ATG-Induced Accelerated Immune Senescence: Clinical Implications in Renal Transplant Recipients

Bonnefoy-Berard, 1991, Antibodies against functional leukocyte surface molecules in polyclonal antilymphocyte and antithymocyte globulins, Transplantation, 51, 669, 10.1097/00007890-199103000-00024 Rebellato, 1994, A comprehensive definition of the major antibody specificities in polyclonal rabbit antithymocyte globulin, Transplantation, 57, 685, 10.1097/00007890-199403150-00010 Müller, 1997, Persistent long-term changes in lymphocyte subsets induced by polyclonal antibodies, Transplantation, 64, 1432, 10.1097/00007890-199711270-00010 Ducloux, 2010, Prolonged CD4 T cell lymphopenia increases morbidity and mortality after renal transplantation, J Am Soc Nephrol, 21, 868, 10.1681/ASN.2009090976 Gruver, 2007, Immunosenescence of ageing, J Pathol, 211, 144, 10.1002/path.2104 Préville, 2001, Mechanisms involved in antithymocyte globulin immunosuppressive activity in a nonhuman primate model, Transplantation, 71, 460, 10.1097/00007890-200102150-00021 Ruzek, 2009, In vivo characterization of rabbit anti-mouse thymocyte globulin: A surrogate for rabbit anti-human thymocyte globulin, Transplantation, 88, 170, 10.1097/TP.0b013e3181abc061 Lewin, 2002, Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations, Blood, 100, 2235, 10.1182/blood.V100.6.2235 Wang, 2010, An association between immunosenescence and CD4(+)CD25(+) regulatory T cells: A systematic review, Biomed Environ Sci, 23, 327, 10.1016/S0895-3988(10)60072-4 Derhovanessian, 2010, Hallmark features of immunosenescence are absent in familial longevity, J Immunol, 185, 4618, 10.4049/jimmunol.1001629 Weng, 2012, Telomeres and immune competency, Cur Opin Immunol, 24, 1, 10.1016/j.coi.2012.05.001 Kohler, 2009, Life after the thymus: CD31+ and CD31− human naive CD4+ T-cell subsets, Blood, 113, 769, 10.1182/blood-2008-02-139154 Ducloux, 1998, CD4 lymphocytopenia in long-term renal transplant recipients, Transplant Proc, 30, 2859, 10.1016/S0041-1345(98)00843-4 Gurkan, 2010, Immune reconstitution following rabbit antithymocyte globulin, Am J Transplant, 10, 2132, 10.1111/j.1600-6143.2010.03210.x Bouvy, 2013, Kinetics of homeostatic proliferation and thymopoiesis after rATG induction therapy in kidney transplant patients, Transplantation, 96, 904, 10.1097/TP.0b013e3182a203e4 Mohty, 2007, Mechanisms of action of antithymocyte globulin: T-cell depletion and beyond, Leukemia, 21, 1387, 10.1038/sj.leu.2404683 Williams, 2009, Single cell analysis of complex thymus stromal cell populations: Rapid thymic epithelia preparation characterizes radiation injury, Clin Trans Sci, 2, 279, 10.1111/j.1752-8062.2009.00128.x Bluestone, 2008, The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation, Am J Transplant, 8, 2086, 10.1111/j.1600-6143.2008.02377.x Wang, 2009, Short-term anti-CD25 monoclonal antibody administration down-regulated CD25 expression without eliminating the neogenetic functional regulatory T cells in kidney transplantation, Clin Exp Immunol, 155, 496, 10.1111/j.1365-2249.2008.03847.x Bouvy, 2014, The impact of induction therapy on the homeostasis and function of regulatory T cells in kidney transplant patients, Nephrol Dial Transplant, 29, 1587, 10.1093/ndt/gfu079 Gregg, 2005, The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age, Clin Exp Immunol, 140, 540, 10.1111/j.1365-2249.2005.02798.x Carrero, 2008, Telomere attrition is associated with inflammation, low fetuin-A levels and high mortality in prevalent haemodialysis patients, Telomere attrition is associated with inflammation, low fetuin-A levels and high mortality in prevalent haemodialysis patients, J Int Med, 263, 302, 10.1111/j.1365-2796.2007.01890.x Strioga, 2011, CD8 + CD28− and CD8 + CD57+ T cells and their role in health and disease, Immunology, 134, 17, 10.1111/j.1365-2567.2011.03470.x Yap, 2014, Expansion of highly differentiated cytotoxic terminally differentiated effector memory CD8+ T cells in a subset of clinically stable kidney transplant recipients: A potential marker for late graft dysfunction, J Am Soc Nephrol, 25, 1856, 10.1681/ASN.2013080848 Broux, 2012, Pathogenic features of CD4 + CD28–T cells in immune disorders, Trends Mol Med, 18, 446, 10.1016/j.molmed.2012.06.003 Miyazaki, 2008, Expansion of CD4 + CD28− T cells producing high levels of interferon-{gamma} in peripheral blood of patients with multiple sclerosis, Mult Scler, 8, 1044, 10.1177/1352458508092809 Thewissen, 2007, CD4 + CD28null T cells in autoimmune disease: Pathogenic features and decreased susceptibility to immunoregulation, J Immunol, 179, 6514, 10.4049/jimmunol.179.10.6514