A randomized and comparative study to assess safety and efficacy of supplemental treatment of a herbal formulation - Aayudh Advance comprising essential oils in patients with corona virus 2019 (COVID-19)

Contemporary Clinical Trials Communications - Tập 22 - Trang 100755 - 2021
Jayesh Dutt1, Bhavdeep Ganatra2, Nilay Suthar3, Mohammedebrahim Malek1, Bhakti Shukla4, Krupali Shukla4, Karna Shukla4, Shreya Pandit5, Manish Rachchh6, Rina Gokani6, Mona Bhalani6
1Smt. NHL Municipal Medical College & SVPIMSR, Ellisbridge, Ahmedabad, 380006, Gujarat, India
2Ganatra Ayurveda & Panchkarma Clinic, 125, Advait Complex, Opp Soham Tower, B /s Sandesh Press, Vastrapur, Ahmedabad, 380054, Gujarat, India
3LG Hospital, Ahmedabad, Gujarat, India
4M/s Shukla Ashar Impex Pvt. Ltd., Rajkot, 360001, Gujarat, India
5Pandit Dindayal Gov. Hospital, Rajkot, 360001, Gujarat, India
6M/s Accuprec Research Labs Pvt Ltd., Ahmedabad, 382213, Gujarat, India

Tài liệu tham khảo

Unhale, 2020, A review on corona virus (COVID-19), World Journal of Pharmaceutical and Life Science, 6, 109 Gennaro, 2020, Coronavirus diseases (covid-19) current status and future perspectives: a narrative review, Int. J. Environ. Res. Publ. Health, 17, 1, 10.3390/ijerph17082690 Namburi, 2020, COVID-19: an applied intervention through ayurveda, Int. J. Ayurveda Pharma Res., 8, 23 Drent, 2020, Ranking self-reported gastrointestinal side effects of pharmacotherapy in sarcoidosis, Lung, 198, 395, 10.1007/s00408-020-00323-8 Srinivasa, 2017, Increased incidence of gastrointestinal side effects in patients taking hydroxychloroquine: a brand-related issue?, J. Rheumatol., 44, 10.3899/jrheum.161063 Tetu, 2018, Prevalence of hydroxychloroquine induced side-effects in dermatology patients: a retrospective survey of 102 patients, Ann. Dermatol. Venereol., 145, 395 Furst, 1999, Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: a randomized, double-blind six-week trial with eighteen-week extension, Arthritis Rheum., 42, 357, 10.1002/1529-0131(199902)42:2<357::AID-ANR19>3.0.CO;2-J Awadhesh, 2020, Remdesivir in COVID-19: a critical review of pharmacology, preclinical and clinical studies,/Diabetes & Metabolic Syndrome, Clin. Res. Rev., 14, 641 Grein, 2020, Compassionate use of remdesivir for patients with severe Covid-19, N. Engl. J. Med., 382, 2327, 10.1056/NEJMoa2007016 Cai, 2020, Experimental treatment with favipiravir for COVID-19: an open-label control study, Engineering, 1 Ling, 2020, Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients, Chin Med J (Engl), 133, 1039, 10.1097/CM9.0000000000000774 Veronese, 2020, Use of corticosteroids in coronavirus disease 2019 pneumonia: a systematic review of the literature, Front. Med., 7, 1, 10.3389/fmed.2020.00170 Rastogi S, Pandey D, Singh R COVID-19 pandemic: a pragmatic plan for ayurveda intervention. J. Ayurveda Integr. Med.; 1-5. Yi, 2020, COVID-19: what has been learned and to be learned about the novel coronavirus disease, Int. J. Biol. Sci., 16, 1753, 10.7150/ijbs.45134 Babu, 2014, Virgin coconut oil and its potential cardioprotective effects, PGM (Postgrad. Med.), 126, 76, 10.3810/pgm.2014.11.2835 Okokon, 2017, Nephroprotective activity of husk extract and fractions of zea mays against alloxan-induced oxidative stress in diabetic rats, Journal of Basic Pharmacology and Toxicology, 1, 1 Abbas, 2014, Phenolic profile, antioxidant potential and DNA damage protecting activity of sugarcane (Saccharum officinarum), Food Chem., 147, 10, 10.1016/j.foodchem.2013.09.113 Ozkalp, 2010, The antibacterial activity of essential oil of oregano (Origanum vulgare L.), J. Food Agric. Environ., 8, 272 Ayoola, 2008, Chemical analysis and antimicrobial activity of the essential oil of Syzigium aromaticum (Clove), Afr. J. Microbiol. Res., 2, 162 Balakrishnan, 2014, Evaluation of the Lemongrass Plant (Cymbopogon citratus) extracted in different solvents for antioxidant and antibacterial activity against human pathogens, Asian Pacific Journal of Tropical Disease, 4, S134, 10.1016/S2222-1808(14)60428-X Abdeen, 2019, Protective effect of cinnamon against acetaminophen-mediated cellular damage and apoptosis in renal tissue, Environ. Sci. Pollut. Control Ser., 26, 240, 10.1007/s11356-018-3553-2 Shijna, 2015, Coconut oil - a review of potential applications, Hygeia J. Drugs Med., 7, 34 Ray, 1996, Modulation of humoral and cell-mediated immune responses by Azadirachta indica (Neem) in Mice, Indian J. Exp. Biol., 34, 698 Emad, 2017, Black seed (Nigella sativa) as antimicrobial drug: a mini-review, Novel Approaches in Drug Designing & Development, 3, 1 Sulieman, 2011, Phytochemical analysis of local spearmint (Mentha spicata) leaves and detection of the antimicrobial activity of its oil, J. Microbiol. Res., 1, 1, 10.5923/j.microbiology.20110101.01 McKay, 2006, A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.), Phytother Res., 20, 619, 10.1002/ptr.1936 Pratibha, 2003, Immunomodulatory activity of boswellic acids of Bowellia serrata roxb, Indian J. Exp. Biol., 41, 1460 Campelo, 2011, Antioxidant and antinociceptive effects of citrus limon essential oil in mice, J. Biomed. Biotechnol., 1, 10.1155/2011/678673 Junior, 2017, Acute and neuropathic orofacial antinociceptive effect of eucalyptol, Inflammopharmacology, 25, 247, 10.1007/s10787-017-0324-5 Silva, 2011, Coriander (Coriandrum sativum L.) essential oil: its antibacterial activity and mode of action evaluated by Flow cytometry, J. Med. Microbiol., 60, 1479, 10.1099/jmm.0.034157-0 Koulivand, 2013, Lavender and the nervous system, Evid. base Compl. Alternative Med., 1 Moreno, 2006, Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition, Free Radic. Res., 40, 223, 10.1080/10715760500473834 Salehi, 2018, Thymol, thyme, and other plant sources: health and potential uses, Physiotherapy Research, 1 Chopade, 2008, Green Tea (Camellia sinensis): chemistry, traditional, medicinal uses and its pharmacological activities - a review, Phcog. Rev., 2, 157 Fidrianny, 2014, Evaluation of antioxidant activities from various extracts of sweet orange peels using DPPH, FRAP assays and correlation with phenolic, flavonoid, carotenoid content, Asian J. Pharmaceut. Clin. Res., 7, 186 Ramarao, 2020, Drugs targeting various stages of the SARS-CoV-2 life cycle: exploring promising drugs for the treatment of Covid-19, Cell. Signal., 74, 109721, 10.1016/j.cellsig.2020.109721