Addition of clopidogrel to aspirin in 45 852 patients with acute myocardial infarction: randomised placebo-controlled trial

The Lancet - Tập 366 Số 9497 - Trang 1607-1621 - 2005
Z M Chen1, Lixin Jiang, Y P Chen, Jingyi Xie, Kiana Shirani, Richard Peto, Rory Collins, L S Liu
1Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Richard Doll Building, Old Road Campus, Oxford OX3 7LF, UK. [email protected]

Tóm tắt

Từ khóa


Tài liệu tham khảo

Yusuf, 2001, Global burden of cardiovascular diseases, part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization, Circulation, 104, 2746, 10.1161/hc4601.099487

1988, Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17 187 cases of suspected acute myocardial infarction: ISIS-2, Lancet, 2, 349

Herbert, 1993, Clopidogrel, a novel antiplatelet and antithrombotic agent, Cardiovasc Drug Rev, 11, 180, 10.1111/j.1527-3466.1993.tb00275.x

Quinn, 1999, Ticlopidine and clopidogrel, Circulation, 100, 1667, 10.1161/01.CIR.100.15.1667

1996, A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE), Lancet, 348, 1329, 10.1016/S0140-6736(96)09457-3

Gregorini, 1997, Ticlopidine and aspirin interactions, Heart, 77, 11, 10.1136/hrt.77.1.11

Mishkel, 1999, Clopidogrel as adjunctive antiplatelet therapy during coronary stenting, JACC, 34, 1884, 10.1016/S0735-1097(99)00443-X

Steinhubl, 2002, Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial, JAMA, 288, 2411, 10.1001/jama.288.19.2411

2001, Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation, NEJM, 345, 494, 10.1056/NEJMoa010746

Sabatine, 2005, Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation, N Engl J Med, 352, 1179, 10.1056/NEJMoa050522

2000, Rationale, design and organisation of the second Chinese cardiac study (CCS-2): a randomized trial of clopidogrel plus aspirin, and of metoprolol, among patients with suspected acute myocardial infarction, J Cardiovasc Risk, 7, 435, 10.1177/204748730000700608

2005, Early intravenous then oral metoprolol in 45 852 patients with acute myocardial infarction: randomised placebo-controlled trial, Lancet, 366, 1622, 10.1016/S0140-6736(05)67661-1

1995, Oral captopril versus placebo among 13 634 patients with suspected acute myocardial infarction: interim report from the Chinese Cardiac Study (CCS-1), Lancet, 345, 686, 10.1016/S0140-6736(95)90866-8

Peto, 1976, Design and analysis of randomised clinical trials requiring prolonged observation of each patient, Br J Cancer, 34, 585, 10.1038/bjc.1976.220

2002, Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients, BMJ, 324, 71, 10.1136/bmj.324.7329.71

Baigent, 1998, ISIS-2: 10-year survival among patients with suspected acute myocardial infarction in randomised comparison of intravenous streptokinase, oral aspirin, both, or neither, BMJ, 316, 1337, 10.1136/bmj.316.7141.1337

Bhatt, 2004, Clopidogrel added to aspirin versus aspirin alone in secondary prevention and high-risk primary prevention: Rationale and design of the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial, Am Heart J, 148, 263, 10.1016/j.ahj.2004.03.028

Roux, 1992, Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: a meta-analysis, JACC, 19, 671, 10.1016/S0735-1097(10)80290-6

Cadroy, 2000, Early potent antithrombotic effect with combined aspirin and a loading dose of clopidogrel on experimental arterial thrombogenesis in humans, Circulation, 101, 2823, 10.1161/01.CIR.101.24.2823

Angiolillo, 2004, High clopidogrel loading dose during coronary stenting: effects on drug response and interindividual variability, Eur Heart J, 25, 1903, 10.1016/j.ehj.2004.07.036

Yusuf, 2003, Early and late effects of clopidogrel in patients with acute coronary syndromes, Circulation, 107, 966, 10.1161/01.CIR.0000051362.96946.15