1038/oncsis.2017.49
Yecies, 2011, Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways, Cell Metab., 14, 21, 10.1016/j.cmet.2011.06.002
Berwick, 2002, The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes, J. Biol. Chem., 277, 33895, 10.1074/jbc.M204681200
Ward, 2012, Signalling in control of cell growth and metabolism, Cold Spring Harb. Perspect. Biol., 10.1101/cshperspect.a006783
Chae, 2016, Mitochondrial Akt regulation of hypoxic tumour reprogramming, Cancer Cell, 30, 257, 10.1016/j.ccell.2016.07.004
Wallace, 2005, A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine, Annu. Rev. Genet., 39, 359, 10.1146/annurev.genet.39.110304.095751
Su, 2011, Mitochondrial Akt-regulated mitochondrial apoptosis signalling in cardiac muscle cells, Am. J. Physiol.-Heart Circul. Physiol., 302, H716, 10.1152/ajpheart.00455.2011
Yang, 1997, Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked, Science, 275, 1129, 10.1126/science.275.5303.1129
Bijur, 2003, Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3‐kinase activation, J. Neurochem., 87, 1427, 10.1046/j.1471-4159.2003.02113.x
Boyer, 1997, The ATP synthase—a splendid molecular machine, Annu. Rev. Biochem., 66, 717, 10.1146/annurev.biochem.66.1.717
Gupta, 2017, PARK2 depletion connects energy and oxidative stress to PI3K/Akt activation via PTEN S-nitrosylation, Mol. Cell, 65, 999, 10.1016/j.molcel.2017.02.019
Coloff, 2006, Metabolic regulation of Akt: roles reversed, J. Cell Biol., 175, 845, 10.1083/jcb.200610119
Pelicano, 2006, Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism, J. Cell Biol., 175, 913, 10.1083/jcb.200512100
Betz, 2013, mTOR complex 2-Akt signalling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology, Proc. Natl. Acad. Sci., 110, 12526, 10.1073/pnas.1302455110
Luo, 2000, Acute modulation of endothelial Akt/PKB activity alters nitric oxide–dependent vasomotor activity in vivo, J. Clin. Invest., 106, 493, 10.1172/JCI9419
Semenza, 2002, HIF-1 and tumour progression: pathophysiology and therapeutics, Trends Mol. Med., 8, S62, 10.1016/S1471-4914(02)02317-1
Asahara, 1998, Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization, Circ. Res., 83, 233, 10.1161/01.RES.83.3.233
Fukuhara, 2008, Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1, Nat. Cell Biol., 10, 513, 10.1038/ncb1714
Sverdlov, 2009, Filamin A regulates caveolae internalization and trafficking in endothelial cells, Mol. Biol. Cell, 20, 4531, 10.1091/mbc.e08-10-0997
Bäumer, 2006, Vascular endothelial cell–specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development, Blood, 107, 4754, 10.1182/blood-2006-01-0141
Zheng, 2009, Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis, Circ. Res., 105, 260, 10.1161/CIRCRESAHA.109.195156
Brasseur, 2017, Chemoresistance and targeted therapies in ovarian and endometrial cancers, Oncotarget, 8, 4008, 10.18632/oncotarget.14021
Nitulescu, 2016, Akt inhibitors in cancer treatment: the long journey from drug discovery to clinical use, Int. J. Oncol., 48, 869, 10.3892/ijo.2015.3306
Thorpe, 2015, PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting, Nat. Rev. Cancer, 15, 7, 10.1038/nrc3860
Lu, 2014, Harnessing allostery: a novel approach to drug discovery, Med. Res. Rev., 34, 1242, 10.1002/med.21317
Lee, 2010, Anthocyanins are novel AMPKα1 stimulators that suppress tumour growth by inhibiting mTOR phosphorylation, Oncol. Rep., 24, 1471
Shen, 2018, Lycorine inhibits glioblastoma multiforme growth through EGFR suppression, J. Exp. Clin. Cancer Res., 37, 157, 10.1186/s13046-018-0785-4
Pal, 2018, Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer, Cell Death Dis., 9, 798, 10.1038/s41419-018-0810-8
Jansen, 2016, Is there a future for AKT inhibitors in the treatment of cancer?, Clin. Cancer Res., 22, 2599, 10.1158/1078-0432.CCR-16-0100
Urak, 2017, Ex vivo Akt inhibition promotes the generation of potent CD19 CAR T cells for adoptive immunotherapy, J. Immunother. Cancer, 5, 26, 10.1186/s40425-017-0227-4