Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Những thay đổi theo tuổi trong nhịp 24 giờ của hàm lượng và tỷ lệ trao đổi catecholamine trong vùng hạ đồi, thể sọ và tuyến yên của chuột cưng được tiêm Freund's adjuvant
Tóm tắt
Thông tin về các hệ quả nhịp sinh học sau một thách thức miễn dịch trong não của chuột già còn rất hạn chế. Để đánh giá, chúng tôi đã nghiên cứu nhịp điệu 24 giờ tại hàm lượng norepinephrine (NE) trong vùng hạ đồi và thể sọ, tỷ lệ trao đổi dopamine (DA) trong vùng hạ đồi và thể sọ cũng như hàm lượng NE và DA ở tuyến yên, trên chuột trẻ (2 tháng) và chuột già (18–20 tháng) bị giết vào 6 thời điểm khác nhau, vào ngày thứ 18 sau khi tiêm Freund's adjuvant hoặc dung dịch tiềm dẫn. Quá trình lão hóa làm giảm hàm lượng NE ở vùng hạ đồi trước và giữa, tỷ lệ trao đổi DA ở vùng hạ đồi giữa và sau, cũng như hàm lượng NE và tỷ lệ trao đổi DA ở thể sọ. Lão hóa cũng làm giảm hàm lượng NE và DA trong thùy giữa của tuyến yên và tăng hàm lượng DA ở thùy trước của tuyến yên. Việc tiêm phòng bằng Freund's adjuvant đã gây ra: (i) sự giảm tỷ lệ trao đổi DA ở vùng hạ đồi trước và thể sọ; (ii) sự trì hoãn của acrophase trong tỷ lệ trao đổi DA ở vùng hạ đồi giữa của chuột già, và hàm lượng NE ở thể sọ của chuột trẻ; (iii) việc loại bỏ nhịp 24 giờ trong hàm lượng NE và DA của thùy giữa tuyến yên, và trong hàm lượng DA của thùy trước, ở chuột già. Sự suy giảm truyền dẫn catecholamine khi lão hóa có thể góp phần vào việc giảm lợi tố nang trứng và tăng tiết prolactin được báo cáo ở các nhóm chuột tương tự. Một số phản ứng nhịp sinh học đối với tiêm phòng, ví dụ như sự ức chế nhịp 24 giờ của NE và DA ở thùy giữa tuyến yên cũng như DA ở thùy trước, chỉ thấy ở chuột già.
Từ khóa
#chuột già #nhịp sinh học #catecholamine #norepinephrine #dopamine #tuyến yên #Freund's adjuvantTài liệu tham khảo
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