Biểu Hiện Tế Bào Mỡ của Yếu Tố Hoại Tử Khối U-α: Vai Trò Trực Tiếp trong Sự Kháng Insulin Liên Quan Đến Béo Phì

American Association for the Advancement of Science (AAAS) - Tập 259 Số 5091 - Trang 87-91 - 1993
Gökhan S. Hotamışlıgil1, Narinder S. Shargill1, Bruce M. Spiegelman1
1Dana-Farber Cancer Institute and the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.

Tóm tắt

Yếu tố hoại tử khối u-α (TNF-α) đã được chứng minh có các tác động dị hóa trên tế bào mỡ cũng như toàn bộ cơ thể. Biểu hiện của TNF-α RNA thông tin đã được quan sát thấy trong mô mỡ từ bốn mô hình chuột cống khác nhau về béo phì và tiểu đường. Protein TNF-α cũng tăng lên cả cục bộ và toàn hệ thống. Việc trung hòa TNF-α trong chuột cống béo phì fa / fa đã gây ra sự tăng đáng kể trong việc hấp thu glucose ngoại vi để đáp ứng với insulin. Những kết quả này chỉ ra vai trò của TNF-α trong béo phì và đặc biệt là trong sự kháng insulin và tiểu đường thường đi kèm với béo phì.

Từ khóa

#TNF-α #biểu hiện mỡ #béo phì #kháng insulin #tiểu đường #động vật gặm nhấm

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