Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response

American Association for the Advancement of Science (AAAS) - Tập 197 Số 4299 - Trang 165-167 - 1977
Charles E. Myers1, William P. McGuire2, Robert H. Liss3, Ina Ifrim3, Karen R. Grotzinger4, Robert C. Young4
1Clinical Pharmacology Branch, National Cancer Institute, Bethesda, Maryland 20014
2Combined Modalities Branch, National Cancer Institute, Bethesda, Maryland 20014
3Arthur D. Little, Inc., Cambridge, Massachusetts 02166
4Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014

Tóm tắt

The antitumor antibiotic, adriamycin, induces severe cardiac toxicity associated with peroxidation of cardiac lipids in mice. Both this lipid peroxidation and cardiac toxicity of adriamycin are reduced by prior treatment of the animals with the free radical scavenger tocopherol. Such treatment with tocopherol does not, however, alter the magnitude or duration of the adriamycin-induced suppression of DNA synthesis in P388 ascites tumor, nor does it diminish the antitumor responsiveness of P388 ascites tumor. These results suggest that adriamycin has at least two mechanisms of tissue damage: one, which involves lipid peroxidation, is blocked by tocopherol and results in cardiac toxicity; the other, which involves binding to DNA, is not antagonized by tocopherol and is responsible for tumor response.

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Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 197 Số 4299

165-167

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