Age-specific influences of chronic administration of the fatty acid amide hydrolase inhibitor URB597 on cardiovascular parameters and organ hypertrophy in DOCA-salt hypertensive rats

Marek Toczek1, Marta Baranowska-Kuczko1, Emilia Grzęda1, Anna Pędzińska-Betiuk1, Jolanta Weresa1, Barbara Malinowska1
1Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, Białystok, Poland

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Malinowska, 2012, Triphasic blood pressure responses to cannabinoids: do we understand the mechanism?, Br J Pharmacol, 165, 2073, 10.1111/j.1476-5381.2011.01747.x

Pacher, 2013, Modulating the endocannabinoid system in human health and disease – successes and failures, FEBS J, 280, 1918, 10.1111/febs.12260

Zubrzycki, 2014, A new face of endocannabinoids in pharmacotherapy. Part I: protective role of endocannabinoids in hypertension and myocardial infarction, J Physiol Pharmacol, 65, 171

Li, 2009, Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in hypertension, J Hypertens, 27, 1224, 10.1097/HJH.0b013e328329bbd7

Engeli, 2012, Circulating anandamide and blood pressure in patients with obstructive sleep apnea, J Hypertens, 30, 2345, 10.1097/HJH.0b013e3283591595

Crawford, 1979, Effects of tetrahydrocannabinol on arterial and intraocular hypertension, Int J Clin Pharmacol Biopharm, 17, 191

Lake, 1997, Cardiovascular effects of anandamide in anesthetized and conscious normotensive and hypertensive rats, Hypertension, 29, 1204, 10.1161/01.HYP.29.5.1204

Bátkai, 2004, Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension, Circulation, 110, 1996, 10.1161/01.CIR.0000143230.23252.D2

Ho, 2009, Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats, Br J Pharmacol, 156, 94, 10.1111/j.1476-5381.2008.00034.x

Duerr, 2013, Myocardial hypertrophy is associated with inflammation and activation of endocannabinoid system in patients with aortic valve stenosis, Life Sci, 92, 976, 10.1016/j.lfs.2013.03.014

Lu, 2014, Ligand activation of cannabinoid receptors attenuates hypertrophy of neonatal rat cardiomyocytes, J Cardiovasc Pharmacol, 64, 420, 10.1097/FJC.0000000000000134

Jenkin, 2010, Role for cannabinoid receptors in human proximal tubular hypertrophy, Cell Physiol Biochem, 26, 879, 10.1159/000323997

Janiak, 2007, Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats, Kidney Int, 72, 1345, 10.1038/sj.ki.5002540

Wang, 2007, Endocannabinoid regulates blood pressure via activation of the transient receptor potential vanilloid type 1 in Wistar rats fed a high-salt diet, J Pharmacol Exp Ther, 321, 763, 10.1124/jpet.106.112904

Schenk, 1992, The pathogenesis of DOCA-salt hypertension, J Pharmacol Toxicol Methods, 27, 161, 10.1016/1056-8719(92)90036-Z

Zicha, 2012, Age-dependent salt hypertension in Dahl rats: fifty years of research, Physiol Res, 61, S35, 10.33549/physiolres.932363

Toczek, 2015, Enhanced function of inhibitory presynaptic cannabinoid CB1 receptors on sympathetic nerves of DOCA-salt hypertensive rats, Life Sci, 10.1016/j.lfs.2015.03.022

Piomelli, 2006, Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597), CNS Drug Rev, 12, 21, 10.1111/j.1527-3458.2006.00021.x

Pertwee, 2014, Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications, Proc Nutr Soc, 73, 96, 10.1017/S0029665113003649

Godlewski, 2010, Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects, Chem Biol, 17, 1256, 10.1016/j.chembiol.2010.08.013

Sarzani, 2008, A human fatty acid amide hydrolase (FAAH) functional gene variant is associated with lower blood pressure in young males, Am J Hypertens, 21, 960, 10.1038/ajh.2008.198

Di Marzo, 2015, Endocannabinoid signalling and the deteriorating brain, Nat Rev Neurosci, 16, 30, 10.1038/nrn3876

Lee, 2013, Temporal changes in N-acylethanolamine content and metabolism throughout the peri-adolescent period, Synapse, 67, 4, 10.1002/syn.21609

Ward, 2009, Age-dependent effects of the cannabinoid CB1 antagonist SR141716A on food intake, body weight change, and pruritus in rats, Psychopharmacology (Berl), 206, 155, 10.1007/s00213-009-1592-6

Zicha, 1986, Experimental hypertension in young and adult animals, Hypertension, 8, 1096, 10.1161/01.HYP.8.12.1096

Zicha, 1987, Haemodynamics and the participation of pressor systems in young and adult rats with age-dependent DOCA-salt hypertension, Physiol Bohemoslov, 36, 89

Okine, 2012, Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system, Br J Pharmacol, 167, 627, 10.1111/j.1476-5381.2012.02028.x

Murphy, 2012, The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation, J Neuroinflammation, 9, 79, 10.1186/1742-2094-9-79

Busquets-Garcia, 2011, Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses, Biol Psychiatry, 70, 479, 10.1016/j.biopsych.2011.04.022

Blankman, 2013, Chemical probes of endocannabinoid metabolism, Pharmacol Rev, 65, 849, 10.1124/pr.112.006387

Kinsey, 2011, Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice, Pharmacol Biochem Behav, 99, 718, 10.1016/j.pbb.2011.06.022

Burnier, 2007, High salt intake: a cause of blood pressure-independent left ventricular hypertrophy?, Nephrol Dial Transplant, 22, 2426, 10.1093/ndt/gfm321

Vaněčková, 2013, Chronic antioxidant therapy lowers blood pressure in adult but not in young Dahl salt hypertensive rats: the role of sympathetic nervous system, Acta Physiol (Oxf), 208, 340, 10.1111/apha.12092

Bátkai, 2007, Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase, Am J Physiol Heart Circ Physiol, 293, H909, 10.1152/ajpheart.00373.2007

Schaich, 2015, Alterations in the medullary endocannabinoid system contribute to age-related impairment of baroreflex sensitivity, J Cardiovasc Pharmacol, 65, 473, 10.1097/FJC.0000000000000216

Idris, 2009, Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells, Cell Metab, 10, 139, 10.1016/j.cmet.2009.07.006

Pulgar, 2014, Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis, Hypertension, 64, 619, 10.1161/HYPERTENSIONAHA.114.03633

Zicha, 2012, Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats, Acta Physiol (Oxf), 205, 124, 10.1111/j.1748-1716.2011.02395.x

Schaich, 2014, Acute and chronic systemic CB1 cannabinoid receptor blockade improves blood pressure regulation and metabolic profile in hypertensive (mRen2)27 rats, Physiol Rep, 2

Mukhopadhyay, 2011, Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury, Free Radic Biol Med, 50, 179, 10.1016/j.freeradbiomed.2010.11.002

Gunduz-Cinar, 2013, Amygdala FAAH and anandamide: mediating protection and recovery from stress, Trends Pharmacol Sci, 34, 637, 10.1016/j.tips.2013.08.008

Huggins, 2012, Pain, 153, 1837, 10.1016/j.pain.2012.04.020