Adult ADHD and Comorbid Somatic Disease: A Systematic Literature Review

Journal of Attention Disorders - Tập 22 Số 3 - Trang 203-228 - 2018
Johanne Telnes Instanes1,2, Kari Klungsøyr3,4, Anne Halmøy1,5,2, Ole Bernt Fasmer6,5,2, Jan Haavik1,5,2
1Department of Biomedicine, University of Bergen, Norway
2K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway
3Department of Global Public Health and Primary Care, University of Bergen, Norway
4Norwegian Institute of Public Health, Bergen, Norway
5Haukeland University Hospital, Bergen, Norway
6Department of clinical medicine, University of Bergen, Norway

Tóm tắt

Objective: To systematically review, synthesize, and appraise available evidence, connecting adult ADHD with somatic disease. Method: Embase, Psychinfo, and Medline databases were searched for studies published from 1994 to 2015 addressing adult ADHD and somatic comorbidity. Somatic conditions were classified according to International Classification of Diseases (ICD-10) codes. Levels of evidence were graded as inconclusive, tentative, or well documented. Results: Most of the 126 studies included in the qualitative synthesis were small and of modest quality. Obesity, sleep disorders, and asthma were well-documented comorbidities in adult ADHD. Tentative evidence was found for an association between adult ADHD and migraine and celiac disease. In a large health registry study, cardiovascular disease was not associated with adult ADHD. Conclusion: There are few large systematic studies using standardized diagnostic criteria evaluating adult ADHD and somatic comorbidities. Significant associations are found between adult ADHD and several somatic diseases, and these are important to consider when assessing and treating either adult ADHD or the somatic diseases.

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Journal of Attention Disorders

Tập 22 Số 3

203-228

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