Age-related changes of RNA and lipid synthesis in vitro by retina and optic nerve of the rat

Springer Science and Business Media LLC - Tập 8 - Trang 131-148 - 1988
M. Alberghina1, M. Viola1, L. Insirello1, A. M. Giuffrida Stella1
1Institute of Biochemistry, Faculty of Medicine, University of Catania, Catania, Italy

Tóm tắt

We examined the effects of age on RNA and lipid formation by whole retina and optic nerve in vitro. Male Wistar rats, aged 4, 12, and 24 mo, were used. From the results obtained the following conclusions may be drawn: The results strongly support the concept that RNA metabolism of rat retina (most likely photoreceptor cell layer) is not altered during aging; on the contrary, phospholipid synthesis is stimulated in comparison with that of the optic nerve, for which a serious impairment was concomitantly observed. The physiological significance of these responses, and the mechanism by which retinal tissue is spared from the general age derangement of the nervous system, remain to be defined.

Tài liệu tham khảo

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