Abnormal Trajectory of Intracortical Myelination in Schizophrenia Implicates White Matter in Disease Pathophysiology and the Therapeutic Mechanism of Action of Antipsychotics

Todd A. Tishler1, George Bartzokis1, Po H. Lu2, Erika P. Raven3,4, Mher Khanoyan1, Chandra J. Kirkpatrick1, Meghan H. Pyle1, J. Pablo Villablanca5, Lori L. Altshuler1, Jim Mintz6, Joseph Ventura1, Laurie R. Casaus1, Kenneth L. Subotnik1, Keith H. Nuechterlein1,7, Benjamin M. Ellingson1,5
1Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, California
2Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California
3Center for Functional and Molecular Imaging, Georgetown University Medical Center, Washington, DC
4Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
5Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California
6Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, Texas
7Department of Psychology, University of California, Los Angeles, Los Angeles, California

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