A systematic review of prevalence studies of dementia in Parkinson's disease

Movement Disorders - Tập 20 Số 10 - Trang 1255-1263 - 2005
Dag Aarsland1, Julia Zaccai, Carol Brayne
1Section of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway. [email protected]

Tóm tắt

AbstractSubstantial variation in the prevalence of dementia in Parkinson's disease (PDD) has been reported. The aim of this study was to review systematically and critically previous studies of the prevalence of PDD using PubMed to search the literature. Studies focusing on PD and PDD, as well as those examining on the epidemiology of dementia subtypes, were included. Predefined inclusion and exclusion criteria were used and the quality of the studies included was rated. Articles were included if: (1) the proportion of PDD among patients with either PD or dementia was reported in an original study; (2) patients had been subjected to prospective clinical examination; and (3) strategies to include all subjects with either PD or dementia within the community or hospital clinics within a geographical area were employed. Twelve studies of the prevalence of PD or PDD (1,767 patients included) and 24 prevalence studies of dementia subtypes (4,711 patients included) met the inclusion criteria. In the PD/PDD studies, the proportion (mean and 95% confidence interval) with PDD in PD was 24.5% (17.4–31.5). There were significant methodological variations between studies and in the four studies that matched the quality criteria most closely, the rate of PDD was 31.1% (20.1–42.1). The prevalence of PDD was estimated as 0.5% in subjects 65 years or older. The percentage of PDD among those with dementia was 3.6% (3.1–4.1), with an estimated prevalence of PDD of 0.2% in subjects aged 65 years or older. Despite methodological variation, this systematic review suggests that 24 to 31% of PD patients have dementia, and that 3 to 4% of the dementia in the population would be due to PDD. The estimated prevalence of PDD in the general population aged 65 years and over is 0.2 to 0.5%. © 2005 Movement Disorder Society

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Tài liệu tham khảo

10.1001/archneur.56.1.33

10.1016/S0140-6736(84)92807-1

10.1212/WNL.23.8.783

10.1177/089198878800100106

10.1212/WNL.47.5.1113

10.1002/(SICI)1099-1166(199910)14:10<866::AID-GPS38>3.0.CO;2-Z

10.1212/01.WNL.0000036610.36834.E0

10.1111/j.1532-5415.2000.tb06891.x

10.1016/S1474-4422(03)00351-X

10.1177/0891988704267463

1987, Diagnostic and Statistical Manual of Mental Disorders (DSM‐III)

1990, International Classification of Disease, Tenth Revision (ICD‐10)

10.1093/brain/89.3.429

Snow B, 1989, A community survey of Parkinson's disease, CMAJ, 141, 418

10.1159/000213219

10.1111/j.1600-0404.1995.tb00478.x

10.1136/bmj.292.6519.534

10.1111/j.1600-0404.1976.tb04375.x

10.1159/000110361

10.1002/mds.870120210

10.1001/archneur.1996.00550010084020

10.1001/archneur.1992.00530290076015

10.1212/WNL.45.4.705

10.1001/archneur.1996.00550060082020

10.2169/internalmedicine1962.29.261

10.1212/WNL.40.4.626

10.1111/j.1600-0404.1982.tb03109.x

10.1016/S0022-510X(98)00225-1

10.1001/archneur.1991.00530180046016

10.1212/WNL.50.6.1572

10.1136/bmj.310.6985.970

10.1136/jnnp.60.6.628

10.1212/WNL.42.1.115

10.1192/bjp.180.3.270

Ogunniyi A, 1997, Profile of dementia in a Nigerian community—types, pattern of impairment, and severity rating, J Natl Med Assoc, 89, 392

10.1159/000048620

10.1017/S1041610201007852

10.1212/WNL.58.2.209

10.1159/000067110

Dartigues JF, 1991, The Paquid research program on the epidemiology of dementia. Methods and initial results, Rev Neurol (Paris), 147, 225

Letenneur L, 1993, Prevalence of dementia in Gironde (France), Rev Epidemiol Sante Publique, 41, 139

1994, Canadian study of health and aging: study methods and prevalence of dementia, Can Med Assoc J, 6, 899

10.1212/WNL.41.12.1886

10.1097/00002093-200204000-00007

10.1097/00002093-199809000-00002

10.1136/jnnp.74.6.720

White L, 1996, Prevalence of dementia in older Japanese‐American men in Hawaii: the Honolulu‐Asia Aging Study, JAMA, 276, 955, 10.1001/jama.1996.03540120033030

10.1111/j.1600-0404.1991.tb04981.x

10.1136/jnnp.62.1.10

10.1001/archneur.60.3.387

Portin R, 1987, Predictive factors for cognitive deterioration and dementia in Parkinson's disease, Adv Neurol, 45, 413

Ritchie K, 2003, Evidence‐based dementia practice, 238

10.1212/WNL.57.8.1497

10.1002/mds.10459

1994, Diagnostic and Statistical Manual of Mental Disorders (DSM‐IV)

10.1159/000068483

10.1093/brain/awh067

10.1177/0891988704267470

10.1002/ana.10219

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Movement Disorders

Tập 20 Số 10

1255-1263

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