A new emerging pandemic of severe fever with thrombocytopenia syndrome (SFTS)

VirusDisease - Tập 32 - Trang 220-227 - 2021
Divya Sharma1, Mohit Kamthania1
1Department of Life Sciences, IAMR College, Ghaziabad, India

Tóm tắt

The aim of this study is to make aware every one of the deadliest diseases named severe fever with thrombocytopenia syndrome (SFTS). It has become the worldwide pandemic in recent few years. It is a kind of haemorrhagic fever, caused by SFTS virus (SFTSV), a novel phlebovirus of family Bunyaviridae. This syndrome is also a tick-borne zoonosis that means the virus transmitted from tick bite (having virus) into human body, i.e. infection spread from animals to humans and also transmitted from human to human. Epidemiological data of SFTS was collected to know the nature/symptoms of SFTSV. First case of this disease has been reported in China, followed by Japan, South korea, Taiwan, USA and many other countries. Vertebrates are the host of this disease and tick functions as a vector, where the virus can undergo brisk changes using gene mutation, homologous recombination and reassortments. The major symptoms of hemorrhagic fever are fever, thrombocytopenia, leucopenia and gastrointestinal abnormalities. Sometimes in very severe cases, full body organ failure may also take place and average death rate in humans is nearly 10 %. Old aged peoples are more prone to SFTSV infection. Apart from the fact of increasing SFTSV related health problems to humans, the pathogenesis of SFTS virus in human is not entirely understood and no treatment to this virus is still available. The simplest way to protect our self from this infection is to refrain from tick bite. Therefore, this disease has evolved to produce serious health issues to humans in various countries of world including china. This review discussing about causative agent, epidemiology, pathogenesis, diagnosis and treatment of SFTS. In order to control the spread of SFTSV, we have to stop the viral transmission or to protect the easily vulnerable population from tick bites, avoiding direct contact of infectious and also to use personal protective devices for SFTS patients. So, the weather conditions, mode of transmission and creation of new therapeutics like vaccines and drugs are the main areas of forthcoming research.

Tài liệu tham khảo

Zhang L, Liu Y, Ni D, Li Q, Yu Y, Yu XJ, et al. Nosocomial transmission of human granulocytic anaplasmosis in China. JAMA. 2008;300:2263–70.

Xu B, Liu L, Huang X, et al. Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus. Plos Pathog. 2011;7(11):e1002369.

Wei J, Li S, Dong J, Tian H, Chowell G, Tian H, et al. The first human infection with severe fever with thrombocytopenia syndrome virus in Shaanxi Province, China. Int J Infect Dis. 2015;35:37–9.

Yu XJ, Liang MF, Zhang SY, Liu Y, et al. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med. 2011;364:1523–32.

Zhang YZ, Zhou DJ, Qin XC, Tian JH, Xiong Y, Wang JB, Chen XP, et al. The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China. J Virol. 2012;86:2864–8.

Bao CJ, Guo XL, Qi X, Hu JL, Zhou MH, Varma JK, Cui LB, et al. A family cluster of infections by a newly recognized bunyavirus in eastern China, 2007: further evidence of person-to-person transmission. Clin Infect Dis. 2011;3:1208–14.

Liu Y, Li Q, Hu W, Wu J, Wang Y, Mei L, Walker DH, et al. Person-to-person transmission of severe fever with thrombocytopenia syndrome virus. Vector Borne Zoonotic Dis. 2012;12:156–60.

Jiang XL, Zhang S, Jiang M, Bi ZQ, Liang MF, Ding SJ, Wang SW, et al. A cluster of person-to-person transmission cases caused by SFTS virus in Penglai, China. Clin Microbiol Infect. 2015;21:274–9. https://doi.org/10.1016/j.cmi.2014.10.006.

Zhan J, Wang Q, Cheng J, et al. Current status of severe fever with thrombocytopenia syndrome in China. Virol Sin. 2017;32(1):51–62. https://doi.org/10.1007/s12250-016-3931-1.

Lam T, Liu W, Bowden TA, Cui N, Zhuang L, Liu K, Zhang Y, Cao W, Pybus OG. Evolutionary and molecular analysis of the emergent severe fever with thrombocytopenia syndrome virus. Epidemic. 2013;5:1–10.

Takahashi T, Maeda K, Suzuki T, et al. The first identification and retrospective study of severe Fever with thrombocytopenia syndrome in Japan. J Infect Dis. 2014;209:816–27.

Hayasaka D, Fuxun Y, Yoshikawa A, Posadas-Herrera G, Shimada S, et al. Seroepidemiological evidence of severe fever with thrombocytopenia syndrome virus infections in wild boars in Nagasaki, Japan. Trop Med Health. 2016;44:6.

Kim KH, Yi J, Kim G, et al. Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect Dis. 2013;19:1892–4.

Kim KH, Ko MK. Seroprevalence of Severe Fever with Thrombocytopenia Syndrome in Southeastern Korea. J Korean Med Sci. 2017;32:29–32.

Yun SM, Lee WG, Ryou J, Yang SC, Park SW, et al. Severe fever with thrombocytopenia syndrome virus in ticks collected from humans, South Korea 2013. Emerg Infect Dis. 2014;20:1358–61.

Mcmullan LK, Folk SM, Kelly AJ, et al. A new phlebovirus associated with severe febrile illness in Missouri. N Engl J Med. 2012;367:834–41.

Lin T-L, Ou S-C, Maeda K, Shimoda H, Chan JP-W, Tu W-C, Hsu W-L, et al. The first discovery of severe fever with thrombocytopenia syndrome virus in Taiwan. Emerg Microbes Infect. 2020;9(1):148–51. https://doi.org/10.1080/22221751.2019.1710436.

Liu Q, Biao H, Si-Yang H, Feng W, Xing-Quan Z, et al. Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis. Lancet Infect Dis. 2014;14:763–72.

Lei X-P, Liu M, Yu X. Severe fever with thrombocytopenia syndrome and its pathogen SFTSV. Microbes Infect. 2015;17:149–54.

Silvas J, Aguilar P. The Emergence of Severe Fever with Thrombocytopenia Syndrome Virus Am. J Trop Med Hyg. 2015;97(4):992–6.

Walter CT, Barr JN. Recent advances in the molecular and cellular biology of bunyaviruses. J Gen Virol. 2011;92:2467–84.

Li JL, Ling JX, Liu DY, et al. Genetic characterization of a new subtype of Hantaan virus isolated from a hemorrhagic fever with renal syndrome (HFRS) epidemic area in Hubei Province, China. Arch Virol. 2012;157:1981–7.

Bishop DH, Calisher CH, Casals J, et al. Bunyaviridae Intervirol. 1980;14:125–43.

Palacios G, Savji N, Travassos DRA, et al. Characterization of the Uukuniemi virus group (Phlebovirus: Bunyaviridae): evidence for seven distinct species. J Virol. 2013;87:3187–95.

Matsuno K, Weisend C, Travassos DRAP, et al. Characterization of the Bhanja serogroup viruses (Bunyaviridae): a novel species of the genus Phlebovirus and its relationship with other emerging tick-borne phleboviruses. J Virol. 2013;87:3719–28.

National Health and Family Planning Commission of the People’s Replublic China. Guide for severe fever with thrombocytopenia syndrome control (2010 edit). http://www.moh.gov.cn/mohwsyjbgs/s8348/201010/49272.html. Accessed 23 Sept 2013 (in Chinese).

Li Y, Zhou H, Mu D, Yin W, Yu H. Epidemiological analysis on severe fever with thrombocytopenia syndrome under the national surveillance data from 2011 to 2014, China. Zhonghua liu xing bing xue za zhi. 2015;36:598–602.

Denic S, Janbeih J, Nair S, Conca W, Tariq WU, Al-Salam S. Acute thrombocytopenia, leucopenia, and multiorgan dysfunction: the first case of SFTS Bunyavirus outside China? Case Rep Infect Dis. 2011: 204056.

South Korea. Four die from tickborne severe fever with thrombocytopenia syndrome (SFTS). http://blogs.uw.edu/apecein/2013/06/07/south-korea-four-die-from-tickborne-severe-feverwith-thrombocytopenia-syndrome-sfts/. Accessed Sept 2013 (2013).

ProMEDmail. Severe fever with thrombocytopenia syndrome-Japan (05): update. Apr 10. 2013. http://www.promedmail.org/direct.php?id=20130410.636456. Accessed Sep 2013.

Cui F, Cao HX, Wang L, et al. Clinical and epidemiological study on severe fever with thrombocytopenia syndrome in Yiyuan County, Shandong Province, China. Am J Trop Med Hyg. 2013;88:510–2.

Liang S, Bao C, Zhou M, et al. Seroprevalence and risk factors for severe Fever with thrombocytopenia syndrome virus infection in jiangsu province, china, 2011. Am J Trop Med Hyg. 2014;90:256–9.

National Centre for Infectious Diseases. (updated on June 2020) https://www.ncid.sg/Health-Professionals/Joint-MOH-NCID-Guidances/Pages/Severe-Fever-with-Thrombocytopenia-Syndrome.aspx.

Kim J, Bae J. Epidemiological and clinical characteristics of confirmed cases of severe fever with thrombocytopenia syndrome in jeju province, korea, 2014–2018. J Prev Med Public Health. 2019;52:195–9.

Maslow JN, Kwon JJ, Mikota SK, Spruill S, et al. Severe fever and thrombocytopenia syndrome virus infection: Considerations for vaccine evaluation of a rare disease. Hum Vaccin Immunother. 2019;15(10):2249–57.

Kobayashi Y, Kato H, Yamagishi T, Shimada T, et al. Severe fever with thrombocytopenia syndrome, Japan, 2013–2017. Emerg Infect Dis. 2020;26(4):692–9.

Sun L, Hu Y, Niyonsaba A, et al. Detection and evaluation of immunofunction of patients with severe fever with thrombocytopenia syndrome. Clin Exp Med. 2013. https://doi.org/10.1007/s10238-013-0259-0.

Deng B, Zhang S, Geng Y, et al. Cytokine and chemokine levels in patients with severe fever with thrombocytopenia syndrome virus. Plos One. 2012;7:41365.

Qu B, Qi X, Wu X, et al. Suppression of the interferon and NF-κB responses by severe fever with thrombocytopenia syndrome virus. J Virol. 2012;86:8388–401.

Sun Y, Jin C, Zhan F, et al. Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome. J Infect Dis. 2012;206:1085–94.

Zoja C, Garcia PB, Remuzzi G. The role of chemokines in progressive renal disease. Front Biosci (Landmark Ed). 2009;14:1815–22.

Temonen M, Mustonen J, Helin H, Pasternack A, Vaheri A, Holthofer H. Cytokines, adhesion molecules and cellular infi ltration in nephropathia epidemica kidneys: an immunohistochemical study. Clin Immunol Immunopathol. 1996;78:47–55.

Wasmuth HE, Tacke F, Trautwein C. Chemokines in liver infl ammation and fibrosis. Semin Liver Dis. 2010;30:215–25.

Petreaca ML, Yao M, Liu Y, Defea K, Martins-Green M. Transactivation of vascular endothelial growth factor receptor-2 by interleukin-8 (IL-8/CXCL8) is required for IL-8/CXCL8-induced endothelial permeability. Mol Biol Cell. 2007;18:5014–23.

Repeke CE, Ferreira SJ, Vieira AE, et al. Dose-response met-RANTES treatment of experimental periodontitis: a narrow edge between the disease severity attenuation and infection control. Plos One. 2011;6:e22526.

Ellis M, al-Ramadi B, Hedstrom U, Frampton C, Alizadeh H, Kristensen J. Significance of the CC chemokine RANTES in patients with haematological malignancy: results from a prospective observational study. Br J Haematol. 2005;128:482–9.

Seynhaeve ALB, Vermeulen CE, Eggermont AMM, Hagen TLMT. Cytokines and vascular permeability: an in vitro study on human endothelial cells in relation to tumor necrosis factor-alpha-primed peripheral blood mononuclear cells. Cell Biochem Biophys. 2006;44:157–69.

Jin C, Liang M, Ning J, et al. Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model. Proc Natl Acad Sci USA. 2012;109:10053–8.

Suzuki T, Sato Y, Sano K, Arashiro T, Katano H, Nakajima N, Morikawa S, et al. Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections. J Clin Investig. 2020;130(2):799–812.

Zhang X, Liu Y, Zhao L, Li B, Yu H, Wen H, et al. An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV. Sci China Life Sci. 2013;56(8):697–700.

Li D. A highly pathogenic new bunyavirus emerged in China. Emerg Microbes Infect. 2013;2(1):1.

Goldsmith CS, Ksiazek TG, Rollin PE, et al. Cell culture and electron microscopy for identifying viruses in diseases of unknown cause. Emerg Infect Dis. 2013;19:886–91.

Sun Y, Liang M, Qu J, Jin C, Zhang Q, Li J, et al. Early diagnosis of novel SFTS bunyavirus infection by quantitative real-time RT-PCR assay. J Clin Virol. 2012;53(1):48–53.

Yang G, Li B, Liu L, Huang W, Zhang W, Liu Y, et al. Development and evaluation of a reverse transcription loop-mediated isothermal amplification assay for rapid detection of a new SFTS bunyavirus. Arch Virol. 2012;157(9):1779–83.

Li Z, Cui L, Zhou M, et al. Development and application of a one-step real-time RT-PCR using a minor-groove-binding probe for the detection of a novel bunyavirus in clinical specimens. J Med Virol. 2013;85:370–7.

Chi YY, Zhai SY, Wen HL, Cui F, Song YY, Wang L, et al. SFTSV RNA detection in seropositive patients. J Shandong Univ (Health Sci). 2012;50:118–21.

Li Z, Qi X, Zhou M, et al. A two-tube multiplex real-time RT-PCR assay for the detection of four hemorrhagic fever viruses: severe fever with thrombocytopenia syndrome virus, Hantaan virus, Seoul virus, and dengue virus. Arch Virol. 2013;158:1857–63.

Cui L, Ge Y, Qi X, Xu G, Li H, Zhao K, et al. Detection of severe fever with thrombocytopenia syndrome virus by reverse transcription-crosspriming amplification coupled with vertical flow visualization. J Clin Microbiol. 2012;50(12):3881–5.

Wu X, Qi X, Qu B, Zhang Z, Liang M, Li C, et al. Evasion of antiviral immunity through sequestering TBK1/IKKε/IRF3 into viral inclusion bodies. J Virol. 2014;88(6):3067–76.

Jiao Y, Zeng X, Guo X, et al. Preparation and evaluation of recombinant severe fever with thrombocytopenia syndrome virus nucleocapsid protein for detection of total antibodies in human and animal sera by double-antigen sandwich enzyme-linked immunosorbent assay. J Clin Microbiol. 2012;50:372–7.

Kim UJ, Kim DM, Ahn JH, Kang SJ, Jang HC, et al. Successful treatment of rapidly progressing severe fever with thrombocytopenia syndrome with neurological complications using intravenous immunoglobulin and corticosteroid. Antivir Ther. 2016;21:637–40.

Liu W, Lu QB, Cui N, Li H, Wang LY, et al. Case-fatality ratio and effectiveness of ribavirin therapy among hospitalized patients in china who had severe fever with thrombocytopenia syndrome. Clin Infect Dis. 2013;57:1292–9.

Xu R, Yang XY, Yang DF, Zou CY, Gong PL, Zeng FD. Phase I evaluation of the safety and pharmacokinetics of a single-dose intravenous injection of a murine monoclonal antibody against Hantaan virus in healthy volunteers. Antimicrob Agents Chemother. 2009;53:5055–9.

Winston DJ, Ho WG, Lin CH, et al. Intravenous immune globulin for prevention of cytomegalovirus infection and interstitial pneumonia after bone marrow transplantation. Ann Intern Med. 1987;106:12–8.

Lang J, Gravenstein S, Briggs D, et al. Evaluation of the safety and immunogenicity of a new, heat-treated human rabies immune globulin using a sham, post-exposure prophylaxis of rabies. Biologicals. 1998;26:7–15.

Casadevall A, Dadachova E, Pirofski LA. Passive antibody therapy for infectious diseases. Nat Rev Microbiol. 2004;2:695–703.

Guo X, Zhang L, Zhang W, et al. Human antibody neutralizes severe Fever with thrombocytopenia syndrome virus, an emerging hemorrhagic Fever virus. Clin Vaccine Immunol. 2013;20:1426–32.

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