Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

Aging - Tập 8 Số 7 - Trang 1294-1315 - 2016
Brandon M. Hall1, Vitaly Balan1, Anatoli S. Gleiberman1, Evguenia Strom1, Peter Krasnov1, Lauren P. Virtuoso1, Elena Rydkina1, Slavoljub Vujcic1, Karina Balan1, Ilya Gitlin2,1, Katerina I. Leonova2, Alexander Polinsky1, Olga B. Chernova1, Andrei V. Gudkov2,1
1Everon Biosciences, Inc., Buffalo, NY 14203, USA
2Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Santambrogio, 2011, Oxidative stress, inflamm-aging and immunosenescence, J Proteomics, 7, 2313

Pawelec, 2008, Aging of the immune system as a prognostic factor for human longevity, Physiology (Bethesda), 2, 64

Krizhanovsky, 2013, Immunosurveillance of senescent cells: The bright side of the senescence program, Biogerontology, 1, 617

Melov, 2011, Cellular senescence: a link between cancer and age-related degenerative disease?, Semin Cancer Biol, 2, 354

Carter C Y, 2009, Molecular Inflammation: Underpinnings of Aging and Age- related Diseases, Ageing Res Rev, 8, 18, 10.1016/j.arr.2008.07.002

Weyand, 2011, Telomere dysfunction, autoimmunity and aging, Aging Dis, 2, 524

De Benedictis, 2000, Inflamm-aging, An evolutionary perspective on immunosenescence. Ann N Y Acad Sci, 90, 244

Salvioli, 2007, Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans, Mech Ageing Dev, 12, 92

Franceschi, 2013, Inflamm-ageing, Curr Opin Clin Nutr Metab Care, 1, 14

Campisi, 2014, Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases, J Gerontol A Biol Sci Med Sci, 6, 4

Kirkwood, 2012, Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study, Mech Ageing Dev, 13, 456

Caruso, 2007, Inflammatory networks in ageing, age-related diseases and longevity, Mech Ageing Dev, 12, 83

Sierra, 2013, The role of inflammation in age-related disease, Aging (Albany NY), 5, 84, 10.18632/aging.100531

Schadt, 2014, Geroscience: linking aging to chronic disease, Cell, 15, 709

Kirkland, 2010, Fat tissue, aging, and cellular senescence, Aging Cell, 9, 667, 10.1111/j.1474-9726.2010.00608.x

Kurz, 2005, Cellular senescence in vivo: its relevance in ageing and cardiovascular disease, Exp Gerontol, 4, 634

Peeper, 2009, Senescence-messaging secretome: SMS-ing cellular stress, Nat Rev Cancer, 9, 81, 10.1038/nrc2560

Krizhanovsky, 2014, Senescent cells: SASPected drivers of age-related pathologies, Biogerontology, 1, 627

Campisi, 2008, Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor, PLoS Biol, 6, 2853

Kirkland, 2014, Cellular senescence and the senescent secretory phenotype in age-related chronic diseases, Curr Opin Clin Nutr Metab Care, 1, 324

van Deursen, 2011, Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders, Nature, 47, 232

Hara, 2014, An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA, Dev Cell, 3, 722

Van Deursen, 2016, Naturally occurring p16 Ink4a -positive cells shorten healthy lifespan, Nature, 53, 1

Campisi, 1995, A Biomarker That Identifies Senescent Human-Cells in Culture and in Aging Skin in-Vivo, Proc Natl Acad Sci U S A, 9, 9363

Lowe, 1998, Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling, Genes Dev, 1, 3008

van Deursen, 2014, Senescence and apoptosis: dueling or complementary cell fates?, EMBO Rep, 1, 1139

Lowe, 1997, Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16(INK4a), Cell, 8, 593

Campisi, 2013, Aging, cellular senescence, and cancer, Annu Rev Physiol, 7, 685, 10.1146/annurev-physiol-030212-183653

Evan, 2004, Intrinsic tumour suppression, Nature, 43, 307

Lowe, 2008, Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology, Cold Spring Harbor Symposia on Quantitative Biology, 513

Sharpless, 2004, Ink4a/Arf expression is a biomarker of aging, J Clin Invest, 11, 1299

Hara, 2004, The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression, J Med Invest, 5, 146

Toussaint, 2009, Protocols to detect senescence-associated beta-galactosidase (SA-beta-gal) activity, a biomarker of senescent cells in culture and in vivo, Nat Protoc, 4, 1798, 10.1038/nprot.2009.191

Hu, 2005, The limitations and validities of senescence associated-beta- galactosidase activity as an aging marker for human foreskin fibroblast Hs68 cells, Exp Gerontol, 4, 813

Kitamura, 2012, Sensitive Detection and Monitoring of Senescence-Associated Secretory Phenotype by SASP-RAP Assay, PLoS One, 7, 52305, 10.1371/journal.pone.0052305

Blagosklonny, 2009, Pseudo-DNA damage response in senescent cells, Cell Cycle, 8, 4112, 10.4161/cc.8.24.10215

Alexeyev, 2014, Aging: A mitochondrial DNA perspective, critical analysis and an update, World J Exp Med, 4, 46, 10.5493/wjem.v4.i4.46

Luz, 2009, The role of stress factors during aging of the immune system, Ann N Y Acad Sci, 115, 139

van Deursen, 2015, Cellular senescence in aging and age-related disease: from mechanisms to therapy, Nat Med, 2, 1424

Sharpless, 2013, Monitoring tumorigenesis and senescence in vivo with a p16 INK4a-luciferase model, Cell, 15, 340

Krizhanovsky, 2013, Granule exocytosis mediates immune surveillance of senescent cells, Oncogene, 3, 1971

Zender, 2012, Immune surveillance of senescent cells-biological significance in cancer-and non-cancer pathologies, Carcinogenesis, 3, 1123

Tannous, 2008, A secreted luciferase for ex vivo monitoring of in vivo processes, Nat Methods, 5, 171, 10.1038/nmeth.1177

Jain, 2009, Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases, PLoS One, 4, 8316, 10.1371/journal.pone.0008316

Weber, 2005, Long-term graft function of adult rat and human islets encapsulated in novel alginate-based microcapsules after transplantation in immunocompetent diabetic mice, Diabetes, 5, 687

Nastruzzi, 2011, Encapsulation of eukaryotic cells in alginate microparticles: Cell signaling by TNF-alpha through capsular structure of cystic fibrosis cells, J Cell Commun Signal, 5, 157, 10.1007/s12079-010-0105-z

Calafiore, 2006, Alginate-based microcapsules for immunoisolation of pancreatic islets, Biomaterials, 5603

Liu, 2013, Intraperitoneal injection of clodronate liposomes eliminates visceral adipose macrophages and blocks high-fat diet-induced weight gain and development of insulin resistance, AAPS J, 1, 1001

Xu, 2011, Clodronate liposomes improve metabolic profile and reduce visceral adipose macrophage content in diet-induced obese mice, PLoS One, 6, 1

Krizhanovsky, 2014, Physiological and pathological consequences of cellular senescence, Cell Mol Life Sci, 7, 4373

Kirkland, 2013, Cellular senescence and the senescent secretory phenotype: therapeutic opportunities, J Clin Invest, 12, 966

Krizhanovsky, 2016, Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL, Nat Commun, 7, 11190, 10.1038/ncomms11190

Tchkonia, 2015, Clinical strategies and animal models for developing senolytic agents, Exp Gerontol, 6, 19

Tchkonia, 2016, Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice, Aging Cell

Aykin-Burns, 2016, Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice, Nat Med, 2, 78

Robbins, 2016, Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors, Aging Cell, 1, 428

Sanders, 1994, Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications, J Immunol Methods, 17, 83

Rooijen N Van, 2010, Hendrikx, E, Liposomes for Specific Depletion of Macrophages from Organs and Tissues. Methods in Molecular Biology, 60, 189

Faragher, 2015, Cellular senescence: from growth arrest to immunogenic conversion, Age (Dordr), 3, 27

Martinez, 2016, The clearance of dying cells: table for two, Cell Death Differ, 2, 1

Soehnlein, 2013, Resolution of inflammation: An integrated view, EMBO Mol Med, 5, 661, 10.1002/emmm.201202382

Headland, 2015, The resolution of inflammation: Principles and challenges, Semin Immunol, 2, 149, 10.1016/j.smim.2015.03.014

Krizhanovsky, 2014, Senescent cells communicate via intercellular protein transfer, Genes Dev. Cold Spring Harbor Laboratory Press, 2, 791

Lowe, 2007, Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas, Nature, 44, 656

Goldman, 1982, Beta-galactosidase--an indicator of the maturational stage of mouse and human mononuclear phagocytes, J Cell Physiol, 11, 385

Blom, 1986, Cytochemical localization of beta-galactosidase in resident and inflammatory peritoneal macrophages from C57BL mice, Histochemistry, 8, 159

Wright, 2001, Induction of endogenous beta-galactosidase by ionizing radiation complicates the analysis of p53-LacZ transgenic mice, Oncogene, 2, 7096

Wright, 2001, Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?, Oncogene, 2, 7085

Dombrowicz, 2011, p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages, Blood, 11, 2556

Paumelle, 2011, Downregulation of the tumour suppressor p16 INK4A contributes to the polarisation of human macrophages toward an adipose tissue macrophage (ATM)-like phenotype, Diabetologia, 5, 3150

Kohsaka, 2012, p16(INK4a) exerts an anti-inflammatory effect through accelerated IRAK1 degradation in macrophages, J Immunol, 18, 5066

Felsher, 2015, ARF: connecting senescence and innate immunity for clearance, Aging (Albany, NY), 7, 613, 10.18632/aging.100813

Hortelano, 2011, The tumor suppressor ARF regulates innate immune responses in mice, J Immunol, 18, 6527

Miller, 2015, The Achilles' Heel of Senescent Cells: From Transcriptome to Senolytic Drugs, Aging Cell, 1, 644

Tao, 2011, Superluminescent variants of marine luciferases for bioassays, Anal Chem, 8, 8732

Kim, 2008, Isolation and characterization of mouse mesenchymal stem cells, Transpl Proc, 4, 2649

Ikeda, 2016, Exercise Prevents Diet-induced Cellular Senescence in Adipose Tissue, Diabetes, 6, 1606