Additional evidence that genetic variation of MAO‐A gene supports a gender subtype in obsessive‐compulsive disorder

Wiley - Tập 105 Số 3 - Trang 279-282 - 2001
Beatríz Camarena1, Gina Rinetti1, Carlos Cruz1, Amalia Gómez-Cotero1, Juan Ramón De La Fuente2, Humberto Nicolini1
1Departamento de Genética Psiquiátrica, Instituto Nacional de Psiquiatría Ramón de la Fuente, México D.F., México
2UNAM, Ciudad Universitaria, Edif. Rectoria, México D.F., México

Tóm tắt

AbstractStudies have recently reported a sexually dimorphic association between obsessive‐compulsive disorder (OCD) and a polymorphism related with variations in MAO‐A activity. These observations suggest the possibility of gender differences in genetic susceptibility for OCD. We thus reexamined the MAO‐A/EcoRV polymorphism in a sample of 122 OCD patients and 124 healthy subjects. An excess of allele 1 in OCD females with major depression disorder was confirmed as previously reported. This difference was more strongly associated with OCD females than males in the total sample. Finally, we analyzed a sample of 51 OCD trios. Haplotype‐based haplotype relative risk (HHRR) analysis of the inheritance of the MAO‐A variants revealed in the female probands that 14 out of 19 transmitted the allele 1, providing significant evidence for an allelic association between OCD and MAO‐A gene. In conclusion, our findings may provide molecular evidence to identify a clinically meaningful gender subtype. However, an effort should be made to replicate the analysis in larger samples of informative parents using strategies such as transmission disequilibrium test to allow definite conclusions. © 2001 Wiley‐Liss, Inc.

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Wiley

Tập 105 Số 3

279-282

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