A multiple-targets alkaloid nuciferine overcomes paclitaxel-induced drug resistance in vitro and in vivo

Abdallah, 2015, P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: a review, J. Adv. Res., 6, 45, 10.1016/j.jare.2014.11.008 Abrams, 2010, The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy, Cell Cycle, 9, 1781, 10.4161/cc.9.9.11483 Cen, 2016, Long-term alteration of reactive oxygen species led to multidrug resistance in MCF-7 cells, Oxidative Med. Cell. Longev., 2016, 10.1155/2016/7053451 Chen, 2018, Nuciferine alleviates LPS-induced mastitis in mice via suppressing the TLR4-NF-κB signaling pathway, Inflamm. Res., 67, 903, 10.1007/s00011-018-1183-2 Choi, 2014, ABC transporters in multidrug resistance and pharmacokinetics, and strategies for drug development, Curr. Pharm. Des., 20, 793, 10.2174/138161282005140214165212 Chou, 2006, Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies, Pharmacol. Rev., 58, 621, 10.1124/pr.58.3.10 Chou, 2010, Drug combination studies and their synergy quantification using the Chou-Talalay method, Cancer Res., 0008 Comerford, 2002, Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene, Cancer Res., 62, 3387 Dinić, 2015, New approaches with natural product drugs for overcoming multidrug resistance in cancer short running title: natural products and cancer MDR, Curr. Pharm. Des., 21, 10.2174/1381612821666151002113546 Elh, 2014, Integrated network-based medicine: the role of traditional Chinese medicine in developing a new generation of medicine, Science, 346, 1569 Feng, 2020, Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents, Acta Pharmaceut. Sinica B, 10, 327, 10.1016/j.apsb.2019.07.007 Feng, 2019, Nobiletin potentiates paclitaxel anticancer efficacy in A549/T xenograft model: pharmacokinetic and pharmacological study, Phytomedicine, 67 Garcia, 2009, PI3K/Akt inhibition modulates multidrug resistance and activates NF-kappaB in murine lymphoma cell lines, Leukemia Res., 33, 288, 10.1016/j.leukres.2008.06.010 Guo, 2017, Salvianolic acid B reverses multidrug resistance in HCT-8/VCR human colorectal cancer cells by increasing ROS levels, Mol. Med. Rep., 15, 724, 10.3892/mmr.2016.6049 Hayakawa, 2000, Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin, Cancer Res., 60, 5988 He, 2016, Hypoxia regulates ABCG2 activity through the activivation of ERK1/2/HIF-1α and contributes to chemoresistance in pancreatic cancer cells, Cancer Biol. Ther., 17, 188, 10.1080/15384047.2016.1139228 Hu, 2002, Inhibition of phosphatidylinositol 3′-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models, Cancer Res., 62, 1087 Huang, 2009, Induction of Akt activity by chemotherapy confers acquired resistance, J. Formos. Med. Asso. = Taiwan yi zhi, 108, 180, 10.1016/S0929-6646(09)60051-6 Katayama, 2007, Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein, Mol. Cancer Ther., 6, 2092, 10.1158/1535-7163.MCT-07-0148 Krajka-Kuźniak, 2017, The Nrf2-ARE signaling pathway: an update on its regulation and possible role in cancer prevention and treatment, Pharmacol. Rep., 69, 393, 10.1016/j.pharep.2016.12.011 Krishna, 2000, Multidrug resistance (MDR) in cancer: Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs, Eur. J. Pharm. Sci., 11, 265, 10.1016/S0928-0987(00)00114-7 Krishnamurthy, 2006, Role of ABCG2/BCRP in biology and medicine, Ann. Rev. Pharmacol. Toxicol., 46, 381, 10.1146/annurev.pharmtox.46.120604.141238 Kung, 2016, Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia, Oncotarget, 7 Lee, 2007, A high nuclear basal level of ERK2 phosphorylation contributes to the resistance of cisplatin-resistant human ovarian cancer cells, Gynecol. Oncol., 104, 338, 10.1016/j.ygyno.2006.08.040 Li, 2019, Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway, J. Exp. Clin. Cancer Res., 38, 139, 10.1186/s13046-019-1134-y Ma, 2015, Nobiletin enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cancer cells, Sci. Rep., 5, 18789, 10.1038/srep18789 Ma, 2015, Nobiletin enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cancer cells, Sci. Rep., 5, 18789, 10.1038/srep18789 Mabuchi, 2002, Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel, J. Biol. Chem., 277, 33490, 10.1074/jbc.M204042200 Mansoori, 2017, The different mechanisms of cancer drug resistance: a brief review, Adv. Pharm. Bull., 7, 339, 10.15171/apb.2017.041 Mehta, 2016, A comprehensive review on pharmacokinetic profile of some traditional Chinese medicines, New J. Sci., 2016, 10.1155/2016/7830367 Mehta, 2017, Pharmacokinetic behaviour of clinically important TCM prescriptions, Orient. Pharm. Exp. Med., 17, 171, 10.1007/s13596-017-0281-y Mehta, 2015, Pharmacokinetic profile of phytoconstituent(s) isolated from medicinal plants—a comprehensive review, J. Tradit. Complement. Med., 5, 207, 10.1016/j.jtcme.2014.11.041 No, 2014, Targeting nrf2 signaling to combat chemoresistance, J. Cancer Prevent., 19, 111, 10.15430/JCP.2014.19.2.111 Ohta, 2006, Inhibition of phosphatidylinositol 3-kinase increases efficacy of cisplatin in in vivo ovarian cancer models, Endocrinology, 147, 1761, 10.1210/en.2005-1450 Persons, 1999, Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin, Clin. Cancer Res., 5, 1007 Pluchino, 2012, Collateral sensitivity as a strategy against cancer multidrug resistance, Drug Resist. Updates, 15, 98, 10.1016/j.drup.2012.03.002 Rojo de la Vega, 2018, NRF2 and the hallmarks of cancer, Cancer Cell, 34, 21, 10.1016/j.ccell.2018.03.022 Roncuzzi, 2014, Involvement of HIF-1alpha activation in the doxorubicin resistance of human osteosarcoma cells, Oncol. Rep., 32, 389, 10.3892/or.2014.3181 Sadeghi, 2018, Nrf2/P-glycoprotein axis is associated with clinicopathological characteristics in colorectal cancer, Biomed. Pharmacother. = Biomed. Pharmacother., 104, 458, 10.1016/j.biopha.2018.05.062 Shu, 2019, Nuciferine alleviates acute alcohol-induced liver injury in mice: Roles of suppressing hepatic oxidative stress and inflammation via modulating miR-144/Nrf2/HO-1 cascade, J. Funct. Foods, 58, 105, 10.1016/j.jff.2019.04.055 Singh, 2010, Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype, Mol. Cancer Ther., 9, 2365, 10.1158/1535-7163.MCT-10-0108 Smorodinsky-Atias, 2020, Mutations that confer drug-resistance, oncogenicity and intrinsic activity on the ERK MAP kinases-current state of the art, Cells, 9, 10.3390/cells9010129 Tamaki, 2011, The controversial role of ABC transporters in clinical oncology, Essays Biochem., 50, 209, 10.1042/bse0500209 Wang, 2016, HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway, Int. J. Oncol., 49, 2529, 10.3892/ijo.2016.3738 Wang, 2008, Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2, Carcinogenesis, 29, 1235, 10.1093/carcin/bgn095 Wong, 2006, Role of the PI3K/Akt pathway in promoting drug resistance of human pancreatic cells, Cancer Res., 66 Wu, 2011, Discovering natural product modulators to overcome multidrug resistance in cancer chemotherapy, Curr. Pharm. Biotechnol., 12, 609, 10.2174/138920111795163887 Xie, S., Wang, Y., Tang, Y., Lu, P., Tian, C., Dai, R.J.J.G.P.C., 2010. Study on absolute bioavailability of nuciferine in rats. 26, 17-19. Ye, 2014, Identification and characterization of potent CYP2D6 inhibitors in lotus leaves, J. Ethnopharmacol., 153, 190, 10.1016/j.jep.2014.02.014 Zhang, 2018, Nuciferine Inhibits Proinflammatory Cytokines via the PPARs in LPS-Induced RAW264. 7 Cells, Molecules, 23, 2723, 10.3390/molecules23102723 Zhang, 2020, The PI3K subunits, P110α; and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer, Mol. Cancer, 19, 10, 10.1186/s12943-019-1112-1 Zhou, 2019, YAP Inhibition by Nuciferine via AMPK-Mediated Downregulation of HMGCR Sensitizes Pancreatic Cancer Cells to Gemcitabine, Biomolecules, 9, 620, 10.3390/biom9100620